LOCUS       NM_001366737            5023 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens glucosaminyl (N-acetyl) transferase 4 (GCNT4), mRNA.
ACCESSION   NM_001366737
VERSION     NM_001366737.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5023)
  AUTHORS   Lan,Z.Z., Sun,F.H., Chen,C., Niu,L., Shi,J.D. and Zhang,W.Y.
  TITLE     CircPRDM5 inhibits the proliferation, migration, invasion, and
            glucose metabolism of gastric cancer cells by reducing GCNT4
            expression in a miR-485-3p-dependent manner
  JOURNAL   Kaohsiung J Med Sci 40 (3), 231-243 (2024)
   PUBMED   38180297
  REMARK    GeneRIF: CircPRDM5 inhibits the proliferation, migration, invasion,
            and glucose metabolism of gastric cancer cells by reducing GCNT4
            expression in a miR-485-3p-dependent manner.
REFERENCE   2  (bases 1 to 5023)
  AUTHORS   Li,P. and Xiao,W.
  TITLE     Circ_0005758 impedes gastric cancer progression through
            miR-1229-3p/GCNT4 feedback loop
  JOURNAL   Toxicol In Vitro 85, 105454 (2022)
   PUBMED   35970245
  REMARK    GeneRIF: Circ_0005758 impedes gastric cancer progression through
            miR-1229-3p/GCNT4 feedback loop.
REFERENCE   3  (bases 1 to 5023)
  AUTHORS   Hu,W., Zheng,X., Liu,J., Zhang,M., Liang,Y. and Song,M.
  TITLE     MicroRNA MiR-130a-3p promotes gastric cancer by targeting
            Glucosaminyl N-acetyl transferase 4 (GCNT4) to regulate the
            TGF-beta1/SMAD3 pathway
  JOURNAL   Bioengineered 12 (2), 11634-11647 (2021)
   PUBMED   34696660
  REMARK    GeneRIF: MicroRNA MiR-130a-3p promotes gastric cancer by targeting
            Glucosaminyl N-acetyl transferase 4 (GCNT4) to regulate the
            TGF-beta1/SMAD3 pathway.
REFERENCE   4  (bases 1 to 5023)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   5  (bases 1 to 5023)
  AUTHORS   Kumar,S., Connor,J.R., Dodds,R.A., Halsey,W., Van Horn,M., Mao,J.,
            Sathe,G., Mui,P., Agarwal,P., Badger,A.M., Lee,J.C., Gowen,M. and
            Lark,M.W.
  TITLE     Identification and initial characterization of 5000 expressed
            sequenced tags (ESTs) each from adult human normal and
            osteoarthritic cartilage cDNA libraries
  JOURNAL   Osteoarthritis Cartilage 9 (7), 641-653 (2001)
   PUBMED   11597177
REFERENCE   6  (bases 1 to 5023)
  AUTHORS   Schwientek,T., Yeh,J.C., Levery,S.B., Keck,B., Merkx,G., van
            Kessel,A.G., Fukuda,M. and Clausen,H.
  TITLE     Control of O-glycan branch formation. Molecular cloning and
            characterization of a novel thymus-associated core 2 beta1,
            6-n-acetylglucosaminyltransferase
  JOURNAL   J Biol Chem 275 (15), 11106-11113 (2000)
   PUBMED   10753916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093259.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.51183.1,
                                           SRR1803611.42263.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157511 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000652361.2/ ENSP00000498836.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AC093259.2         97410-97539         c
            131-189             AC093259.2         97150-97208         c
            190-330             AC093259.2         92878-93018         c
            331-5023            AC093259.2         70327-75019         c
FEATURES             Location/Qualifiers
     source          1..5023
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.3"
     gene            1..5023
                     /gene="GCNT4"
                     /gene_synonym="C2GNT3; LINC01336"
                     /note="glucosaminyl (N-acetyl) transferase 4"
                     /db_xref="GeneID:51301"
                     /db_xref="HGNC:HGNC:17973"
                     /db_xref="MIM:616782"
     exon            1..130
                     /gene="GCNT4"
                     /gene_synonym="C2GNT3; LINC01336"
                     /inference="alignment:Splign:2.1.0"
     exon            131..189
                     /gene="GCNT4"
                     /gene_synonym="C2GNT3; LINC01336"
                     /inference="alignment:Splign:2.1.0"
     exon            190..330
                     /gene="GCNT4"
                     /gene_synonym="C2GNT3; LINC01336"
                     /inference="alignment:Splign:2.1.0"
     exon            331..5023
                     /gene="GCNT4"
                     /gene_synonym="C2GNT3; LINC01336"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..1693
                     /gene="GCNT4"
                     /gene_synonym="C2GNT3; LINC01336"
                     /EC_number="2.4.1.102"
                     /note="glucosaminyl (N-acetyl) transferase 4, core 2
                     (beta-1,6-N-acetylglucosaminyltransferase); core 2
                     beta-1,6-N-acetylglucosaminyltransferase 3; core
                     2-branching enzyme 3; core2-GlcNAc-transferase 3; long
                     intergenic non-protein coding RNA 1336"
                     /codon_start=1
                     /product="beta-1,3-galactosyl-O-glycosyl-glycoprotein
                     beta-1,6-N-acetylglucosaminyltransferase 4"
                     /protein_id="NP_001353666.1"
                     /db_xref="CCDS:CCDS4026.1"
                     /db_xref="GeneID:51301"
                     /db_xref="HGNC:HGNC:17973"
                     /db_xref="MIM:616782"
                     /translation="MKIFKCYFKHTLQQKVFILFLTLWLLSLLKLLNVRRLFPQKDIY
                     LVEYSLSTSPFVRNRYTHVKDEVRYEVNCSGIYEQEPLEIGKSLEIRRRDIIDLEDDD
                     VVAMTSDCDIYQTLRGYAQKLVSKEEKSFPIAYSLVVHKDAIMVERLIHAIYNQHNIY
                     CIHYDRKAPDTFKVAMNNLAKCFSNIFIASKLEAVEYAHISRLQADLNCLSDLLKSSI
                     QWKYVINLCGQDFPLKSNFELVSELKKLNGANMLETVKPPNSKLERFTYHHELRRVPY
                     EYVKLPIRTNISKEAPPHNIQIFVGSAYFVLSQAFVKYIFNNSIVQDFFAWSKDTYSP
                     DEHFWATLIRVPGIPGEISRSAQDVSDLQSKTRLVKWNYYEGFFYPSCTGSHLRSVCI
                     YGAAELRWLIKDGHWFANKFDSKVDPILIKCLAEKLEEQQRDWITLPSEKLFMDRNLT
                     TTS"
     regulatory      4998..5003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GCNT4"
                     /gene_synonym="C2GNT3; LINC01336"
                     /note="hexamer: AATAAA"
     polyA_site      5023
                     /gene="GCNT4"
                     /gene_synonym="C2GNT3; LINC01336"
                     /note="major polyA site"
ORIGIN      
        1 agagcgggcc gggatcgtct gcctgcgagg tggcggtgcc taccacagcg ggtcgggagc
       61 ttctgggatc cgagccgaga aacgggacgc tcgagtccat ttgcagtctt cacgtaggaa
      121 acggtgctag aacaacaaac cagaagatta acagagttgg ggctaatata atgcgtttaa
      181 ttgtctcatg gcccatgttc tagaactaca tcctcggtca ctgtcccagt acagccatct
      241 gtagcacctc ctcagtaact gacggtgatg ttcctttccc tacgctgttt ataccatcag
      301 cctggggttt tctttggagg tgacacaaag aatgaagata ttcaaatgtt attttaaaca
      361 taccctacag cagaaagttt tcatcctgtt tttaacccta tggctgctct ctttgttaaa
      421 gcttctaaat gtgagacgac tctttccgca aaaagacatt tacttggttg agtactccct
      481 aagtacctcg ccttttgtaa gaaacagata cactcatgtt aaggatgaag tcaggtatga
      541 agttaactgt tcgggtatct atgaacagga gcctttggaa attggaaaga gtctggaaat
      601 aagaagaagg gacatcattg acttggagga tgatgatgtt gtggcaatga ccagtgattg
      661 tgacatttat cagactctaa gaggttatgc tcaaaagctt gtctcaaagg aggagaaaag
      721 cttcccaata gcctattctt tggttgtcca caaagatgca attatggttg aaaggcttat
      781 ccatgctata tacaaccagc acaatattta ctgcatccat tatgatcgta aggcacctga
      841 taccttcaaa gttgccatga acaatttagc taagtgcttc tccaatattt tcattgcttc
      901 caaattagag gctgtggaat atgcccacat ttccagactc caggctgatt taaattgctt
      961 gtcggacctt ctgaagtctt caatccagtg gaaatatgtt atcaacttgt gtgggcaaga
     1021 ttttcccctg aagtcaaatt ttgaattggt gtcagagttg aaaaaactca atggagcaaa
     1081 tatgttggag acggtgaaac ccccaaacag taaattggaa agattcactt accatcatga
     1141 acttagacgg gtgccttatg aatatgtgaa gctaccaata aggacaaaca tctccaagga
     1201 agcacccccc cataacattc agatatttgt tggcagtgct tattttgttt taagtcaagc
     1261 atttgttaaa tatattttca acaactccat cgttcaagac ttttttgcct ggtctaaaga
     1321 cacatactct cctgatgagc acttttgggc taccttgatt cgggttccag gaatacctgg
     1381 ggagatttcc agatcagccc aggatgtgtc tgatctgcag agtaagactc gccttgtcaa
     1441 gtggaattac tatgaaggct ttttctatcc cagttgtact ggatctcacc ttcgaagcgt
     1501 gtgtatttat ggagctgcag aattaaggtg gcttatcaaa gatggacatt ggtttgctaa
     1561 taaatttgat tctaaggtgg accctatctt gattaaatgc ttggcagaaa agcttgaaga
     1621 acagcagaga gactggatca ctttgccctc agaaaagtta tttatggata gaaatctcac
     1681 taccacatca tgatagtaaa atcaggatgg aaataagagg gtgcctgata aatggagtca
     1741 gtgtggaatt gaataccata ctatgcccaa tactgtttaa actcagtcct cccatatttt
     1801 aaaaggtgtc caaaattcca tacacaaggg aaagtgatct agcctttgat gttattagcc
     1861 tgcagttggc taggtttttt taatatttgt ttttgcttgt aatctcactg agccaaatca
     1921 gagatcttaa acattcagtc agtcatcaaa cattattgag cacctaacta tatgacaggc
     1981 acttttttag agactgcggc ttatcctcat catagcaacc tcggtatctt taagttctcc
     2041 acataacagt caggattcta ctgaagaagc ttttgaagtt tgtggtaatc gtctgatcat
     2101 ataaaccacc catttcagag tagtgtttaa gtactgtgac caacactcca cttgtctctt
     2161 aactcagctt tcaagacatt tcttaaccat cagagcagag gaggaaagac tcactacctc
     2221 agaaaaatct caaagaatag tccaatttcc tgcttgccaa agcataatct gccttttggt
     2281 gcattacttg gtcaattcag ggttgaggag actgttgggg ggcatttata atgtatgaaa
     2341 gttaaggaag ggggtgagga tgtgggttgg gacaggtagt acctaaagag gagcgaaggg
     2401 atttatacaa catttttatc atgttacaaa acagtatcat gaatggcctc ctttttagtt
     2461 caactgtttc tttaaaatgc atttactgat taaaaataag aactgaccaa tagctccaag
     2521 tgtcacacac cagaacatta agcctaagtc ctcaattcat aagttatcat tctagataag
     2581 tttctttaca atggaatact ttctgtggaa tcattataat tctgttgtat ggaactatca
     2641 agctaagagt cactaaactt tcttcaaaag gttgtgtgaa atatgacagc tttctaaatt
     2701 aatttgtata gtcatttaaa attttttctt ctctggcaac tgtccaactg gaatccagat
     2761 ttaaagtgat aaaagctcta agtttcttgc agtctttttc tcagcttagt tccagagaga
     2821 aaaaagctaa ttttcctaag gacacagcaa gaatattcat taaggatatt ttctaaaacc
     2881 cacacttgag aaaaccaccc aatgagtcaa aaatatatat atataatata tattttatat
     2941 atatgtaata tatatttatg ttatatatta tatatagaac aattccatta catatataat
     3001 atataaatat atatattata tatacatata ttgtatatga atatatatta tatatacata
     3061 taattatata tatataaata tatattatat aacatataat gaatatatat tatatatata
     3121 atggaattgt tctggaagta aaatggggta ggaatggggt tctgagaata ggcaataaca
     3181 ttttcaccag tctcttggga aattgtagaa ctcatgtaaa aatttcttgg tcatgatatg
     3241 tctcaatggc agcctcagta aataaaaatg tagcctcaga tattatattt aaagatgtag
     3301 taaatctagc ccaaaatagg acaatttgga agatttaagt attacatatt ttttaaatgt
     3361 ctgtgttcta aatgtgaaat gcactttgct cattttaaag ttcataatac taactgccaa
     3421 ctgacaccac ttctcgctcc ctttcttctc ttgaactcat ttttctccct ttttatttac
     3481 ccccttcaaa ttacttcatt ctttggaaat aactattacc aagccccatt cttcaaaata
     3541 agtaaacatt gtatagagcc aagttctgca aaagatccat accagttcac tcgtgtgcga
     3601 ctgtggacag gtaagtcact ttggtctcta tgaacctcag ttttccagat ctttgaaatg
     3661 agcacttgga tgcctatcct tgcttccaca caagtgtttt tttttttttt tttttttttt
     3721 tgtgagaatc gattgaaata gtatatgaag tggtttgaaa ataggtacaa actattgaca
     3781 tttcaatgtc agagagtgat acctgtagta gtataggcaa aggtccaacc ccatcgaaag
     3841 gcttaaacat ttaccttttc tgaaaaacta ttgaaatata aagagagtcc ccagtcacag
     3901 gggcaacttc tgtaaccaaa tccagatctg aggaaactcc tgtaacccca tttggggttt
     3961 ctttctaagc caatagggtt acaggttggt acagtgacac attgagaatg gggctacaaa
     4021 tacttttccc accatctagg atgaaataca cgaaatcctg ttgaaatctt ggtttttatg
     4081 cctttgctca tcagaataaa cgtaaatgct gaaaaacaaa taacctcctg atccactgtc
     4141 ttgcctcctg gtgagaaatg attctatccc ctgtttattg ggaaatttcc aaagttgttc
     4201 atcacttaaa tgccgtattc aaagggaaca tggaaggatg aagcggagaa agtgccttcg
     4261 agacattcac acatttctct ggactcagtc tgttaacata tcagggagct tgtcagatca
     4321 cacctttttg ccttggaaat cctacagatt tcctgtacgc cttcatatct gattcttccc
     4381 taaaaccttt gggtatgatt tcctccctgg tcttgataat gtcctgcagt ctgtgtttta
     4441 taattattct ttgtatttat tgaatctaga ctttaagtta ttcagagatc agaccagaac
     4501 cttagagttt ctaaactgta tgtggatatt aaataatatt aataatgaaa gagctaccaa
     4561 aatagtctat attgtgtgaa caatctcttg ggatattaga cgtgtttaaa gaccagtgtt
     4621 gctgctattt ttaatatttt ggttaattta agtgaaatgt acatatttta atttgaagat
     4681 ttatcttgcc catcagaatg tgaagatata cttgcatata ttttgacata tttcatggaa
     4741 aataaaaatg ataatccact ttgtgagtgt aagtgaatgt attcatatgt atgttattat
     4801 aaatgatttt tgtttgcact gatgatgaaa tgagagtttt gggggctttt tatacattta
     4861 tatcgactgg tctctaaatc tcctattttg ttttcttatc atttttgaaa tacagttccc
     4921 attacatgag ttttaaatag attggtgttt cattttgtat tatgctacta ctagatgttg
     4981 attctctggt attgtaaaat aaaatgtgct ccaaaaaccc aaa
//
