LOCUS       NM_024523               4128 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens GRIP and coiled-coil domain containing 1 (GCC1), mRNA.
ACCESSION   NM_024523
VERSION     NM_024523.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4128)
  AUTHORS   Liang,X.H., Nichols,J.G., De Hoyos,C.L., Sun,H., Zhang,L. and
            Crooke,S.T.
  TITLE     Golgi-58K can re-localize to late endosomes upon cellular uptake of
            PS-ASOs and facilitates endosomal release of ASOs
  JOURNAL   Nucleic Acids Res 49 (14), 8277-8293 (2021)
   PUBMED   34244781
  REMARK    GeneRIF: Golgi-58K can re-localize to late endosomes upon cellular
            uptake of PS-ASOs and facilitates endosomal release of ASOs.
REFERENCE   2  (bases 1 to 4128)
  AUTHORS   Shin,J.J.H., Crook,O.M., Borgeaud,A.C., Cattin-Ortola,J.,
            Peak-Chew,S.Y., Breckels,L.M., Gillingham,A.K., Chadwick,J.,
            Lilley,K.S. and Munro,S.
  TITLE     Spatial proteomics defines the content of trafficking vesicles
            captured by golgin tethers
  JOURNAL   Nat Commun 11 (1), 5987 (2020)
   PUBMED   33239640
  REMARK    GeneRIF: Spatial proteomics defines the content of trafficking
            vesicles captured by golgin tethers.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4128)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4128)
  AUTHORS   Cui,Y., Yang,Z. and Teasdale,R.D.
  TITLE     A role of GCC88 in the retrograde transport of CI-M6PR and the
            maintenance of lysosomal activity
  JOURNAL   Cell Biol Int 43 (11), 1234-1244 (2019)
   PUBMED   30791178
  REMARK    GeneRIF: The authors show that GCC88 is required for the
            maintenance of the trans-Golgi network (TGN) structure and the
            efficient endosome-to-TGN trafficking of the cation-independent
            mannose 6-phosphate receptor (CI-M6PR).
REFERENCE   5  (bases 1 to 4128)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4128)
  AUTHORS   Lieu,Z.Z., Derby,M.C., Teasdale,R.D., Hart,C., Gunn,P. and
            Gleeson,P.A.
  TITLE     The golgin GCC88 is required for efficient retrograde transport of
            cargo from the early endosomes to the trans-Golgi network
  JOURNAL   Mol Biol Cell 18 (12), 4979-4991 (2007)
   PUBMED   17914056
  REMARK    GeneRIF: identified an essential role for GCC88 in the localization
            of TGN fusion machinery for transport from early endosomes to the
            trans-Golgi network
REFERENCE   7  (bases 1 to 4128)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 4128)
  AUTHORS   Luke,M.R., Houghton,F., Perugini,M.A. and Gleeson,P.A.
  TITLE     The trans-Golgi network GRIP-domain proteins form alpha-helical
            homodimers
  JOURNAL   Biochem J 388 (Pt 3), 835-841 (2005)
   PUBMED   15654769
  REMARK    GeneRIF: The ability of the four mammalian GRIP domain proteins,
            p230, golgin-97, GCC88, and GCC185 to interact is reported.
REFERENCE   9  (bases 1 to 4128)
  AUTHORS   Luke,M.R., Kjer-Nielsen,L., Brown,D.L., Stow,J.L. and Gleeson,P.A.
  TITLE     GRIP domain-mediated targeting of two new coiled-coil proteins,
            GCC88 and GCC185, to subcompartments of the trans-Golgi network
  JOURNAL   J Biol Chem 278 (6), 4216-4226 (2003)
   PUBMED   12446665
  REMARK    GeneRIF: targeting to subcompartments of trans-Golgi network by
            GRIP domain
REFERENCE   10 (bases 1 to 4128)
  AUTHORS   Kjer-Nielsen,L., Teasdale,R.D., van Vliet,C. and Gleeson,P.A.
  TITLE     A novel Golgi-localisation domain shared by a class of coiled-coil
            peripheral membrane proteins
  JOURNAL   Curr Biol 9 (7), 385-388 (1999)
   PUBMED   10209125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC000357.1.
            
            On Nov 26, 2018 this sequence version replaced NM_024523.5.
            
            Summary: The protein encoded by this gene is a peripheral membrane
            protein. It is sensitive to brefeldin A. This encoded protein
            contains a GRIP domain which is thought to be used in targeting. It
            may play a role in the organization of trans-Golgi network
            subcompartment involved with membrane transport. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014100.2, SRR1803616.115256.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321407.3/ ENSP00000318821.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1446              AC000357.1         29739-31184         c
            1447-4128           AC000357.1         26216-28897         c
FEATURES             Location/Qualifiers
     source          1..4128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..4128
                     /gene="GCC1"
                     /gene_synonym="GCC1P; GCC88"
                     /note="GRIP and coiled-coil domain containing 1"
                     /db_xref="GeneID:79571"
                     /db_xref="HGNC:HGNC:19095"
                     /db_xref="MIM:607418"
     exon            1..1446
                     /gene="GCC1"
                     /gene_synonym="GCC1P; GCC88"
                     /inference="alignment:Splign:2.1.0"
     CDS             415..2742
                     /gene="GCC1"
                     /gene_synonym="GCC1P; GCC88"
                     /note="golgi coiled-coil 1; peripheral membrane Golgi
                     protein; golgi coiled-coil protein 1"
                     /codon_start=1
                     /product="GRIP and coiled-coil domain-containing protein
                     1"
                     /protein_id="NP_078799.2"
                     /db_xref="CCDS:CCDS5796.1"
                     /db_xref="GeneID:79571"
                     /db_xref="HGNC:HGNC:19095"
                     /db_xref="MIM:607418"
                     /translation="MEKFGMNFGGGPSKKDLLETIETQKKQLLQYQARLKDVVRAYKS
                     LLKEKEALEASIKVLSVSHEADVGLAGVQLPGLTFPDSVDDRCSTHSEDSTGTATSLD
                     TAASLTSTKGEFGVEDDRPARGPPPPKSEEASWSESGVSSSSGDGPFAGGEVDKRLHQ
                     LKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGL
                     QEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALA
                     GRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHF
                     QAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQ
                     KLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKS
                     QVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNT
                     KDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQE
                     LERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGG
                     GGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVH
                     QLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLKNIIYRFLTLPDSLGRQ
                     QTLTAILTILHFSPEEKQVIMRLPTSASWWPSGKR"
     exon            1447..4128
                     /gene="GCC1"
                     /gene_synonym="GCC1P; GCC88"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4109..4114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GCC1"
                     /gene_synonym="GCC1P; GCC88"
                     /note="hexamer: ATTAAA"
     polyA_site      4128
                     /gene="GCC1"
                     /gene_synonym="GCC1P; GCC88"
                     /note="major polyA site"
ORIGIN      
        1 gttgtcggca ggcagcttta gttaggatgt cgtgatggga ccgagctcag cgtaaccctc
       61 tggccgacgt gggccgaggg ggccggcccg ggctgctgtg gcccagacga gcggagagtg
      121 cggagcggct tctgggccag cgctaacgag ccctggcagt gcgcacctct ggtgccagtg
      181 tcgccccgcc tccggggtag aatccgcccc agccctccgg gcctgggacc gggcggccgc
      241 tttcgccagt ccgtccggcc gttccgcatt aggtccggga taactaggtg gagtaggtgt
      301 gcggcccgcc gccggacagc ccgctcgctg tttctttaag cccccgcctg cgtcttcacg
      361 gccctctccc gttctgctgg aaagctgacg tggggcaatc cgttcagacc ctccatggag
      421 aagtttggga tgaatttcgg gggcggcccg agcaagaagg acttgctgga gactatagag
      481 acccagaaga agcagcttct ccagtaccag gcacggctca aggatgtggt ccgtgcctat
      541 aaaagcctgc tgaaggagaa agaggcatta gaggccagca tcaaggtgct gtcggtatcc
      601 cacgaggcag atgtgggcct cgcaggtgtc cagcttccag gcctcacctt tcctgactct
      661 gtggatgacc ggtgctccac tcacagcgag gatagcactg ggaccgccac tagcttggat
      721 actgcggcca gtctcaccag caccaagggt gagtttgggg tagaagatga cagaccggcc
      781 cgtggaccac cacctccaaa gtccgaagag gccagttggt ccgagagtgg cgttagcagt
      841 agcagtgggg atgggccatt tgcaggtggg gaggtggaca aaagactgca ccagctgaag
      901 actcagttgg ctactttgac cagttctttg gctacagtca ctcaggagaa gtcccgcatg
      961 gaggcttctt acttggctga caagaaaaag atgaaacagg acttagagga tgccagtaac
     1021 aaggcggagg aggagagggc ccgcctggag ggagaattga aggggctgca ggagcaaata
     1081 gcagaaacca aagcccggct tatcacgcag cagcatgatc gggcccaaga gcagagtgac
     1141 catgccttga tgctgcgtga gctccagaag ctgctgcagg aggagaggac ccagcgccag
     1201 gacttggagc ttaggttaga agagacccga gaagccttgg caggacgagc atatgcagct
     1261 gaacagatgg aaggatttga actgcagacc aagcagctga cccgtgaggt ggaggagctg
     1321 aaaagtgaac tgcaggccat tcgagatgag aagaatcagc cagatccccg gctgcaagaa
     1381 cttcaggaag aggctgcccg ccttaagagc catttccagg ctcagttaca gcaggaaatg
     1441 agaaagacag ctcttgcaga ggatcaactc cgtcagcaat ctcaggtaga agaacagagg
     1501 gtggcagccc tggagaatca aatatccgag gtgtctgagc tgctaggcac ctacgagaaa
     1561 gccaagcaga aggaccagct ggccattcag aagctgaagg agcgcattct gcagctggac
     1621 ctggagaaca agacactggc tctagcagcc tccagcaggt cccctttaga cagccatgga
     1681 gaggagtcca gtctggatgt caatgtcctg aaagataaga tggagaagct gaagaggctg
     1741 ctgcaggttg cggccaggaa aagccaggtg accctggatg tggagaagct ctgtgacctg
     1801 gagataatgc ccagctcgga ggctgctgat ggggagaagg ctactgcact ctattaccaa
     1861 caggagctga aacagctgaa ggaagagttt gagaggtaca agatgagagc ccaggttgtc
     1921 ctcaaaagca agaataccaa agatggtaac ctgggaaagg agctggaggc agcccaggaa
     1981 cagcttgcag agctgaagga gaagtatatt tccctgcggc tctcctgcga ggagctggag
     2041 caccaacacc agcaggaggc tgatgactgg aagcaggagc tggcccggct gcagcagctc
     2101 caccggcagg agctggagcg gtgccagctg gacttcaggg accgcacact gaaactggag
     2161 gaggagctgc acaagcagcg ggatcgtgcc ctagctgtgc tcaccgagaa ggacttggaa
     2221 ctggagcaac tgcgttctgt ggccttggcc tctgggctgc caggacgcag aagtcctgtg
     2281 ggtggtggcg gtcctgggga cccagctgac acatcatcct ctgatagcct gacccaagca
     2341 ttacaacttg cagcggccaa tgagcccact ttctttctgt acgctgagca actggcccgc
     2401 aaggaggtgg agatcacatc actgaggaag cagaagcaca ggctggaggt cgaggtgcat
     2461 cagctgcagg atcggctgct ggaggagggc gaacggcatc gtgaggaggt tgcagccctg
     2521 cagagccaca tcgaaaagaa catcagggac cagagcaggg agggagccaa tctggagtac
     2581 ctcaaaaaca tcatctaccg cttcctgacc ttacctgact ccctgggccg ccagcagact
     2641 ctcacagcca tactgactat cttgcacttc agtccagagg agaaacaagt gataatgcga
     2701 ctcccaacca gtgccagctg gtggccttct ggcaagagat gatgccattt tcatgaattc
     2761 ctggaatttc tgtgcctctt ttatgtggga aagggcaggc tctggtttct gctgcctctt
     2821 ctcttacatt gtcatttatt tcttcactgt gttgagctgg gaggagtctt caatgtggga
     2881 agggattttc tgccaaatgc cattaatgct gctttatcct taggccctag agatactgaa
     2941 agtcctgggg cagtatcttc tgatggtgtg catgtgagga gaagatgagg ttaggactga
     3001 gaagtgcaga agttggaaca gtggtaaggc tgttttaaaa taagatgttt tgttttaata
     3061 atatgctcct ggcacaaagc taggagtaaa tgtgactcca aagggagttc agttaatctc
     3121 tgaaatgcac aaaacctagc tattttctcc ctctcatcac agtctgagtc tggtccattg
     3181 ctaccccaat tctctgggga cataaaacca ggctggaaag ggaccaggaa gtttgaaata
     3241 gtgacatatc atccactagt cccaagggct aaggaatagt gagtttattc tggaaggaac
     3301 tgggaagctt agtctaatta gtgcctgggg atgacctatg caatcacacc gcttatgacc
     3361 atcctagaga gggccctgag caccagcttg atcttaggga tttccaaagt aacctgcttt
     3421 ttgcctggat agggttaaaa tagacctttc ttgcctatcc ttgccttaac ctatctgcct
     3481 gaggttggcc tgagattgtg agtcaacgac tttgctatct tttcctcagt gttgaacttt
     3541 cattaagaaa taaagtccta gcttcttaca gagaggggtc caaatggtga atgctcatcc
     3601 tgcctggatt caaggaatta gctcagagat tggcccctag cttttctgcc tttgtaggga
     3661 cagcaaaagg ggaaaatttg ctgcagaaaa ttccaaaaga ttgctgtagc tctcacaggg
     3721 aagtggtaaa gatcagctaa acctgggttg gggtgctttc tgcccagtgg gtcttggcat
     3781 aagtagatta atcctgctct tttaagaaaa ggcaacttat tcaggcagtc tggaaagggg
     3841 gttctcagaa aactcagttt ctttattcct tcttttctcc caactactgt tactggttat
     3901 agaggtcttt ggactctaaa gaccaatgtt tggccactaa ctggactaat atgtatcttt
     3961 ctgtgatttc atcatagagg tctgttttgt gagggtttgg ggtgcagaaa actttgatta
     4021 aatcttaatg ggaggctggg tgacctggat tatctacagt gagcagactt aaatggaaca
     4081 gaagtttatg tgtccaaatg atggaatcat taaacctgag tgacttga
//
