LOCUS       NM_016641               2907 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens glycerophosphodiester phosphodiesterase 1 (GDE1),
            transcript variant 1, mRNA.
ACCESSION   NM_016641
VERSION     NM_016641.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2907)
  AUTHORS   Lacedonia,D., Scioscia,G., Soccio,P., Conese,M., Catucci,L.,
            Palladino,G.P., Simone,F., Quarato,C.M.I., Di Gioia,S., Rana,R.,
            Sollitto,F. and Foschino-Barbaro,M.P.
  TITLE     Downregulation of exosomal let-7d and miR-16 in idiopathic
            pulmonary fibrosis
  JOURNAL   BMC Pulm Med 21 (1), 188 (2021)
   PUBMED   34088304
  REMARK    GeneRIF: Downregulation of exosomal let-7d and miR-16 in idiopathic
            pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2907)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2907)
  AUTHORS   Zheng,Y., Li,L., Gao,Q., Niu,B. and Wang,H.
  TITLE     Solanine inhibits proliferation and promotes apoptosis of the human
            leukemia cells by targeting the miR-16/Bcl-2 axis
  JOURNAL   J BUON 25 (3), 1614-1618 (2020)
   PUBMED   32862612
  REMARK    GeneRIF: Solanine inhibits proliferation and promotes apoptosis of
            the human leukemia cells by targeting the miR-16/Bcl-2 axis.
REFERENCE   4  (bases 1 to 2907)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2907)
  AUTHORS   Xie,F., Xie,G. and Sun,Q.
  TITLE     Long Noncoding RNA DLX6-AS1 Promotes the Progression in Cervical
            Cancer by Targeting miR-16-5p/ARPP19 Axis
  JOURNAL   Cancer Biother Radiopharm 35 (2), 129-136 (2020)
   PUBMED   32077747
  REMARK    GeneRIF: Long Noncoding RNA DLX6-AS1 Promotes the Progression in
            Cervical Cancer by Targeting miR-16-5p/ARPP19 Axis.
REFERENCE   6  (bases 1 to 2907)
  AUTHORS   Ma,J., Dempsey,A.A., Stamatiou,D., Marshall,K.W. and Liew,C.C.
  TITLE     Identifying leukocyte gene expression patterns associated with
            plasma lipid levels in human subjects
  JOURNAL   Atherosclerosis 191 (1), 63-72 (2007)
   PUBMED   16806233
REFERENCE   7  (bases 1 to 2907)
  AUTHORS   Bachmann,A.S., Duennebier,F.F. and Mocz,G.
  TITLE     Genomic organization, characterization, and molecular 3D model of
            GDE1, a novel mammalian glycerophosphoinositol phosphodiesterase
  JOURNAL   Gene 371 (1), 144-153 (2006)
   PUBMED   16472945
REFERENCE   8  (bases 1 to 2907)
  AUTHORS   Zheng,B., Berrie,C.P., Corda,D. and Farquhar,M.G.
  TITLE     GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated
            by stimulation of G protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 100 (4), 1745-1750 (2003)
   PUBMED   12576545
  REMARK    GeneRIF: regulation by by stimulation of G protein-coupled
            receptors
REFERENCE   9  (bases 1 to 2907)
  AUTHORS   Zheng,B., Chen,D. and Farquhar,M.G.
  TITLE     MIR16, a putative membrane glycerophosphodiester phosphodiesterase,
            interacts with RGS16
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 3999-4004 (2000)
   PUBMED   10760272
REFERENCE   10 (bases 1 to 2907)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ897064.1, BC012153.1 and AF306698.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016641.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF306698.1, SRR1803614.58978.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000353258.8/ ENSP00000261386.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-722               BQ897064.1         31-752
            723-2217            BC012153.1         705-2199
            2218-2907           AF306698.1         2152-2841
FEATURES             Location/Qualifiers
     source          1..2907
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..2907
                     /gene="GDE1"
                     /gene_synonym="363E6.2; MIR16"
                     /note="glycerophosphodiester phosphodiesterase 1"
                     /db_xref="GeneID:51573"
                     /db_xref="HGNC:HGNC:29644"
                     /db_xref="MIM:605943"
     exon            1..395
                     /gene="GDE1"
                     /gene_synonym="363E6.2; MIR16"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1130
                     /gene="GDE1"
                     /gene_synonym="363E6.2; MIR16"
                     /EC_number="3.1.4.44"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RGS16-interacting membrane protein; membrane interacting
                     protein of RGS16; lysophospholipase D GDE1;
                     glycerophosphoinositol glycerophosphodiesterase GDE1"
                     /codon_start=1
                     /product="glycerophosphodiester phosphodiesterase 1
                     isoform 1"
                     /protein_id="NP_057725.1"
                     /db_xref="CCDS:CCDS10578.1"
                     /db_xref="GeneID:51573"
                     /db_xref="HGNC:HGNC:29644"
                     /db_xref="MIM:605943"
                     /translation="MWLWEDQGGLLGPFSFLLLVLLLVTRSPVNACLLTGSLFVLLRV
                     FSFEPVPSCRALQVLKPRDRISAIAHRGGSHDAPENTLAAIRQAAKNGATGVELDIEF
                     TSDGIPVLMHDNTVDRTTDGTGRLCDLTFEQIRKLNPAANHRLRNDFPDEKIPTLREA
                     VAECLNHNLTIFFDVKGHAHKATEALKKMYMEFPQLYNNSVVCSFLPEVIYKMRQTDR
                     DVITALTHRPWSLSHTGDGKPRYDTFWKHFIFVMMDILLDWSMHNILWYLCGISAFLM
                     QKDFVSPAYLKKWSAKGIQVVGWTVNTFDEKSYYESHLGSSYITDSMVEDCEPHF"
     exon            396..571
                     /gene="GDE1"
                     /gene_synonym="363E6.2; MIR16"
                     /inference="alignment:Splign:2.1.0"
     exon            572..677
                     /gene="GDE1"
                     /gene_synonym="363E6.2; MIR16"
                     /inference="alignment:Splign:2.1.0"
     exon            678..770
                     /gene="GDE1"
                     /gene_synonym="363E6.2; MIR16"
                     /inference="alignment:Splign:2.1.0"
     exon            771..982
                     /gene="GDE1"
                     /gene_synonym="363E6.2; MIR16"
                     /inference="alignment:Splign:2.1.0"
     exon            983..2907
                     /gene="GDE1"
                     /gene_synonym="363E6.2; MIR16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1587..1592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GDE1"
                     /gene_synonym="363E6.2; MIR16"
                     /note="hexamer: ATTAAA"
     polyA_site      1610
                     /gene="GDE1"
                     /gene_synonym="363E6.2; MIR16"
                     /note="major polyA site"
     regulatory      2882..2887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GDE1"
                     /gene_synonym="363E6.2; MIR16"
                     /note="hexamer: AACAAA"
     polyA_site      2907
                     /gene="GDE1"
                     /gene_synonym="363E6.2; MIR16"
                     /note="major polyA site"
ORIGIN      
        1 attgtgcggc gctggtcccc tcagagggtt cctgctgctg ccggtgcctt ggaccctccc
       61 cctcgcttct cgttctactg ccccaggagc ccggcgggtc cgggactccc gtccgtgccg
      121 gtgcgggcgc cggcatgtgg ctgtgggagg accagggcgg cctcctgggc cctttctcct
      181 tcctgctgct agtgctgctg ctggtgacgc ggagcccggt caatgcctgc ctcctcaccg
      241 gcagcctctt cgttctactg cgcgtcttca gctttgagcc ggtgccctct tgcagggccc
      301 tgcaggtgct caagccccgg gaccgcattt ctgccatcgc ccaccgtggc ggcagccacg
      361 acgcgcccga gaacacgctg gcggccattc ggcaggcagc taagaatgga gcaacaggcg
      421 tggagttgga cattgagttt acttctgacg ggattcctgt cttaatgcac gataacacag
      481 tagataggac gactgatggg actgggcgat tgtgtgattt gacatttgaa caaattagga
      541 agctgaatcc tgcagcaaac cacagactca ggaatgattt ccctgatgaa aagatcccta
      601 ccctaaggga agctgttgca gagtgcctaa accataacct cacaatcttc tttgatgtca
      661 aaggccatgc acacaaggct actgaggctc taaagaaaat gtatatggaa tttcctcaac
      721 tgtataataa tagtgtggtc tgttctttct tgccagaagt tatctacaag atgagacaaa
      781 cagatcggga tgtaataaca gcattaactc acagaccttg gagcctaagc catacaggag
      841 atgggaaacc acgctatgat actttctgga aacattttat atttgttatg atggacattt
      901 tgctcgattg gagcatgcat aatatcttgt ggtacctgtg tggaatttca gctttcctca
      961 tgcaaaagga ttttgtatcc ccggcctact tgaagaagtg gtcagctaaa ggaatccagg
     1021 ttgttggttg gactgttaat acctttgatg aaaagagtta ctacgaatcc catcttggtt
     1081 ccagctatat cactgacagc atggtagaag actgcgaacc tcacttctag actttcacgg
     1141 tgggacgaaa cgggttcaga aactgccagg ggcctcatac agggatatca aaataccctt
     1201 tgtgctagcc caggccctgg ggaatcaggt gactcacaca aatgcaatag ttggtcactg
     1261 catttttacc tgaaccaaag ctaaacccgg tgttgccacc atgcaccatg gcatgccaga
     1321 gttcaacact gttgctcttg aaaatctggg tctgaaaaaa cgcacaagag cccctgccct
     1381 gccctagctg aggcacacag ggagacccag tgaggataag cacagattga attgtacagt
     1441 ttgcagatgc agatgtaaat gcatgggaca tgcatgataa ctcagagttg acattttaaa
     1501 acttgccaca cttatttcaa atatttgtac tcagctatgt taacatgtac tgtagacatc
     1561 aaacttgtgg ccatactaat aaaattatta aaaggagcac taaaggaaaa ctgtgtgcca
     1621 agcatcatat cctaaggcat acggaatttg gggaagccac catgcaatcc agtgaggctt
     1681 cagtgtacag caaccaaaat ggtagggagg tcttgaagcc aatgagggat ttatagcatc
     1741 ttgaatagag agctgcaaac caccaggggg cagagttgca tttttccagg ctttttagga
     1801 agctctgcaa cagatgtgat ctgatcatag gcaattagaa ctggaagaaa cttccaaaaa
     1861 tatctaggtt tgtcctcatt ttacaaatga ggaaactaaa ctctgtggaa gggaaggggt
     1921 tgcctcaaaa gtcacagctt agctgggcac agtggctcat gccgataatc ccagcaattc
     1981 agaaagctga ggcaggagga ttacttgagg ccagactggg caatatagca agaccccatc
     2041 tctaaaaaat taggcatggt ggtgcatgcc tgtattccca gctactcagg aggttgaggt
     2101 gggaggatca cttgagccca gaagttcaag gctgcaatga gccatgatta caccacggca
     2161 ctacaacctt ggtggcacag tgagaacctg actcttaaaa aaaaaaaaaa aaaaaaaaaa
     2221 aaaaagataa ctagaacttc tagaacatct tgtttacagt tagccagaaa ctatacaagt
     2281 ggtttaacat gcattatctt actcaatcca tacaaaagtc ttatggaggt gttagcactc
     2341 tttctactga tgaagaactg aggtacttca taaaaccact tacccaaggt gtcttgagtc
     2401 tggtacaact ggcattcaaa tctaggtcag tctgccccca gagccactac ccttacccct
     2461 cactgaatct gcctttatat tgttgagccc atgaccccaa actgctcttt ccaatttgaa
     2521 cttccaggga ttttattgtg aacttacata gcaacattaa aatgaagttg aattgttttt
     2581 aatggcaacg ccgtctgtct cctctagctt accgcttctc acctttcaac cccatctgtg
     2641 gcctttgtcc aggcccacag cttagccatg gcttccctcc tgcatccctg ccgtgggttg
     2701 ctggcctcac acttgcagca gctggacagt gattttagaa ggccaccagt ccccatagct
     2761 atgtgacaat gagaagcaaa cttttttgtg acagattgta ttggcatagg catgatagat
     2821 ggggattggt acgttttgaa tcagcatttg caaaaaaatt gtcttgaatt ttaaaataaa
     2881 caacaaagat ttgttcattg agtgcaa
//
