LOCUS       NM_052941               6141 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens guanylate binding protein 4 (GBP4), mRNA.
ACCESSION   NM_052941
VERSION     NM_052941.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6141)
  AUTHORS   Zhou,W., Yeerkenbieke,G., Zhang,Y., Zhou,M. and Li,J.
  TITLE     Guanylate binding protein 4 shapes an inflamed tumor
            microenvironment and identifies immuno-hot tumors
  JOURNAL   J Cancer Res Clin Oncol 150 (2), 90 (2024)
   PUBMED   38347243
  REMARK    GeneRIF: Guanylate binding protein 4 shapes an inflamed tumor
            microenvironment and identifies immuno-hot tumors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6141)
  AUTHORS   Britzen-Laurent,N., Bauer,M., Berton,V., Fischer,N., Syguda,A.,
            Reipschlager,S., Naschberger,E., Herrmann,C. and Sturzl,M.
  TITLE     Intracellular trafficking of guanylate-binding proteins is
            regulated by heterodimerization in a hierarchical manner
  JOURNAL   PLoS One 5 (12), e14246 (2010)
   PUBMED   21151871
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6141)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 6141)
  AUTHORS   Tripal,P., Bauer,M., Naschberger,E., Mortinger,T., Hohenadl,C.,
            Cornali,E., Thurau,M. and Sturzl,M.
  TITLE     Unique features of different members of the human guanylate-binding
            protein family
  JOURNAL   J Interferon Cytokine Res 27 (1), 44-52 (2007)
   PUBMED   17266443
REFERENCE   5  (bases 1 to 6141)
  AUTHORS   Olszewski,M.A., Gray,J. and Vestal,D.J.
  TITLE     In silico genomic analysis of the human and murine
            guanylate-binding protein (GBP) gene clusters
  JOURNAL   J Interferon Cytokine Res 26 (5), 328-352 (2006)
   PUBMED   16689661
REFERENCE   6  (bases 1 to 6141)
  AUTHORS   Vestal,D.J.
  TITLE     The guanylate-binding proteins (GBPs): proinflammatory
            cytokine-induced members of the dynamin superfamily with unique
            GTPase activity
  JOURNAL   J Interferon Cytokine Res 25 (8), 435-443 (2005)
   PUBMED   16108726
  REMARK    Review article
REFERENCE   7  (bases 1 to 6141)
  AUTHORS   Han,B.H., Park,D.J., Lim,R.W., Im,J.H. and Kim,H.D.
  TITLE     Cloning, expression, and characterization of a novel
            guanylate-binding protein, GBP3 in murine erythroid progenitor
            cells
  JOURNAL   Biochim Biophys Acta 1384 (2), 373-386 (1998)
   PUBMED   9659399
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC008421.1, AF288814.1, BC070055.1, AC104459.2 and CA309701.1.
            
            On Nov 22, 2018 this sequence version replaced NM_052941.4.
            
            Summary: Guanylate-binding proteins, such as GBP4, are induced by
            interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005
            [PubMed 16108726]).[supplied by OMIM, Dec 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312417.1, SRR1803613.167664.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355754.7/ ENSP00000359490.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1316              BC008421.1         9-1324
            1317-1728           AF288814.1         1209-1620
            1729-3407           BC070055.1         1674-3352
            3408-5987           AC104459.2         106318-108897       c
            5988-6137           CA309701.1         16-165              c
            6138-6141           AC104459.2         106164-106167       c
FEATURES             Location/Qualifiers
     source          1..6141
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.2"
     gene            1..6141
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /note="guanylate binding protein 4"
                     /db_xref="GeneID:115361"
                     /db_xref="HGNC:HGNC:20480"
                     /db_xref="MIM:612466"
     exon            1..148
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2031
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /note="GBP-4; GTP-binding protein 4; guanine
                     nucleotide-binding protein 4"
                     /codon_start=1
                     /product="guanylate-binding protein 4"
                     /protein_id="NP_443173.2"
                     /db_xref="CCDS:CCDS721.1"
                     /db_xref="GeneID:115361"
                     /db_xref="HGNC:HGNC:20480"
                     /db_xref="MIM:612466"
                     /translation="MGERTLHAAVPTPGYPESESIMMAPICLVENQEEQLTVNSKALE
                     ILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKRNGFPLGSTVQSETKGIWMWCVPHLS
                     KPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSFVYNSVSTINHQALEQLHYV
                     TELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRDFTLELKLDGNPITEDEYLENA
                     LKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTNDKQYLNHMDEVPEENLERHF
                     LMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDAINSGAVPCLENAVTALA
                     QLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENH
                     EFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLY
                     LEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERA
                     MKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKH
                     KLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRLLKILDMASNIMIVTLPG
                     ASKLLGVGTKYLGSRI"
     exon            149..343
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            344..471
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            472..581
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            582..778
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            779..1024
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1305
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1518
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1621
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1815
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..6141
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5490..5495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /note="hexamer: AATAAA"
     polyA_site      5512
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /note="major polyA site"
     regulatory      6115..6120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /note="hexamer: ATTAAA"
     polyA_site      6141
                     /gene="GBP4"
                     /gene_synonym="Mpa2"
                     /note="major polyA site"
ORIGIN      
        1 aatttcggtt ctcacagact cttacttgga tgtctgtaaa tccggctgga ctttcagctt
       61 ctaagaacag tccgtttctc gaggatccag gcgcaggagg acagagcaat gggtgagaga
      121 actcttcacg ctgcagtgcc cacaccaggt tatccagaat ctgaatccat catgatggcc
      181 cccatttgtc tagtggaaaa ccaggaagag cagctgacag tgaattcaaa ggcattagag
      241 attcttgaca agatttctca gcccgtggtg gtggtggcca ttgtagggct ataccgcaca
      301 ggaaaatcct atctcatgaa tcgtcttgca ggaaagcgca atggcttccc tctgggctcc
      361 acggtgcagt ctgaaactaa gggcatctgg atgtggtgtg tgccccacct ctctaagcca
      421 aaccacaccc tggtccttct ggacaccgag ggcctgggcg atgtagaaaa gagtaaccct
      481 aagaatgact cgtggatctt tgccctggct gtgcttctaa gcagcagctt tgtctataac
      541 agcgtgagca ccatcaacca ccaggccctg gagcagctgc actatgtgac tgagctagca
      601 gagctaatca gggcaaaatc ctgccccaga cctgatgaag ctgaggactc cagcgagttt
      661 gcgagtttct ttccagactt tatttggact gttcgggatt ttaccctgga gctaaagtta
      721 gatggaaacc ccatcacaga agatgagtac ctggagaatg ccttgaagct gattccaggc
      781 aagaatccca aaattcaaaa ttcaaacatg cctagagagt gtatcaggca tttcttccga
      841 aaacggaagt gctttgtctt tgaccggcct acaaatgaca agcaatattt aaatcatatg
      901 gacgaagtgc cagaagaaaa tctggaaagg catttcctta tgcaatcaga caacttctgt
      961 tcttatatct tcacccatgc aaagaccaag accctgagag agggaatcat tgtcactgga
     1021 aagcggctgg ggactctggt ggtgacttat gtagatgcca tcaacagtgg agcagtacct
     1081 tgtctggaga atgcagtgac agcactggcc cagcttgaga acccagcggc tgtgcagagg
     1141 gcagccgacc actatagcca gcagatggcc cagcaactga ggctccccac agacacgctc
     1201 caggagctgc tggacgtgca tgcagcctgt gagagggaag ccattgcagt cttcatggag
     1261 cactccttca aggatgaaaa ccatgaattc cagaagaagc ttgtggacac catagagaaa
     1321 aagaagggag actttgtgct gcagaatgaa gaggcatctg ccaaatattg ccaggctgag
     1381 cttaagcggc tttcagagca cctgacagaa agcattttga gaggaatttt ctctgttcct
     1441 ggaggacaca atctctactt agaagaaaag aaacaggttg agtgggacta taagctagtg
     1501 cccagaaaag gagttaaggc aaacgaggtc ctccagaact tcctgcagtc acaggtggtt
     1561 gtagaggaat ccatcctgca gtcagacaaa gccctcactg ctggagagaa ggccatagca
     1621 gcggagcggg ccatgaagga agcagctgag aaggaacagg agctgctaag agaaaaacag
     1681 aaggagcagc agcaaatgat ggaggctcaa gagagaagct tccaggaata catggcccaa
     1741 atggagaaga agttggagga ggaaagggaa aaccttctca gagagcatga aaggctgcta
     1801 aaacacaagc tgaaggtaca agaagaaatg cttaaggaag aatttcaaaa gaaatctgag
     1861 cagttaaata aagagattaa tcaactgaaa gaaaaaattg aaagcactaa aaatgaacag
     1921 ttaaggctct taaagatcct tgacatggct agcaacataa tgattgtcac tctacctggg
     1981 gcttccaagc tacttggagt agggacaaaa tatcttggct cacgtattta agagcctgaa
     2041 tattccaggt aagaaaatat aaaatgaggt ttattttatt ttaataacat aacactgttg
     2101 ctcattttgt aagtatatgt gttatagcag tttcattcaa gaaaagttta aaattaaaaa
     2161 gtgattatca aagaatatca gggcctgaca tccacaaaaa acaaacttaa ttttgattga
     2221 actaataatt tataaacatg ggaaacaagt cagaagtagt gacattattc ctagaaaaga
     2281 tttaaggaaa gcaaaaagac aactggtaag attaagaagc cattaaccat ttgcaattta
     2341 tattatagtc acagaaataa tttcagttat gactagctct tgccgattaa tgagaagaga
     2401 gcagctccac aatttttaat ttttttaact tttattttag attcaggggt atatgtgcag
     2461 gtttgttaca taggtaaact gcatgtcatg ggggtttggt gtgcagataa ttttatcaca
     2521 caattattaa tcataatacc caataggttt ttttctgatc ttctccctcc tcccaaccta
     2581 caccctcaag tagaccccag tgtctcttgt tctcctctga gtatccatgt gttctctttg
     2641 tttggccccc atttataagt gagaacatgt ggtatttggg tttctgttcc tgtgttagtt
     2701 tgcttatgat aatggcttcc agctccatcc atattgctac agaggacatg atcttgttgt
     2761 tttttatggc tgcatagtat tccatggtgt ttgtatatac cacattttca ttatccagcc
     2821 tattattaat gcacatttag gttgattcct tatctttgct attgtgaaca gtgctgcaat
     2881 ggacatacac gtgcatgtgc ctttatggta caatgattta tatttccttg ggatatgcat
     2941 tcctttggga ataatgggat tgctgagttg aatggtaatt ctgagttctt tgaggaatca
     3001 ccaacctgct ttccacagtg gctaaactaa tttacactcc caccaacagt gtatgtgttc
     3061 cattttctcc acaaccttgc cagcatctgt tatttattga ctttctagta acagccattc
     3121 tgactggtgt gagatggtat gcatttctgt agtgattagt gatgatgagt gatttttata
     3181 tgctttttaa atgcatatat gtcttctttt gaaatgtgtt catgttcttt gcccactttc
     3241 tttttaatgg ggttgcttgt ttttcgcttg taaatttttt gaagcttctt atagattctg
     3301 gatattagat ctttgttgga tgcatagttg gcaaatattt tctaccattc tgtaggttgt
     3361 ctgttacttt gttaattgtt tcattttgtt ttgtttttgt tttttgaaac agggtctcac
     3421 tttgacaccc aggctggagt gcagtagcac aaacatgggt cattgtagcc tcaacctccc
     3481 aggctcaagc agtcctttca cctcaacccc ccacatagct gggactacag gtgcttacac
     3541 ccaagaccag ttaatttttt gtatttgttt gtagagatgt gtttttccat gttgcccaag
     3601 ctggtcttga actactgagc tcaagcaatc tgcctgcttc agcctcccaa agtactggga
     3661 tttaggcatg agccaccaca tctggccaat agtttctttt gatgtgcaga agctctttaa
     3721 tttaattaga tctcctttgt cagtttttgt ttttgctgca attgcttatg ttatcttcat
     3781 catgaaattt tagccaagtc ttatgtccag aatggtattt cttaggttat ttttcagagt
     3841 ttttatagtt taatgtttta tatttaagtc tttaatcctt cttaagttga tttttgtatg
     3901 cagagtaagc tgggggccca gtttcaatct tctgcatatg gctagccagt aatcccagca
     3961 ccatttatta aatggggact tctttcccca ttgcttgttt ttgtcagctt tgtccaagat
     4021 cagatgattg taggtgtaca gcattatttc tggactctct gttatgttcc atttatctgt
     4081 gtgtctgttt ttctactaat accatgctgt tttggttact gtagctctgt agtatggttt
     4141 gaggtttggt aacttgatgc ctcccctttt gttctttatg tttaggattg ccttggctag
     4201 gctctttttt ggttccatat gaattttaaa gtagtttcta attctgtgaa gaatgtcatt
     4261 ggtagtttga tagggatagc attgaactat ttgctcaact caacatttta ggaatttatt
     4321 tctgctgtct agtgctcaaa acttgcagct agaattgagg gaagagagag accttcttat
     4381 attgttttat attgtttgat actcagtacc tgttttaaga aaaaacaaca aggaagtaaa
     4441 accaaagaca ggcagcccag cgccaggccc aaaaccaggc ctgggcctgc ctggcctaaa
     4501 cccagtagtt aaaaatcaac tcattgcctg taatcccagc actttgggag gccgagacgg
     4561 gtggatcacg aggtcaggag atcgagacca tcctggctaa cacggtgaaa ccccgtctct
     4621 actaaaaata caaaaattag ccgggcatgg tggcacgcgc ctgtagtccc agctacacgg
     4681 gaggctgagg caggagaatg gcgtgaaccc aggaggcgga gcttgcagtg agtcgagatc
     4741 gcgccactgc actccagcct gggcgacaga gcgaaactcc gtctcaaaaa aaaaaaaaaa
     4801 aaatcaactc ataacttaga aaccgatgtt attcatagat tccagacatt gtatagaaga
     4861 acatttggaa actcactgcc ttgttctgtt tctctctgac caccagtgca tgcagcccct
     4921 gtcatgtacc gcctgtttgc tcaaatcaat catgaccctt tcatgtgaaa tctttagtgt
     4981 tgtgagccct taaaagggac agaaattgtg cattcaagga gcttggattt taaggcagca
     5041 gcttgctgat gccaccagct gaaaaaagcc cttccttctc caactcggtg tctgagaagt
     5101 tttgtctgca gctcatcctg ctacagaatg aactccttgt aattctacaa gatatgccat
     5161 gggccttttc acaggggaca caggcttctt aaaacaaccc ggcttcctca ccctatgtcc
     5221 tttatttaca aagctgtgct cctattcatg agcatggaat gtttttccat ttgtttgtga
     5281 catctcttat ttctttcagg ggtatcttgt aattctcatt atatatatct tttgcttcct
     5341 tggttagctg tatttttagg tattttagtc ttcttgtggc aattgtgaat gggattgcat
     5401 tcctgatttg gctcttggct taatgttatt aacgccacat tttttaaata gacaaaaata
     5461 tgagattaaa aatgttgaat tttactaaca ataaaagttg ttcaaaggaa aactataagg
     5521 ttcttgtttc aactctgtca taggaagaac aggacagtga gctggcacag agttagggaa
     5581 actgactgtg tctcatattg gctagtgaga gtgatctgtt ggaattgtat atcaaaattt
     5641 taatgtacat acattttgtc tagcaattct actattgggt atttatatag tacatataaa
     5701 tataaatgta tatgtttagt aaatatatac ttatagttag taaatatatt ttatatctat
     5761 ttagtaaata tactaaatgt caggcctctg agcccaagct aagccatcat atcccctgtg
     5821 acctgcatgt acatacgtcc agatggcctg aagcaagtga agaatcacaa aagaagtgaa
     5881 aatggcctgt tcctgcctta actgatgaca ttaccttgtg aaattccttc tcctggctca
     5941 tcctggctca aaagctcccc cactaagcaa cttgtgacac ccacctctgc ccgccagaga
     6001 acaaccccct ttgactgtaa ttttccttta ccaacccaaa tcctgtaaaa tggtcccaac
     6061 cctatctccc ttcactgact gtcttttcgg actcagccag cctgcaccca ggtgattaaa
     6121 aagctttatt gctcacacaa a
//
