LOCUS       NM_052942               6812 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens guanylate binding protein 5 (GBP5), transcript variant
            1, mRNA.
ACCESSION   NM_052942
VERSION     NM_052942.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6812)
  AUTHORS   Veler,H., Lun,C.M., Waheed,A.A. and Freed,E.O.
  TITLE     Guanylate-binding protein 5 antagonizes viral glycoproteins
            independently of furin processing
  JOURNAL   mBio 15 (10), e0208624 (2024)
   PUBMED   39212413
  REMARK    GeneRIF: Guanylate-binding protein 5 antagonizes viral
            glycoproteins independently of furin processing.
REFERENCE   2  (bases 1 to 6812)
  AUTHORS   Hasegawa,M., Amano,Y., Kihara,A., Matsubara,D., Fukushima,N.,
            Takahashi,H., Chikamatsu,K., Nishino,H., Mori,Y., Yoshida,N. and
            Niki,T.
  TITLE     Guanylate binding protein 5 is an immune-related biomarker of oral
            squamous cell carcinoma: A retrospective prognostic study with
            bioinformatic analysis
  JOURNAL   Cancer Med 13 (13), e7431 (2024)
   PUBMED   38978333
  REMARK    GeneRIF: Guanylate binding protein 5 is an immune-related biomarker
            of oral squamous cell carcinoma: A retrospective prognostic study
            with bioinformatic analysis.
REFERENCE   3  (bases 1 to 6812)
  AUTHORS   Luu,L.D.W., Pandey,A., Paramsothy,S., Ngo,C., Castano-Rodriguez,N.,
            Liu,C., Kamm,M.A., Borody,T.J., Man,S.M. and Kaakoush,N.O.
  TITLE     Profiling the colonic mucosal response to fecal microbiota
            transplantation identifies a role for GBP5 in colitis in humans and
            mice
  JOURNAL   Nat Commun 15 (1), 2645 (2024)
   PUBMED   38531874
  REMARK    GeneRIF: Profiling the colonic mucosal response to fecal microbiota
            transplantation identifies a role for GBP5 in colitis in humans and
            mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6812)
  AUTHORS   Chiu,H.W., Lin,C.H., Lee,H.H., Lu,H.W., Lin,Y.K., Lin,Y.F. and
            Lee,H.L.
  TITLE     Guanylate binding protein 5 triggers NF-kappaB activation to foster
            radioresistance, metastatic progression and PD-L1 expression in
            oral squamous cell carcinoma
  JOURNAL   Clin Immunol 259, 109892 (2024)
   PUBMED   38185269
  REMARK    GeneRIF: Guanylate binding protein 5 triggers NF-kappaB activation
            to foster radioresistance, metastatic progression and PD-L1
            expression in oral squamous cell carcinoma.
REFERENCE   5  (bases 1 to 6812)
  AUTHORS   Huang,M., Zhan,C., Yang,B., Lu,Y., Yang,X. and Hou,J.
  TITLE     Guanylate-binding protein 5-mediated cell-autonomous immunity
            suppresses inflammation in dental pulpitis: An in vitro study
  JOURNAL   Int Endod J 57 (2), 208-218 (2024)
   PUBMED   38050666
  REMARK    GeneRIF: Guanylate-binding protein 5-mediated cell-autonomous
            immunity suppresses inflammation in dental pulpitis: An in vitro
            study.
REFERENCE   6  (bases 1 to 6812)
  AUTHORS   Ito,Y., Shibata-Watanabe,Y., Ushijima,Y., Kawada,J., Nishiyama,Y.,
            Kojima,S. and Kimura,H.
  TITLE     Oligonucleotide microarray analysis of gene expression profiles
            followed by real-time reverse-transcriptase polymerase chain
            reaction assay in chronic active Epstein-Barr virus infection
  JOURNAL   J Infect Dis 197 (5), 663-666 (2008)
   PUBMED   18260761
  REMARK    GeneRIF: 3 genes were upregulated in patients with chronic EBV
            infection: guanylate binding protein 1, tumor necrosis
            factor-induced protein 6, and guanylate binding protein 5; they may
            be associated with the inflammatory reaction or with cell
            proliferation.
REFERENCE   7  (bases 1 to 6812)
  AUTHORS   Tripal,P., Bauer,M., Naschberger,E., Mortinger,T., Hohenadl,C.,
            Cornali,E., Thurau,M. and Sturzl,M.
  TITLE     Unique features of different members of the human guanylate-binding
            protein family
  JOURNAL   J Interferon Cytokine Res 27 (1), 44-52 (2007)
   PUBMED   17266443
  REMARK    GeneRIF: GBP5 is constitutively localized in the Golgi apparatus of
            endothelial cells.
REFERENCE   8  (bases 1 to 6812)
  AUTHORS   Fellenberg,F., Hartmann,T.B., Dummer,R., Usener,D., Schadendorf,D.
            and Eichmuller,S.
  TITLE     GBP-5 splicing variants: New guanylate-binding proteins with
            tumor-associated expression and antigenicity
  JOURNAL   J Invest Dermatol 122 (6), 1510-1517 (2004)
   PUBMED   15175044
  REMARK    GeneRIF: Eight of nine melanoma cell lines expressed GBP-5a/b and
            four of nine additionally low levels of GBP-5ta.
REFERENCE   9  (bases 1 to 6812)
  AUTHORS   Hartmann,T.B., Thiel,D., Dummer,R., Schadendorf,D. and
            Eichmuller,S.
  TITLE     SEREX identification of new tumour-associated antigens in cutaneous
            T-cell lymphoma
  JOURNAL   Br J Dermatol 150 (2), 252-258 (2004)
   PUBMED   14996095
REFERENCE   10 (bases 1 to 6812)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099063.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 17, 2021 this sequence version replaced NM_052942.4.
            
            Summary: This gene belongs to the TRAFAC class dynamin-like GTPase
            superfamily. The encoded protein acts as an activator of NLRP3
            inflammasome assembly and has a role in innate immunity and
            inflammation. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.21692.1, BC031639.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2158569
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370459.8/ ENSP00000359488.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-409               AC099063.2         17439-17847
            410-517             AC099063.2         19437-19544
            518-726             AC099063.2         20725-20933
            727-854             AC099063.2         21443-21570
            855-964             AC099063.2         22773-22882
            965-1161            AC099063.2         23146-23342
            1162-1404           AC099063.2         23711-23953
            1405-1685           AC099063.2         25333-25613
            1686-1898           AC099063.2         26351-26563
            1899-2001           AC099063.2         27514-27616
            2002-2183           AC099063.2         27898-28079
            2184-6812           AC099063.2         29482-34110
FEATURES             Location/Qualifiers
     source          1..6812
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.2"
     gene            1..6812
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /note="guanylate binding protein 5"
                     /db_xref="GeneID:115362"
                     /db_xref="HGNC:HGNC:19895"
                     /db_xref="MIM:611467"
     exon            1..409
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            410..517
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            518..726
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             537..2297
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GBP-TA antigen; GTP-binding protein 5; guanine
                     nucleotide-binding protein 5"
                     /codon_start=1
                     /product="guanylate-binding protein 5 isoform 1"
                     /protein_id="NP_443174.1"
                     /db_xref="CCDS:CCDS722.1"
                     /db_xref="GeneID:115362"
                     /db_xref="HGNC:HGNC:19895"
                     /db_xref="MIM:611467"
                     /translation="MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIV
                     GLYRTGKSYLMNKLAGKNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLG
                     DVEKADNKNDIQIFALALLLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDL
                     DRVEDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFN
                     LPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSM
                     TKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLALAQRENSAAVQKAIAHYD
                     QQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQND
                     ICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPR
                     KGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQ
                     RQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSL
                     LSELQHAQRTVNNDDPCVLL"
     exon            727..854
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            855..964
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1161
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1404
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1685
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1898
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2001
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2183
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..6812
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2389..2394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /note="hexamer: AATAAA"
     polyA_site      2421
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /note="major polyA site"
     regulatory      4024..4029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /note="hexamer: CATAAA"
     polyA_site      4051
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
     regulatory      5460..5465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /note="hexamer: AATAAA"
     polyA_site      5480
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
     regulatory      6787..6792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
                     /note="hexamer: AATAAA"
     polyA_site      6812
                     /gene="GBP5"
                     /gene_synonym="GBP-5"
ORIGIN      
        1 actgaggtca ccctccaggc tgtggaacct ttgttctttc actctttgca ataaatcttg
       61 ctgctgctca ctctttgggt ccacactgcc tttatgagct gtaacactca ctgggaatgt
      121 ctgcagcttc actcctgaag ccagcgagac cacgaaccca ccaggaggaa caaacaactc
      181 cagacgcgca gccttaagag ctgtaacact caccgcgaag gtctgcagct tcactcctga
      241 gccagccaga ccacgaaccc accagaagga agaaactcca aacacatccg aacatcagaa
      301 ggagcaaact cctgacacgc cacctttaag aaccgtgaca ctcaacgcta gggtccgcgg
      361 cttcattctt gaagtcagtg agaccaagaa cccaccaatt ccggacacgc taattgttgt
      421 agatcatcac ttcaaggtgc ccatatcttt ctagtggaaa aattattctg gcctccgctg
      481 catacaaatc aggcaaccag aattctacat atataaggca aagtaacatc ctagacatgg
      541 ctttagagat ccacatgtca gaccccatgt gcctcatcga gaactttaat gagcagctga
      601 aggttaatca ggaagctttg gagatcctgt ctgccattac gcaacctgta gttgtggtag
      661 cgattgtggg cctctatcgc actggcaaat cctacctgat gaacaagctg gctgggaaga
      721 acaagggctt ctctgttgca tctacggtgc agtctcacac caagggaatt tggatatggt
      781 gtgtgcctca tcccaactgg ccaaatcaca cattagttct gcttgacacc gagggcctgg
      841 gagatgtaga gaaggctgac aacaagaatg atatccagat ctttgcactg gcactcttac
      901 tgagcagcac ctttgtgtac aatactgtga acaaaattga tcagggtgct atcgacctac
      961 tgcacaatgt gacagaactg acagatctgc tcaaggcaag aaactcaccc gaccttgaca
     1021 gggttgaaga tcctgctgac tctgcgagct tcttcccaga cttagtgtgg actctgagag
     1081 atttctgctt aggcctggaa atagatgggc aacttgtcac accagatgaa tacctggaga
     1141 attccctaag gccaaagcaa ggtagtgatc aaagagttca aaatttcaat ttgccccgtc
     1201 tgtgtataca gaagttcttt ccaaaaaaga aatgctttat ctttgactta cctgctcacc
     1261 aaaaaaagct tgcccaactt gaaacactgc ctgatgatga gctagagcct gaatttgtgc
     1321 aacaagtgac agaattctgt tcctacatct ttagccattc tatgaccaag actcttccag
     1381 gtggcatcat ggtcaatgga tctcgtctaa agaacctggt gctgacctat gtcaatgcca
     1441 tcagcagtgg ggatctgcct tgcatagaga atgcagtcct ggccttggct cagagagaga
     1501 actcagctgc agtgcaaaag gccattgccc actatgacca gcaaatgggc cagaaagtgc
     1561 agctgcccat ggaaaccctc caggagctgc tggacctgca caggaccagt gagagggagg
     1621 ccattgaagt cttcatgaaa aactctttca aggatgtaga ccaaagtttc cagaaagaat
     1681 tggagactct actagatgca aaacagaatg acatttgtaa acggaacctg gaagcatcct
     1741 cggattattg ctcggcttta cttaaggata tttttggtcc tctagaagaa gcagtgaagc
     1801 agggaattta ttctaagcca ggaggccata atctcttcat tcagaaaaca gaagaactga
     1861 aggcaaagta ctatcgggag cctcggaaag gaatacaggc tgaagaagtt ctgcagaaat
     1921 atttaaagtc caaggagtct gtgagtcatg caatattaca gactgaccag gctctcacag
     1981 agacggaaaa aaagaagaaa gaggcacaag tgaaagcaga agctgaaaag gctgaagcgc
     2041 aaaggttggc ggcgattcaa aggcagaacg agcaaatgat gcaggagagg gagagactcc
     2101 atcaggaaca agtgagacaa atggagatag ccaaacaaaa ttggctggca gagcaacaga
     2161 aaatgcagga acaacagatg caggaacagg ctgcacagct cagcacaaca ttccaagctc
     2221 aaaatagaag ccttctcagt gagctccagc acgcccagag gactgttaat aacgatgatc
     2281 catgtgtttt actctaaagt gctaaatatg ggagtttcct ttttttactc tttgtcactg
     2341 atgacacaac agaaaagaaa ctgtagacct tgggacaatc aacatttaaa taaactttat
     2401 aattattttt tcaaactttc atatagagtt ataagattat gatgctggta tctggtaaaa
     2461 tgtacatccc agtagtccaa tagtttaaat gtttattgct tcctttaaga gattataaat
     2521 tgtataaggg acattgtatc actgccttca tttatgcgtg atattgggat ggtttcatca
     2581 ggagatgctt tccttgcatc tcaatgtcat ctgtctaatt tctcataagg ggattatgtt
     2641 acctagagca gggcttccca accctcaggc catagactag ctctgatctg tggcctctta
     2701 ggaacccggc cacacagcag gaggtgagca gcaggtaagt gagcattaca gcctgagctc
     2761 cacctcctgt cagatcagca gtgacattag attctcacag gagtgggaac cctattgtga
     2821 actgtgcatg caaaagatct aggttgtgtg atccttgtgg aacaatataa accagaaacc
     2881 aataacgcca ccccacctcc aacccccgcc aaccctctgt ggaaaaatta ccttccacga
     2941 aactggtccc tgatgccaaa taggttgggg gaccgctgac ctagagggag ttatgcacat
     3001 gggcttataa ggttagccaa gagaaaggac aagaagaccc aaagtcggca agcaaattta
     3061 ttaacctgct gggctgctct acagaaatct gaggaggcag acaccgggct tacaggctaa
     3121 ggggtataag taggtctgca ggggttttgt gtgtgtgtgc gggggtgtcg ggggggcaag
     3181 gccatttgtg gagacttttc ctcccagtat ggccacatcc tgcagtttgt cagtttttgc
     3241 ccccgcctgg ctcagggtac caggatgtgg tttagcttag gggtggttat agtggcacct
     3301 aagttctggg aacttgcggt gggggcgacc ttttggacga aaaataagct gcagggcagc
     3361 taggggaggg ggcttgttat attcctctgg gggcagggtg tccctaactg ggctcagtcg
     3421 gaaggaactt gaccaaagtc tgggctcagt tgggcatcac tcaggctaat ggtcgtgtgc
     3481 tggatgccat cagagggaag taccaatggt aaagtggaaa caatgtgcag ctttcaactg
     3541 ggtggaggct gctattctgt ggacagtgag atgtttcctt ggcactgtca atagacaatc
     3601 tgcgtagaga aattccaagc tgaaagccaa taatgttata ataaaataga gattcttcag
     3661 aagatgaaag gaattaccag catggaaatt gtgtcatagg cttaagggct aaagaagaag
     3721 ccttttcttt tctgttcacc ctcaccaaga gcacaactta aatagggcat tttataacct
     3781 gaacacaatt tatattggac ttaattatta tgtgtaatat gtttataatc ctttagatct
     3841 tataaatatg tggtataagg aatgccatat aatgtgccaa aaatctgagt gcatttaatt
     3901 taatgcttgc ttatagtgct aaagttaaat gatcttaatt ctttgcaatt atatatgaaa
     3961 aatgactgat ttttcttaaa atatgtaact tatataaata tatctgtttg tacagatttt
     4021 aaccataaaa acatttttgg aaaaccataa atcagttcct ttgtttgtat ttttctcaaa
     4081 gttaaaagtc tatagagaaa gactgaattt ccctaaggag attaagaatt gctttaagac
     4141 tagaattaaa acacacttta ttacatcttt ttatgtactt tttgttactt tgttttgtat
     4201 atctccagta aaattttttt tgtttaaatt atagaaacat tacacaaagc tctgtttttc
     4261 tcccttataa gtacttactc atataaggaa ttttccactt aggtaatatg ataggagctt
     4321 gaattttttt agtcacccaa aatatgattt acttatatac agaaaaaagc cgaaaaattt
     4381 tagtgtctgc tctttttact gttctttgaa gagctttaat atgaggaatt tttcatatca
     4441 gataggatgt ggtgctactc agcagtattt ctagatttga actgaagttc agaaggtacc
     4501 agcatattca actgagcatt tgtctagcaa taccctacaa ttaccttttc aagctgtgca
     4561 atttataaag aaaaaaatac attttatcat ccaaggaaat gttatcagta aaaagaatag
     4621 ctctatctcc aaattaaata ttgatatctt tattacccat cttaaagaaa ttttttaaaa
     4681 tcctgagact cagaaaatta agtcatttaa ggtttcacac cttgttactg ttaacctaga
     4741 ccatgttaca aagtagttga tttctagtct aatttaactt ttgctattat atctccccca
     4801 ccaaaaacca gagaggcatg ctgctttcat tagtgatcca cagatattct tccccaccag
     4861 cttccctgga tcccactcat ccccaaatac tctgatctca caggttagag atctgtcact
     4921 gggtgcaaaa gaacaagaaa aggcactgta aggtaaacat tgatgatttc ttgaaactac
     4981 cagtaagtag cttatatttt ctgactttct ttgtcttact gttgtgaaat caactgatct
     5041 agttttaaat gtaatgaaaa gcaaagcaat agattctccc ctagagcctg cagatggaat
     5101 gcagccttgt taacatcttg atttaagctt cacagacttc tgatttccaa aactgtaaga
     5161 taataagctt ctgttgtttt aagccacaaa attagtaata atttgttata gcagcaatag
     5221 gaaacaagta caaaatcttt attagttaat actatgaata gttattcata ccagctaaga
     5281 gatatttgga atttattatg gatcacttta ttatggtcac tgtagtaatt cacctgttgc
     5341 tcataaaaac cttataaaca tttagtattg ttttatggca attgttattt taaacaatat
     5401 tatcaatgta tgttagtgtt atcattatta aagttattat tgttaaagca ttgaaattaa
     5461 ataaattaag gtcagtacca cagaaggcct tttgaattta gaacccacat taataaccat
     5521 cttgtggtac tttcttatct tgcttagtga tacggtttgg ctgtgtccac tcaaatctca
     5581 tcttgaatta tggctcccat aatgcccacg tgttgtggga gggaccaggt gggaggtaat
     5641 caaatcatgg gggtgggttt tcatgtgctt ttttcatgat agtgaataag tcgcctgaga
     5701 tctgatggct tcataaaggg caattcccct gcacatgctc tcttgcctga caccatgtaa
     5761 gatgtgcctt tgttcctctt tcatcttctg ctgtggttgt gaggcctccc cacccatgtg
     5821 aaactacaag tccattacat ctcttttcct ttataaatta cccagtcttg agtatttctt
     5881 catagcagta tgaaaatgga ctaatatact taggaaaaca tagaaatact gaataatgtg
     5941 ttaaaattta gaaggaatta ctaaaataat tgaaatcaaa agcatagatt caaaacaatg
     6001 tataagaatt cagcacaaaa taagcaggta aagaaatttc taaaatgaag tagagaaaat
     6061 gtggtaatga ctctagtgta taacgatcac caacagaata gaaagtccaa aaaatagact
     6121 ttataggaat aatacagggt aaagatagac ttcttagtag gttgggacta ctggatggcc
     6181 atataggaaa agatcaagtt gtaaccagac ctcacacaca atacactaaa ataagaaaaa
     6241 ggaaccacac ccaaattgat aaaatataaa atgtaaaact atgaaaatgc atttgaagaa
     6301 atcaaggtta tgttcttcat aaacctgtag aggagagggc ctttctaaat gtgactcaaa
     6361 actcttgaaa tctctcttga ccccatgtct cagtcagttt caacacaatc tttgttccct
     6421 ttcaaagcaa tattttagtt agttacatcc cattctctgt ttttcaaaat tattaaatgt
     6481 gacacatact gaagagtaca aaaaacataa aatgtacaat attcaatata aataaattac
     6541 aagatgaacg cacaagtaac aacccaggta catacattca gcattactaa aattctatag
     6601 gtgtatatga caacttctga caaccctgct agagccaact aatatcacaa ctttcacaac
     6661 tattttctag gattttatta taaacatgtg agctcctaag taatgtaatt ttgtttggcc
     6721 tgttttcaaa ctttatttaa atggaattac attgtttgta ttcttttatg ccttgcttca
     6781 tttgttaata aaatctttat aagattcatc ta
//
