LOCUS       NM_004120               4088 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens guanylate binding protein 2 (GBP2), mRNA.
ACCESSION   NM_004120
VERSION     NM_004120.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4088)
  AUTHORS   Kubo,Y., Hans,M.B., Nakamura,T. and Hayashi,H.
  TITLE     The Furin Protease Dependence and Antiviral GBP2 Sensitivity of
            Murine Leukemia Virus Infection Are Determined by the Amino Acid
            Sequence at the Envelope Glycoprotein Cleavage Site
  JOURNAL   Int J Mol Sci 25 (18), 9987 (2024)
   PUBMED   39337476
  REMARK    GeneRIF: The Furin Protease Dependence and Antiviral GBP2
            Sensitivity of Murine Leukemia Virus Infection Are Determined by
            the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4088)
  AUTHORS   AmeliMojarad,M., AmeliMojarad,M. and Cui,X.
  TITLE     Weighted gene co-expression network analysis identified GBP2
            connected to PPARalpha activity and liver cancer
  JOURNAL   Sci Rep 14 (1), 20745 (2024)
   PUBMED   39251636
  REMARK    GeneRIF: Weighted gene co-expression network analysis identified
            GBP2 connected to PPARalpha activity and liver cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4088)
  AUTHORS   Xu,X., Ding,X., Wang,Z., Ye,S., Xu,J., Liang,Z., Luo,R., Xu,J.,
            Li,X. and Ren,Z.
  TITLE     GBP2 inhibits pathological angiogenesis in the retina via the
            AKT/mTOR/VEGFA axis
  JOURNAL   Microvasc Res 154, 104689 (2024)
   PUBMED   38636926
  REMARK    GeneRIF: GBP2 inhibits pathological angiogenesis in the retina via
            the AKT/mTOR/VEGFA axis.
REFERENCE   4  (bases 1 to 4088)
  AUTHORS   Li,X., Liu,J., Zeng,M., Yang,K., Zhang,S., Liu,Y., Yin,X., Zhao,C.,
            Wang,W. and Xiao,L.
  TITLE     GBP2 promotes M1 macrophage polarization by activating the notch1
            signaling pathway in diabetic nephropathy
  JOURNAL   Front Immunol 14, 1127612 (2023)
   PUBMED   37622120
  REMARK    GeneRIF: GBP2 promotes M1 macrophage polarization by activating the
            notch1 signaling pathway in diabetic nephropathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4088)
  AUTHORS   Ye,S., Li,S., Qin,L., Zheng,W., Liu,B., Li,X., Ren,Z., Zhao,H.,
            Hu,X., Ye,N. and Li,G.
  TITLE     GBP2 promotes clear cell renal cell carcinoma progression through
            immune infiltration and regulation of PD-L1 expression via STAT1
            signaling
  JOURNAL   Oncol Rep 49 (3) (2023)
   PUBMED   36660930
  REMARK    GeneRIF: GBP2 promotes clear cell renal cell carcinoma progression
            through immune infiltration and regulation of PDL1 expression via
            STAT1 signaling.
REFERENCE   6  (bases 1 to 4088)
  AUTHORS   Tripal,P., Bauer,M., Naschberger,E., Mortinger,T., Hohenadl,C.,
            Cornali,E., Thurau,M. and Sturzl,M.
  TITLE     Unique features of different members of the human guanylate-binding
            protein family
  JOURNAL   J Interferon Cytokine Res 27 (1), 44-52 (2007)
   PUBMED   17266443
REFERENCE   7  (bases 1 to 4088)
  AUTHORS   King,J.K., Yeh,S.H., Lin,M.W., Liu,C.J., Lai,M.Y., Kao,J.H.,
            Chen,D.S. and Chen,P.J.
  TITLE     Genetic polymorphisms in interferon pathway and response to
            interferon treatment in hepatitis B patients: A pilot study
  JOURNAL   Hepatology 36 (6), 1416-1424 (2002)
   PUBMED   12447867
  REMARK    GeneRIF: Observational study of gene-environment interaction. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4088)
  AUTHORS   Vestal,D.J., Gorbacheva,V.Y. and Sen,G.C.
  TITLE     Different subcellular localizations for the related
            interferon-induced GTPases, MuGBP-1 and MuGBP-2: implications for
            different functions?
  JOURNAL   J Interferon Cytokine Res 20 (11), 991-1000 (2000)
   PUBMED   11096456
REFERENCE   9  (bases 1 to 4088)
  AUTHORS   Neun,R., Richter,M.F., Staeheli,P. and Schwemmle,M.
  TITLE     GTPase properties of the interferon-induced human guanylate-binding
            protein 2
  JOURNAL   FEBS Lett 390 (1), 69-72 (1996)
   PUBMED   8706832
REFERENCE   10 (bases 1 to 4088)
  AUTHORS   Cheng,Y.S., Patterson,C.E. and Staeheli,P.
  TITLE     Interferon-induced guanylate-binding proteins lack an N(T)KXD
            consensus motif and bind GMP in addition to GDP and GTP
  JOURNAL   Mol Cell Biol 11 (9), 4717-4725 (1991)
   PUBMED   1715024
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB274428.1, BC073163.1,
            BC022272.1, AI400402.1, AI445567.1, AI085798.1, AC104459.2,
            DB229415.1 and BM993865.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004120.4.
            
            Summary: This gene belongs to the guanine-binding protein (GBP)
            family, which includes interferon-induced proteins that can bind to
            guanine nucleotides (GMP, GDP and GTP). The encoded protein is a
            GTPase which hydrolyzes GTP, predominantly to GDP. The protein may
            play a role as a marker of squamous cell carcinomas. [provided by
            RefSeq, Jul 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.151866.1,
                                           SRR1803613.146996.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153932, SAMEA2467144
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370466.4/ ENSP00000359497.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DB274428.1         46-63
            19-1197             BC073163.1         1-1179
            1198-1419           BC022272.1         1198-1419
            1420-2150           BC073163.1         1402-2132
            2151-2593           AI400402.1         24-466              c
            2594-3003           AI445567.1         1-410               c
            3004-3068           AI085798.1         12-76               c
            3069-3159           AC104459.2         32081-32171         c
            3160-3701           DB229415.1         2-543
            3702-4088           BM993865.1         16-402              c
FEATURES             Location/Qualifiers
     source          1..4088
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.2"
     gene            1..4088
                     /gene="GBP2"
                     /note="guanylate binding protein 2"
                     /db_xref="GeneID:2634"
                     /db_xref="HGNC:HGNC:4183"
                     /db_xref="MIM:600412"
     exon            1..252
                     /gene="GBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            253..459
                     /gene="GBP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..2045
                     /gene="GBP2"
                     /note="interferon-induced guanylate-binding protein 2;
                     GTP-binding protein 2; guanine nucleotide-binding protein
                     2; guanylate binding protein 2, interferon-inducible"
                     /codon_start=1
                     /product="guanylate-binding protein 2"
                     /protein_id="NP_004111.2"
                     /db_xref="CCDS:CCDS719.1"
                     /db_xref="GeneID:2634"
                     /db_xref="HGNC:HGNC:4183"
                     /db_xref="MIM:600412"
                     /translation="MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIV
                     GLYRTGKSYLMNKLAGKKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLG
                     DIEKGDNENDSWIFALAILLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGN
                     NSVDDSADFVSFFPAFVWTLRDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFN
                     DPRLCIRKFFPKRKCFVFDWPAPKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSN
                     VKTLSGGIPVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVEKAIAHYE
                     QQMGQKVQLPTETLQELLDLHRDSEREAIEVFMKNSFKDVDQMFQRKLGAQLEARRDD
                     FCKQNSKASSDCCMALLQDIFGPLEEDVKQGTFSKPGGYRLFTQKLQELKNKYYQVPR
                     KGIQAKEVLKKYLESKEDVADALLQTDQSLSEKEKAIEVERIKAESAEAAKKMLEEIQ
                     KKNEEMMEQKEKSYQEHVKQLTEKMERDRAQLMAEQEKTLALKLQEQERLLKEGFENE
                     SKRLQKDIWDIQMRSKSLEPICNIL"
     exon            460..587
                     /gene="GBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..697
                     /gene="GBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..894
                     /gene="GBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1137
                     /gene="GBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1418
                     /gene="GBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1631
                     /gene="GBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1734
                     /gene="GBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1928
                     /gene="GBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..4088
                     /gene="GBP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2133..2138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP2"
                     /note="hexamer: ATTAAA"
     polyA_site      2153
                     /gene="GBP2"
                     /note="major polyA site"
     regulatory      2177..2182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP2"
                     /note="hexamer: CATAAA"
     polyA_site      2202
                     /gene="GBP2"
     regulatory      2575..2580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP2"
                     /note="hexamer: AATAAA"
     polyA_site      2599
                     /gene="GBP2"
     regulatory      3047..3052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP2"
                     /note="hexamer: AATACA"
     polyA_site      3068
                     /gene="GBP2"
     regulatory      3371..3376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP2"
                     /note="hexamer: AACAAA"
     polyA_site      3391
                     /gene="GBP2"
     polyA_site      4088
                     /gene="GBP2"
ORIGIN      
        1 atattagtgc atttctttgc agaggttacc tctttttctt gtctctcgtc aggtctctga
       61 cattgacaga gcctggacgt tggaggaagc cccaggacgt tggaggggta aagtaaaagt
      121 ccacagttac cgtgagagaa aaaagaggga gaaagcagtg cagccaaact cggaagaaaa
      181 gagaggagga aaaggactcg actttcacat tggaacaacc ttctttccag tgctaaagga
      241 tctctgatct ggggaacaac accctggaca tggctccaga gatcaacttg ccgggcccaa
      301 tgagcctcat tgataacact aaagggcagc tggtggtgaa tccagaagct ctgaagatcc
      361 tatctgcaat tacgcagcct gtggtggtgg tggcgattgt gggcctctat cgcacaggca
      421 aatcctacct gatgaacaag ctggctggga agaaaaacgg cttctctcta ggctccacag
      481 tgaagtctca caccaaggga atctggatgt ggtgtgtgcc tcatcccaag aagccagaac
      541 acaccctagt tctgctcgac actgagggcc tgggagatat agagaagggt gacaatgaga
      601 atgactcctg gatctttgcc ttggccatcc tcctgagcag caccttcgtg tacaatagca
      661 tgggaaccat caaccagcag gccatggacc aacttcacta tgtgacagag ctgacagatc
      721 gaatcaaggc aaactcctca cctggtaaca attctgtaga cgactcagct gactttgtga
      781 gcttttttcc agcatttgtg tggactctca gagatttcac cctggaactg gaagtagatg
      841 gagaacccat cactgctgat gactacttgg agctttcgct aaagctaaga aaaggtactg
      901 ataagaaaag taaaagcttt aatgatcctc ggttgtgcat ccgaaagttc ttccccaaga
      961 ggaagtgctt cgtcttcgat tggcccgctc ctaagaagta ccttgctcac ctagagcagc
     1021 taaaggagga agagctgaac cctgatttca tagaacaagt tgcagaattt tgttcctaca
     1081 tcctcagcca ttccaatgtc aagactcttt caggtggcat tccagtcaat gggcctcgtc
     1141 tagagagcct ggtgctgacc tacgtcaatg ccatcagcag tggggatcta ccctgcatgg
     1201 agaacgcagt cctggccttg gcccagatag agaactcagc cgcagtggaa aaggctattg
     1261 cccactatga acagcagatg ggccagaagg tgcagctgcc cacggaaacc ctccaggagc
     1321 tgctggacct gcacagggac agtgagagag aggccattga agtcttcatg aagaactctt
     1381 tcaaggatgt ggaccaaatg ttccagagga aattaggggc ccagttggaa gcaaggcgag
     1441 atgacttttg taagcagaat tccaaagcat catcagattg ttgcatggct ttacttcagg
     1501 atatatttgg ccctttagaa gaagatgtca agcagggaac attttctaaa ccaggaggtt
     1561 accgtctctt tactcagaag ctgcaggagc tgaagaataa gtactaccag gtgccaagga
     1621 aggggataca ggccaaagag gtgctgaaaa aatatttgga gtccaaggag gatgtggctg
     1681 atgcacttct acagactgat cagtcactct cagaaaagga aaaagcgatt gaagtggaac
     1741 gtataaaggc tgaatctgca gaagctgcaa agaaaatgtt ggaggaaata caaaagaaga
     1801 atgaggagat gatggaacag aaagagaaga gttatcagga acatgtgaaa caattgactg
     1861 agaagatgga gagggacagg gcccagttaa tggcagagca agagaagacc ctcgctctta
     1921 aacttcagga acaggaacgc cttctcaagg agggattcga gaatgagagc aagagacttc
     1981 aaaaagacat atgggatatc cagatgagaa gcaaatcatt ggagccaata tgtaacatac
     2041 tctaaaagtc caaggagcaa aatttgcctg tccagctccc tctccccaag aaacaacatg
     2101 aatgagcaac ttcagagtgt caaacaactg ccattaaact taactcaaaa tcatgatgca
     2161 tgcatttttg ttgaaccata aagtttgcaa agtaaaggtt aagtatgagg tcaatgtttt
     2221 acctacagag caattcaact catgcttatt tatagtacta acttttaata tgatctttaa
     2281 ctaaatccta tatttgaaat catacacaag gactcaagag agatattgtg taactaggat
     2341 gcattttcca atgagatatc ttgcagtttc tgttctgggt agattttttt ctctcatatg
     2401 caccaccctt actgtatatt cagtcctata ctcttattca gggatttaac tatggtcgta
     2461 gcatagggct gaagtgttgt gaatatgatg aaaatgtgat gagaccaaac aaaccatggg
     2521 gcacagtaga gcatcactcc tgccaagtgg tctttgtatg gcatgctggc tgcaaataaa
     2581 ggagatctgg gacacttaac taggctttta aagtacagac agtgcacagt tctcatttgg
     2641 gtggaggctg catgatctgt gggcactagc agagaaagtg gttgcctctg tgcagaatgc
     2701 atttatgagt agaggctcca ccttctctgt ccatgtaaac cctctaggta attactgccc
     2761 cattcccagg ccacctagat ctctcttctc tagtctccct tagtcttttc tctttcctga
     2821 agtttagaaa ataacttcta caatcacaga aaggaaagct ttaactcaaa ctcaaattac
     2881 tttccattct tctgaggacc aggactataa tcctataaag cctaaaactt gactgcattt
     2941 ttctctctgc tcctctgcta tgacattata tcctcaaagc tactcagggt aaatgactta
     3001 ctaaaaaaaa aaaaatgaca gattgaaaaa tcaagaataa ttcattaata caaaacatta
     3061 tcctactaca attgtttcag gatgtgtatt attcagagtt cttcatggca aataacaatc
     3121 tgctcagcaa tttaagtaaa aagtaattta ctttttaata ccattaggtt gcacaccgat
     3181 gctccagaat tgtgagggag ccatactcta cagctattcc accgaggata atactaccat
     3241 tgtaaaggca tctcacggga aaacaacaca gctaccatga accagcacca tgatctctgg
     3301 atgaaatgct ggaagcttct gcagtgtcag ctatgagtaa atggatgcca ccaccttcac
     3361 attttcagta aacaaatact cccctacccc atgaaaagtt gcatctttga gctgctcaca
     3421 tctccagcta agcctcacaa aagtcaatct gcagggaaga atctaaatca tatgcctacc
     3481 catgggaaag tctgagaatt agagtatttt tgtcttctac ttttggagga agaaactaat
     3541 aacgtgggaa attttcctgt atgtttagtc aaccagtttt tccatgcaga tgtatggaga
     3601 taaatcttat agtaggaata acctaagact tgagttagta tttttgtgta catcagatac
     3661 aacactcttc tcatcttttt tgtcattatt tttcaatgtt gttttaatct ttccactgtt
     3721 gtttcatgtc atgcactttg ttaatattct ttaagttatt cttagttttt aacaatgata
     3781 cttaagaaag acttaatagg actatagaat aggtactccc tattccccaa ccctgggaac
     3841 acaatttaac atattagttc atttgtattt aagatctatc ttgtttatgc ctcagtttag
     3901 ttattgctct tacctttcaa acagttagta ttttgtatct agttctgtga aagcaaaaag
     3961 caactttatt ctttcttaca attccccttt tacttaatcg gaacatttct ttcctgtttg
     4021 ttcattagtc actctcagat aaatgaatag tctctttttc taaaaaaaaa aataacattt
     4081 gacctaaa
//
