LOCUS       NM_003643               2780 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens glial cells missing transcription factor 1 (GCM1),
            mRNA.
ACCESSION   NM_003643
VERSION     NM_003643.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2780)
  AUTHORS   Jeyarajah,M.J., Jaju Bhattad,G., Kelly,R.D., Baines,K.J.,
            Jaremek,A., Yang,F.P., Okae,H., Arima,T., Dumeaux,V. and
            Renaud,S.J.
  TITLE     The multifaceted role of GCM1 during trophoblast differentiation in
            the human placenta
  JOURNAL   Proc Natl Acad Sci U S A 119 (49), e2203071119 (2022)
   PUBMED   36442132
  REMARK    GeneRIF: The multifaceted role of GCM1 during trophoblast
            differentiation in the human placenta.
            Erratum:[Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2300603120.
            doi: 10.1073/pnas.2300603120.. PMID: 36730209]
REFERENCE   2  (bases 1 to 2780)
  AUTHORS   Wang,L.J., Chen,C.P., Lee,Y.S., Ng,P.S., Chang,G.D., Pao,Y.H.,
            Lo,H.F., Peng,C.H., Cheong,M.L. and Chen,H.
  TITLE     Functional antagonism between DeltaNp63alpha and GCM1 regulates
            human trophoblast stemness and differentiation
  JOURNAL   Nat Commun 13 (1), 1626 (2022)
   PUBMED   35338152
  REMARK    GeneRIF: Functional antagonism between DeltaNp63alpha and GCM1
            regulates human trophoblast stemness and differentiation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2780)
  AUTHORS   Armistead,B., Kadam,L., Siegwald,E., McCarthy,F.P., Kingdom,J.C.,
            Kohan-Ghadr,H.R. and Drewlo,S.
  TITLE     Induction of the PPARgamma (Peroxisome Proliferator-Activated
            Receptor gamma)-GCM1 (Glial Cell Missing 1) Syncytialization Axis
            Reduces sFLT1 (Soluble fms-Like Tyrosine Kinase 1) in the
            Preeclamptic Placenta
  JOURNAL   Hypertension 78 (1), 230-240 (2021)
   PUBMED   34024123
  REMARK    GeneRIF: Induction of the PPARgamma (Peroxisome
            Proliferator-Activated Receptor gamma)-GCM1 (Glial Cell Missing 1)
            Syncytialization Axis Reduces sFLT1 (Soluble fms-Like Tyrosine
            Kinase 1) in the Preeclamptic Placenta.
REFERENCE   4  (bases 1 to 2780)
  AUTHORS   Li,J., Xie,Q., Gao,J., Wang,F., Bao,Y., Wu,L., Yang,L., Liu,Z.,
            Guo,R., Khan,A., Dan,Liu., Li,C., Wu,J. and Xie,J.
  TITLE     Aberrant Gcm1 expression mediates Wnt/beta-catenin pathway
            activation in folate deficiency involved in neural tube defects
  JOURNAL   Cell Death Dis 12 (3), 234 (2021)
   PUBMED   33664222
  REMARK    GeneRIF: Aberrant Gcm1 expression mediates Wnt/beta-catenin pathway
            activation in folate deficiency involved in neural tube defects.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2780)
  AUTHORS   Chiu,Y.H., Yang,M.R., Wang,L.J., Chen,M.H., Chang,G.D. and Chen,H.
  TITLE     New insights into the regulation of placental growth factor gene
            expression by the transcription factors GCM1 and DLX3 in human
            placenta
  JOURNAL   J Biol Chem 293 (25), 9801-9811 (2018)
   PUBMED   29743241
REFERENCE   6  (bases 1 to 2780)
  AUTHORS   Yu,C., Shen,K., Lin,M., Chen,P., Lin,C., Chang,G.D. and Chen,H.
  TITLE     GCMa regulates the syncytin-mediated trophoblastic fusion
  JOURNAL   J Biol Chem 277 (51), 50062-50068 (2002)
   PUBMED   12397062
  REMARK    GeneRIF: GCMa regulates the syncytin-mediated trophoblastic fusion
            in human cells
REFERENCE   7  (bases 1 to 2780)
  AUTHORS   Yamada,K., Ogawa,H., Tamiya,G., Ikeno,M., Morita,M., Asakawa,S.,
            Shimizu,N. and Okazaki,T.
  TITLE     Genomic organization, chromosomal localization, and the complete 22
            kb DNA sequence of the human GCMa/GCM1, a placenta-specific
            transcription factor gene
  JOURNAL   Biochem Biophys Res Commun 278 (1), 134-139 (2000)
   PUBMED   11071865
REFERENCE   8  (bases 1 to 2780)
  AUTHORS   Nait-Oumesmar,B., Copperman,A.B. and Lazzarini,R.A.
  TITLE     Placental expression and chromosomal localization of the human Gcm
            1 gene
  JOURNAL   J Histochem Cytochem 48 (7), 915-922 (2000)
   PUBMED   10858268
REFERENCE   9  (bases 1 to 2780)
  AUTHORS   Yamada,K., Ogawa,H., Honda,S., Harada,N. and Okazaki,T.
  TITLE     A GCM motif protein is involved in placenta-specific expression of
            human aromatase gene
  JOURNAL   J Biol Chem 274 (45), 32279-32286 (1999)
   PUBMED   10542267
REFERENCE   10 (bases 1 to 2780)
  AUTHORS   Akiyama,Y., Hosoya,T., Poole,A.M. and Hotta,Y.
  TITLE     The gcm-motif: a novel DNA-binding motif conserved in Drosophila
            and mammals
  JOURNAL   Proc Natl Acad Sci U S A 93 (25), 14912-14916 (1996)
   PUBMED   8962155
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512347.15, D88613.1,
            BC096288.1, BC096289.1, AB026493.1 and AI219562.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003643.3.
            
            Summary: This gene encodes a DNA-binding protein with a gcm-motif
            (glial cell missing motif). The encoded protein is a homolog of the
            Drosophila glial cells missing gene (gcm). This protein binds to
            the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of
            DNA-binding proteins. The N-terminal DNA-binding domain confers the
            unique DNA-binding activity of this protein. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096289.1, D88613.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2149398
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259803.8/ ENSP00000259803.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL512347.15        49520-49534
            16-57               D88613.1           4-45
            58-1708             BC096288.1         1-1651
            1709-2038           BC096289.1         1651-1980
            2039-2492           AB026493.1         1893-2346
            2493-2780           AI219562.1         17-304              c
FEATURES             Location/Qualifiers
     source          1..2780
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.1"
     gene            1..2780
                     /gene="GCM1"
                     /gene_synonym="GCMA; hGCMa"
                     /note="glial cells missing transcription factor 1"
                     /db_xref="GeneID:8521"
                     /db_xref="HGNC:HGNC:4197"
                     /db_xref="MIM:603715"
     exon            1..88
                     /gene="GCM1"
                     /gene_synonym="GCMA; hGCMa"
                     /inference="alignment:Splign:2.1.0"
     exon            89..299
                     /gene="GCM1"
                     /gene_synonym="GCMA; hGCMa"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1535
                     /gene="GCM1"
                     /gene_synonym="GCMA; hGCMa"
                     /note="GCM motif protein 1; glial cells missing homolog 1"
                     /codon_start=1
                     /product="chorion-specific transcription factor GCMa"
                     /protein_id="NP_003634.2"
                     /db_xref="CCDS:CCDS4950.1"
                     /db_xref="GeneID:8521"
                     /db_xref="HGNC:HGNC:4197"
                     /db_xref="MIM:603715"
                     /translation="MEPDDFDSEDKEILSWDINDVKLPQNVKKTDWFQEWPDSYAKHI
                     YSSEDKNAQRHLSSWAMRNTNNHNSRILKKSCLGVVVCGRDCLAEEGRKIYLRPAICD
                     KARQKQQRKRCPNCDGPLKLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPKPETK
                     LEAEARRAMKKVNTAPSSVSLSLKGSTETRSLPGETQSQGSLPLTWSFQEGVQLPGSY
                     SGHLIANTPQQNSLNDCFSFSKSYGLGGITDLTDQTSTVDPMKLYEKRKLSSSRTYSS
                     GDLLPPSASGVYSDHGDLQAWSKNAALGRNHLADNCYSNYPFPLTSWPCSFSPSQNSS
                     EPFYQQLPLEPPAAKTGCPPLWPNPAGNLYEEKVHVDFNSYVQSPAYHSPQEDPFLFT
                     YASHPHQQYSLPSKSSKWDFEEEMTYLGLDHCNNDMLLNLCPLR"
     exon            300..552
                     /gene="GCM1"
                     /gene_synonym="GCMA; hGCMa"
                     /inference="alignment:Splign:2.1.0"
     exon            553..665
                     /gene="GCM1"
                     /gene_synonym="GCMA; hGCMa"
                     /inference="alignment:Splign:2.1.0"
     exon            666..794
                     /gene="GCM1"
                     /gene_synonym="GCMA; hGCMa"
                     /inference="alignment:Splign:2.1.0"
     exon            795..2780
                     /gene="GCM1"
                     /gene_synonym="GCMA; hGCMa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2433..2438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GCM1"
                     /gene_synonym="GCMA; hGCMa"
                     /note="hexamer: CATAAA"
     polyA_site      2478
                     /gene="GCM1"
                     /gene_synonym="GCMA; hGCMa"
     regulatory      2760..2765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GCM1"
                     /gene_synonym="GCMA; hGCMa"
                     /note="hexamer: AACAAG"
     polyA_site      2780
                     /gene="GCM1"
                     /gene_synonym="GCMA; hGCMa"
                     /note="major polyA site"
ORIGIN      
        1 agaaaatgac cagagcctgc tgggacttga accagcagta agattttcac gacacagtgc
       61 tgtctgcttc tccgtaagaa gttagaagcc ctagaaaaca atctcctggt ccaaggtgct
      121 tgagtgggcc gatccagcta tatcaagaac ctttgagaac aaaattctca agcatttctg
      181 aggggagtcg aataggtgaa aaccttggct ggcctgacct tatcatggaa cctgacgact
      241 ttgattctga agacaaagag atattaagct gggatattaa tgatgtgaaa ctgccacaga
      301 acgtgaaaaa aaccgactgg ttccaggagt ggccagattc ctatgccaaa cacatctaca
      361 gctcggagga caagaatgcg cagcggcacc tgagcagctg ggccatgcgc aataccaaca
      421 accacaactc ccgcatcctc aagaagtcct gcctgggtgt ggtggtgtgc ggccgcgact
      481 gtctcgcaga ggaggggcgc aagatctacc tgagacctgc catctgtgac aaggcccggc
      541 agaagcagca gcggaaacgc tgtcccaact gtgacgggcc tctgaagctc atcccttgcc
      601 gaggtcatgg gggcttcccg gtcaccaact tctggaggca cgacggacgc tttatatttt
      661 tccagtcaaa gggagagcat gatcatccaa aaccagaaac caagttagaa gctgaggcaa
      721 gaagagccat gaagaaagtg aacacagcac cttcctccgt ctcattgagc ctgaagggga
      781 gcacagagac caggtctctt ccaggtgaaa cacaaagtca ggggagttta cctttaactt
      841 ggtctttcca ggaaggcgtc caattgcctg gtagttacag tggacattta atagctaaca
      901 ctcctcagca gaactcacta aatgattgct tttccttctc caagagttat ggtctgggag
      961 gaatcacaga tctgactgac cagacttcca ctgtggaccc catgaagctc tatgaaaagc
     1021 gcaaattgtc cagtagcaga acctacagta gtggagacct gcttcctcct tctgcctccg
     1081 gagtctactc tgatcatggc gatctacaag cgtggagtaa aaatgctgct ttggggagaa
     1141 atcatcttgc tgacaactgt tattccaatt atccttttcc tctgaccagc tggccttgca
     1201 gcttctctcc ttcccaaaac tcttcagaac ccttttacca gcagcttcca ttggagccac
     1261 ctgcagccaa aactggctgt cccccattat ggccaaatcc agcgggtaat ctttatgaag
     1321 agaaagtaca tgtggatttt aacagctacg tccagtctcc tgcataccat tcacctcaag
     1381 aagacccctt tctcttcacc tacgcctctc atcctcatca gcaatattca ctgccaagca
     1441 agagcagcaa atgggatttt gaggaagaaa tgacatactt gggtttggat cactgcaaca
     1501 atgatatgct tctgaacctg tgtcctttga gatgacccaa atctttcact atgtgcaccc
     1561 cagcccctca aaaatgggga agggctgaaa gaatttcctt aggaaataat ttttaaaaca
     1621 taaccacaga taaatgagaa tcatgataag cagtagacaa ggcttttttc tttttctttt
     1681 ttccttcttt tttttttttt tttttttttt ttgagacaga gtcttgctct tttgcccagg
     1741 caggaatgca gtggcgccat ctcggctcac tgcaacctct gcctcccggg tttgagtgat
     1801 tctcctgcgt cagcctcccg agtagctggg attacaggca cctgccactg cgcctggcta
     1861 atttttctat ttttagtaga gacagggttt tgccatgttg gtcaggctgc tctcaaactc
     1921 ctgatctcaa gtgatctgcc cacctcacca tcccaaagtg ctgggattac aggcgtgagc
     1981 cattgtgccc ggctgacaag gcttttttct tcacatgagt aatttttttg gcttcttctc
     2041 ctccactcta gtatttccac cctcagtaag gaatggaaac ctgtcccgtc tggggtgtga
     2101 agtgccctct gctttttccc ccacattgtt tggggttccc agcacctcag ccacattgca
     2161 tgctgggttt tcattgtcat tgttgcaaat gaaatggagt agacatgtga aatgctaacc
     2221 tatctaggac ctgatctatg ccttcttggg aactgagaat gaagaaacag aaatagatgg
     2281 tggaagaact gcctaaggtg tgaaaagctg aagattctac cactgaagta ctgaatatgt
     2341 tgtctagttg tgagactagt gtgtaaaata tatgttttct agatgatttc tgagacttgt
     2401 gatgacaagg aacctgacct aaccccattt ttcataaaga caaagaacag caatgttaaa
     2461 ttgccatatg aagagaaaca ctagtgatgt gcgtggtctc cttgcctctt gtttccttcc
     2521 ctcttcctca ctgacttccc cttgcacagg ggcttctgtt ttatcccatt tattatttgt
     2581 ggcacctata tcaatgtggg gtttgtaata ggtgagaaat atttgcttgg agaagctctt
     2641 gtgcaattag cctggcaatg attggccggc catgtttgaa tgccagtttc tcttctttgc
     2701 tgaagtactt tatgataaaa gtaagcctag acataaaatc tggagagaac catgcaataa
     2761 acaagtattt ttgaaataaa
//
