LOCUS       NM_145278               3774 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens germinal center associated signaling and motility like
            (GCSAML), transcript variant 1, mRNA.
ACCESSION   NM_145278
VERSION     NM_145278.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3774)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3774)
  AUTHORS   de Sa Machado Araujo,G., da Silva Francisco Junior,R., Dos Santos
            Ferreira,C., Mozer Rodrigues,P.T., Terra Machado,D., Louvain de
            Souza,T., Teixeira de Souza,J., Figueiredo Osorio da Silva,C.,
            Alves da Silva,A.F., Andrade,C.C.F., da Silva,A.T., Ramos,V.,
            Garcia,A.B., Machado,F.B. and Medina-Acosta,E.
  TITLE     Maternal 5mCpG Imprints at the PARD6G-AS1 and GCSAML Differentially
            Methylated Regions Are Decoupled From Parent-of-Origin Expression
            Effects in Multiple Human Tissues
  JOURNAL   Front Genet 9, 36 (2018)
   PUBMED   29545821
  REMARK    GeneRIF: Maternal 5mCpG imprints at the GCSAML somatic (secondary)
            differentially methylated region (iDMR) are decoupled from
            parent-of-origin expression effects in multiple human tissues.
            Despite the constitutive methylation asymmetry observed for the
            parental alleles at the iDMR, GCSAML was expressed biallelically in
            five tissues: visceral adipose tissue, brain - cerebellar
            hemisphere, brain cerebellum, prostate, and testis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3774)
  AUTHORS   Gieger,C., Radhakrishnan,A., Cvejic,A., Tang,W., Porcu,E.,
            Pistis,G., Serbanovic-Canic,J., Elling,U., Goodall,A.H.,
            Labrune,Y., Lopez,L.M., Magi,R., Meacham,S., Okada,Y., Pirastu,N.,
            Sorice,R., Teumer,A., Voss,K., Zhang,W., Ramirez-Solis,R.,
            Bis,J.C., Ellinghaus,D., Gogele,M., Hottenga,J.J., Langenberg,C.,
            Kovacs,P., O'Reilly,P.F., Shin,S.Y., Esko,T., Hartiala,J.,
            Kanoni,S., Murgia,F., Parsa,A., Stephens,J., van der Harst,P.,
            Ellen van der Schoot,C., Allayee,H., Attwood,A., Balkau,B.,
            Bastardot,F., Basu,S., Baumeister,S.E., Biino,G., Bomba,L.,
            Bonnefond,A., Cambien,F., Chambers,J.C., Cucca,F., D'Adamo,P.,
            Davies,G., de Boer,R.A., de Geus,E.J., Doring,A., Elliott,P.,
            Erdmann,J., Evans,D.M., Falchi,M., Feng,W., Folsom,A.R.,
            Frazer,I.H., Gibson,Q.D., Glazer,N.L., Hammond,C.,
            Hartikainen,A.L., Heckbert,S.R., Hengstenberg,C., Hersch,M.,
            Illig,T., Loos,R.J., Jolley,J., Khaw,K.T., Kuhnel,B.,
            Kyrtsonis,M.C., Lagou,V., Lloyd-Jones,H., Lumley,T., Mangino,M.,
            Maschio,A., Mateo Leach,I., McKnight,B., Memari,Y., Mitchell,B.D.,
            Montgomery,G.W., Nakamura,Y., Nauck,M., Navis,G., Nothlings,U.,
            Nolte,I.M., Porteous,D.J., Pouta,A., Pramstaller,P.P., Pullat,J.,
            Ring,S.M., Rotter,J.I., Ruggiero,D., Ruokonen,A., Sala,C.,
            Samani,N.J., Sambrook,J., Schlessinger,D., Schreiber,S.,
            Schunkert,H., Scott,J., Smith,N.L., Snieder,H., Starr,J.M.,
            Stumvoll,M., Takahashi,A., Tang,W.H., Taylor,K., Tenesa,A., Lay
            Thein,S., Tonjes,A., Uda,M., Ulivi,S., van Veldhuisen,D.J.,
            Visscher,P.M., Volker,U., Wichmann,H.E., Wiggins,K.L.,
            Willemsen,G., Yang,T.P., Hua Zhao,J., Zitting,P., Bradley,J.R.,
            Dedoussis,G.V., Gasparini,P., Hazen,S.L., Metspalu,A., Pirastu,M.,
            Shuldiner,A.R., Joost van Pelt,L., Zwaginga,J.J., Boomsma,D.I.,
            Deary,I.J., Franke,A., Froguel,P., Ganesh,S.K., Jarvelin,M.R.,
            Martin,N.G., Meisinger,C., Psaty,B.M., Spector,T.D., Wareham,N.J.,
            Akkerman,J.W., Ciullo,M., Deloukas,P., Greinacher,A., Jupe,S.,
            Kamatani,N., Khadake,J., Kooner,J.S., Penninger,J., Prokopenko,I.,
            Stemple,D., Toniolo,D., Wernisch,L., Sanna,S., Hicks,A.A.,
            Rendon,A., Ferreira,M.A., Ouwehand,W.H. and Soranzo,N.
  TITLE     New gene functions in megakaryopoiesis and platelet formation
  JOURNAL   Nature 480 (7376), 201-208 (2011)
   PUBMED   22139419
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3774)
  AUTHORS   Trevino,L.R., Yang,W., French,D., Hunger,S.P., Carroll,W.L.,
            Devidas,M., Willman,C., Neale,G., Downing,J., Raimondi,S.C.,
            Pui,C.H., Evans,W.E. and Relling,M.V.
  TITLE     Germline genomic variants associated with childhood acute
            lymphoblastic leukemia
  JOURNAL   Nat Genet 41 (9), 1001-1005 (2009)
   PUBMED   19684603
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK124520.1, BC024174.1,
            AL606804.11 and BU852381.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145278.4.
            
            Summary: This gene encodes a protein thought to be a signaling
            molecule associated with germinal centers, the sites of
            proliferation and differentiation of mature B lymphocytes.
            Alternate splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). The 5' UTR splicing pattern has not been determined for this
            variant. Variants 1 and 7 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.75240.1, BC024174.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366488.5/ ENSP00000355444.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AK124520.1         440-454
            16-653              BC024174.1         5-642
            654-654             AL606804.11        132510-132510
            655-2641            BC024174.1         644-2630
            2642-3737           AL606804.11        134498-135593
            3738-3774           BU852381.1         679-715
FEATURES             Location/Qualifiers
     source          1..3774
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..3774
                     /gene="GCSAML"
                     /gene_synonym="C1orf150"
                     /note="germinal center associated signaling and motility
                     like"
                     /db_xref="GeneID:148823"
                     /db_xref="HGNC:HGNC:29583"
     exon            1..87
                     /gene="GCSAML"
                     /gene_synonym="C1orf150"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..466
                     /gene="GCSAML"
                     /gene_synonym="C1orf150"
                     /note="isoform a is encoded by transcript variant 1;
                     germinal center-associated signaling and motility-like
                     protein"
                     /codon_start=1
                     /product="germinal center-associated signaling and
                     motility-like protein isoform a"
                     /protein_id="NP_660321.1"
                     /db_xref="CCDS:CCDS1635.1"
                     /db_xref="GeneID:148823"
                     /db_xref="HGNC:HGNC:29583"
                     /translation="MGNYLLRKLSCLGENQKKPKKGNPDEERKRQEMTTFERKLQDQD
                     KKSQEVSSTSNQENENGSGSEEVCYTVINHIPHQRSSLSSNDDGYENIDSLTRKVRQF
                     RERSETEYALLRTSVSRPCSCTHEHDYEVVFPH"
     exon            88..147
                     /gene="GCSAML"
                     /gene_synonym="C1orf150"
                     /inference="alignment:Splign:2.1.0"
     exon            148..197
                     /gene="GCSAML"
                     /gene_synonym="C1orf150"
                     /inference="alignment:Splign:2.1.0"
     exon            198..226
                     /gene="GCSAML"
                     /gene_synonym="C1orf150"
                     /inference="alignment:Splign:2.1.0"
     exon            227..3774
                     /gene="GCSAML"
                     /gene_synonym="C1orf150"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3733..3738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GCSAML"
                     /gene_synonym="C1orf150"
                     /note="hexamer: AATAAA"
     regulatory      3752..3757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GCSAML"
                     /gene_synonym="C1orf150"
                     /note="hexamer: AATAAA"
     polyA_site      3753
                     /gene="GCSAML"
                     /gene_synonym="C1orf150"
                     /note="major polyA site"
     polyA_site      3774
                     /gene="GCSAML"
                     /gene_synonym="C1orf150"
ORIGIN      
        1 agaacttccc caagtggagt gaaactcagg agctgagaaa ccgagtcact gtgaaaagat
       61 gggaaattat ctcctgcgaa aactcagttg cctgggagag aatcaaaaga agcccaagaa
      121 aggaaaccca gatgaggaaa gaaaacggca ggaaatgact acatttgaaa gaaaacttca
      181 agatcaagat aagaaaagcc aagaagtttc atccacttct aatcaggaaa acgagaatgg
      241 cagtggttct gaagaagtgt gctacactgt cattaatcac atcccccatc agagatcctc
      301 cctgagctcc aatgatgatg gctatgagaa cattgactcc ctcacaagga aagtgagaca
      361 gtttagagaa aggtcagaga cagaatatgc ccttcttagg acttctgtta gtaggccttg
      421 ttcctgcacc catgagcatg attatgaagt tgtgtttcca cactaaaatc ctcaagctgc
      481 tttatcacct tccagcaatg aagacaatgc agaatagcag actctggcga agttgttcac
      541 cctgagcagt gcatgaaaca ttcctttctg gctaaagttt agaaatatta tcttattata
      601 tatccttagg caactctgat atgtggcatc tctgtggctt aggtgaaatc atagaaattg
      661 acacaatgac ctaaaatatt ctatgtgttt ttgcttgtaa agtttgagga catggaggtg
      721 ataaaaaaaa ctttcttagg acaataatgt aaaatgaaaa taaatttcta atccccctga
      781 ctaactgaat ggaccctctt ctaggccaaa gagacctcag atgaacctga aagactgaat
      841 tctggccatg ataggaaggg aggtgagaca caccttgtta taccccttcc cttttggagt
      901 ttatgcacaa gtgaccagga tgagtcataa gactgatgaa atagactgat tgtggcaata
      961 agagtcccaa ttccaacctg actctggtgt agatcacaca ctgtctgagg gattccatct
     1021 atgagacttt gtctacataa cagagacctt ggtttccaca acccctttat tttagctaaa
     1081 gcattctttt ctactgactt cttaagtctt tagacaaagc ttaactcttt caaccaattg
     1141 ccaatcagac aaactttgaa tctacctatg acctgtaagc tctctcctgc ttcaagatct
     1201 tgcctcttta agctgaaccg atgtgcactt tccatttaat gatttatgtc tttgcttgta
     1261 actcctgtct ccctaaaatg tataaaagta aacggtgacc tgaccacctc aggcacactt
     1321 tctcaggacc tcctgagagt gtatcccagg ccatggtaag tcatgttggc tcagaatcaa
     1381 cctctttaaa tattttacag aatttgggtt ttggttacca ataagtctcc acaaatatat
     1441 gtccaagaat cttcaattcc aagcctgctc accaaatttc aaatgccaac atctccccat
     1501 ccaattacct atttcatctt tgaggtgtaa tctactcaat aaactgtgta agaccagtga
     1561 ccagaccctt tgctaacctg acatttactt caatttttct ttttctatgt actggatatt
     1621 tttgcatata aacttgcagt aatagttcaa aaattaatag tttttgacat tggcttttct
     1681 gagaagagaa attgaaagtg tcacaaaata aaaaaagatg aaatgaagca tatataattg
     1741 tcaatttttt caattttcta gccaacagag aatcgaagga ttctgttcaa atattagtaa
     1801 aaattgaaaa taaacttgtg cttatatttt gtttgcaaca cactagttaa tttaacctgt
     1861 gactagttat ctctaccgaa ggtggatgtg tagtttctgg ttttaaaatt caagcaaact
     1921 ggaaaataat ccatctaatt atgctttctt tcccaagaag ttttttaatg atatgccagc
     1981 ttcctaattt ggagacaaaa gccttaattg acaatgcatt cattatatat ttttttgtat
     2041 agttacagta tacgagttga gtatccctta gatgagatgc ttgggaccag aagtgttttg
     2101 gatttcagat ttatttttgg attttggaat atttccatac atataatgag agagttggaa
     2161 aatgggattc aagtctaatc ataaaattca cttatgtttg atatacacct tatctgaata
     2221 gcctgaaggt aattttatac aatattttaa ataattttat gcctgaaaca gagtttgcgc
     2281 acattggacc atcagaaagc agaagtgtca ctatttcaag tcagtgctca aaaagtttca
     2341 gatgttaagc tggtgatgca gttcatgcca gtgatccgag tactttggga agccaagaca
     2401 ggtggatctc ttgagcccag gagtttgagg ccagactgca caacacagtg agacctcgtt
     2461 tctacaaata attaaaaaat tagccaggtg tggtggtgca cacctgtagt cccaggtact
     2521 caggaggctg aggtagtagg attgtttgag actgggaggt tgaggctgaa ctgagccagg
     2581 atcttgccac cacattccag cttgggcaac agagtgagac cctgtctcaa aaaaaaaaaa
     2641 agtttcagat tttggagcat ttcagatctt cagattaggg attttcaacc tgtactgacc
     2701 ttttagtcat tgacaagcat taatcaatag gtggactcca gataactcat ttgctgtata
     2761 cacattttgc ctctctattc aacgaattct tatgccctct tgtggtgatt ttaatgtgcg
     2821 gaagggaaac aatagaaatt ttgcaattct agaaaagtca ttctgtcaaa atatgtcagt
     2881 cctgtagata ttagccaatt ttaggaaaat gacaaaattt tttacttttc gtctgccttt
     2941 gtagctgttt tatgatataa ataccttatt tgtaataaaa ttaattttaa tttgagtaac
     3001 aatctggaat tatcagagaa ggggcaagca ataggttaat aaacagtatt gattggtaga
     3061 aggaacgttg aaatccaaga gcatcaatgt cttctggtgg ttcaccataa gccacagcag
     3121 atgtcttaat ctttccgaga tctagttttt cagcaaagca ggatttaaga aatgtaacta
     3181 tcttatgtgg ttatgaagaa caatagaatc attgctgtat aagtgctttt taacctgtaa
     3241 attttgtgaa gcttatcttt tatgcatata aatatttgaa cattttacat tgtttatatt
     3301 tttaatcagt tttactcaag tgtgattata tacaagaaaa tgtaaccact gtaagggtag
     3361 agttataaga attttgtcaa atgtattcac ccatgtagtc acctccttat gaagagacag
     3421 aacacgtaca tcctcccaga aagttccaca gtgctccttt tccctgagtt tcaccagtcc
     3481 tggcaaccaa tgatctgctt cgtataatta taactgttct agatatttgt agcaatgtac
     3541 cctttccata tttattttgt gtgtgtaagg cttcttttag tcattataat atttttgaga
     3601 ttcatctatg tttaatgttc tatcagtagt tgtacatctt acttgtctca gcatatcacc
     3661 atatagatat actataattt gttaatctaa tcactgatgg atatgtagga tatttaagtt
     3721 tttgacatta tgaataaagt ggctataaat gaataaagcg actacaaatt tgaa
//
