LOCUS       NM_080473               2620 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens GATA binding protein 5 (GATA5), mRNA.
ACCESSION   NM_080473
VERSION     NM_080473.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2620)
  AUTHORS   Fraile,A., Cebrian,J., Thuissard-Vasallo,I., Perez-Martin,S.,
            Casado,R., Gil-Fournier,B., Alonso-Martin,J., Tamargo,J.,
            Caballero,R., Delpon,E. and Cosio,F.G.
  TITLE     Coexistent HCN4 and GATA5 Rare Variants and Atrial Fibrillation in
            a Large Spanish Family
  JOURNAL   Can J Cardiol 40 (7), 1270-1280 (2024)
   PUBMED   38432398
  REMARK    GeneRIF: Coexistent HCN4 and GATA5 Rare Variants and Atrial
            Fibrillation in a Large Spanish Family.
REFERENCE   2  (bases 1 to 2620)
  AUTHORS   Jaouadi,H., Gerard,H., Theron,A., Collod-Beroud,G., Collart,F.,
            Avierinos,J.F. and Zaffran,S.
  TITLE     Identification of non-synonymous variations in ROBO1 and GATA5
            genes in a family with bicuspid aortic valve disease
  JOURNAL   J Hum Genet 67 (9), 515-518 (2022)
   PUBMED   35534675
  REMARK    GeneRIF: Identification of non-synonymous variations in ROBO1 and
            GATA5 genes in a family with bicuspid aortic valve disease.
REFERENCE   3  (bases 1 to 2620)
  AUTHORS   Ji,W., Zhang,L. and Zhu,H.
  TITLE     GATA binding protein 5 (GATA5) induces Rho GTPase activating
            protein 9 (ARHGAP9) to inhibit the malignant process of lung
            adenocarcinoma cells
  JOURNAL   Bioengineered 13 (2), 2878-2888 (2022)
   PUBMED   35040754
  REMARK    GeneRIF: GATA binding protein 5 (GATA5) induces Rho GTPase
            activating protein 9 (ARHGAP9) to inhibit the malignant process of
            lung adenocarcinoma cells.
REFERENCE   4  (bases 1 to 2620)
  AUTHORS   Song,Z., Chen,L., Pang,S. and Yan,B.
  TITLE     Molecular genetic study on GATA5 gene promoter in acute myocardial
            infarction
  JOURNAL   PLoS One 16 (3), e0248203 (2021)
   PUBMED   33684162
  REMARK    GeneRIF: Molecular genetic study on GATA5 gene promoter in acute
            myocardial infarction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2620)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2620)
  AUTHORS   van Wering,H.M., Huibregtse,I.L., van der Zwan,S.M., de Bie,M.S.,
            Dowling,L.N., Boudreau,F., Rings,E.H., Grand,R.J. and
            Krasinski,S.D.
  TITLE     Physical interaction between GATA-5 and hepatocyte nuclear
            factor-1alpha results in synergistic activation of the human
            lactase-phlorizin hydrolase promoter
  JOURNAL   J Biol Chem 277 (31), 27659-27667 (2002)
   PUBMED   12011060
  REMARK    GeneRIF: demonstrate that GATA-5 and HNF-1alpha physically
            associate both in vivo and in vitro and that this interaction is
            necessary for cooperative activation of the lactase-phlorizin
            hydrolase promoter
REFERENCE   7  (bases 1 to 2620)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   8  (bases 1 to 2620)
  AUTHORS   Krasinski,S.D., Van Wering,H.M., Tannemaat,M.R. and Grand,R.J.
  TITLE     Differential activation of intestinal gene promoters: functional
            interactions between GATA-5 and HNF-1 alpha
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 281 (1), G69-G84 (2001)
   PUBMED   11408257
REFERENCE   9  (bases 1 to 2620)
  AUTHORS   Kakita,T., Hasegawa,K., Morimoto,T., Kaburagi,S., Wada,H. and
            Sasayama,S.
  TITLE     p300 protein as a coactivator of GATA-5 in the transcription of
            cardiac-restricted atrial natriuretic factor gene
  JOURNAL   J Biol Chem 274 (48), 34096-34102 (1999)
   PUBMED   10567378
REFERENCE   10 (bases 1 to 2620)
  AUTHORS   Gao,X., Sedgwick,T., Shi,Y.B. and Evans,T.
  TITLE     Distinct functions are implicated for the GATA-4, -5, and -6
            transcription factors in the regulation of intestine epithelial
            cell differentiation
  JOURNAL   Mol Cell Biol 18 (5), 2901-2911 (1998)
   PUBMED   9566909
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL499627.23.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_080473.4.
            
            Summary: The protein encoded by this gene is a transcription factor
            that contains two GATA-type zinc fingers. The encoded protein is
            known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and
            this interaction is essential for cooperative activation of the
            intestinal lactase-phlorizin hydrolase promoter. In other
            organisms, similar proteins may be involved in the establishment of
            cardiac smooth muscle cell diversity. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138522.1108272.1,
                                           ERR279825.7333.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252997.3/ ENSP00000252997.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AL499627.23        19589-19613         c
            26-66               AL499627.23        19548-19588         c
            67-610              AL499627.23        18617-19160         c
            611-786             AL499627.23        17021-17196         c
            787-912             AL499627.23        10044-10169         c
            913-1000            AL499627.23        9452-9539           c
            1001-1125           AL499627.23        8958-9082           c
            1126-2620           AL499627.23        7115-8609           c
FEATURES             Location/Qualifiers
     source          1..2620
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..2620
                     /gene="GATA5"
                     /gene_synonym="bB379O24.1; CHTD5; GATAS"
                     /note="GATA binding protein 5"
                     /db_xref="GeneID:140628"
                     /db_xref="HGNC:HGNC:15802"
                     /db_xref="MIM:611496"
     exon            1..66
                     /gene="GATA5"
                     /gene_synonym="bB379O24.1; CHTD5; GATAS"
                     /inference="alignment:Splign:2.1.0"
     exon            67..610
                     /gene="GATA5"
                     /gene_synonym="bB379O24.1; CHTD5; GATAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1281
                     /gene="GATA5"
                     /gene_synonym="bB379O24.1; CHTD5; GATAS"
                     /note="GATA binding factor-5"
                     /codon_start=1
                     /product="transcription factor GATA-5"
                     /protein_id="NP_536721.1"
                     /db_xref="CCDS:CCDS13499.1"
                     /db_xref="GeneID:140628"
                     /db_xref="HGNC:HGNC:15802"
                     /db_xref="MIM:611496"
                     /translation="MYQSLALAASPRQAAYADSGSFLHAPGAGSPMFVPPARVPSMLS
                     YLSGCEPSPQPPELAARPGWAQTATADSSAFGPGSPHPPAAHPPGATAFPFAHSPSGP
                     GSGGSAGGRDGSAYQGALLPREQFAAPLGRPVGTSYSATYPAYVSPDVAQSWTAGPFD
                     GSVLHGLPGRRPTFVSDFLEEFPGEGRECVNCGALSTPLWRRDGTGHYLCNACGLYHK
                     MNGVNRPLVRPQKRLSSSRRAGLCCTNCHTTNTTLWRRNSEGEPVCNACGLYMKLHGV
                     PRPLAMKKESIQTRKRKPKTIAKARGSSGSTRNASASPSAVASTDSSAATSKAKPSLA
                     SPVCPGPSMAPQASGQEDDSLAPGHLEFKFEPEDFAFPSTAPSPQAGLRGALRQEAWC
                     ALALA"
     exon            611..786
                     /gene="GATA5"
                     /gene_synonym="bB379O24.1; CHTD5; GATAS"
                     /inference="alignment:Splign:2.1.0"
     exon            787..912
                     /gene="GATA5"
                     /gene_synonym="bB379O24.1; CHTD5; GATAS"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1000
                     /gene="GATA5"
                     /gene_synonym="bB379O24.1; CHTD5; GATAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1125
                     /gene="GATA5"
                     /gene_synonym="bB379O24.1; CHTD5; GATAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..2620
                     /gene="GATA5"
                     /gene_synonym="bB379O24.1; CHTD5; GATAS"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2015
                     /gene="GATA5"
                     /gene_synonym="bB379O24.1; CHTD5; GATAS"
                     /note="major polyA site"
     regulatory      2602..2607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GATA5"
                     /gene_synonym="bB379O24.1; CHTD5; GATAS"
                     /note="hexamer: AATAAA"
     polyA_site      2620
                     /gene="GATA5"
                     /gene_synonym="bB379O24.1; CHTD5; GATAS"
                     /note="major polyA site"
ORIGIN      
        1 agtcttcggc ccgccggtcg ccgacccacc gccaccgccg tgccctgccg ccctccctgc
       61 ccgctggtca agaccacgcc tgggaggatg taccagagcc tggcgctggc cgcgagcccc
      121 cgccaggccg cctacgccga ctcgggctcc ttcctgcacg ctccgggcgc cggctctccg
      181 atgtttgtgc cgccggcgcg cgtcccctcg atgctgtcct acctgtccgg gtgtgagccg
      241 agcccgcagc cccccgagct cgctgcgcgc cccggctggg cgcagacagc caccgcggat
      301 tcgtcggcct tcggcccggg cagtccgcac cccccagccg cgcacccgcc cggggccacc
      361 gccttccctt tcgcgcacag cccctcgggg cccggcagcg gcggcagcgc ggggggccga
      421 gacggcagtg cctaccaggg cgcgctgttg cctcgagaac agttcgcggc cccgcttggg
      481 cggccggtgg ggacctcgta ctccgccacc tacccggcct acgtgagccc cgacgtggcc
      541 cagtcctgga ctgccgggcc cttcgatggc agcgtcctgc acggcctccc aggccgcagg
      601 cccaccttcg tgtccgactt cttggaggag ttcccgggtg agggtcgtga gtgtgtcaac
      661 tgcggggccc tgtccacacc gctgtggcgc cgagacggca ccggccacta cctgtgcaat
      721 gcctgcggcc tctaccacaa gatgaatggc gtcaaccggc cgctcgttcg gcctcagaag
      781 cgcctgtcct cgtcccgccg cgccggcctc tgctgcacca actgccacac gaccaacacc
      841 acgctgtggc ggcggaactc ggagggggag cccgtgtgca atgcctgcgg cctctacatg
      901 aagctgcacg gggtgccgcg gcctctggct atgaagaagg aaagcatcca gacacggaag
      961 cggaagccaa agaccatcgc caaggccagg ggctcctcag gatccacaag gaatgcctcg
     1021 gcctccccat ctgctgtcgc cagcactgac agctcagcag ccacttcgaa agccaagccc
     1081 agcctggcgt ccccagtgtg ccctgggccc agcatggccc cccaggcctc tggccaggag
     1141 gatgactctc ttgcccccgg ccacttggag ttcaagttcg agcctgagga ctttgccttc
     1201 ccctccacgg ccccaagccc ccaggctggc ctcagggggg ctctgcgcca agaggcctgg
     1261 tgtgcgctgg ccttggccta ggtccccagg ccagcccatg tcaggggaac agcctggaac
     1321 agaccaccca ctgagtcacc tccgtgcctg ctttgctcca gcacagcaga gaccagcagg
     1381 ccccccaacc cagagactgg gtctgctgga gtctccacac agtggtgggg aggccttctg
     1441 gacagacggc agtcgggccc cagagcaaga aggctggtga gggaagggct cagcttccca
     1501 ccccacgtac agcaagggac tccccaggtg cggcccaagg ctccggacca cactggcccc
     1561 ctgcggcgga ggccaacgca gggcaccacc accaccaact tgaattccgt catcaatgct
     1621 caccgtcaat atgtttacaa gttgtagcag ttgggggaaa acagtcaacc tcccagtgta
     1681 aaaccaagat tcccagtgaa gcacctgagg ccaagcaggg gagaggaatg aggggagcag
     1741 ctggacatgg gcctcctgag gcctcggggc tgtccttcat tgcccacatg gatagacgga
     1801 gctgtggtgc agagaacttt tcccgcaaca ggtgcaggac tgccagggat cggagtgcgg
     1861 gccgcgcacg gtgccaggat tccgccgagg ggaagccgct cacattgcag tcatcacaga
     1921 cttacgcact tgtttggaca gtttttccag aggggatggg aaagggcctt gttctagctg
     1981 aatctgtgta tcatgaccat ttctgacagg cagaatgaat tgtctggtag ccctgtcctg
     2041 acccatccaa gcgctgttgg ggctggtggt gacgtggtca catgtcctgg catatctggg
     2101 gccacgcagt ttagtctctt gtcccaggag aattgttagt gacccctctt tctcttgcaa
     2161 gccccctcca cactgggttg gatgatacct taatgagtga cgctggcgag aggcacccta
     2221 cccgacgcag ctgtgaatgg ccggtgatgt atgtcaggag gccacaggga gcagaggagc
     2281 ggggcaggca gccacagggc cctgcgggga gcacatcctc gcctccgtcc ggctgctgcc
     2341 cttcaacaac aagccctgat ttttccagca atgccagaaa cctggatttt aagtcttcca
     2401 atttgattca aaaatatttt taacattgtg agccagctag acccccagtg caccacccca
     2461 tattgaaaaa cagttgtctg gcatcagctt caggagcggg tccggtcatt ctgaaactgt
     2521 ccctccagag gttcttccag ccccacttct atgcgatgtc atcttttcta aaagagacaa
     2581 atgaagccac agggaaagtg aaataaagcc ttgaacctca
//
