LOCUS       NM_198460               4685 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens guanylate binding protein family member 6 (GBP6),
            transcript variant 1, mRNA.
ACCESSION   NM_198460 XM_088830
VERSION     NM_198460.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4685)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4685)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 4685)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 4685)
  AUTHORS   Suarez-Gestal,M., Perez-Pampin,E., Calaza,M., Gomez-Reino,J.J. and
            Gonzalez,A.
  TITLE     Lack of replication of genetic predictors for the rheumatoid
            arthritis response to anti-TNF treatments: a prospective case-only
            study
  JOURNAL   Arthritis Res Ther 12 (2), R72 (2010)
   PUBMED   20423481
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 4685)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (bases 1 to 4685)
  AUTHORS   Olszewski,M.A., Gray,J. and Vestal,D.J.
  TITLE     In silico genomic analysis of the human and murine
            guanylate-binding protein (GBP) gene clusters
  JOURNAL   J Interferon Cytokine Res 26 (5), 328-352 (2006)
   PUBMED   16689661
REFERENCE   7  (bases 1 to 4685)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131356.1, AL691464.4 and AI199897.1.
            
            On Nov 30, 2019 this sequence version replaced NM_198460.2.
            
            Summary: Guanylate-binding proteins, such as GBP6, are induced by
            interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al.,
            2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315834.1, BX537949.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370456.5/ ENSP00000359485.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2079              AK131356.1         167-2245
            2080-4400           AL691464.4         30898-33218
            4401-4685           AI199897.1         1-285               c
FEATURES             Location/Qualifiers
     source          1..4685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.2"
     gene            1..4685
                     /gene="GBP6"
                     /note="guanylate binding protein family member 6"
                     /db_xref="GeneID:163351"
                     /db_xref="HGNC:HGNC:25395"
                     /db_xref="MIM:612467"
     exon            1..69
                     /gene="GBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            70..282
                     /gene="GBP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1994
                     /gene="GBP6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     guanylate-binding protein 6; GBP-6; GTP-binding protein 6;
                     guanine nucleotide-binding protein 6"
                     /codon_start=1
                     /product="guanylate-binding protein 6 isoform 1"
                     /protein_id="NP_940862.2"
                     /db_xref="CCDS:CCDS723.1"
                     /db_xref="GeneID:163351"
                     /db_xref="HGNC:HGNC:25395"
                     /db_xref="MIM:612467"
                     /translation="MESGPKMLAPVCLVENNNEQLLVNQQAIQILEKISQPVVVVAIV
                     GLYRTGKSYLMNHLAGQNHGFPLGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLG
                     DVEKGDPKNDSWIFALAVLLCSTFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRP
                     DGVEDSTEFVSFFPDFLWTVRDFTLELKLNGHPITEDEYLENALKLIQGNNPRVQTSN
                     FPRECIRRFFPKRKCFVFDRPTNDKDLLANIEKVSEKQLDPKFQEQTNIFCSYIFTHA
                     RTKTLREGITVTGNRLGTLAVTYVEAINSGAVPCLENAVITLAQRENSAAVQRAADYY
                     SQQMAQRVKLPTDTLQELLDMHAACEREAIAIFMEHSFKDENQEFQKKFMETTMNKKG
                     DFLLQNEESSVQYCQAKLNELSKGLMESISAGSFSVPGGHKLYMETKERIEQDYWQVP
                     RKGVKAKEVFQRFLESQMVIEESILQSDKALTDREKAVAVDRAKKEAAEKEQELLKQK
                     LQEQQQQMEAQDKSRKENIAQLKEKLQMEREHLLREQIMMLEHTQKVQNDWLHEGFKK
                     KYEEMNAEISQFKRMIDTTKNDDTPWIARTLDNLADELTAILSAPAKLIGHGVKGVSS
                     LFKKHKLPF"
     exon            283..410
                     /gene="GBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            411..520
                     /gene="GBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            521..717
                     /gene="GBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            718..963
                     /gene="GBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1244
                     /gene="GBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1457
                     /gene="GBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1560
                     /gene="GBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1754
                     /gene="GBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..4685
                     /gene="GBP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2772..2777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP6"
                     /note="hexamer: AATATA"
     polyA_site      2793
                     /gene="GBP6"
                     /note="major polyA site"
     regulatory      2959..2964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP6"
                     /note="hexamer: AATAAA"
     polyA_site      2981
                     /gene="GBP6"
                     /note="major polyA site"
ORIGIN      
        1 gaggaaagaa aacaagaggt gagtgaggca actgaaaact gttcttggac ctgcggtgct
       61 atagagcagg ctcttctagg ttggcagttg ccatggaatc tggacccaaa atgttggccc
      121 ccgtttgcct ggtggaaaat aacaatgagc agctattggt gaaccagcaa gctatacaga
      181 ttcttgaaaa gatttctcag ccagtggtgg tggtggccat tgtaggactg taccgtacag
      241 ggaaatccta cttgatgaac catctggcag gacagaatca tggcttccct ctgggctcca
      301 cggtgcagtc tgaaaccaag ggcatctgga tgtggtgcgt gccccaccca tccaagccaa
      361 accacaccct ggtccttctg gacaccgaag gtctgggcga tgtggaaaag ggtgacccta
      421 agaatgactc ctggatcttt gccctggctg tgctcctgtg cagcaccttt gtctacaaca
      481 gcatgagcac catcaaccac caggccctgg agcagctgca ttatgtgacg gagctcacag
      541 aactaattaa ggcaaagtcc tccccaaggc ctgatggagt agaagattcc acagagtttg
      601 tgagtttctt cccagacttt ctttggacag tacgggattt cactctggag ctgaagttga
      661 acggtcaccc tatcacagaa gatgaatacc tggagaatgc cttgaagctg attcaaggca
      721 ataatcccag agttcaaaca tccaattttc ccagggagtg catcaggcgt ttctttccaa
      781 aacggaagtg tttcgtcttt gaccggccaa caaatgacaa agaccttcta gccaatattg
      841 agaaggtgtc agaaaagcaa ctggatccca aattccagga acaaacaaac attttctgtt
      901 cttacatctt cactcatgca agaaccaaga ccctcaggga gggaatcaca gtcactggga
      961 atcgtctggg aactctggca gtgacttatg tagaggccat caacagtgga gcagtgcctt
     1021 gtctggagaa tgcagtgata actctggccc agcgtgagaa ctcagcggcc gtgcagaggg
     1081 cagctgacta ctacagccag cagatggccc agcgagtgaa gctccccaca gacacgctcc
     1141 aggagctgct ggacatgcat gcggcctgtg agagggaagc cattgcaatc ttcatggagc
     1201 actccttcaa ggatgaaaat caggaattcc agaagaagtt catggaaacc acaatgaata
     1261 agaaggggga tttcttgctg cagaatgaag agtcatctgt tcaatactgc caggctaaac
     1321 tcaatgagct ctcaaaggga ctaatggaaa gtatctcagc aggaagtttc tctgttcctg
     1381 gagggcacaa gctctacatg gaaacaaagg aaaggattga acaggactat tggcaagttc
     1441 ccaggaaagg agtaaaggca aaagaggtct tccagaggtt cctggagtca cagatggtga
     1501 tagaggaatc catcttgcag tcagataaag ccctcactga tagagagaag gcagtagcag
     1561 tggatcgggc caagaaggag gcagctgaga aggaacagga acttttaaaa cagaaattac
     1621 aggagcagca gcaacagatg gaggctcaag ataagagtcg caaggaaaac atagcccaac
     1681 tgaaggagaa gctgcagatg gagagagaac acctactgag agagcagatt atgatgttgg
     1741 agcacacgca gaaggtccaa aatgattggc ttcatgaagg atttaagaag aagtatgagg
     1801 agatgaatgc agagataagt caatttaaac gtatgattga tactacaaaa aatgatgata
     1861 ctccctggat tgcacgaacc ttggacaacc ttgccgatga gctaactgca atattgtctg
     1921 ctcctgctaa attaattggt catggtgtca aaggtgtgag ctcactcttt aaaaagcata
     1981 agctcccctt ttaaggatat tatagattgt acatatatgc tttggactat ttttgatctg
     2041 tatgtttttc attttcattc agcaagtttt tttttttttt cagagtctta ctctgttgcc
     2101 caggctggag tacagtggtg caatctcagc tcactgcaac ctctgcctcc tgggttcaag
     2161 agattcacct gcctcagccc cctagtagct gggattatag gtgtacacca ccacacccag
     2221 ctaatttttg tatttttagt agagatgggg tttcactatg ttggccaggc tggtctcgaa
     2281 ctcttgacct caaatgatcc acccgcctcg gcctcccaaa gtgctgggtt tacaggcatg
     2341 agccaccatg cccagccctc atttagcaaa gttttaaaca taaaaagtgc ttattagagg
     2401 atatcagtgc ctggcccaca tgagagaaca gatccataca cactttgaaa aactttgttc
     2461 acttttagga aatataattt tgaaaaatca tttacataca agaggtccac tgaggcattg
     2521 cttttaatgg caaaatattg caatgtactt gaatgtcctt cacattagat tggtaagata
     2581 aattttagta tgtgcatgta ctggaatatt atatagccag taaacaaatt gacaatgaag
     2641 ctctatttgt accagtaaag aatggtcttg aagagacatt gtaaaatgaa aaaaaaaaaa
     2701 accaagttgt aaagcaatgt agattatctt atcagcatgg aaaaaatgca attattatat
     2761 ggaagcatgc aaatatatct ctggaaagat taatcaaaat ctattattat tggctccttc
     2821 tgggaagaac caagtgaatg taggggttga aggaacacat actcttcact ttatactctt
     2881 gaattttgta aagaaatctt attttaccga ttcagaaata aataagaaaa tgtaagagac
     2941 aatgctaata atgataacaa taaaaaaata gtgaaattgg ctatcagatg atgaaattcc
     3001 ttgttgcttc taggaattac atcagccagc ccaatgaggg gtctaagact aagatctgag
     3061 tactagaatg caaaaaattt gcatcatatt cttgttttca ttttggcctg gtttttcgat
     3121 cccttctatt tgtttcgaga ctaaggcata cacttttctg tggcctttga aatctcagct
     3181 acagtagcct ctacttcctt tctctgaatt caagttttaa ggtgttagaa gcataaatta
     3241 ccaaacatta agattaagca ctgataggaa ggatcctgcc aaccttgtca gtagtggtct
     3301 ttttgcggta gcctcagata gaaaggacaa tgtgcctttc cagaactgaa ccccctgatg
     3361 ggggatgata gacccagaca catagaggcc tggtgttgac ccttaattgt tagaatctaa
     3421 gaagattcag ttatagtaat gagtggcaga ctgcaaggcc tgatggagat aattctgaag
     3481 atggtcaata caatggacca gccatagggt taaatgggat ggggagaaaa caatcaagtg
     3541 aagtaaatgc tgtctatcag gatgttgaga ggtagccctg ataaagtgtc acatccatag
     3601 ccttgatctg agctaatttc agaccctgaa ctcagttgga gtggagggca gtaccccagg
     3661 aaaggacact gcaactccag gacccaaata aatgataatg atttcccaag ttctcctcct
     3721 aggaaacgtc tggagccatt tactagatat ccatatacta gggaaataca aacacccaaa
     3781 tatttcaagg acccttggaa tcaggatcca agttgcccat ggtacctaga tcatggagag
     3841 tcatcgtaaa atgcctgtta aaatagggaa ttagggcctc caggttgtaa ttatagtctt
     3901 ggcacacatg aacttattgc aatatagtat ttgtttgaaa tgtaaaggta aagtttgttt
     3961 gaagacagat accttatttt tctgtacatc tccttgggag tatgttcagg cataggttgt
     4021 gctaaataag cttcttttat aaaaacaata ggctgatgca tgggtgatta ttttcaattg
     4081 ataaaatatc atgaactttc cagagatcag tggtaataag ttgtttgaat tttcgacacc
     4141 agattaaggt ctctgaggtg gtttaaaggc tatgaggcca ggtgcagtgg ctcacgccta
     4201 taatctcagc aacttgggag gccgaagcag gcagatcact tgaggtcaga agtttgagac
     4261 cagcctggcc aacatggcga aaccctgcct ttactaaaaa tacaaaaatt aaccaagtgt
     4321 ggtggcacac gcctgtcatg ccagctacac aggaggatga ggcaggaaaa tcacttgaac
     4381 ctgggaggtg gaggttgcag tgagccgaga ttgtgccatt gcactccagc ccgggcaaca
     4441 gagcctgggc gacagagtga ggctctgtct caaaaaatta aactaaatta aagctatgag
     4501 aagaaaataa attttcctgg tatagtgtcc ttctctagac ctcatgtcct acagtctctg
     4561 tgaaactggg ccaaagatag aatttttttt tctgtgcttt atacagtgac tcagacaaac
     4621 ctatgacctc acacaaatct gtaacttcat gtatcacagt ctctataaaa ctatatcaaa
     4681 gaaag
//
