LOCUS       NM_002053               2883 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens guanylate binding protein 1 (GBP1), mRNA.
ACCESSION   NM_002053
VERSION     NM_002053.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2883)
  AUTHORS   Gu,T., Qu,S., Zhang,J., Ying,Q., Zhang,X., Lv,Y., Liu,R., Feng,Y.,
            Wang,F. and Wu,X.
  TITLE     Guanylate-binding protein 1 inhibits Hantaan virus infection by
            restricting virus entry
  JOURNAL   J Med Virol 96 (6), e29730 (2024)
   PUBMED   38860570
  REMARK    GeneRIF: Guanylate-binding protein 1 inhibits Hantaan virus
            infection by restricting virus entry.
REFERENCE   2  (bases 1 to 2883)
  AUTHORS   Yu,S., Li,Y., Feng,W., Zeng,J., Cui,X., Zhou,S. and Zhang,P.
  TITLE     GBP1 promotes cutaneous squamous cell carcinoma proliferation and
            invasion through activation of STAT3 by SP1
  JOURNAL   Exp Dermatol 33 (6), e15112 (2024)
   PUBMED   38840385
  REMARK    GeneRIF: GBP1 promotes cutaneous squamous cell carcinoma
            proliferation and invasion through activation of STAT3 by SP1.
REFERENCE   3  (bases 1 to 2883)
  AUTHORS   Xu,M., Lin,M.C. and Li,Z.H.
  TITLE     Interferon-gamma-induced GBP1 is an inhibitor of human
            papillomavirus 18
  JOURNAL   BMC Womens Health 24 (1), 240 (2024)
   PUBMED   38622605
  REMARK    GeneRIF: Interferon-gamma-induced GBP1 is an inhibitor of human
            papillomavirus 18.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2883)
  AUTHORS   Bender,D., Koulouri,A., Wen,X., Glitscher,M., Schollmeier,A.,
            Fernandes da Costa,L., Murra,R.O., Carra,G.P., Haberger,V.,
            Praefcke,G.J.K. and Hildt,E.
  TITLE     Guanylate-binding protein 1 acts as a pro-viral factor for the life
            cycle of hepatitis C virus
  JOURNAL   PLoS Pathog 20 (2), e1011976 (2024)
   PUBMED   38315728
  REMARK    GeneRIF: Guanylate-binding protein 1 acts as a pro-viral factor for
            the life cycle of hepatitis C virus.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2883)
  AUTHORS   Wang,S., Zhang,Y., Ma,X. and Feng,Y.
  TITLE     Function and mechanism of GBP1 in the development and progression
            of cervical cancer
  JOURNAL   J Transl Med 22 (1), 11 (2024)
   PUBMED   38167153
  REMARK    GeneRIF: Function and mechanism of GBP1 in the development and
            progression of cervical cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2883)
  AUTHORS   Saunders,N.A., Smith,R.J. and Jetten,A.M.
  TITLE     Regulation of guanylate-binding protein expression in
            interferon-gamma-treated human epidermal keratinocytes and squamous
            cell carcinoma cells
  JOURNAL   J Invest Dermatol 112 (6), 977-983 (1999)
   PUBMED   10383748
REFERENCE   7  (bases 1 to 2883)
  AUTHORS   Nantais,D.E., Schwemmle,M., Stickney,J.T., Vestal,D.J. and
            Buss,J.E.
  TITLE     Prenylation of an interferon-gamma-induced GTP-binding protein: the
            human guanylate binding protein, huGBP1
  JOURNAL   J Leukoc Biol 60 (3), 423-431 (1996)
   PUBMED   8830800
REFERENCE   8  (bases 1 to 2883)
  AUTHORS   Strehlow,I., Lohmann-Matthes,M.L. and Decker,T.
  TITLE     The interferon-inducible GBP1 gene: structure and mapping to human
            chromosome 1
  JOURNAL   Gene 144 (2), 295-299 (1994)
   PUBMED   7518790
REFERENCE   9  (bases 1 to 2883)
  AUTHORS   Schwemmle,M. and Staeheli,P.
  TITLE     The interferon-induced 67-kDa guanylate-binding protein (hGBP1) is
            a GTPase that converts GTP to GMP
  JOURNAL   J Biol Chem 269 (15), 11299-11305 (1994)
   PUBMED   7512561
REFERENCE   10 (bases 1 to 2883)
  AUTHORS   Cheng,Y.S., Patterson,C.E. and Staeheli,P.
  TITLE     Interferon-induced guanylate-binding proteins lack an N(T)KXD
            consensus motif and bind GMP in addition to GDP and GTP
  JOURNAL   Mol Cell Biol 11 (9), 4717-4725 (1991)
   PUBMED   1715024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK291783.1, CB164272.1, BF058809.1 and CD676970.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002053.2.
            
            Summary: Guanylate binding protein expression is induced by
            interferon. Guanylate binding proteins are characterized by their
            ability to specifically bind guanine nucleotides (GMP, GDP, and
            GTP) and are distinguished from the GTP-binding proteins by the
            presence of 2 binding motifs rather than 3. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M55542.1, AK291783.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370473.5/ ENSP00000359504.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2084              AK291783.1         1-2084
            2085-2573           CB164272.1         138-626
            2574-2879           BF058809.1         1-306               c
            2880-2883           CD676970.1         612-615
FEATURES             Location/Qualifiers
     source          1..2883
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.2"
     gene            1..2883
                     /gene="GBP1"
                     /gene_synonym="hGBP1"
                     /note="guanylate binding protein 1"
                     /db_xref="GeneID:2633"
                     /db_xref="HGNC:HGNC:4182"
                     /db_xref="MIM:600411"
     exon            1..49
                     /gene="GBP1"
                     /gene_synonym="hGBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            50..258
                     /gene="GBP1"
                     /gene_synonym="hGBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1847
                     /gene="GBP1"
                     /gene_synonym="hGBP1"
                     /note="guanylate binding protein 1, interferon-inducible,
                     67kDa; interferon-induced guanylate-binding protein 1;
                     GBP-1; huGBP-1; GTP-binding protein 1; guanine
                     nucleotide-binding protein 1"
                     /codon_start=1
                     /product="guanylate-binding protein 1"
                     /protein_id="NP_002044.2"
                     /db_xref="CCDS:CCDS718.1"
                     /db_xref="GeneID:2633"
                     /db_xref="HGNC:HGNC:4182"
                     /db_xref="MIM:600411"
                     /translation="MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIV
                     GLYRTGKSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLG
                     DVEKGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDE
                     NENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDET
                     FNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSN
                     SKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAH
                     YEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKR
                     DDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEE
                     PRKGIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQE
                     MQRKNEQMMEQKERSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQ
                     KESRIMKNEIQDLQTKMRRRKACTIS"
     exon            259..386
                     /gene="GBP1"
                     /gene_synonym="hGBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..496
                     /gene="GBP1"
                     /gene_synonym="hGBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..699
                     /gene="GBP1"
                     /gene_synonym="hGBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..942
                     /gene="GBP1"
                     /gene_synonym="hGBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1223
                     /gene="GBP1"
                     /gene_synonym="hGBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1436
                     /gene="GBP1"
                     /gene_synonym="hGBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1539
                     /gene="GBP1"
                     /gene_synonym="hGBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1733
                     /gene="GBP1"
                     /gene_synonym="hGBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..2883
                     /gene="GBP1"
                     /gene_synonym="hGBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2858..2863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GBP1"
                     /gene_synonym="hGBP1"
                     /note="hexamer: ATTAAA"
     polyA_site      2883
                     /gene="GBP1"
                     /gene_synonym="hGBP1"
                     /note="major polyA site"
ORIGIN      
        1 acagaagtgc tagaagccag tgctcgtgaa ctaaggagaa aaagaacaga caagggaaca
       61 gcctggacat ggcatcagag atccacatga caggcccaat gtgcctcatt gagaacacta
      121 atgggcgact gatggcgaat ccagaagctc tgaagatcct ttctgccatt acacagccta
      181 tggtggtggt ggcaattgtg ggcctctacc gcacaggcaa atcctacctg atgaacaagc
      241 tggctggaaa gaaaaagggc ttctctctgg gctccacggt gcagtctcac actaaaggaa
      301 tctggatgtg gtgtgtgccc caccccaaga agccaggcca catcctagtt ctgctggaca
      361 ccgagggtct gggagatgta gagaagggtg acaaccagaa tgactcctgg atcttcgccc
      421 tggccgtcct cctgagcagc accttcgtgt acaatagcat aggaaccatc aaccagcagg
      481 ctatggacca actgtactat gtgacagagc tgacacatag aatccgatca aaatcctcac
      541 ctgatgagaa tgagaatgag gttgaggatt cagctgactt tgtgagcttc ttcccagact
      601 ttgtgtggac actgagagat ttctccctgg acttggaagc agatggacaa cccctcacac
      661 cagatgagta cctgacatac tccctgaagc tgaagaaagg taccagtcaa aaagatgaaa
      721 cttttaacct gcccagactc tgtatccgga aattcttccc aaagaaaaaa tgctttgtct
      781 ttgatcggcc cgttcaccgc aggaagcttg cccagctcga gaaactacaa gatgaagagc
      841 tggaccccga atttgtgcaa caagtagcag acttctgttc ctacatcttt agtaattcca
      901 aaactaaaac tctttcagga ggcatccagg tcaacgggcc tcgtctagag agcctggtgc
      961 tgacctacgt caatgccatc agcagtgggg atctgccgtg catggagaac gcagtcctgg
     1021 ccttggccca gatagagaac tcagctgcag tgcaaaaggc tattgcccac tatgaacagc
     1081 agatgggcca gaaggtgcag ctgcccacag aaaccctcca ggagctgctg gacctgcaca
     1141 gggacagtga gagagaggcc attgaagtct tcatcaggag ttccttcaaa gatgtggacc
     1201 atctatttca aaaggagtta gcggcccagc tagaaaaaaa gcgggatgac ttttgtaaac
     1261 agaatcagga agcatcatca gatcgttgct cagctttact tcaggtcatt ttcagtcctc
     1321 tagaagaaga agtgaaggcg ggaatttatt cgaaaccagg gggctatcgt ctctttgttc
     1381 agaagctaca agacctgaag aaaaagtact atgaggaacc gaggaagggg atacaggctg
     1441 aagagattct gcagacatac ttgaaatcca aggagtctat gactgatgca attctccaga
     1501 cagaccagac tctcacagaa aaagaaaagg agattgaagt ggaacgtgtg aaagctgagt
     1561 ctgcacaggc ttcagcaaaa atgttgcagg aaatgcaaag aaagaatgag cagatgatgg
     1621 aacagaagga gaggagttat caggaacact tgaaacaact gactgagaag atggagaacg
     1681 acagggtcca gttgctgaaa gagcaagaga ggaccctcgc tcttaaactt caggaacagg
     1741 agcaactact aaaagaggga tttcaaaaag aaagcagaat aatgaaaaat gagatacagg
     1801 atctccagac gaaaatgaga cgacgaaagg catgtaccat aagctaaaga ccagagcctt
     1861 cctgtcaccc ctaaccaagg cataattgaa acaattttag aatttggaac aagcgtcact
     1921 acatttgata ataattagat cttgcatcat aacaccaaaa gtttataaag gcatgtggta
     1981 caatgatcaa aatcatgttt tttcttaaaa aaaaaaaaag actgtaaatt gtgcaacaaa
     2041 gatgcattta cctctgtatc aactcaggaa atctcataag ctggtaccac tcaggagaag
     2101 tttattcttc cagatgacca gcagtagaca aatggatact gagcagagtc ttaggtaaaa
     2161 gtcttgggaa atatttgggc attggtctgg ccaagtctac aatgtcccaa tatcaaggac
     2221 aaccacccta gcttcttagt gaagacaatg tacagttatc cgttagatca agactacacg
     2281 gtctatgagc aataatgtga tttctggaca ttgcccatgt ataatcctca ctgatgattt
     2341 caagctaaag caaaccacct tatacagaga tctagaatct ctttatgttc tccagaggaa
     2401 ggtggaagaa accatgggca ggagtaggaa ttgagtgata aacaattggg ctaatgaaga
     2461 aaacttctct tattgttcag ttcatccaga ttataacttc aatgggacac tttagaccat
     2521 tagacaattg acactggatt aaacaaattc acataatgcc aaatacacaa tgtatttata
     2581 gcaacgtata atttgcaaag atggacttta aaagatgctg tgtaactaaa ctgaaataat
     2641 tcaattactt attatttaga atgttaaagc ttatgatagt cttttctaac tcttaacact
     2701 catacttgaa aactttctga gtttccccag aagagaatat gggatttttt ttgacatttt
     2761 tgactcattt aataatgctc ttgtgtttac ctagtatatg tagactttgt cttatgtgtg
     2821 aaaagtccta ggaaagtggt tgatgtttct tatagcaatt aaaaattatt tttgaactga
     2881 aaa
//
