LOCUS       NM_020699               7475 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens GATA zinc finger domain containing 2B (GATAD2B), mRNA.
ACCESSION   NM_020699
VERSION     NM_020699.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7475)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 7475)
  AUTHORS   Spruijt,C.G., Grawe,C., Kleinendorst,S.C., Baltissen,M.P.A. and
            Vermeulen,M.
  TITLE     Cross-linking mass spectrometry reveals the structural topology of
            peripheral NuRD subunits relative to the core complex
  JOURNAL   FEBS J 288 (10), 3231-3245 (2021)
   PUBMED   33283408
REFERENCE   3  (bases 1 to 7475)
  AUTHORS   Lee,H.E., Park,S.J., Huh,J.W., Imai,H. and Kim,H.S.
  TITLE     The enhancer activity of long interspersed nuclear element derived
            microRNA 625 induced by NF-kappaB
  JOURNAL   Sci Rep 11 (1), 3139 (2021)
   PUBMED   33542430
  REMARK    GeneRIF: The enhancer activity of long interspersed nuclear element
            derived microRNA 625 induced by NF-kappaB.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7475)
  AUTHORS   Nikam,V. and Shaik Mohammad,N.
  TITLE     Tissue-specific DNase I footprint analysis confirms the association
            of GATAD2B Q470* variant with intellectual disability
  JOURNAL   J Genet 100 (2021)
   PUBMED   34470925
  REMARK    GeneRIF: Tissue-specific DNase I footprint analysis confirms the
            association of GATAD2B Q470* variant with intellectual disability.
REFERENCE   5  (bases 1 to 7475)
  AUTHORS   Willemsen,M.H., Nijhof,B., Fenckova,M., Nillesen,W.M.,
            Bongers,E.M., Castells-Nobau,A., Asztalos,L., Viragh,E., van
            Bon,B.W., Tezel,E., Veltman,J.A., Brunner,H.G., de Vries,B.B., de
            Ligt,J., Yntema,H.G., van Bokhoven,H., Isidor,B., Le Caignec,C.,
            Lorino,E., Asztalos,Z., Koolen,D.A., Vissers,L.E., Schenck,A. and
            Kleefstra,T.
  TITLE     GATAD2B loss-of-function mutations cause a recognisable syndrome
            with intellectual disability and are associated with learning
            deficits and synaptic undergrowth in Drosophila
  JOURNAL   J Med Genet 50 (8), 507-514 (2013)
   PUBMED   23644463
  REMARK    GeneRIF: Detailed clinical description showed that all four
            individuals with a GATAD2B aberration had a distinctive phenotype
            with childhood hypotonia, severe intellectual disability.
REFERENCE   6  (bases 1 to 7475)
  AUTHORS   de Ligt,J., Willemsen,M.H., van Bon,B.W., Kleefstra,T.,
            Yntema,H.G., Kroes,T., Vulto-van Silfhout,A.T., Koolen,D.A., de
            Vries,P., Gilissen,C., del Rosario,M., Hoischen,A., Scheffer,H., de
            Vries,B.B., Brunner,H.G., Veltman,J.A. and Vissers,L.E.
  TITLE     Diagnostic exome sequencing in persons with severe intellectual
            disability
  JOURNAL   N Engl J Med 367 (20), 1921-1929 (2012)
   PUBMED   23033978
REFERENCE   7  (bases 1 to 7475)
  AUTHORS   Brackertz,M., Gong,Z., Leers,J. and Renkawitz,R.
  TITLE     p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and
            histone interaction
  JOURNAL   Nucleic Acids Res 34 (2), 397-406 (2006)
   PUBMED   16415179
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7475)
  AUTHORS   Feng,Q., Cao,R., Xia,L., Erdjument-Bromage,H., Tempst,P. and
            Zhang,Y.
  TITLE     Identification and functional characterization of the p66/p68
            components of the MeCP1 complex
  JOURNAL   Mol Cell Biol 22 (2), 536-546 (2002)
   PUBMED   11756549
REFERENCE   9  (bases 1 to 7475)
  AUTHORS   Zhang,Y., Ng,H.H., Erdjument-Bromage,H., Tempst,P., Bird,A. and
            Reinberg,D.
  TITLE     Analysis of the NuRD subunits reveals a histone deacetylase core
            complex and a connection with DNA methylation
  JOURNAL   Genes Dev 13 (15), 1924-1935 (1999)
   PUBMED   10444591
REFERENCE   10 (bases 1 to 7475)
  AUTHORS   Zhang,Y., LeRoy,G., Seelig,H.P., Lane,W.S. and Reinberg,D.
  TITLE     The dermatomyositis-specific autoantigen Mi2 is a component of a
            complex containing histone deacetylase and nucleosome remodeling
            activities
  JOURNAL   Cell 95 (2), 279-289 (1998)
   PUBMED   9790534
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA161156.1, AF411836.1,
            AL513523.33 and BQ446626.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_020699.3.
            
            Summary: This gene encodes a zinc finger protein transcriptional
            repressor. The encoded protein is part of the methyl-CpG-binding
            protein-1 complex, which represses gene expression by deacetylating
            methylated nucleosomes. Mutations in this gene are linked to
            intellectual disability and dysmorphic features associated with
            cognitive disability. [provided by RefSeq, Jun 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK094665.1, SRR1163658.234612.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368655.5/ ENSP00000357644.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               DA161156.1         4-243
            241-3400            AF411836.1         17-3176
            3401-5571           AF411836.1         3178-5348
            5572-7197           AL513523.33        89431-91056         c
            7198-7293           BQ446626.1         17-112              c
            7294-7475           AL513523.33        89153-89334         c
FEATURES             Location/Qualifiers
     source          1..7475
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..7475
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /note="GATA zinc finger domain containing 2B"
                     /db_xref="GeneID:57459"
                     /db_xref="HGNC:HGNC:30778"
                     /db_xref="MIM:614998"
     exon            1..240
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            241..576
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..2023
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /note="transcription repressor p66 beta component of the
                     MeCP1 complex; GATA zinc finger domain-containing protein
                     2B"
                     /codon_start=1
                     /product="transcriptional repressor p66-beta"
                     /protein_id="NP_065750.1"
                     /db_xref="CCDS:CCDS1054.1"
                     /db_xref="GeneID:57459"
                     /db_xref="HGNC:HGNC:30778"
                     /db_xref="MIM:614998"
                     /translation="MDRMTEDALRLNLLKRSLDPADERDDVLAKRLKMEGHEAMERLK
                     MLALLKRKDLANLEVPHELPTKQDGSGVKGYEEKLNGNLRPHGDNRTAGRPGKENIND
                     EPVDMSARRSEPERGRLTPSPDIIVLSDNEASSPRSSSRMEERLKAANLEMFKGKGIE
                     ERQQLIKQLRDELRLEEARLVLLKKLRQSQLQKENVVQKTPVVQNAASIVQPSPAHVG
                     QQGLSKLPSRPGAQGVEPQNLRTLQGHSVIRSATNTTLPHMLMSQRVIAPNPAQLQGQ
                     RGPPKPGLVRTTTPNMNPAINYQPQSSSSVPCQRTTSSAIYMNLASHIQPGTVNRVSS
                     PLPSPSAMTDAANSQAAAKLALRKQLEKTLLEIPPPKPPAPLLHFLPSAANSEFIYMV
                     GLEEVVQSVIDSQGKSCASLLRVEPFVCAQCRTDFTPHWKQEKNGKILCEQCMTSNQK
                     KALKAEHTNRLKNAFVKALQQEQEIEQRLQQQAALSPTTAPAVSSVSKQETIMRHHTL
                     RQAPQPQSSLQRGIPTSARSMLSNFAQAPQLSVPGGLLGMPGVNIAYLNTGIGGHKGP
                     SLADRQREYLLDMIPPRSISQSISGQK"
     exon            577..706
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            707..838
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            839..970
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1141
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1457
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1660
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1771
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1889
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..7475
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6080..6085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /note="hexamer: AATATA"
     polyA_site      6099
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /note="major polyA site"
     regulatory      7454..7459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /note="hexamer: AAGAAA"
     polyA_site      7475
                     /gene="GATAD2B"
                     /gene_synonym="GANDS; MRD18; P66beta; p68"
                     /note="major polyA site"
ORIGIN      
        1 gtccttgttt gtgtggtgcc gccgccgccg gtgcagccgt cgccgccgcc gctgcccccg
       61 tctgtaccgc agtgtctgct ccgcccgccc gccccggtcc ggcccgcccc cctcccctac
      121 ccccgtccct agtcccgtca gcagggtctg gatcccctgt gccgtcgcct cttccttttt
      181 cgacgcctcc gccgccgcct gaggaggcga gctagccggg agttacaccg ccaccgccag
      241 gatggataga atgacagaag atgctcttcg cttgaatctg ttgaagcgga gcttggaccc
      301 agcagatgag cgagatgatg tcctggcaaa gcgactcaaa atggaggggc atgaggccat
      361 ggaacgtctg aaaatgttgg cattgctcaa aaggaaggat ttggcaaatc ttgaggtgcc
      421 acatgagtta cccaccaaac aggatggcag tggtgtcaag ggctatgaag aaaaacttaa
      481 cgggaatctc aggcctcatg gagacaacag gactgctgga aggccaggca aagaaaacat
      541 caatgatgag cctgtggata tgagtgctag acggagtgag ccagagcgag gaaggctaac
      601 tccctcacca gacatcattg ttttgtctga caatgaggct tccagtcccc gttccagttc
      661 cagaatggaa gaaagactca aagcagccaa cttagagatg tttaagggga aaggcattga
      721 ggagcggcag cagcttatca agcagctgag ggatgagcta cgattggaag aagcccgact
      781 ggtcctgtta aagaaactga gacagagtca gctacagaaa gagaatgtgg tccagaagac
      841 tccagttgta cagaatgcag catctattgt tcagccatct cctgcccatg tgggacagca
      901 gggcctatct aagcttccct ctcggcctgg ggcccaaggg gttgaacctc aaaatttgag
      961 aacattacag ggtcacagtg tcatccgttc agctaccaat accacccttc cacacatgtt
     1021 gatgtctcaa cgtgttattg caccaaaccc agcccagcta cagggtcagc ggggcccgcc
     1081 taagcctggc cttgtacgca ccacaacacc caacatgaat cccgccatca attatcaacc
     1141 gcagtcaagt tcttctgttc catgtcagcg tacaacatcc tctgccatct atatgaacct
     1201 tgcttctcat atccagccag ggacggtgaa cagagtgtcc tcgccacttc ctagccccag
     1261 cgccatgact gatgctgcca actcacaggc tgcagccaaa ttggctcttc gcaaacagct
     1321 ggaaaagaca ctcctggaga tcccaccccc taaacctcct gctcccttac ttcatttctt
     1381 gcctagtgca gccaatagcg agttcatcta catggtaggc ttggaagaag tcgtacagag
     1441 tgtcattgac agccaaggca aaagctgtgc ctcacttctg cgggttgaac cctttgtatg
     1501 tgcccagtgc cgcacagatt tcacccctca ctggaagcaa gaaaagaatg gtaagattct
     1561 atgtgagcag tgtatgacct ccaaccagaa aaaggctcta aaagctgaac acaccaaccg
     1621 gctgaaaaat gcatttgtga aagccctaca gcaggaacag gaaattgaac agcgattaca
     1681 gcagcaggca gccctctccc ccactacggc tccagctgtg tccagtgtca gtaaacaaga
     1741 gaccatcatg agacatcata cgcttcggca ggctccacag ccccagagca gcctccagcg
     1801 tggcataccc acatctgccc gctccatgct ttcaaacttt gcacaggcac cccagttgtc
     1861 tgtgccaggt ggcctccttg gtatgccagg tgtcaacatt gcatacttga atactggcat
     1921 cggaggacac aaaggcccca gtttggcaga ccgacagcgt gaataccttt tagacatgat
     1981 ccctccccgg tctatatcgc agtccatcag tggacagaaa taacgcctgt tccacttgta
     2041 ctgccccatc cttgaatcct ttatcccttt cctctttcat tcccccaact tctgtcgcat
     2101 gcagtgcctg tactggtgcc taccatacac ggaaagcaaa acagaaaaac agaagacaaa
     2161 aaatagagat cagcaagaaa acacacgccc tgccctgcca cctccccttt atttcacact
     2221 gctgcgatct gttcttctgc cgctctgtct tctctcttca gttttcttta acagtgaggt
     2281 ggatctttac ctctgataga ggtcagaatg aggtcctggg gagaatctaa gccctccgat
     2341 gtgtgtttct aaagttgttt tatgctataa ttattaccat ttttaatgat gttgtgtgtc
     2401 ctccctttgt tcagtggacg gttaaacctt cccccactca accaatcttt ttctttttcc
     2461 ttttcttcct tttttttttt tttttttgta aacacaaatg acattcagtt caatgatacg
     2521 agcattgcag attgcagtag gggtcccagc tgccaagtag gacatgacta ggagtgttag
     2581 gggcagaagt tttgaatgca cttaaccgga ggagggcgca gggtgggggg tatcaaagaa
     2641 ggacgaatag caccctacct gtgggtgttt gggggctgga caatttgggt ggcagtgttt
     2701 ggtactgaag ttgggctcta agaatgaggg gaaagagcct ggggaggagc ttaaaactca
     2761 accactctgg aatttaccca tagaagacgg gaagaaagag gtatgaagat gggctcaatt
     2821 atgagccagg gaggattgaa actaggtcct gcctttctgt atcttgggga aataagaccg
     2881 atctcctgac cccattggga acacggaagt ctattccagg ccaaccagcc caaaattatt
     2941 tcatcttgta ttctttgtaa aattctccct caccccaccc tgcttttaaa aattctaatc
     3001 tatcccctct aaccatagcc ccatctataa tacagaggaa cggctgttcc aaggctgttt
     3061 gctgggtgtc ccacaagttg ggtggacata aatgagtcaa gtgacaacag gaggaaatag
     3121 acttagacga aagaaaggat ttctcttcca acagttgaga ttcgcatatt tgcctattct
     3181 ttcaccctct gagtgccagg agatgagagg ctgggggtac acaatcaggt tggagtcctg
     3241 tccttactct gctgcaccag ctgcagaacc aactgctcaa agccaaacag ctcatggcaa
     3301 aaccagctta ggacctctgc tgtacaaata gttgcttccc actgcccccc gcccgccccc
     3361 agaatgatat taattttgcc tttttttttt tttttttttt aagcgctact aatgtagaga
     3421 atgaattgaa ttgtgcaatg ttgctgttct ggggactggg gagattagca tcccatttgc
     3481 ccacactgtg ggaagacgga gtggaccagg ctgtttttga agtaagggaa gccccttaaa
     3541 ggtacgggtt tctgctcttc tcatagtgta cacccacctg cctctctggc tccagaagct
     3601 gccagagtgc actgggggga atgttctcag cagagaagaa tgaggagaag tttaatattt
     3661 tgcccttgaa agtcacctga ggaagtttcc ccacttttat tttttaaaat taagtaattt
     3721 tttaaagaag gcacttttaa aattaacaca cacatgaact gcacaccttc cccataaaat
     3781 ttggaggtgg ggtgggagaa agagctaaaa tcaggctcag ttcccctact ctggcctcta
     3841 ctccccacac cccagtgcca ctgtgggtga ctatactggc cctacgggcc ttcctggctt
     3901 ttttctttcc tcccttaccc caaattcatt gagcacttaa aggagcagag atgcagccag
     3961 tgtctgggct cccccagtgg tgaaatgatc tggaagctag atgctagtaa caggtagtga
     4021 ttgggttttt tgagtatttt tccggggaat gtggtacccc tgactgtaag tggtgggaga
     4081 gggagggggg ttaatggaac tgggtctggg attattttaa aattatatat atatatataa
     4141 agatatattc ttacatcttt tctttgccct ctgtgctttg aaagcactgg ataaattgtt
     4201 tggttttgct tttctctctt ccacaaaatt ggaagctttt tttaaaaatg ttttccccac
     4261 aagtcatctt gccttgtggc atgtctgtct agcctcttcc tccctccctc atgatgaagt
     4321 gccatttctg ttacgtctcc ctctccccaa gctcagaggt gctcagaggt acgagatgcc
     4381 caagtttgtc agttgagatt aaaagtaagg aacagagaat gtgcaatacc gtctggctgg
     4441 gggctgtccc tgccctgccc tgagctgagt cctttccctg ggagccaggc caccttagaa
     4501 tggggtttgg aagtaagatg tatagagttg gggaatcatg gagaaggaaa gcctatagtc
     4561 gagtgcctgc ttaggtgctg aggtcacagg ggagatggtg gaatcttccc tgtttttatc
     4621 ccctcagggt cagttacata gaagctgctt cttgactagt atagctcggt gaccctttgt
     4681 tcaaccgctg aggtttgatt tcttaccctt tcttctcccc attttcatac tcttcccagg
     4741 gattagtgat ggaggtgagg tctccctaat catggtaaag tgttaacctt ccacctcctc
     4801 ccttccctcc tccttcctca tccttctgtc ttcctcaatt ctccgtctct tttttttcat
     4861 cactgattgc cttgtgtccc tccaagtcta cttgttacta tccatctcca ggctctgggc
     4921 cgtgtagaca ctaaacctca tgccctaagg acaggaggaa agaccctctg tttggagcat
     4981 tattagtaga gtgaggatcc caccagttct gcctggcttc ctccatcccc agaggcacta
     5041 aaagcagtat tttaaggttg gtgtcttact ccctggaagc ctgaaatggg tggaatagcg
     5101 gtaaggcttg agtaaaacta ggggacagag gttcttattt gtcgatttta ttttataatt
     5161 tgaccacagc atctgaactc cctctctccc tggaataagt atttttccca catttttgga
     5221 tatatgtatg gtagacaatt tttttttaag acacagagat aaatgttttc ctgctttggt
     5281 tacctttcct ttccccttta aaaggaatta gctatagaac tgctttgtaa agatgcttct
     5341 tgatatttta cttttgttcc ttttccctaa tcattccctt ttctccccac tcctccagaa
     5401 ggcataaccc ttctctccac accccctacc cccacccccg tcctaggctc ccatcctttc
     5461 catcaagacc ttcattagct tatgatattt gctgccgaga tgttataaca aggactcgtt
     5521 catgtatata agctatttct tgatccattt aaaaggaatt gtacattgtg tagaaaaaaa
     5581 aaaaaacctg aaaaagagaa aaaaaagccc tagccatgga tattgtgaaa ctgtgttatg
     5641 tcattttgta atgtgcccgt ttgtgtatga tccgtgcaaa agggtttctg gggaagggga
     5701 gggggtaggg aggcagggct gtggagggtg ggtaggggag tgggccgggc ccagcacact
     5761 gagactggca gctgctccaa ccccatccct ccttagagat gccacctccc ccaccaccca
     5821 cccctaattt gtgccttgcc tccccaccct ggagtagtcc ctccgggtca ccagcactgc
     5881 cttggcagag cccactccct accctaacct gcccaccctc cctatccccc agcattaggt
     5941 tgatactgtg gggaagtgct gggggctggg aggtagccga ggaatggggc agttcccggg
     6001 ggcatcgaaa ccaagtatta ttatgaattg taattgtatt tgcactgttt ttttcctctg
     6061 attgcatcag catatataca atatacctat ataacaaaat tcagtgtcaa gctttcttat
     6121 gcaagggatt tcccccaccc cacctcctca aaaaagaaag aacctagtct tatgggcctt
     6181 tgagggtgga ttgtcagggg atgatagaaa ggattttaat aagtcatcct gaggaaattt
     6241 cacctagtga gagccacatc catctgcaca gccttaggct gcgtgaaccg aggtgaggct
     6301 gagctcctgt gaaagccaag acctcctggt ccaggacttt gtagagtaaa aagaaccacc
     6361 aacacaaaag gggttgaggg ggctacaatc tggagacctg gggtctccta ctaacttgct
     6421 atatgatctt tggtagagtt aattttctga gtatcaattt tcttatctgt gaagtgaaga
     6481 gggggatcat ctggccacca agtttaaaat tctatacttc tcacctgcca aaaccaaaaa
     6541 acaacttgag gtgaggaaag tgttgggccc agaaaccagg gaggaactga aagtgactcg
     6601 cgttgaagtg gttatgtgta tgacaatgct cttggagaac tgccagtcct ctatggttac
     6661 ccttgatttg ggagaggcag cagagtcatg tccagggcat cagaccagtg acatctttgc
     6721 ctttatgcct ctagtcatct gagggcgggg actaggcctc aagccccatc tcacagccaa
     6781 ccacagagcc cttaagggtg gttgacaatt gaatgcccca ggttggtgct ttagttattt
     6841 actccctttg tgagctacag gatgtgtaac ttttccccca tcttggtgat aaaataggag
     6901 agcgcagaca cagcccacat tttgtctcct ttcctcagat ttcatctgaa ccccgctaaa
     6961 ggcagctgtt tcacagtctg tctccttcag gggcccaatt tccccacagc ctgggctgag
     7021 tactcctact ctcttcttta ggttctgggc tgataaagcc tggagagggt acagggtgat
     7081 gggtgaagcc ctggtgaagg tgaaaggata gattggggtt ggggggtggg gagcagggag
     7141 gtgggatggg gaatggcctt ccctgaatag ggtgggtggg aggggaacaa gacccttttg
     7201 cacaactctc tttaagtttc ctttatttct tttttaactc attctgattt tctgcattgt
     7261 gtttgggaaa taaaatgaaa aaactaagac caatagaaac tggttttcaa aaaggcaaat
     7321 acactcccat ctgtttcaga tgctgctgag catttcagca gtgacagatt caaataataa
     7381 gctaattttt ggagaaagga ttaaaagaaa aaaaaacttt gtaatattta tcacttgcaa
     7441 gctatgttta ataaagaaag gaatggtttc taaaa
//
