LOCUS       NM_000160               2030 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens glucagon receptor (GCGR), mRNA.
ACCESSION   NM_000160
VERSION     NM_000160.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2030)
  AUTHORS   Carney,E.F.
  TITLE     The renal glucagon receptor is essential to kidney metabolic and
            homeostatic functions
  JOURNAL   Nat Rev Nephrol 20 (4), 203 (2024)
   PUBMED   38424242
  REMARK    GeneRIF: The renal glucagon receptor is essential to kidney
            metabolic and homeostatic functions.
REFERENCE   2  (bases 1 to 2030)
  AUTHORS   Cajulao,J.M.B., Hernandez,E., von Zastrow,M.E. and Sanchez,E.L.
  TITLE     Glucagon receptor-mediated regulation of gluconeogenic gene
            transcription is endocytosis-dependent in primary hepatocytes
  JOURNAL   Mol Biol Cell 33 (10), ar90 (2022)
   PUBMED   35767325
  REMARK    GeneRIF: Glucagon receptor-mediated regulation of gluconeogenic
            gene transcription is endocytosis-dependent in primary hepatocytes.
REFERENCE   3  (bases 1 to 2030)
  AUTHORS   McGlone,E.R., Ansell,T.B., Dunsterville,C., Song,W., Carling,D.,
            Tomas,A., Bloom,S.R., Sansom,M.S.P., Tan,T. and Jones,B.
  TITLE     Hepatocyte cholesterol content modulates glucagon receptor
            signalling
  JOURNAL   Mol Metab 63, 101530 (2022)
   PUBMED   35718339
  REMARK    GeneRIF: Hepatocyte cholesterol content modulates glucagon receptor
            signalling.
REFERENCE   4  (bases 1 to 2030)
  AUTHORS   Jia,Y., Liu,Y., Feng,L., Sun,S. and Sun,G.
  TITLE     Role of Glucagon and Its Receptor in the Pathogenesis of Diabetes
  JOURNAL   Front Endocrinol (Lausanne) 13, 928016 (2022)
   PUBMED   35784565
  REMARK    GeneRIF: Role of Glucagon and Its Receptor in the Pathogenesis of
            Diabetes.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2030)
  AUTHORS   Fujisawa,T., Ikegami,H., Yamato,E., Takekawa,K., Nakagawa,Y.,
            Hamada,Y., Ueda,H., Fukuda,M. and Ogihara,T.
  TITLE     A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity
            in the association with diabetes mellitus
  JOURNAL   Diabetologia 38 (8), 983-985 (1995)
   PUBMED   7589886
REFERENCE   6  (bases 1 to 2030)
  AUTHORS   Lok,S., Kuijper,J.L., Jelinek,L.J., Kramer,J.M., Whitmore,T.E.,
            Sprecher,C.A., Mathewes,S., Grant,F.J., Biggs,S.H., Rosenberg,G.B.
            et al.
  TITLE     The human glucagon receptor encoding gene: structure, cDNA sequence
            and chromosomal localization
  JOURNAL   Gene 140 (2), 203-209 (1994)
   PUBMED   8144028
REFERENCE   7  (bases 1 to 2030)
  AUTHORS   MacNeil,D.J., Occi,J.L., Hey,P.J., Strader,C.D. and Graziano,M.P.
  TITLE     Cloning and expression of a human glucagon receptor
  JOURNAL   Biochem Biophys Res Commun 198 (1), 328-334 (1994)
   PUBMED   7507321
REFERENCE   8  (bases 1 to 2030)
  AUTHORS   Nakamura,S. and Rodbell,M.
  TITLE     Glucagon induces disaggregation of polymer-like structures of the
            alpha subunit of the stimulatory G protein in liver membranes
  JOURNAL   Proc Natl Acad Sci U S A 88 (16), 7150-7154 (1991)
   PUBMED   1908089
REFERENCE   9  (bases 1 to 2030)
  AUTHORS   Horuk,R. and Wright,D.E.
  TITLE     Partial purification and characterization of the glucagon receptor
  JOURNAL   FEBS Lett 155 (2), 213-217 (1983)
   PUBMED   6303843
REFERENCE   10 (bases 1 to 2030)
  AUTHORS   Levey,G.S., Weiss,S.R. and Ruiz,E.
  TITLE     Characterization of the glucagon receptor in a pheochromocytoma
  JOURNAL   J Clin Endocrinol Metab 40 (4), 720-723 (1975)
   PUBMED   165216
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA639395.1, BC104854.1,
            U03469.1 and L20316.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000160.4.
            
            Summary: The protein encoded by this gene is a glucagon receptor
            that is important in controlling blood glucose levels. Defects in
            this gene are a cause of non-insulin-dependent diabetes mellitus
            (NIDDM).[provided by RefSeq, Jan 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L20316.1, SRR5189664.113037.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400723.8/ ENSP00000383558.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               DA639395.1         21-252
            233-1751            BC104854.1         1-1519
            1752-1788           U03469.1           1536-1572
            1789-2030           L20316.1           1788-2029
FEATURES             Location/Qualifiers
     source          1..2030
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2030
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /note="glucagon receptor"
                     /db_xref="GeneID:2642"
                     /db_xref="HGNC:HGNC:4192"
                     /db_xref="MIM:138033"
     exon            1..100
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /inference="alignment:Splign:2.1.0"
     exon            101..337
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..1711
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /codon_start=1
                     /product="glucagon receptor precursor"
                     /protein_id="NP_000151.1"
                     /db_xref="CCDS:CCDS54177.1"
                     /db_xref="GeneID:2642"
                     /db_xref="HGNC:HGNC:4192"
                     /db_xref="MIM:138033"
                     /translation="MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCH
                     HNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGP
                     DGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLAL
                     AILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSD
                     GAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPM
                     LFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLR
                     ARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQ
                     GLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQF
                     GRGGGSQDSSAETPLAGGLPRLAESPF"
     exon            338..440
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /inference="alignment:Splign:2.1.0"
     exon            441..548
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /inference="alignment:Splign:2.1.0"
     exon            549..670
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /inference="alignment:Splign:2.1.0"
     exon            671..777
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /inference="alignment:Splign:2.1.0"
     exon            778..934
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1094
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1155
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1225
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1314
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1453
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1495
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..2030
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2010..2015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /note="hexamer: AATAAA"
     polyA_site      2030
                     /gene="GCGR"
                     /gene_synonym="GGR; GL-R; MVAH"
                     /note="major polyA site"
ORIGIN      
        1 gatctggcag cgccgcgaag acgagcggtc accggcgccc gacccgagcg cgcccagagg
       61 acggcgggga gccaagccga cccccgagca gcgccgcgcg gaccctgagg ctcagagggg
      121 cagcttcagg ggaggacacc ccactggcca ggacgcccca ggctctgctg ctctgccact
      181 cagctgccct cggaggagcg tacacaccca ccaggactgc attgccccag ctgtgcagcc
      241 cctgccagat gtgggaggca gctagctgcc cagaggcatg cccccctgcc agccacagcg
      301 acccctgctg ctgttgctgc tgctgctggc ctgccagcca caggtcccct ccgctcaggt
      361 gatggacttc ctgtttgaga agtggaagct ctacggtgac cagtgtcacc acaacctgag
      421 cctgctgccc cctcccacgg agctggtgtg caacagaacc ttcgacaagt attcctgctg
      481 gccggacacc cccgccaata ccacggccaa catctcctgc ccctggtacc tgccttggca
      541 ccacaaagtg caacaccgct tcgtgttcaa gagatgcggg cccgacggtc agtgggtgcg
      601 tggaccccgg gggcagcctt ggcgtgatgc ctcccagtgc cagatggatg gcgaggagat
      661 tgaggtccag aaggaggtgg ccaagatgta cagcagcttc caggtgatgt acacagtggg
      721 ctacagcctg tccctggggg ccctgctcct cgccttggcc atcctggggg gcctcagcaa
      781 gctgcactgc acccgcaatg ccatccacgc gaatctgttt gcgtccttcg tgctgaaagc
      841 cagctccgtg ctggtcattg atgggctgct caggacccgc tacagccaga aaattggcga
      901 cgacctcagt gtcagcacct ggctcagtga tggagcggtg gctggctgcc gtgtggccgc
      961 ggtgttcatg caatatggca tcgtggccaa ctactgctgg ctgctggtgg agggcctgta
     1021 cctgcacaac ctgctgggcc tggccaccct ccccgagagg agcttcttca gcctctacct
     1081 gggcatcggc tggggtgccc ccatgctgtt cgtcgtcccc tgggcagtgg tcaagtgtct
     1141 gttcgagaac gtccagtgct ggaccagcaa tgacaacatg ggcttctggt ggatcctgcg
     1201 gttccccgtc ttcctggcca tcctgatcaa cttcttcatc ttcgtccgca tcgttcagct
     1261 gctcgtggcc aagctgcggg cacggcagat gcaccacaca gactacaagt tccggctggc
     1321 caagtccacg ctgaccctca tccctctgct gggcgtccac gaagtggtct tcgccttcgt
     1381 gacggacgag cacgcccagg gcaccctgcg ctccgccaag ctcttcttcg acctcttcct
     1441 cagctccttc cagggcctgc tggtggctgt cctctactgc ttcctcaaca aggaggtgca
     1501 gtcggagctg cggcggcgtt ggcaccgctg gcgcctgggc aaagtgctat gggaggagcg
     1561 gaacaccagc aaccacaggg cctcatcttc gcccggccac ggccctccca gcaaggagct
     1621 gcagtttggg aggggtggtg gcagccagga ttcatctgcg gagaccccct tggctggtgg
     1681 cctccctaga ttggctgaga gccccttctg aaccctgctg ggaccccagc tagggctgga
     1741 ctctggcacc cagagggcgt cgctggacaa cccagaactg gacgcccagc tgaggctggg
     1801 ggcgggggag ccaacagcag cccccaccta ccccccaccc ccagtgtggc tgtctgcgag
     1861 attgggcctc ctctccctgc acctgccttg tccctggtgc agaggtgagc agaggagtcc
     1921 agggcgggag tgggggctgt gccgtgaact gcgtgccagt gtccccacgt atgtcggcac
     1981 gtcccatgtg catggaaatg tcctccaaca ataaagagct caagtggtca
//
