LOCUS       NM_001384531            5833 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens GATA zinc finger domain containing 2A (GATAD2A),
            transcript variant 23, mRNA.
ACCESSION   NM_001384531
VERSION     NM_001384531.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5833)
  AUTHORS   Werren,E.A., Guxholli,A., Jones,N., Wagner,M., Hannibal,I.,
            Granadillo,J.L., Tyndall,A.V., Moccia,A., Kuehl,R.,
            Levandoski,K.M., Day-Salvatore,D.L., Wheeler,M., Chong,J.X.,
            Bamshad,M.J., Innes,A.M., Pierson,T.M., Mackay,J.P., Bielas,S.L.
            and Martin,D.M.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     De novo variants in GATAD2A in individuals with a
            neurodevelopmental disorder: GATAD2A-related neurodevelopmental
            disorder
  JOURNAL   HGG Adv 4 (3), 100198 (2023)
   PUBMED   37181331
  REMARK    GeneRIF: De novo variants in GATAD2A in individuals with a
            neurodevelopmental disorder: GATAD2A-related neurodevelopmental
            disorder.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5833)
  AUTHORS   Dias,K.R., Carlston,C.M., Blok,L.E.R., De Hayr,L., Nawaz,U.,
            Evans,C.A., Bayrak-Toydemir,P., Htun,S., Zhu,Y., Ma,A., Lynch,S.A.,
            Moorwood,C., Stals,K., Ellard,S., Bainbridge,M.N., Friedman,J.,
            Pappas,J.G., Rabin,R., Nowak,C.B., Douglas,J., Wilson,T.E., Guillen
            Sacoto,M.J., Mullegama,S.V., Palculict,T.B., Kirk,E.P.,
            Pinner,J.R., Edwards,M., Montanari,F., Graziano,C., Pippucci,T.,
            Dingmann,B., Glass,I., Mefford,H.C., Shimoji,T., Suzuki,T.,
            Yamakawa,K., Streff,H., Schaaf,C.P., Slavotinek,A.M., Voineagu,I.,
            Carey,J.C., Buckley,M.F., Schenck,A., Harvey,R.J. and Roscioli,T.
  TITLE     De Novo ZMYND8 variants result in an autosomal dominant
            neurodevelopmental disorder with cardiac malformations
  JOURNAL   Genet Med 24 (9), 1952-1966 (2022)
   PUBMED   35916866
REFERENCE   3  (bases 1 to 5833)
  AUTHORS   Zhang,M., Wu,L., Wang,X. and Chen,J.
  TITLE     lncKRT16P6 promotes tongue squamous cell carcinoma progression by
            sponging miR-3180 and regulating GATAD2A expression
  JOURNAL   Int J Oncol 61 (3) (2022)
   PUBMED   35904180
  REMARK    GeneRIF: lncKRT16P6 promotes tongue squamous cell carcinoma
            progression by sponging miR3180 and regulating GATAD2A expression.
REFERENCE   4  (bases 1 to 5833)
  AUTHORS   Zhang,Q., Zhang,Y., Zhang,J., Zhang,D., Li,M., Yan,H., Zhang,H.,
            Song,L., Wang,J., Hou,Z., Yang,Y. and Zou,X.
  TITLE     p66alpha Suppresses Breast Cancer Cell Growth and Migration by
            Acting as Co-Activator of p53
  JOURNAL   Cells 10 (12), 3593 (2021)
   PUBMED   34944103
  REMARK    GeneRIF: p66alpha Suppresses Breast Cancer Cell Growth and
            Migration by Acting as Co-Activator of p53.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5833)
  AUTHORS   Liang,Y., Zhang,X., Liu,Y., Wang,L., Ye,Y., Tan,X., Pu,J.,
            Zhang,Q., Bao,X., Wei,X., Li,D., Kurita,R., Nakamura,Y., Li,D. and
            Xu,X.
  TITLE     GATA zinc finger domain-containing protein 2A (GATAD2A) deficiency
            reactivates fetal haemoglobin in patients with beta-thalassaemia
            through impaired formation of methyl-binding domain protein 2
            (MBD2)-containing nucleosome remodelling and deacetylation (NuRD)
            complex
  JOURNAL   Br J Haematol 193 (6), 1220-1227 (2021)
   PUBMED   33997955
  REMARK    GeneRIF: GATA zinc finger domain-containing protein 2A (GATAD2A)
            deficiency reactivates fetal haemoglobin in patients with
            beta-thalassaemia through impaired formation of methyl-binding
            domain protein 2 (MBD2)-containing nucleosome remodelling and
            deacetylation (NuRD) complex.
REFERENCE   6  (bases 1 to 5833)
  AUTHORS   Le Guezennec,X., Vermeulen,M., Brinkman,A.B., Hoeijmakers,W.A.,
            Cohen,A., Lasonder,E. and Stunnenberg,H.G.
  TITLE     MBD2/NuRD and MBD3/NuRD, two distinct complexes with different
            biochemical and functional properties
  JOURNAL   Mol Cell Biol 26 (3), 843-851 (2006)
   PUBMED   16428440
REFERENCE   7  (bases 1 to 5833)
  AUTHORS   Brackertz,M., Gong,Z., Leers,J. and Renkawitz,R.
  TITLE     p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and
            histone interaction
  JOURNAL   Nucleic Acids Res 34 (2), 397-406 (2006)
   PUBMED   16415179
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5833)
  AUTHORS   Brackertz,M., Boeke,J., Zhang,R. and Renkawitz,R.
  TITLE     Two highly related p66 proteins comprise a new family of potent
            transcriptional repressors interacting with MBD2 and MBD3
  JOURNAL   J Biol Chem 277 (43), 40958-40966 (2002)
   PUBMED   12183469
REFERENCE   9  (bases 1 to 5833)
  AUTHORS   Zhang,Y., Ng,H.H., Erdjument-Bromage,H., Tempst,P., Bird,A. and
            Reinberg,D.
  TITLE     Analysis of the NuRD subunits reveals a histone deacetylase core
            complex and a connection with DNA methylation
  JOURNAL   Genes Dev 13 (15), 1924-1935 (1999)
   PUBMED   10444591
REFERENCE   10 (bases 1 to 5833)
  AUTHORS   Zhang,Y., LeRoy,G., Seelig,H.P., Lane,W.S. and Reinberg,D.
  TITLE     The dermatomyositis-specific autoantigen Mi2 is a component of a
            complex containing histone deacetylase and nucleosome remodeling
            activities
  JOURNAL   Cell 95 (2), 279-289 (1998)
   PUBMED   9790534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC003030.1, KC877710.1 and AC011448.5.
            
            Transcript Variant: This variant (23) differs in the 5' UTR
            compared to variant 2. Variants 2 and 21-25 all encode the same
            isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY186731.1, SRR14038193.4028742.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968968, SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               AC003030.1         55153-55448
            297-467             KC877710.1         230-400             c
            468-742             AC011448.5         27439-27713
            743-875             AC011448.5         54405-54537
            876-1007            AC011448.5         54680-54811
            1008-1097           AC011448.5         56393-56482
            1098-1229           AC011448.5         57853-57984
            1230-1397           AC011448.5         58151-58318
            1398-1677           AC011448.5         60542-60821
            1678-1973           AC011448.5         63220-63515
            1974-2048           AC011448.5         64068-64142
            2049-2244           AC011448.5         64430-64625
            2245-5833           AC011448.5         67443-71031
FEATURES             Location/Qualifiers
     source          1..5833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..5833
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:54815"
                     /db_xref="HGNC:HGNC:29989"
                     /db_xref="MIM:614997"
     exon            1..296
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            297..467
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            468..742
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             474..2375
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /note="isoform 2 is encoded by transcript variant 23;
                     transcriptional repressor p66-alpha; GATA zinc finger
                     domain-containing protein 2A"
                     /codon_start=1
                     /product="transcriptional repressor p66-alpha isoform 2"
                     /protein_id="NP_001371460.1"
                     /db_xref="CCDS:CCDS12402.2"
                     /db_xref="GeneID:54815"
                     /db_xref="HGNC:HGNC:29989"
                     /db_xref="MIM:614997"
                     /translation="MTEEACRTRSQKRALERDPTEDDVESKKIKMERGLLASDLNTDG
                     DMRVTPEPGAGPTQGLLRATEATAMAMGRGEGLVGDGPVDMRTSHSDMKSERRPPSPD
                     VIVLSDNEQPSSPRVNGLTTVALKETSTEALMKSSPEERERMIKQLKEELRLEEAKLV
                     LLKKLRQSQIQKEATAQKPTGSVGSTVTTPPPLVRGTQNIPAGKPSLQTSSARMPGSV
                     IPPPLVRGGQQASSKLGPQASSQVVMPPLVRGAQQIHSIRQHSSTGPPPLLLAPRASV
                     PSVQIQGQRIIQQGLIRVANVPNTSLLVNIPQPTPASLKGTTATSAQANSTPTSVASV
                     VTSAESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEE
                     VVQNLLETQGRMSAATVLSREPYMCAQCKTDFTCRWREEKSGAIMCENCMTTNQKKAL
                     KVEHTSRLKAAFVKALQQEQEIEQRLLQQGTAPAQAKAEPTAAPHPVLKQVIKPRRKL
                     AFRSGEARDWSNGAVLQASSQLSRGSATTPRGVLHTFSPSPKLQNSASATALVSRTGR
                     HSERTVSAGKGSATSNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPR
                     SIPQSATWK"
     exon            743..875
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1007
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1097
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1229
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1397
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1677
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1973
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2048
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2244
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..5833
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3858..3863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /note="hexamer: AATAAA"
     polyA_site      3880
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /note="major polyA site"
     regulatory      4221..4226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /note="hexamer: AATAAA"
     polyA_site      4242
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
     regulatory      5808..5813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /note="hexamer: AATAAA"
     polyA_site      5833
                     /gene="GATAD2A"
                     /gene_synonym="p66alpha"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgagac tgagccgcga gactgagctg cggctccgag cgctgcgcgg cggctcctcc
       61 cgcccagggt cagcgccccg gcgcgcgcac gcgcaccccc gccgcccgag cgcgccccgc
      121 gccgcccgcg cagtcggtcg gtcggtcgtc tgtcctgtcg ccgctgccgc cgccgccaca
      181 gcggccgccg cgggcgccac ctgagggagt cgcctccgcg ggacgccaca agacctgacc
      241 ggactgcgcc gcccgaggcc gtcggccgcc gtcagcgagg gcgccgagca acttcggttg
      301 gtcagcacat tgtctcaagt agccttttga tgtcactgtg gccatggcca actggtagga
      361 ccagcacccc ataccccgaa gccaggtgag tgcttggggt gtagtgtctg tggaaggaag
      421 gttccacgca tccagcaggc ttcggtcagc ttcttggaca ctttaaattc agaatgaccg
      481 aagaagcatg ccgaacacgg agtcagaaac gagcgcttga acgggaccca acagaggacg
      541 atgtggagag caagaaaata aaaatggaga gaggattgtt ggcttcagat ttaaacactg
      601 acggagacat gagggtgaca cctgagccgg gagcaggtcc aacccaagga ttgctgaggg
      661 caacagaggc cacggccatg gccatgggca gaggcgaagg gctggtgggc gatgggcccg
      721 tggacatgcg cacctcacac agtgacatga agtccgagag gagacccccc tcacctgacg
      781 tgattgtgct ctccgacaac gagcagccct cgagcccgag agtgaatggg ctgaccacgg
      841 tggccttgaa ggagactagc accgaggccc tcatgaaaag cagtcctgaa gaacgagaaa
      901 ggatgatcaa gcagctgaag gaagaattga ggttagaaga agcaaaactc gtgttgttga
      961 aaaagttgcg gcagagtcaa atacaaaagg aagccaccgc ccagaagccc acaggttctg
     1021 ttgggagcac cgtgaccacc cctcccccgc ttgttcgggg cactcagaac attcctgctg
     1081 gcaagccatc actccagacc tcttcagctc ggatgcccgg cagtgtcata cccccgcccc
     1141 tggtccgagg tgggcagcag gcgtcctcga agctggggcc acaggcgagc tcacaggtcg
     1201 tcatgccccc actcgtcagg ggggctcagc aaatccacag cattaggcaa cattccagca
     1261 cagggccacc gcccctcctc ctggcccccc gggcgtcggt gcccagtgtg cagattcagg
     1321 gacagaggat catccagcag ggcctcatcc gcgtcgccaa tgttcccaac accagcctgc
     1381 tcgtcaacat cccacagccc accccagcat cactgaaggg gacaacagcc acctccgctc
     1441 aggccaactc cacccccact agtgtggcct ctgtggtcac ctctgccgag tctccagcaa
     1501 gccgacaggc ggccgccaag ctggcgctgc gcaaacagct ggagaagacg ctactcgaga
     1561 tccccccacc caagccccca gccccagaga tgaacttcct gcccagcgcc gccaacaacg
     1621 agttcatcta cctggtcggc ctggaggagg tggtgcagaa cctactggag acacaaggca
     1681 ggatgtcggc cgccactgtg ctgtcccggg agccctacat gtgtgcacag tgcaagacgg
     1741 acttcacgtg ccgctggcgg gaggagaaga gcggcgccat catgtgtgag aactgcatga
     1801 caaccaacca gaagaaggcg ctcaaggtgg agcacaccag ccggctgaag gccgcctttg
     1861 tgaaggcgct gcagcaggaa caggagattg agcagcggct cctgcagcag ggcacggccc
     1921 ctgcacaggc caaggccgag cccaccgctg ccccacaccc cgtgctgaag caggtcataa
     1981 aaccccggcg taagttggcg ttccgctcag gagaggcccg cgactggagt aacggggctg
     2041 tgctacaggc ctccagccag ctgtcccggg gttcggccac gacgccccga ggtgtcctgc
     2101 acacgttcag tccgtcaccc aaactgcaga actcagcctc ggccacagcc ctggtcagca
     2161 ggaccggcag acattctgag agaaccgtga gcgccggcaa gggcagcgcc acctccaact
     2221 ggaagaagac gcccctcagc acaggcggga cccttgcgtt tgtcagccca agcctggcgg
     2281 tgcacaagag ctcctcggcc gtggaccgcc agcgagagta cctcctggac atgatcccac
     2341 cccgctccat cccccagtca gccacgtgga aatagtgcga gccaggcccc gtggaagacg
     2401 ggctccctcc tcccccacct ggcccctggt ctagaaggac ccactgcacc accctccgct
     2461 ggctcgggaa gacaccgtgc ccgccccaag agcaagcacc ggccatgctg cagaggcaag
     2521 acctcaattc ttggctgcaa agtttcatca gggctagggg gctggtgccg cctcataggc
     2581 agacgaggat catcgctggg ggacctttcc cgtgggcttt cttcctttct ctctttgcct
     2641 ttagtttgcc cgacaccagc agaaaagtgg accttggggg ctggttctgc tcctggcccc
     2701 cttgttcagc ccctgccggc acacgggcgg ctcaccctgg acactgtgat gcgcatgggc
     2761 aaggccagcg cccggggctt ctgaaccgag cggggtgttt catttttttg cttttccctg
     2821 tcttaggctc ccagtctttg actgccttcc catggcgatc tataagttga aagatttttt
     2881 ttttttttaa tcacctcatg atgatggagt taaaagtaaa ccgtgcagac cctggggtcc
     2941 ctgttgtacg ctgcatcatc ccgctggccc tgtgccctgg agggtgggcg gctcatggtg
     3001 ccacagcccc tggcagggac ggccggcccg cccccgtgac tgactgacag atgcagggat
     3061 ggccgaggca gccctcgctc cagctgaacg cctccattgc tgcttgttct ggagaccccc
     3121 gcccccgcac cttccagact tagcagaaga acaaactgaa gaacagaccc agccagagaa
     3181 gcagggattc cagaagctgc ccattaaggg agaaggagag gatccggtcg gcagcagccc
     3241 tgagcagaaa gctggagggg ggactgtcgc ggggtttttc tgttgtggtt tattttatta
     3301 aattttttcc ttttttctat tcatttcgat ggacgcaatc ttaagccacc ctggccttgc
     3361 tcctgggagg tgagcgtgca caggtgtgtg caggtcagga ggtgccgtcc aggtgtgcgg
     3421 cgagccgctg cgcacagatg tcaggatttc cgtttgggtc tagtttagaa cctgtcctta
     3481 aacctagggg ttgctgtcag gatttgcttt cagacttttt ttttttttgt aattcccttt
     3541 agagtctaca aaaatgtttt taaaaggatc aggtctgctt ttagtttcat ttttgtttct
     3601 ttcccgtccc actctttaaa aactggttcc gtgaggaaag gcagaagccg ttccgtgtct
     3661 cttgcaggct gggccggctt catgccagtg cgagggcgtc ccgtgcccac gtacatacgt
     3721 atgtctccat gagttctggg ctccactggt tccaattgag ctccagccct ggttttccta
     3781 cccatgcagt tagggacttt aatttaattt tttttttgta gggccaccgc cttcaaacac
     3841 aactgctaca acattctaat aaaggctcat ttaaccccca ggctcctgtc gtgtgaatat
     3901 cctcagtctg taggaaactt tttttgacac agcatagaag acctagtttt ggaaaacatt
     3961 atctaatttt ttgttgtgca aatccccaaa tttctcacta atttttgttt ttttgtgcat
     4021 aacttggatg ggctgaagga ggtgaggaca gattggggaa gggtggcttt cattccaaga
     4081 tccagggatt tggggaaaag gaaggaattt gatgtttttt ggggtgggag gggagggtgt
     4141 gttttttaca ccaaaaaaaa aaaaaaaaat caagagtatg caagcatttc tattcctcgc
     4201 atttttctgt gtgcctggca aataaatacc tgtctcctac gaccctgagc tgttagccct
     4261 ctctgttcca tgacaggggc cagatcttcc agctcctccc agaaggagca cccaggctgg
     4321 cttcttccca ctgaaagccc tccccagcga accaacctca gttctatgca gtggctgggg
     4381 atcaggcatc cagaccgaag tcacctctgc ctgctccagc ttgggtcagc tgggtctgac
     4441 cagggggcca gatccgagcc gcacctgccg gcccccagcc ccagctccag ctcctgacct
     4501 ctcccagcct ggcctggctg ttcctccagg gctgatggct gtcaacccat ccttgtgagt
     4561 tcatatggac tgctgcccct cgaaagggag agggtcggcc ccatgtcccc agggagcatt
     4621 ccatcaggga caacgtacat actgtgatgt aaactttttt tttttccccc cagggggcaa
     4681 aagtgtgaga tgccttaatc tttccttcat ttctgctgtc tcgaacactc tagcccatta
     4741 tttcctttca gttccttgca gcataacctc tacgataagc cccaagcggg ttgttgtatt
     4801 atgacgttta tgatgttcca ggtgaaggca ttattaagta cctctctggg tgtggggttt
     4861 ggacgcacca ggatagctat tgattaatgt taagggtgtt ctacccacag caaagcacac
     4921 cctcttaaac caggcactgc ctgggtcctg gtcccgagag ccctaccagg atcaggttcc
     4981 tgcaagccgt cagaatgtgg gagcccccag cccaactgat tgtaactgtc ccctgttacc
     5041 tgtgacatga acctccaaca gcacctggaa acggttccct ctgtcagctg ctctgtagac
     5101 agggctgggg agatctcaga gttcacacct cgcctgttgt aggggaggtt gggggtaggg
     5161 tttggaatgg ccaagtgccc ttggaacctc ccacagctat ggccgtcctg acctcatccc
     5221 aggaactcta cggtgaccag gaaccacccc tctgacgagg tctgtagcgg cccttctcag
     5281 agtggaacag cccacagtgc tagttgtgcc tggtcttacc tgtactccac ggacctcggt
     5341 gaagcaaaag cttcagggca gagggaatga ggcaacccag tggcagcccc gctgggcccc
     5401 gtggctcctg ctctcctatt ggacgtagag gcaggggaga gacttctcta tacaaatatt
     5461 ctcatcacag aagggatgat ccttgctgct ctgccgtagg gtttttgatg ctgagctatg
     5521 ctgcacatga cgttaaccta aagaacttgg actgagcttt taaaaaagga cagcaaacaa
     5581 ttttataatc cttaaagtgt aatagacggt tacactagtg cagggtattg gggaggctct
     5641 ttgggtgtgg aggctgtcac ttgtatttat tgtgactcta aatctttgat agtaaaacaa
     5701 atgtaaaaag aaatgtttgc caccagatgg gaatagaagt tccaataagc aggctggaat
     5761 gggtggctat acgttgtatc acgaggaagt tttagactct gaaggataat aaatggatga
     5821 tgtgtcaact gga
//
