LOCUS       NM_018284               3037 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens guanylate binding protein 3 (GBP3), transcript variant
            1, mRNA.
ACCESSION   NM_018284
VERSION     NM_018284.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3037)
  AUTHORS   Jiang,T., Jin,P., Huang,G. and Li,S.C.
  TITLE     The function of guanylate binding protein 3 (GBP3) in human cancers
            by pan-cancer bioinformatics
  JOURNAL   Math Biosci Eng 20 (5), 9511-9529 (2023)
   PUBMED   37161254
  REMARK    GeneRIF: The function of guanylate binding protein 3 (GBP3) in
            human cancers by pan-cancer bioinformatics.
REFERENCE   2  (bases 1 to 3037)
  AUTHORS   Xu,H., Jin,J., Chen,Y., Wu,G., Zhu,H., Wang,Q., Wang,J., Li,S.,
            Grigore,F.N., Ma,J., Chen,C.C., Lan,Q. and Li,M.
  TITLE     GBP3 promotes glioblastoma resistance to temozolomide by enhancing
            DNA damage repair
  JOURNAL   Oncogene 41 (31), 3876-3885 (2022)
   PUBMED   35780181
  REMARK    GeneRIF: GBP3 promotes glioblastoma resistance to temozolomide by
            enhancing DNA damage repair.
REFERENCE   3  (bases 1 to 3037)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3037)
  AUTHORS   Xu,H., Sun,L., Zheng,Y., Yu,S., Ou-Yang,J., Han,H., Dai,X., Yu,X.,
            Li,M. and Lan,Q.
  TITLE     GBP3 promotes glioma cell proliferation via SQSTM1/p62-ERK1/2 axis
  JOURNAL   Biochem Biophys Res Commun 495 (1), 446-453 (2018)
   PUBMED   29128363
  REMARK    GeneRIF: GBP3 over-expression promotes glioma growth in mice and is
            inversely correlated with patients survival rate.
REFERENCE   5  (bases 1 to 3037)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3037)
  AUTHORS   Britzen-Laurent,N., Bauer,M., Berton,V., Fischer,N., Syguda,A.,
            Reipschlager,S., Naschberger,E., Herrmann,C. and Sturzl,M.
  TITLE     Intracellular trafficking of guanylate-binding proteins is
            regulated by heterodimerization in a hierarchical manner
  JOURNAL   PLoS One 5 (12), e14246 (2010)
   PUBMED   21151871
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3037)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3037)
  AUTHORS   Tripal,P., Bauer,M., Naschberger,E., Mortinger,T., Hohenadl,C.,
            Cornali,E., Thurau,M. and Sturzl,M.
  TITLE     Unique features of different members of the human guanylate-binding
            protein family
  JOURNAL   J Interferon Cytokine Res 27 (1), 44-52 (2007)
   PUBMED   17266443
REFERENCE   9  (bases 1 to 3037)
  AUTHORS   Luan,Z., Zhang,Y., Liu,A., Man,Y., Cheng,L. and Hu,G.
  TITLE     A novel GTP-binding protein hGBP3 interacts with NIK/HGK
  JOURNAL   FEBS Lett 530 (1-3), 233-238 (2002)
   PUBMED   12387898
REFERENCE   10 (bases 1 to 3037)
  AUTHORS   Strehlow,I., Lohmann-Matthes,M.L. and Decker,T.
  TITLE     The interferon-inducible GBP1 gene: structure and mapping to human
            chromosome 1
  JOURNAL   Gene 144 (2), 295-299 (1994)
   PUBMED   7518790
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR936755.1, CR936758.1 and
            AL160008.3.
            
            On Nov 23, 2018 this sequence version replaced NM_018284.2.
            
            Summary: This gene encodes a member of the guanylate-binding
            protein (GBP) family. GBPs specifically bind guanine nucleotides
            (GMP, GDP, and GTP) and contain two of the three consensus motifs
            found in typical GTP-binding proteins. The encoded protein
            interacts with a member of the germinal center kinase family.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR936755.1, SRR1660809.33747.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370481.9/ ENSP00000359512.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                CR936755.1         2-60
            60-866              CR936758.1         1-807
            867-878             AL160008.3         4011-4022           c
            879-3037            CR936758.1         820-2978
FEATURES             Location/Qualifiers
     source          1..3037
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.2"
     gene            1..3037
                     /gene="GBP3"
                     /note="guanylate binding protein 3"
                     /db_xref="GeneID:2635"
                     /db_xref="HGNC:HGNC:4184"
                     /db_xref="MIM:600413"
     exon            1..183
                     /gene="GBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            184..395
                     /gene="GBP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1993
                     /gene="GBP3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GTP-binding protein 3; guanine nucleotide-binding protein
                     3; guanylate-binding protein 3 delta C"
                     /codon_start=1
                     /product="guanylate-binding protein 3 isoform 1"
                     /protein_id="NP_060754.2"
                     /db_xref="CCDS:CCDS717.2"
                     /db_xref="GeneID:2635"
                     /db_xref="HGNC:HGNC:4184"
                     /db_xref="MIM:600413"
                     /translation="MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIV
                     GLYRTGKSYLMNKLAGKNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLG
                     DVKKGDNQNDSWIFTLAVLLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDE
                     NENEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFN
                     LPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSK
                     TKTLSGGIKVNGPRLESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYD
                     QQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDD
                     FCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPR
                     KGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQ
                     IKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGE
                     STQLQNEIQKLQKTLKKKTKRYMSHKLKI"
     exon            396..523
                     /gene="GBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            524..633
                     /gene="GBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            634..830
                     /gene="GBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1073
                     /gene="GBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1354
                     /gene="GBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1567
                     /gene="GBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1670
                     /gene="GBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1864
                     /gene="GBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..3037
                     /gene="GBP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2899..2904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP3"
                     /note="hexamer: AATAAA"
     polyA_site      2919
                     /gene="GBP3"
     regulatory      3020..3025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP3"
                     /note="hexamer: ACTAAA"
     polyA_site      3037
                     /gene="GBP3"
                     /note="major polyA site"
ORIGIN      
        1 actttcagtt tcattaggct ctgaagccat tacaaaggtt gcttaacttc taattatttg
       61 atcactgagg aaaatccaga aagctacaca acactgaagg ggtgaaataa aagtccagcg
      121 atccagcgaa agaaaagaga agtgacagaa acaactttac ctggactgaa gataaaagca
      181 cagacaagag aacaatgccc tggacatggc tccagagatc cacatgacag gcccaatgtg
      241 cctcattgag aacactaatg gggaactggt ggcgaatcca gaagctctga aaatcctgtc
      301 tgccattaca cagcctgtgg tggtggtggc aattgtgggc ctctaccgca caggaaaatc
      361 ctacctgatg aacaagctag ctgggaagaa taagggcttc tctctgggct ccacagtgaa
      421 atctcacacc aaaggaatct ggatgtggtg tgtgcctcac cccaaaaagc cagaacacac
      481 cttagtcctg cttgacactg agggcctggg agatgtaaag aagggtgaca accagaatga
      541 ctcctggatc ttcaccctgg ccgtcctcct gagcagcact ctcgtgtaca atagcatggg
      601 aaccatcaac cagcaggcta tggaccaact gtactatgtg acagagctga cacatcgaat
      661 ccgatcaaaa tcctcacctg atgagaatga gaatgaggat tcagctgact ttgtgagctt
      721 cttcccagat tttgtgtgga cactgagaga tttctccctg gacttggaag cagatggaca
      781 acccctcaca ccagatgagt acctggagta ttccctgaag ctaacgcaag gtaccagtca
      841 aaaagataaa aattttaatc tgccccgact ctgtatccgg aagttcttcc caaagaaaaa
      901 atgttttgtc ttcgatctgc ccattcaccg caggaagctt gcccagcttg agaaactaca
      961 agatgaagag ctggaccctg aatttgtgca acaagtagca gacttctgtt cctacatctt
     1021 tagcaattcc aaaactaaaa ctctttcagg aggcatcaag gtcaatgggc ctcgtctaga
     1081 gagcctagtg ctgacctata tcaatgctat cagcagaggg gatctgccct gcatggagaa
     1141 cgcagtcctg gccttggccc agatagagaa ctcagccgca gtgcaaaagg ctattgccca
     1201 ctatgaccag cagatgggcc agaaggtgca gctgcccgca gaaaccctcc aggagctgct
     1261 ggacctgcac agggttagtg agagggaggc cactgaagtc tatatgaaga actctttcaa
     1321 ggatgtggac catctgtttc aaaagaaatt agcggcccag ctagacaaaa agcgggatga
     1381 cttttgtaaa cagaatcaag aagcatcatc agatcgttgc tcagctttac ttcaggtcat
     1441 tttcagtcct ctagaagaag aagtgaaggc gggaatttat tcgaaaccag ggggctattg
     1501 tctctttatt cagaagctac aagacctgga gaaaaagtac tatgaggaac caaggaaggg
     1561 gatacaggct gaagagattc tgcagacata cttgaaatcc aaggagtctg tgaccgatgc
     1621 aattctacag acagaccaga ttctcacaga aaaggaaaag gagattgaag tggaatgtgt
     1681 aaaagctgaa tctgcacagg cttcagcaaa aatggtggag gaaatgcaaa taaagtatca
     1741 gcagatgatg gaagagaaag agaagagtta tcaagaacat gtgaaacaat tgactgagaa
     1801 gatggagagg gagagggccc agttgctgga agagcaagag aagaccctca ctagtaaact
     1861 tcaggaacag gcccgagtac taaaggagag atgccaaggt gaaagtaccc aacttcaaaa
     1921 tgagatacaa aagctacaga agaccctgaa aaaaaaaacc aagagatata tgtcgcataa
     1981 gctaaagatc taaacaacag agcttttctg tcatcctaac ccaaggcata actgaaacaa
     2041 ttttagaatt tggaacaagt gtcactatat ttgataataa ttagatcttg catcataaca
     2101 ctaaaagttt acaagaacat gcagttcaat gatcaaaatc atgttttttc cttaaaaaga
     2161 ttgtaaattg tgcaacaaag atgcatttac ctctgtacca acagaggagg gatcatgagt
     2221 tgccaccact cagaagttta ttcttccaga cgaccagtgg atactgagga aagtcttagg
     2281 taaaaatctt gggacatatt tgggcactgg tttggccaag tgtacaatgg gtcccaatat
     2341 cagaaacaac catcctagct tcctagggaa gacagtgtac agttctccat tatatcaagg
     2401 ctacaaggtc tatgagcaat aatgtgattt ctggacattg cccatggata attctcactg
     2461 atggatctca agctaaagca aaccatctta tacagagatc tagaatctta tattttccat
     2521 aggaaggtaa agaaatcatt agcaagagta ggaattgaat cataaacaaa ttggctaatg
     2581 aagaaatctt ttctttcttg ttcaattcat ctagattata accttaatgt gacacctgag
     2641 acctttagac agttgaccct gaattaaata gtcacatggt aacaattatg cactgtgtaa
     2701 ttttagtaat gtataacatg caatgatgca ctttaactga agatagagac tatgttagaa
     2761 aattgaacta atttaattat ttgattgttt taatcctaaa gcataagtta gtcttttcct
     2821 gattcttaaa ggtcatactt gaaatcctgc caattttccc caaagggaat atggaatttt
     2881 tttgactttc ttttgagcaa taaaataatt gtcttgccat tacttagtat atgtagactt
     2941 catcccaatt gtcaaacatc ctaggtaagt ggttgacatt tcttacagca attacagatt
     3001 atttttgaac tagaaataaa ctaaactaga aataaaa
//
