LOCUS       NM_001285900            5307 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens GCOM1, MYZAP-POLR2M combined locus (GCOM1), transcript
            variant 14, mRNA.
ACCESSION   NM_001285900
VERSION     NM_001285900.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5307)
  AUTHORS   Roginski,R.S., Lau,C.W., Santoiemma,P.P., Weaver,S.J., Du,P.,
            Soteropoulos,P. and Yang,J.
  TITLE     The human GCOM1 complex gene interacts with the NMDA receptor and
            internexin-alpha
  JOURNAL   Gene 648, 42-53 (2018)
   PUBMED   29339073
  REMARK    GeneRIF: Yeast two-hybrid (Y2H) screens indicate 27 novel GRINL1A
            complex locus 1 (GCOM1) interacting genes, many of which are
            synaptic proteins and/or play roles in neurologic diseases.
REFERENCE   2  (bases 1 to 5307)
  AUTHORS   Seeger,T.S., Frank,D., Rohr,C., Will,R., Just,S., Grund,C.,
            Lyon,R., Luedde,M., Koegl,M., Sheikh,F., Rottbauer,W., Franke,W.W.,
            Katus,H.A., Olson,E.N. and Frey,N.
  TITLE     Myozap, a novel intercalated disc protein, activates serum response
            factor-dependent signaling and is required to maintain cardiac
            function in vivo
  JOURNAL   Circ Res 106 (5), 880-890 (2010)
   PUBMED   20093627
  REMARK    GeneRIF: Reveal myozap as a previously unrecognized component of a
            Rho-dependent signaling pathway that links the intercalated disc to
            cardiac gene regulation.
REFERENCE   3  (bases 1 to 5307)
  AUTHORS   Roginski,R.S., Goubaeva,F., Mikami,M., Fried-Cassorla,E., Nair,M.R.
            and Yang,J.
  TITLE     GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit
            and reduces N-methyl D-aspartate toxicity
  JOURNAL   Neuroreport 19 (17), 1721-1726 (2008)
   PUBMED   18849881
REFERENCE   4  (bases 1 to 5307)
  AUTHORS   Guinn,B.A., Bland,E.A., Lodi,U., Liggins,A.P., Tobal,K.,
            Petters,S., Wells,J.W., Banham,A.H. and Mufti,G.J.
  TITLE     Humoral detection of leukaemia-associated antigens in presentation
            acute myeloid leukaemia
  JOURNAL   Biochem Biophys Res Commun 335 (4), 1293-1304 (2005)
   PUBMED   16112646
REFERENCE   5  (bases 1 to 5307)
  AUTHORS   Roginski,R.S., Mohan Raj,B.K., Birditt,B. and Rowen,L.
  TITLE     The human GRINL1A gene defines a complex transcription unit, an
            unusual form of gene organization in eukaryotes
  JOURNAL   Genomics 84 (2), 265-276 (2004)
   PUBMED   15233991
  REMARK    GeneRIF: genetic and transcriptional organization of gene
REFERENCE   6  (bases 1 to 5307)
  AUTHORS   Roginski,R.S., Mohan Raj,B.K., Finkernagel,S.W. and Sciorra,L.J.
  TITLE     Assignment of an ionotropic glutamate receptor-like gene (GRINL1A)
            to human chromosome 15q22.1 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 93 (1-2), 143-144 (2001)
   PUBMED   11474202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025271.7, JF419331.1, AC090651.3 and KF456061.1.
            
            On Mar 12, 2014 this sequence version replaced NM_001285900.2.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring MYZAP (myocardial zonula
            adherens protein) and POLR2M (polymerase (RNA) II (DNA directed)
            polypeptide M) genes on chromosome 15. Alternative splicing results
            in multiple readthrough transcript variants. Readthrough variants
            may encode proteins that share sequence identity with the upstream
            gene product or with both the upstream and downstream gene
            products. Some readthrough transcript variants are also expected to
            be candidates for nonsense-mediated decay (NMD). [provided by
            RefSeq, Oct 2013].
            
            Transcript Variant: This variant (14, also known as Gcom15B)
            contains an alternate in-frame exon in the 3' coding region,
            compared to variant 1. The resulting isoform (3) is longer than
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JF419331.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 81488,
                                      100820829
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AC025271.7         157230-157339
            111-655             JF419331.1         1-545
            656-656             AC090651.3         7601-7601
            657-1387            JF419331.1         547-1277
            1388-1388           KF456061.1         195-195
            1389-2439           JF419331.1         1279-2329
            2440-5307           AC090651.3         96399-99266
FEATURES             Location/Qualifiers
     source          1..5307
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..5307
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /note="GCOM1, MYZAP-POLR2M combined locus"
                     /db_xref="GeneID:145781"
                     /db_xref="HGNC:HGNC:26424"
     exon            1..206
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..2429
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /note="isoform 3 is encoded by transcript variant 14;
                     glutamate receptor, ionotropic, N-methyl D-aspartate-like
                     1A combined protein; DNA-directed RNA polymerase II
                     subunit GRINL1A; MYZAP-POLR2M readthrough; myocardial
                     zonula adherens protein; NMDAR1 subunit-interacting
                     protein; GRINL1A combined protein Gcom12; DNA-directed RNA
                     polymerase II subunit M; Glutamate receptor-like protein
                     1A; GRINL1A complex locus 1"
                     /codon_start=1
                     /product="GRINL1A combined protein isoform 3"
                     /protein_id="NP_001272829.1"
                     /db_xref="GeneID:145781"
                     /db_xref="HGNC:HGNC:26424"
                     /translation="MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQ
                     CEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMN
                     YIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRF
                     NAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQV
                     ENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLK
                     AIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDS
                     DKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLL
                     EKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRKFICKLPDKGKKIFD
                     SFAKLKAAIAECEEVRRKSELFNPVSLDCKLRQKAIAEVDVGTDKAQNSDPILDTSSL
                     VPGCSSVDNIKSSQTSQNQGLGRPTLEGDEETSEVEYTVNKGPASSNRDRVPPSSEAS
                     EHHPRHRVSSQAEDTSSSFDNLFIDRLQRITIADQGEQQSEENASTKNLTGLSSGTEK
                     KPHYMEVLEMRAKNPVPQLRKFKTNVLPFRQNDSSSHCQKSGSPISSEERRRRDKQHL
                     DDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLAERLNIKMRSY
                     NPEGESSGRYREVRDEDDDWSSDEF"
     exon            207..293
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /inference="alignment:Splign:2.1.0"
     exon            294..449
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /inference="alignment:Splign:2.1.0"
     exon            450..542
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /inference="alignment:Splign:2.1.0"
     exon            543..656
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /inference="alignment:Splign:2.1.0"
     exon            657..809
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /inference="alignment:Splign:2.1.0"
     exon            810..935
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1064
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1144
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1250
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1334
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1435
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..2080
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2285
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..5307
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2642..2647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /note="hexamer: ATTAAA"
     polyA_site      2660
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /note="major polyA site"
     regulatory      3982..3987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /note="hexamer: ATTAAA"
     polyA_site      4001
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /note="major polyA site"
     regulatory      5296..5301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /note="hexamer: AATAAT"
     polyA_site      5307
                     /gene="GCOM1"
                     /gene_synonym="gcom; Gcom2; GRINL1A; MYZAP; MYZAP-POLR2M"
                     /note="major polyA site"
ORIGIN      
        1 cttcgcggtg cagctgaggc tgcaagtagc cggcgccgtc ccgcgtcgcc cccgcgcagg
       61 gcgggccccg cacgcttatt ctgcccggga ggaacgccgg cgtccagccc gctaccgacc
      121 gccgctgcgg gatgctgcgc tccacgtcca cggtcaccct gctctcgggc ggcgccgcca
      181 ggacgcccgg ggcgcccagc aggagggcaa atgtttgcag actacggctg accgtacctc
      241 ctgagagtcc agttcctgag caatgtgaaa agaagattga gagaaaagag cagcttcttg
      301 acctgagcaa tggagaacct accaggaaac ttcctcaggg tgttgtttat ggtgtggtgc
      361 gaagatcaga tcaaaatcag cagaaagaaa tggtggtgta tgggtggtcc accagtcagc
      421 tgaaagaaga gatgaactac atcaaagatg tgagagccac tttggaaaag gtgagaaagc
      481 gaatgtatgg agactatgat gagatgagac agaagattcg acagctcacc caggaactat
      541 cagtttccca tgctcagcag gagtatctgg agaatcacat ccaaacccag tcgtctgccc
      601 tggatcgttt taatgccatg aactcagcct tggcatcaga ttccattggc ctgcagaaaa
      661 ccctcgtgga tgtgactttg gaaaacagca acattaagga tcaaatcaga aatctgcagc
      721 agacgtatga agcatccatg gacaagctga gggaaaagca gaggcagttg gaggtagcgc
      781 aagttgaaaa ccagctgcta aaaatgaagg tggaatcgtc ccaagaagcc aatgctgagg
      841 tgatgcgaga gatgaccaag aagctgtaca gccagtatga ggagaagctg caggaagaac
      901 agaggaagca cagtgctgag aaggaggctc ttttggaaga aaccaatagt tttctgaaag
      961 cgattgaaga agccaataaa aagatgcaag cagcagagat cagcctagag gagaaagacc
     1021 agaggatcgg ggagctggac aggctgattg agcgcatgga aaaggaacgt catcaactgc
     1081 aacttcaact cctagaacat gaaacagaaa tgtctgggga gttaactgat tctgacaagg
     1141 aaaggtatca gcagttggag gaggcatcag ccagcctccg tgagcggatc agacacctag
     1201 atgacatggt gcattgccag cagaagaaag tcaagcagat ggtcgaggag attgaatcat
     1261 taaagaaaaa gttgcaacag aaacagctct taatactgca gcttttagaa aagatatctt
     1321 tcttagaagg agagaataat gaactacaaa gcaggttgga ctatttaaca gaaacccagg
     1381 ccaagaccga agtggaaacc agagagatag gagtgggctg tgatcttcta cccagaaaat
     1441 tcatttgcaa attgcccgac aaaggtaaaa agatctttga ctcttttgcc aaactgaaag
     1501 ctgccattgc agaatgtgaa gaagttagaa gaaaaagtga actgtttaac cctgttagtt
     1561 tagactgtaa gctaaggcaa aaagcaattg cagaagttga tgtgggtaca gataaggccc
     1621 agaattctga cccgatactt gatacttcat cactagttcc tggatgttcc tctgtagata
     1681 acatcaagtc atctcaaacc tcacaaaacc agggacttgg acgtcctact cttgaaggtg
     1741 atgaagagac ttcagaggtt gagtacacag tgaataaggg cccagcttcc agcaatagag
     1801 acagggtacc accttcatct gaagctagtg agcatcaccc gcggcatcgt gtttcaagtc
     1861 aagcggaaga tacttccagc agctttgaca acctgtttat tgacaggtta cagaggatca
     1921 ccattgcgga ccaaggtgaa caacagtcag aagaaaacgc aagtactaag aacttgacag
     1981 gcctttccag tgggactgag aagaaacctc attacatgga agtgctagaa atgcgagcca
     2041 aaaacccagt gccccagctg cgtaaattta aaaccaatgt gttacctttt cgacaaaatg
     2101 attcatctag tcattgccag aagagtgggt ctcctatttc ctcagaagag cggcggcgca
     2161 gggataagca gcatcttgat gacatcacag cagctcggct tctaccactt caccatatgc
     2221 ccacgcagct gctctccata gaagaatcct tggcacttca gaaacagcag aaacagaatt
     2281 atgaggagat gcaagcaaag ctcgcagcgc aaaaattagc tgaaagactg aatattaaaa
     2341 tgcggagtta taatccagaa ggggagtctt cagggagata ccgagaagta agggatgaag
     2401 atgacgattg gtcctctgat gaattctgaa gataatctcc taaatcactg acgttgagat
     2461 gtcatcatct tacatcagac tttctaacta gtatcaagat cagtgtcaga tattgttgag
     2521 ggaagtaatt ttataaagtt acacaaaggt agttataaaa aaagcccagt ttgtctttca
     2581 gaaggtgact ttcatgtgct tgaaaagttt aatatttgaa tattgtgttt aaccacatgg
     2641 tattaaaatt ttgcaatata ttgtgtattg gtctgatatt ttagtatata gtagaacata
     2701 cttttttttt ctttaagcca aatgaaaaga ggtaactttg cttttttcct ttttcttacc
     2761 tatcaaatag catttattac atgtctttca gtgaaatact tagttgttcc aggcacctaa
     2821 aatcaattag gaagacatag ttcccttctt ttttgggtaa tgaagggagc agtctaaaga
     2881 attgtatgca tgtttgcatg gggttattga gacattggat gtgaaatacc taggaagaca
     2941 tgtatggaga atgcttaaca aatgctcttc tcctttttct gtcttccctt aggaagaacg
     3001 ttatctctct tctgattagg aaggacttcc cttttgagta gatgctggaa agtggaggtt
     3061 ttttttgttg gtttgtttgt ttggttttgt gttttttttt gagatggggt cttgctctgt
     3121 cgcccaggct ggagtgcagt ggcaggatct cggctcactg caatctaggt ggaggtcttt
     3181 ttaaataacc tcatgttact tcaggcaaat ctggtacagg agaagcccaa gctaactgag
     3241 ctgggtgaag gcttgtgcat cacctggctt gagttccttg ctgtcacaga tgataggttc
     3301 atgtacacaa cattaatgtt tgataaggaa agcatttttt ttttgttaaa attgaattgt
     3361 cagtacttta cttttttccc cccaaatagg tatatataga ctgcagaagc ttcagtccca
     3421 tatataaacg ttcatgtcat tttagaggat tatatggttg tctccagaga aattaactta
     3481 cattatcaaa aaattctttg tctaatatat tggagtcttt aaaagtgttg aagaataaaa
     3541 tattaattag aacaacttca aatgctaagg tgatgtttta ccgggactta attaaataca
     3601 actttttcct ttcgaaaaag actgttcaca tttgcttcca ggtgtaatta ttgctttcat
     3661 tccttacccc cctcaagcaa atgtgaaaag tatactgacc taagattctc attagtttta
     3721 gttcttaaaa cgaatagtaa atgatttcac agcgtaaaat ttgatgttat ttctggaagc
     3781 tggatgatat ggaagagttc atgtgcctgg acacacagtt ccctgtaatc ctgccatcta
     3841 gggagataaa ctctgttaac attttgatgt tgtgtttttg cttatttttc tatgcatagt
     3901 tatgcattta tattctcaaa aatgaaatca taatgtacat tgctttgtag tctgctctat
     3961 atattgtcaa tatgttccca tattaaatat tttgcttttt agacagctgt aggatatttt
     4021 atttcatggg tataccataa ctttaagatt tatttcctat tcagcaattt gattatgtat
     4081 tataatgtaa tctgtaaata gtgatatgat taacatctta atcacatcca tagaaaatga
     4141 cttatttcca gaagataccg ctctaaaaat gaaattgtta ggtgaaagtg tttttgagaa
     4201 tttttatata tattactcac tgcagagatc atgttcattt acattcccat tagcaatata
     4261 tccaatgctc agaattgaaa attactactt aaaatctttg caaattgaat aattacagaa
     4321 aagggctaca tttaaaattt gtatttgttt ttcttactta gtgaaggttg tgtttttttt
     4381 catattcatt ggccatgcta tattcattct tttgagaatt gctcattcat attttttctg
     4441 ttgcttgctt ggagaatttg ctcttttttt ggcatataag ttcttaagaa tgtccgtcct
     4501 ttgtcatata ttgtaacttt ttttagcctt atttgtcatt taacatagtt tgtggtattt
     4561 cagtatagaa gttgttttct ttaggagtct acctttgtgt atgtgcttga aagtattttt
     4621 gtaatccaag aatggataaa tgtccttatt ttcttctagt attttcttat ttcactttta
     4681 cacctatctt taaaaggaat ttaaattttg tttatataca ttaactaaat cagtacaagt
     4741 ttggggtgaa aaggaaattt ttaatccatc tcaaatgtat ttggttatat tatataaggt
     4801 agggatttga ttttatttcg aagaatttac caattggttc agtatgtgaa accaccattt
     4861 cccctctgat tagtaatgct atttttatag aatattaaat tcttatgtgt cttttgtgtc
     4921 ttaggccaat ttctgggcct tctgggtttt ttctacactg tcaataatta tcgctttaat
     4981 tggtgttaat atttggtagt acacaggttc tcccttgttc ttttaaattt tgtgaaatat
     5041 aacttacaaa taagtactta aaacagagct taatgggtaa agcaacagct gtgtaatcac
     5101 aaactagatg cagaggaggt cttgccagca ctccaaaatc tctgtgtgtc ccctcttgac
     5161 actcactgtt tcccccagag ctaactatcc tgacgtatgg taattctccc tctgtccttt
     5221 taagaattat tttaccagtt atgtgtataa caatatggtt tacattttgc tcacttttga
     5281 cttatataaa aatagaataa tactata
//
