LOCUS       NM_001098834            1818 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens gastrulation brain homeobox 1 (GBX1), mRNA.
ACCESSION   NM_001098834
VERSION     NM_001098834.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1818)
  AUTHORS   Proudfoot,A., Geralt,M., Elsliger,M.A., Wilson,I.A., Wuthrich,K.
            and Serrano,P.
  TITLE     Dynamic Local Polymorphisms in the Gbx1 Homeodomain Induced by DNA
            Binding
  JOURNAL   Structure 24 (8), 1372-1379 (2016)
   PUBMED   27396829
  REMARK    GeneRIF: Dynamic local polymorphisms in the Gbx1 homeodomain
            induced by DNA binding have been reported.
REFERENCE   2  (bases 1 to 1818)
  AUTHORS   Wilming,L.G., Boychenko,V. and Harrow,J.L.
  TITLE     Comprehensive comparative homeobox gene annotation in human and
            mouse
  JOURNAL   Database (Oxford) 2015 (2015)
   PUBMED   26412852
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1818)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 1818)
  AUTHORS   Huntriss,J., Hinkins,M. and Picton,H.M.
  TITLE     cDNA cloning and expression of the human NOBOX gene in oocytes and
            ovarian follicles
  JOURNAL   Mol Hum Reprod 12 (5), 283-289 (2006)
   PUBMED   16597639
  REMARK    GeneRIF: Study reveals the preferential expression of GBX1 by
            germinal vesicle (GV) oocytes.
REFERENCE   5  (bases 1 to 1818)
  AUTHORS   Matsui,T., Hirai,M., Hirano,M. and Kurosawa,Y.
  TITLE     The HOX complex neighbored by the EVX gene, as well as two other
            homeobox-containing genes, the GBX-class and the EN-class, are
            located on the same chromosomes 2 and 7 in humans
  JOURNAL   FEBS Lett 336 (1), 107-110 (1993)
   PUBMED   7903253
REFERENCE   6  (bases 1 to 1818)
  AUTHORS   Matsui,T., Hirai,M., Wakita,M., Hirano,M. and Kurosawa,Y.
  TITLE     Expression of a novel human homeobox-containing gene that maps to
            chromosome 7q36.1 in hematopoietic cells
  JOURNAL   FEBS Lett 322 (2), 181-185 (1993)
   PUBMED   8097731
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010973.7.
            
            On Sep 16, 2020 this sequence version replaced NM_001098834.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DR731410.1, SRR12921934.4596424.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297537.5/ ENSP00000297537.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-684               AC010973.7         183729-184412       c
            685-1818            AC010973.7         164727-165860       c
FEATURES             Location/Qualifiers
     source          1..1818
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..1818
                     /gene="GBX1"
                     /gene_synonym="Huh-17"
                     /note="gastrulation brain homeobox 1"
                     /db_xref="GeneID:2636"
                     /db_xref="HGNC:HGNC:4185"
                     /db_xref="MIM:603354"
     exon            1..684
                     /gene="GBX1"
                     /gene_synonym="Huh-17"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1238
                     /gene="GBX1"
                     /gene_synonym="Huh-17"
                     /note="gastrulation and brain-specific homeobox protein 1"
                     /codon_start=1
                     /product="homeobox protein GBX-1"
                     /protein_id="NP_001092304.1"
                     /db_xref="CCDS:CCDS43682.1"
                     /db_xref="GeneID:2636"
                     /db_xref="HGNC:HGNC:4185"
                     /db_xref="MIM:603354"
                     /translation="MQRAGGGSAPGGNGGGGGGGPGTAFSIDSLIGPPPPRSGHLLYT
                     GYPMFMPYRPLVLPQALAPAPLPAGLPPLAPLASFAGRLTNTFCAGLGQAVPSMVALT
                     TALPSFAEPPDAFYGPQELAAAAAAAAATAARNNPEPGGRRPEGGLEADELLPAREKV
                     AEPPPPPPPHFSETFPSLPAEGKVYSSDEEKLEASAGDPAGSEQEEEGSGGDSEDDGF
                     LDSSAGGPGALLGPKPKLKGSLGTGAEEGAPVTAGVTAPGGKSRRRRTAFTSEQLLEL
                     EKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRIKAGNVSSRSGEPVRN
                     PKIVVPIPVHVNRFAVRSQHQQMEQGARP"
     exon            685..1818
                     /gene="GBX1"
                     /gene_synonym="Huh-17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1801..1806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBX1"
                     /gene_synonym="Huh-17"
                     /note="hexamer: AATGAA"
     polyA_site      1818
                     /gene="GBX1"
                     /gene_synonym="Huh-17"
                     /note="major polyA site"
ORIGIN      
        1 acactgcgcc gagcccgcgc cccgccgcca cctcggcccg ggagccaggg agcgagccct
       61 gcgtgtccgc gcggggcgcc cgagccgcgg ggcgcacgga ggcgcccaga gaggagcgcc
      121 ccggggcggc cgcagctccg aacaagatgc agcgggccgg aggcggtagc gcccctgggg
      181 gcaacggcgg gggcggcggc gggggcccgg gcactgcctt ctccatcgac tccctaatcg
      241 ggccgccgcc gccgcgctcc ggccacttgc tgtacaccgg ctaccccatg ttcatgccct
      301 accggccgct cgtgctgccg caggcgctgg cccctgcgcc gctgcccgct ggcctcccgc
      361 ccctcgcccc gctagcctct ttcgccggcc gccttaccaa caccttctgc gcggggctgg
      421 gtcaggctgt gccctcgatg gtggcgctga ccaccgcgct gcccagcttc gcggagccgc
      481 ccgacgcttt ctacgggccc caggagctcg ccgccgccgc tgccgccgcc gccgccactg
      541 ccgcccgaaa caaccccgag ccaggcggcc gacgcccaga gggtgggctg gaagctgatg
      601 agctgctgcc ggcccgggag aaagtggcag agcccccacc acctccgcct ccgcacttct
      661 cagagacttt tccaagtctg cccgcagagg ggaaggtgta cagctcagat gaggagaagc
      721 tggaggcatc agcaggagac ccagcaggca gcgaacagga ggaagagggc tcaggcggtg
      781 acagcgagga tgacggtttc ctggacagtt ctgcaggggg cccaggggct cttctgggac
      841 ctaaaccgaa gctaaaggga agcctgggga ctggagctga ggagggggca ccggtgacag
      901 caggggtcac agctcctggg gggaaaagcc gacggcgccg cacagcattt accagcgagc
      961 agcttttgga attggagaag gaatttcatt gcaagaaata cctgagcttg acagagcgct
     1021 ctcagatcgc ccacgccctc aagctcagtg aggtgcaggt caagatctgg tttcagaatc
     1081 gacgggccaa gtggaagcgc atcaaagctg gcaatgtgag cagccgttct ggggagcccg
     1141 taagaaaccc caagattgtt gtccccatac ctgtgcatgt caacaggttt gctgtgcgga
     1201 gccagcacca acaaatggag cagggggccc ggccctgaat gggcacccaa gaacttagga
     1261 aggcgaggga tctgtacctg agcctgctct gagactgtca gggttctgtg gaccagaggg
     1321 gctgcaactg tgattctgcc ttgagagggg ctagttggca attaacctag ccctgggtgt
     1381 gctcttccca gactcctccc agaacctgag atgtgagcac ttggccctga gcctgttcca
     1441 gagaacttca ggactagggg cttcaaggtt aaaggggctg gggttctatt gctgaggagc
     1501 tgttgggact gaggtggact cctggggagg gggtgggttc taagatgcct aaggcctgaa
     1561 ggttctgtgg caaatgccct ggaacagctt ctgatgggtg gagggaacag gcgataccta
     1621 gccaagtaga tcgcagctcc ttatttattt gtgtaaatgt gtatatatgg agctatctgt
     1681 ctctgtacgt ctgtctgcac ccctgagagg gattgggaaa gttgtttcct caatcctcag
     1741 ccagagttcg tctgtcctac tgctttgggg taggccccat cttgcctctc tttacaaaga
     1801 aatgaaatgc aaccgtca
//
