LOCUS       NM_182612               4363 bp    mRNA    linear   PRI 16-JUN-2024
DEFINITION  Homo sapiens glutamine amidotransferase class 1 domain containing 1
            (GATD1), transcript variant 1, mRNA.
ACCESSION   NM_182612 XM_938705
VERSION     NM_182612.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4363)
  AUTHORS   Schuhmacher,J.S., Tom Dieck,S., Christoforidis,S., Landerer,C.,
            Davila Gallesio,J., Hersemann,L., Seifert,S., Schafer,R., Giner,A.,
            Toth-Petroczy,A., Kalaidzidis,Y., Bohnsack,K.E., Bohnsack,M.T.,
            Schuman,E.M. and Zerial,M.
  TITLE     The Rab5 effector FERRY links early endosomes with mRNA
            localization
  JOURNAL   Mol Cell 83 (11), 1839-1855 (2023)
   PUBMED   37267905
REFERENCE   2  (bases 1 to 4363)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC364167.1, AK293559.1, AP006621.1 and BU625376.1.
            
            On Nov 22, 2018 this sequence version replaced NM_182612.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.1168158.1,
                                           SRR11853565.4308.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319863.13/ ENSP00000321691.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               DC364167.1         16-573
            559-1377            AK293559.1         482-1300
            1378-3835           AP006621.1         62645-65102         c
            3836-4363           BU625376.1         16-543              c
FEATURES             Location/Qualifiers
     source          1..4363
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..4363
                     /gene="GATD1"
                     /gene_synonym="FERRY5; Fy-5; PDDC1"
                     /note="glutamine amidotransferase class 1 domain
                     containing 1"
                     /db_xref="GeneID:347862"
                     /db_xref="HGNC:HGNC:26616"
     exon            1..89
                     /gene="GATD1"
                     /gene_synonym="FERRY5; Fy-5; PDDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..688
                     /gene="GATD1"
                     /gene_synonym="FERRY5; Fy-5; PDDC1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; parkinson disease 7 domain-containing protein
                     1; Parkinson disease 7 domain containing 1; glutamine
                     amidotransferase-like class 1 domain-containing protein 1;
                     glutamine amidotransferase like class 1 domain containing
                     1; ferry endosomal RAB5 effector complex subunit 5"
                     /codon_start=1
                     /product="glutamine amidotransferase-like class 1
                     domain-containing protein 1 isoform 1 precursor"
                     /protein_id="NP_872418.1"
                     /db_xref="CCDS:CCDS7713.1"
                     /db_xref="GeneID:347862"
                     /db_xref="HGNC:HGNC:26616"
                     /translation="MASERLPNRPACLLVASGAAEGVSAQSFLHCFTMASTAFNLQVA
                     TPGGKAMEFVDVTESNARWVQDFRLKAYASPAKLESIDGARYHALLIPSCPGALTDLA
                     SSGSLARILQHFHSESKPICAVGHGVAALCCATNEDRSWVFDSYSLTGPSVCELVRAP
                     GFARLPLVVEDFVKDSGACFSASEPDAVHVVLDRHLVTGQNASSTVPAVQNLLFLCGS
                     RK"
     exon            90..166
                     /gene="GATD1"
                     /gene_synonym="FERRY5; Fy-5; PDDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            167..272
                     /gene="GATD1"
                     /gene_synonym="FERRY5; Fy-5; PDDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            273..380
                     /gene="GATD1"
                     /gene_synonym="FERRY5; Fy-5; PDDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..475
                     /gene="GATD1"
                     /gene_synonym="FERRY5; Fy-5; PDDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..569
                     /gene="GATD1"
                     /gene_synonym="FERRY5; Fy-5; PDDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..681
                     /gene="GATD1"
                     /gene_synonym="FERRY5; Fy-5; PDDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..4363
                     /gene="GATD1"
                     /gene_synonym="FERRY5; Fy-5; PDDC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4338..4343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GATD1"
                     /gene_synonym="FERRY5; Fy-5; PDDC1"
                     /note="hexamer: AATAAA"
     polyA_site      4363
                     /gene="GATD1"
                     /gene_synonym="FERRY5; Fy-5; PDDC1"
                     /note="major polyA site"
ORIGIN      
        1 gcagacccag cgccgagccc gagccatggc gtccgagcgg ctccctaaca ggcccgcctg
       61 tctgctcgtg gccagcggcg ccgccgaagg tgtgtcggcc cagtccttcc tccactgttt
      121 cacgatggcc agcaccgcct tcaacctgca ggtggccacc cctgggggga aagccatgga
      181 atttgtggat gtgactgaga gcaatgcacg ctgggtgcaa gacttccgcc tcaaggctta
      241 cgccagcccc gccaagctcg agtccatcga tggtgcccgg taccatgccc tcctgatccc
      301 cagctgtcct ggggccctga ccgacctggc cagcagtggc tccctggccc gtatcctgca
      361 gcacttccac tctgagagca aacccatctg cgccgtcggc cacggtgtcg ccgccctgtg
      421 ctgtgccacc aacgaggaca gatcctgggt gttcgacagc tacagcctga cagggccctc
      481 tgtgtgtgag ctcgtcaggg cccccggctt cgcccgcctg ccgctcgtgg tggaggactt
      541 cgtgaaggat tcgggcgcct gcttcagtgc aagcgagcct gacgctgtcc acgtcgtgct
      601 ggaccgccac ctggtcacag gccagaatgc cagctccact gtcccggccg tgcagaacct
      661 gctcttcctc tgtggcagcc ggaaatgaac ctgctgggta gatgcacccc ctgagacagc
      721 ccaggtgtct ccagaggcag ccccgtctca ggcttcaggg accccgcctc ttccctcctg
      781 acaagggccc tggatggcag cctggtctgg ccctgatggg attgttggag gcctcctgga
      841 atcagctctg agggggtgtc ggctctcctg gagggtccaa acccccatcc tcctgcatgt
      901 tctctggtag gaggcagaga aaagacccca cgtgcctgga gagctgtgct agctgctagg
      961 tggtcctcgg gaattccagg ctgggttttc tagggaggac tggttgtcac gtgtggtcac
     1021 tgttgactag acagagtcgg ctcgggggtc ctctgtgtgg gtttgccctg ctgtggcctg
     1081 tctgccaccc accacctctt tcactgttgg tgggggcctt gaggggaggg cccagccggc
     1141 gggagctggc tcagaacttt ggccaaaggt gaacggaatt ttttaggagc agcagcctcc
     1201 tgccccaagg ccgaccggca ctggcagcac tttcctgttg aagaaatctt cctggcgtgt
     1261 ggtttcaaag tgtaagcacc tcagtgatgc accctgtcct aagcattgag aggcacgttt
     1321 acttgtgaat atgagaccat gagattctca atgataggaa agtgctgtcc cccacggcct
     1381 tgcacagtgg cctcgggtag agcggctatc aagagcagac agtggtccag cctgctgggc
     1441 acctggcctg ggctgtggcc ctccagcggg ctgccccctg gccccaggtt agggcgtcca
     1501 ggagaggctt aggccctcta cttcctcaca gttccccagt ttgagccatc gaaggccttc
     1561 ttcctgccca cctccccgtc tcagccacag ccgttcccaa gcaccagcgt ggctcctggt
     1621 gccagtgacc tgccaggagg ccccttgtga ttataaaacc gttcagttgg gccgggcgca
     1681 gtggctcaca cctgtaaccc cagcactttg ggaggccgag gcgggcggat cacgaggtca
     1741 ggagatcgag accatcctgg ctaacatggt gaaaccccat ctctactaaa aaacaaaaat
     1801 acaaaaagtt agcctggcat ggtggtgggt gtgtgtagtc ccagctactt gggaggctga
     1861 ggcaggagaa tggcgtgaac ctgggaggca gagcttgcag tgagctgaga tcgtgccact
     1921 gcactccagc ctgggcaata gagtgagact ccatctcaaa aaaaaaacgt tcagttggct
     1981 gggcgcggtg gctcacgcct gtaatcccag cactttggga ggccaaggtg ggtggatcat
     2041 ctgaagtcag gagtttggga aaagcctggc caacatggtg aaactaaaat acaaaaatga
     2101 gccgggtgtg gtgtcaggcg cctgtattcc cagctacttg ggaggctgag acgtgagaat
     2161 tgcttgaacc tgggaggcgg aagttgcagt gagccaagat tgcgccattg cactccaacc
     2221 tgggcaatga gtgaaactcc gtctcaaaaa taaaaaataa taaaataaag ccgttcaata
     2281 aggagaattt ggaaaaaagt ggaagaagga agcgctgcag ccacatcccc gccctgaagg
     2341 ctgcgtccct ccagtgcctc gcagattagt caggatgccc acttagcact ggccacgggg
     2401 ccttgctctg tcccgggtcc actctcatcc ccgtgtggtg atggacctct gtggacaaat
     2461 gctttttatt ttatttattt tttgagatgg agtttgtctc tcgtcaccca ggctggagtg
     2521 cagtggcaca atcttggctc actgcaacct ctgtctcccg ggttcaagcg attctcctgc
     2581 ctcagcctcc ggagtagctg ggattacagg tgtgcgccac cacgcctggc taatttttgt
     2641 atttttcgta gagaccgagt ttcaccatgt tggccaggct ggtctcgaac tcctgacctc
     2701 aagtgatcct cccgcctcgg cctcccaaag tgttaggatt acaggcgtga gccactgcgc
     2761 ccggcgtaat ttttgttttt agtagagatg gggtttcatc atgttggcca ggctggtctt
     2821 gaactcctga cctcaggtga tccatcttcc tcagcctccc aaagtgctgg gattacaggc
     2881 gtgagccgcc acgtccggct aacaagtact tttttatttt tattttattt tttggatgga
     2941 gtctcactct gtcgcccagg ctggaacaca gtggcacgat ctcggctcac tgcagcctcc
     3001 gcctcccggg ttcaagtgat tctcctgcct cagcctccca agtagctagg actacaggtg
     3061 cacaccacca cacccagcta atttttgtat ttttcctttt tttttttttt tgagatggag
     3121 tcttgctctg ttggcaggct ggagtgcagt ggcgcgatct cagctcactg caacctctgc
     3181 ctctgcctcc cagattcaag cagttctcct gcctcagcct cccgagtaac tgggactaca
     3241 ggtgcatgcc actacgccca gctagttttt gtattttcag tagagacggg gtttcaccat
     3301 gttggccagg atggtctcga tctcttgacc tcatgatctg cccgcctcgg cttcccaaag
     3361 tgctgggact acaggcaagc tcatgtctta atgtcctagt ccatttgggc tcctataaga
     3421 aaatactgta aactggccgg gcacggtggc tcacgcctgt aatcccagca ctttgggagg
     3481 ctgaggcagg tggatcacct gaggtcagga gttcgagacc agcctggcca agatggtgaa
     3541 accccgtctc tactaaaaat acagaaatta gccgggcgcg gtggtgggcg cctgtaatcc
     3601 catttacttg ggaggctgag gcaggagaat cgcttgaacc caggaggcgg aggttgcagt
     3661 gagctgacat cgtgccactg cactctagtc tgggtgacag agcaagactc catctcaaaa
     3721 aaaaaaaaaa agaaaatatt gtaaacctag tggcttataa acaacagaaa tcagtttcag
     3781 ttttggaggc tggaagccca agatgaaagc accagtagat gcaacctctt ttgtgagggt
     3841 gatggtccca tgatgaggct gtgcccctgc cctgtgaccg gatgacctcc caaatgcccc
     3901 acctaatacc atccccttgc aggtgaggac ttaagcaggt gggttttggg gggacgtgct
     3961 caggccacag cagggtgcat gaagagccag tgagcctcat tgagcccctc tggtcagcca
     4021 gatctgacat tgagcccagc attgaagatc aaagcaggtg gggctttggg atgtgaagtg
     4081 ggttctgacg cggggcccca cagacctgtc tccgcgtgag ctgcctgcag gcccctgcgt
     4141 cattcctcag ctgcgtgcga ggcctctggc ttggagagcc tccccgctgt gcacagttct
     4201 ctctttgcca gggcagggct tggggcagca ccaggctggg gcagaggagg aaagcaagag
     4261 gacagacctc cagaagagca gcggagggcg ggtgaggatt tccccatata ccagtgtgtg
     4321 ttcatctacc catgaggaat aaaaccatgc agcagcatgc aaa
//
