LOCUS       NM_207398               2426 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens guanylate binding protein 7 (GBP7), mRNA.
ACCESSION   NM_207398
VERSION     NM_207398.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2426)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2426)
  AUTHORS   Feng,M., Zhang,Q., Wu,W., Chen,L., Gu,S., Ye,Y., Zhong,Y., Huang,Q.
            and Liu,S.
  TITLE     Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus
            Replication by Suppressing Innate Immunity via NF-kappaB and
            JAK-STAT Signaling Pathways
  JOURNAL   J Virol 95 (6), e02038-20 (2021)
   PUBMED   33408175
  REMARK    GeneRIF: Inducible Guanylate-Binding Protein 7 Facilitates
            Influenza A Virus Replication by Suppressing Innate Immunity via
            NF-kappaB and JAK-STAT Signaling Pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2426)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2426)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2426)
  AUTHORS   Eid,N.A., Hussein,A.A., Elzein,A.M., Mohamed,H.S., Rockett,K.A.,
            Kwiatkowski,D.P. and Ibrahim,M.E.
  TITLE     Candidate malaria susceptibility/protective SNPs in hospital and
            population-based studies: the effect of sub-structuring
  JOURNAL   Malar J 9, 119 (2010)
   PUBMED   20459687
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2426)
  AUTHORS   Olszewski,M.A., Gray,J. and Vestal,D.J.
  TITLE     In silico genomic analysis of the human and murine
            guanylate-binding protein (GBP) gene clusters
  JOURNAL   J Interferon Cytokine Res 26 (5), 328-352 (2006)
   PUBMED   16689661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096141.1 and AC104459.2.
            
            On Nov 23, 2018 this sequence version replaced NM_207398.2.
            
            Summary: Guanylate-binding proteins, such as GBP7, are induced by
            interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al.,
            2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008].
            
            Sequence Note: This sequence has been modified as follows: removed
            36 bp suspected to be vector contamination from the 3' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096141.1, DRR138522.1630274.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294671.3/ ENSP00000294671.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AK096141.1         38-179
            143-143             AC104459.2         96915-96915         c
            144-2095            AK096141.1         181-2132
            2096-2096           AC104459.2         57092-57092         c
            2097-2417           AK096141.1         2134-2454
            2418-2426           AC104459.2         56762-56770         c
FEATURES             Location/Qualifiers
     source          1..2426
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.2"
     gene            1..2426
                     /gene="GBP7"
                     /gene_synonym="GBP4L"
                     /note="guanylate binding protein 7"
                     /db_xref="GeneID:388646"
                     /db_xref="HGNC:HGNC:29606"
                     /db_xref="MIM:612468"
     exon            1..83
                     /gene="GBP7"
                     /gene_synonym="GBP4L"
                     /inference="alignment:Splign:2.1.0"
     exon            84..292
                     /gene="GBP7"
                     /gene_synonym="GBP4L"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2019
                     /gene="GBP7"
                     /gene_synonym="GBP4L"
                     /note="GBP-7; GTP-binding protein 7; guanine
                     nucleotide-binding protein 7"
                     /codon_start=1
                     /product="guanylate-binding protein 7"
                     /protein_id="NP_997281.2"
                     /db_xref="CCDS:CCDS720.1"
                     /db_xref="GeneID:388646"
                     /db_xref="HGNC:HGNC:29606"
                     /db_xref="MIM:612468"
                     /translation="MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIV
                     GLYRTGKSYLMNKLAGKNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLG
                     DMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRP
                     DEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSN
                     KPREWIRHFFPKQKCFVFDRPINDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHA
                     KTKTLREGILVTGNRLGMLVETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHY
                     SQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKE
                     DFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVP
                     RKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQK
                     QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKE
                     IFESLNEEINRLKEQIEAAENEEPSVFSQILDVAGSIFIAALPGAAKLVDLGMKILSS
                     LCNRLRNPGKKIIS"
     exon            293..420
                     /gene="GBP7"
                     /gene_synonym="GBP4L"
                     /inference="alignment:Splign:2.1.0"
     exon            421..530
                     /gene="GBP7"
                     /gene_synonym="GBP4L"
                     /inference="alignment:Splign:2.1.0"
     exon            531..727
                     /gene="GBP7"
                     /gene_synonym="GBP4L"
                     /inference="alignment:Splign:2.1.0"
     exon            728..973
                     /gene="GBP7"
                     /gene_synonym="GBP4L"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1254
                     /gene="GBP7"
                     /gene_synonym="GBP4L"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1467
                     /gene="GBP7"
                     /gene_synonym="GBP4L"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1570
                     /gene="GBP7"
                     /gene_synonym="GBP4L"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1764
                     /gene="GBP7"
                     /gene_synonym="GBP4L"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..2426
                     /gene="GBP7"
                     /gene_synonym="GBP4L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2404..2409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP7"
                     /gene_synonym="GBP4L"
                     /note="hexamer: AATAAA"
     polyA_site      2426
                     /gene="GBP7"
                     /gene_synonym="GBP4L"
                     /note="major polyA site"
ORIGIN      
        1 agaactaaag agaagagaat aaagactcat aactttctca ttgaagctgc cttcttacca
       61 agtccagagg atctctactc tggacagagg aacgccctga acatggcatc agagatccac
      121 atgccaggcc cagtgtgcct cactgagaac actaaagggc atctggtggt gaattcagaa
      181 gctctggaaa tcctgtctgc cattacacag cctgtagtag tggtggcaat tgtgggcctc
      241 taccgcacag gcaaatccta cctaatgaac aagctggctg ggaagaacaa aggcttccct
      301 ctgggctgca cagtgaagtc tgaaaccaaa ggcatctgga tgtggtgtgt gccccacccc
      361 tccaagccaa accacaccct gatccttctg gacacggagg gcctgggtga tatggaaaag
      421 agtgacccta agagtgactc gtggatcttt gccctggctg tgcttctaag cagcagcttt
      481 gtctacaaca gcatgggcac catcaaccac caggccctgg agcagctgca ctacgtgact
      541 gagctaacag agctaatcag ggcaaaatcg tgccccagac ctgatgaagt tgaggactcc
      601 agcgagtttg tgagtttctt tccagacttt atttggactg ttcgagattt taccctggag
      661 ctgaagttag atggacaccc catcacagaa gatgagtacc tggagaatgc cttgaagctg
      721 atttcaggca agaatcccca aatccaaaat tctaacaagc ccagggagtg gatcaggcat
      781 ttctttccaa aacagaagtg ctttgtcttt gaccggccaa taaatgacaa aaaactctta
      841 ctccatgttg aagaagtacg agaagaccaa ctggatagta atttccagat gcaatcagaa
      901 aatttctgtt cttatatctt cacccatgca aagaccaaga ccctgagaga gggaatcctt
      961 gtcactggaa accggctggg gatgctggtg gagacctacc tggatgccat caacagtgga
     1021 gcgactcctt gtctggagaa tgcaatggca gttctggccc agtgtgagaa ctcagcagcc
     1081 gtgcagaggg cagccaacca ctacagccag cagatggccc agcaagtgag attccccaca
     1141 gacacactcc aggagctgct ggacgtgcat gcagtttgtg agagggaagc cattgcagtc
     1201 ttcatggagt actccttcaa agataaaagc caggaatttc agaagaagct tgtggacacc
     1261 atggagaaaa agaaggaaga ctttgtgctg cagaatgaag aggcatctgc caaatattgt
     1321 caggctgagc ttaagcggct ttcagagctc ttgacagaaa gtatttcaag aggaactttc
     1381 tttgttccgg gggggcacaa tatctactta gaagcaaaaa agaagattga acaggactat
     1441 acactagtgc ccagaaaagg agttaaggca gacgaggtcc tccagagctt cctgcagtca
     1501 caggtggtta tagaggaatc catcctgcag tcagacaaag ccctcactgc tggagagaag
     1561 gccatagcag ctaagcaggc taagaaggag gcagctgaaa aggaacagga gctgctaaga
     1621 caaaaacaga aggaacagca gcaaatgatg gaggctcaag agagaagttt ccaggaaaac
     1681 atagctcaac tcaagaagaa gatggagagg gaaagggaaa actatatgag agaactgaga
     1741 aagatgttga gtcacaagat gaaggtccta gaagaactgc ttactgaagg atttaaagag
     1801 atatttgagt cgttaaatga agagattaat cgactgaaag aacaaattga agcagctgaa
     1861 aatgaagagc cctcagtgtt ttcacagatt cttgatgtgg ctggcagtat atttattgca
     1921 gcactacctg gggctgctaa gctagttgat ttaggaatga aaattcttag ctcattatgt
     1981 aataggctga gaaatcctgg taagaaaatt ataagctgag gtttcttttg ttaaaatggt
     2041 ataacgctgt tgctcatttt aaaagtatat gtgttattgc agtttcattt aagaaaagtt
     2101 taaaattaaa aagcaaattt caaagaatat tatggcctga agttcataaa aacaaactta
     2161 attttgacta aagtaataat taatagaaat ggggaacaag ttagaagata aaattattcc
     2221 tagaaaagat ttaagtaaag caaaaggaca aatggtaata taaagaaatt attttcaatt
     2281 aatgttatag tcacagagat aatttaagtt ataattagct cttgcaaatc agtgagaaga
     2341 gagtaacgcc acatatttta aacaggcaaa aatatgataa taaaaatgtt taattttact
     2401 gacaataaaa gttgtgcaaa gaaaaa
//
