LOCUS       XM_006718049            6490 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens golgi brefeldin A resistant guanine
            nucleotide exchange factor 1 (GBF1), transcript variant X2, mRNA.
ACCESSION   XM_006718049
VERSION     XM_006718049.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000010.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_006718049.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6490
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
     gene            1..6490
                     /gene="GBF1"
                     /gene_synonym="ARF1GEF; CMT2GG; CMTDI2; CMTDIA"
                     /note="golgi brefeldin A resistant guanine nucleotide
                     exchange factor 1; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 3 mRNAs, 277 ESTs, 1380
                     long SRA reads, 1 Protein, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     18 samples with support for all annotated introns"
                     /db_xref="GeneID:8729"
                     /db_xref="HGNC:HGNC:4181"
                     /db_xref="MIM:603698"
     CDS             261..5930
                     /gene="GBF1"
                     /gene_synonym="ARF1GEF; CMT2GG; CMTDI2; CMTDIA"
                     /codon_start=1
                     /product="Golgi-specific brefeldin A-resistance guanine
                     nucleotide exchange factor 1 isoform X2"
                     /protein_id="XP_006718112.1"
                     /db_xref="GeneID:8729"
                     /db_xref="HGNC:HGNC:4181"
                     /db_xref="MIM:603698"
                     /translation="MVDKNIYIIQGEINIVVGAIKRNARWSTHTPLDEERDPLLHSFG
                     HLKEVLNSITELSEIEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSYALIDPTH
                     EGTAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGAHLTNESVCEI
                     MQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFKEEPKNYVGTNMKKISPCL
                     LNKLELSSGEQTKALNQLERVLLFKNLKLKMRAGGMSDSSKWKKQKRSPRPPRHMTKV
                     TPGSELPTPNGTTLSSNLTGGMPFIDVPTPISSASSEAASAVVSPSTDSGLEFSSQTT
                     SKEDLTDLEQPGSPGYSTATEPGSSELGVPEQPDLQQEGTHVEKSQSASVESIPEVLE
                     ECTSPADHSDSASVHDMDYVNPRGVRFTQSSQKEGTALVPYGLPCIRELFRFLISLTN
                     PHDRHNSEVMIHMGLHLLTVALESAPVAQCQTLLGLIKDEMCRHLFQLLSIERLNLYA
                     ASLRVCFLLFESMREHLKFQMEMYIKKLMEIITVENPKMPYEMKEMALEAIVQLWRIP
                     SFVTELYINYDCDYYCSNLFEELTKLLSKNAFPVSGQLYTTHLLSLDALLTVIDSTEA
                     HCQAKVLNSLTQQEKKETARPSCEIVDGTREASNTERTASDGKAVGMASDIPGLHLPG
                     GGRLPPEHGKSGCSDLEEAVDSGADKKFARKPPRFSCLLPDPRELIEIKNKKKLLITG
                     TEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSDRKNIDLL
                     ESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSPFANSDA
                     CFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIK
                     NEEIVMPEEQTGLVRENYVWNVLLHRGATPEGIFLRVPTASYDLDLFTMTWGPTIAAL
                     SYVFDKSLEETIIQKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENLP
                     SVFGSNPKAHIAAKTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMIEVEDFV
                     DPNGKISLQREETPSNRGESTVLSFVSWLTLSGPEQSSVRGPSTENQEAKRVALECIK
                     QCDPEKMITESKFLQLESLQELMKALVSVTPDEETYDEEDAAFCLEMLLRIVLENRDR
                     VGCVWQTVRDHLYHLCVQAQDFCFLVERAVVGLLRLAIRLLRREEISAQVLLSLRILL
                     LMKPSVLSRVSHQVAYGLHELLKTNAANIHSGDDWATLFTLLECIGSGVKPPAALQAT
                     ARADAPDAGAQSDSELPSYHQNDVSLDRGYTSDSEVYTDHGRPGKIHRSATDADVVNS
                     GWLVVGKDDVDNSKPGPSRPGPSPLINQYSLTVGLDLGPHDTKSLLKCVESLSFIVRD
                     AAHITPDNFELCVKTLRIFVEASLNGGCKSQEKRGKSHKYDSKGNRFKKKSKEGSMLR
                     RPRTSSQHASRGGQSDDDEDEGVPASYHTVSLQLLDLMHTLHTRAASIYSSWAEEQRH
                     LETGGQKIEADSRTLWAHCWCPLLQGIACLCCDARRQVRMQALTYLQRALLVHDLQKL
                     DALEWESCFNKVLFPLLTKLLENISPADVGGMEETRMRASTLLSKVFLQHLSPLLSLS
                     TFAALWLTILDFMDKYMHAGSSDLLSEAIPESLKNMLLVMDTAEIFHSADARGGGPSA
                     LWEITWERIDCFLPHLRDELFKQTVIQDPMPMEPQGQKPLASAHLTSAAGDTRTPGHP
                     PPPEIPSELGACDFEKPESPRAASSSSPGSPVASSPSRLSPTPDGPPPLAQPPLILQP
                     LASPLQVGVPPMTLPIILNPALIEATSPVPLLATPRPTDPIPTSEVN"
ORIGIN      
        1 agttaccacg tcagtgagct gacagggaag gtacccggct ctactgcccg tcccggacga
       61 ctcatcctgg cggactgtgc agtcccaccc tgacttcggc ctcaatttcc aggaaacagg
      121 ctccttctct tctcccatct gctaccagag ccgggagagc tgctcggaga cgcctccggg
      181 gtgcgggctg gacatgagca gcggctgccg gtcctgggac taggccccgc cattttggat
      241 ccgctgacag gtttgccaag atggtggata agaatattta catcattcaa ggggagatta
      301 acattgtggt tggggccatc aaacgaaatg cccgatggag cacccataca ccactggatg
      361 aagaacggga tcctctgctg catagtttcg gtcatctaaa ggaggtttta aacagtataa
      421 cagaactctc agaaattgag cccaatgtat tccttcgacc ttttctggaa gtgattcgct
      481 ctgaagatac cactggccct atcactggac tggcactcac ctctgtcaac aagttcctgt
      541 cctatgcact catagatccc acccatgagg gcacagcaga gggcatggag aacatggcag
      601 atgctgtcac ccatgctcgt tttgtgggca cggatcctgc cagtgatgaa gttgtcctga
      661 tgaaaatcct tcaggttcta cggactctgc tgctaacccc agtgggtgcc cacctaacca
      721 atgaatctgt gtgtgagatt atgcagtctt gcttccggat ctgctttgaa atgaggctca
      781 gtgagttatt gagaaaatcc gcagagcaca ctctcgtaga catggtgcag ctgctcttca
      841 caaggttacc tcagtttaaa gaagaaccca agaactatgt ggggaccaac atgaagaaga
      901 tatctccatg tctcctcaac aaactggagc taagtagtgg ggagcagacc aaagccctga
      961 accagttaga gagggtacta ctctttaaga acctcaagct gaaaatgaga gccggaggca
     1021 tgagtgattc atccaaatgg aagaaacaga agagatcccc tcggccccca cgccatatga
     1081 ccaaagtcac accaggttca gagctgccca ctcccaatgg aaccacctta tcatctaacc
     1141 tcactggtgg catgcccttc attgatgtgc ccactcccat ctcctctgca agttcagaag
     1201 ctgcctcagc agtggtcagt ccctctacag acagtggcct ggaattctcc tcccaaacca
     1261 cttccaagga agaccttact gatctagagc aacctggctc tccagggtac agcacagcta
     1321 cagagcctgg aagcagtgag ctaggtgttc ccgagcagcc tgacctccag caggaaggga
     1381 cccatgtgga aaagtcccag tcagcatctg tggagtccat ccctgaagtg ttagaggagt
     1441 gcacgtcccc tgccgaccac tctgactctg cctctgtcca tgacatggat tacgtcaatc
     1501 cccggggcgt gcgctttaca cagtcctccc agaaagaagg cacagctttg gtcccctatg
     1561 gtcttccctg catccgcgag ctcttccgct tcctcatctc cctcaccaat ccacacgacc
     1621 gccataactc agaggttatg attcacatgg gactgcattt gctgacagtg gcccttgagt
     1681 cagcccctgt agcccagtgc cagaccctct tgggcctcat caaggatgag atgtgccgtc
     1741 acttattcca gctactcagc atagagcgac taaaccttta tgctgcttcc ctgcgagtat
     1801 gcttcctact gtttgagagc atgcgagagc acctcaagtt ccaaatggag atgtacatca
     1861 aaaagcttat ggagatcatc actgtggaga accccaagat gccttatgag atgaaggaga
     1921 tggcactgga ggccattgtg cagctctggc gcatccccag ctttgtcaca gagctctaca
     1981 tcaactatga ttgtgactac tactgttcca acctctttga ggaactcaca aagctgctgt
     2041 ccaagaatgc cttccctgtg tctggtcaac tctatacaac acacctacta tctcttgatg
     2101 ccctattgac agtgattgac agcaccgagg cccactgcca ggctaaagtc ctcaacagcc
     2161 tcacccagca agagaagaag gagacagcca gaccaagctg tgagatagta gatggcaccc
     2221 gagaagctag caatactgag agaactgcca gcgatgggaa agctgtaggc atggcctcag
     2281 acatcccagg cctgcatctg ccaggtggag ggcggctgcc accagaacat gggaaatcag
     2341 gatgcagtga tctggaggaa gctgttgact ctggggctga caaaaagttt gcccggaagc
     2401 caccccgatt ttcctgtctc ctgccagatc cacgggaact aattgaaatt aaaaacaaaa
     2461 agaagctgct aatcactggc acagagcagt tcaatcagaa accaaagaag gggattcagt
     2521 ttctgcaaga gaaaggcctc ctcaccatcc caatggacaa cacagaggtt gctcagtggc
     2581 tccgagagaa ccctcggctg gacaagaaga tgattggaga gtttgtgagt gaccgcaaaa
     2641 acattgacct gttggagagc tttgtgagca ccttcagttt tcagggtctg cgactggacg
     2701 aagccctccg cctctacctg gaagccttcc gtttgcctgg ggaagcacca gtcatccaga
     2761 ggttgctgga ggcattcaca gagcgttgga tgaattgtaa tggctcccca tttgccaata
     2821 gcgatgcctg cttttccctg gcctatgctg tcatcatgct taatactgac cagcacaacc
     2881 acaatgttcg taaacagaat gcacccatga ccctggagga gtttcgcaaa aatctgaaag
     2941 gtgtgaatgg aggcaaggac tttgagcaag acatcctgga ggacatgtac catgccatca
     3001 agaatgagga aattgtaatg cctgaggagc agacaggctt ggttcgggag aactatgtgt
     3061 ggaatgtgct gcttcatcga ggtgccaccc ctgagggcat attcctgcgt gtgcctactg
     3121 ccagctatga tcttgacctc ttcaccatga cctggggccc cactattgct gctctctctt
     3181 atgtctttga caaaagcctt gaggagacaa tcatccagaa agccatctca ggcttcagga
     3241 agtgcgccat gatctccgcc cactatggcc tcagcgatgt gtttgacaat ctcatcatct
     3301 ctctatgcaa attcacagct ctcagcagtg agtctattga gaacctgccc agtgtatttg
     3361 gaagcaaccc taaagcccat attgcagcca agacagtatt ccatttggcc catcgtcatg
     3421 gtgacatcct gcgggagggc tggaagaata tcatggaggc catgctgcag ctcttccgag
     3481 cccaactact gcccaaggct atgatagagg tagaagattt cgtggatccc aatggcaaga
     3541 tctctctaca gcgggaagag acaccatcaa accgaggaga gtcaacagtg ctgagctttg
     3601 tgagctggct aacactgagt ggtcctgagc agtctagtgt tcggggccca tccactgaaa
     3661 accaagaggc caagagagtg gccttagagt gtataaagca atgtgaccca gaaaaaatga
     3721 tcacagaaag caagttcctc cagctggagt cactacagga gctcatgaag gctctggtct
     3781 cagtgacacc agatgaagag acatatgatg aggaagatgc tgctttctgc ctagagatgc
     3841 tgctaaggat tgtgttggag aacagggatc gtgtgggctg tgtgtggcag actgttcgag
     3901 accatctata ccacctctgt gttcaggcac aagatttctg cttccttgtg gagcgggcag
     3961 tggtggggtt gctacgcctg gccattcggc ttctccggag agaagagatc agtgctcagg
     4021 tgctgctctc cctgcgcatt ttgctactga tgaagcccag tgtgctatcc cgagtcagcc
     4081 accaggttgc gtatgggctc catgaactcc tgaagaccaa tgcagccaac atccactcag
     4141 gtgatgactg ggccacactc ttcacactgc tggagtgcat cggctcaggt gtgaagcctc
     4201 cagctgctct gcaggccaca gccagggcag atgcacctga tgccggggcc cagtcagata
     4261 gtgagctccc atcctaccat cagaatgacg tgagcctgga tcgagggtac acttccgact
     4321 cagaggtcta cactgaccat ggcaggccgg gcaagataca ccgatcagcc acagatgccg
     4381 atgtggtcaa cagtggttgg ttagtggttg ggaaggatga cgttgataac tccaagccag
     4441 ggcccagccg cccaggccct tcacccctga tcaatcaata cagcctaaca gtgggactgg
     4501 atttggggcc acacgacact aagtctctgc ttaagtgtgt ggaatcgctg tccttcattg
     4561 tgcgtgatgc tgcccacatc acacctgaca actttgagct ctgcgtcaag actctccgga
     4621 tctttgtgga ggccagtctg aatggcggat gcaagtccca ggagaaacgt ggcaagagtc
     4681 acaaatatga cagcaaaggg aaccgcttca agaagaaatc caaagaggga tcaatgcttc
     4741 gccggcctcg aacctccagc caacatgcct ctcggggcgg gcagagtgat gatgatgagg
     4801 acgaaggcgt gcctgccagc taccatacgg tgtctttaca gttgctagac ctgatgcaca
     4861 ccctgcacac gcgggcagcc tctatctaca gctcatgggc ggaggagcaa cgccacctgg
     4921 agacaggtgg ccagaagatt gaagctgatt ctcgcaccct ctgggcccac tgctggtgcc
     4981 ctttactgca gggtattgcc tgcctgtgct gcgatgcccg gcgccaggta cggatgcagg
     5041 cactgaccta tctgcagcga gcactacttg tacatgatct gcaaaagcta gatgccctgg
     5101 aatgggagtc ctgttttaac aaggtgctgt ttcctctact taccaagctc ttggagaaca
     5161 tcagccctgc agatgtgggt gggatggagg agacccggat gagggcttcc acattgctct
     5221 ctaaggtctt cctgcagcac ctgtctccac tgctgtcact ctctaccttt gcggccctct
     5281 ggctcaccat cttggacttc atggacaagt acatgcacgc aggctccagc gacttactgt
     5341 cagaggcgat ccctgagtct ctgaagaaca tgcttctggt gatggacaca gcggagattt
     5401 tccacagtgc agatgcacgg ggaggcggcc cctcggccct ctgggagatc acctgggaac
     5461 gcattgactg ttttctccct cacctacgag atgaactctt caagcagacc gtcatccagg
     5521 accccatgcc catggagcct caaggccaaa agcctctcgc ctcagcccac ctgacttccg
     5581 ctgctggcga cactaggaca cctggccatc caccgccccc agagattcca tctgagctgg
     5641 gggcctgtga ctttgagaag cccgagagcc cccgagccgc cagcagcagc tccccaggat
     5701 caccagtggc ctcaagcccc agcaggctga gccccacccc cgacgggcct ccacccttgg
     5761 ctcagccccc actgatcctg cagcccttgg cctccccact gcaggtgggc gtgccaccta
     5821 tgactctgcc catcatcctc aaccctgcgc tcatcgaggc cacctcacca gtgcccctcc
     5881 tggccacacc ccgccccaca gatcccatac ccacctctga ggtcaactaa ggcaggtcac
     5941 tcagagatca ggaccagtgc ttcccaccag gctttccttg accccacttc tggctgtcct
     6001 gcgggccaca agctcttcag gccaagtcag agctgctgtt gctgccactt ggatggggac
     6061 ctgaaaaaga gaatgttgat agccccagct aagaccccca atcagctgtg ggaccttttt
     6121 cctcctctgc gctccattcc tgggggttca gcctgagagt gaactcagct gtcatctgca
     6181 gcctctgcct ccagcccggc agctctgggg aggcatccgt gtgccggccc tgcagtgcct
     6241 gcccacggtc aggcattgaa aactaagccc aaccactctg cactttgttt cccactccca
     6301 ttagccctgg gccacctcct ccagttcttc ctcttttact aattagttgg tcagtttgga
     6361 gagttgactg gcaccatgga gggtaggcag gtgggggctg ggtgggggac tgcccacagg
     6421 agcatgtaca tatggaaaaa cagaacaaca gtggactttt tatgatataa taaatgtctt
     6481 agtaccagca
//
