LOCUS       NM_001002295            3083 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens GATA binding protein 3 (GATA3), transcript variant 1,
            mRNA.
ACCESSION   NM_001002295
VERSION     NM_001002295.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3083)
  AUTHORS   Zhu,X., Chan,E., Turski,M.L., Mendez,C.E., Hsu,S.C., Kumar,V.,
            Shipp,C., Jindal,T., Chang,K., Onodera,C., Devine,W.P.,
            Grenert,J.P., Stohr,B.A., Ding,C.C., Stachler,M.D., Quigley,D.A.,
            Feng,F.Y., Chu,C.E., Porten,S.P., Chou,J., Friedlander,T.W. and
            Koshkin,V.S.
  TITLE     HER2 overexpression in urothelial carcinoma with GATA3 and PPARG
            copy number gains
  JOURNAL   Oncologist 29 (8), e1094-e1097 (2024)
   PUBMED   38908022
  REMARK    GeneRIF: HER2 overexpression in urothelial carcinoma with GATA3 and
            PPARG copy number gains.
REFERENCE   2  (bases 1 to 3083)
  AUTHORS   Chen,X., Zhao,W., Huang,Y., Luo,S., Tang,X. and Yi,Q.
  TITLE     Association of GATA3 expression in triple-positive breast cancer
            with overall survival and immune cell infiltration
  JOURNAL   Sci Rep 14 (1), 17795 (2024)
   PUBMED   39090342
  REMARK    GeneRIF: Association of GATA3 expression in triple-positive breast
            cancer with overall survival and immune cell infiltration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3083)
  AUTHORS   Keshavarz,F., Mokhtari,M.J. and Poursadeghfard,M.
  TITLE     Increased level of GATA3-AS1 long non-coding RNA is correlated with
            the upregulation of GATA3 and IL-4 genes in multiple sclerosis
            patients
  JOURNAL   Mol Biol Rep 51 (1), 874 (2024)
   PUBMED   39080124
  REMARK    GeneRIF: Increased level of GATA3-AS1 long non-coding RNA is
            correlated with the upregulation of GATA3 and IL-4 genes in
            multiple sclerosis patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3083)
  AUTHORS   Goto,K., Kiniwa,Y., Kukita,Y., Ohe,S., Hiraki,T., Hishima,T.,
            Takai,T. and Honma,K.
  TITLE     Recurrent GATA3 P409Afs*99 Frameshift Extension Mutations in
            Sweat-gland Carcinoma With Neuroendocrine Differentiation
  JOURNAL   Am J Surg Pathol 48 (5), 528-537 (2024)
   PUBMED   38353459
  REMARK    GeneRIF: Recurrent GATA3 P409Afs*99 Frameshift Extension Mutations
            in Sweat-gland Carcinoma With Neuroendocrine Differentiation.
REFERENCE   5  (bases 1 to 3083)
  AUTHORS   Varchulova Novakova,Z., Harsanyi,S., Bevizova,K., Kuniakova,M.,
            Schwarzova,L., Trebaticky,B., Danisovic,L. and Ziaran,S.
  TITLE     Expression of BCL2, TP53, FOXA1, and GATA3 in pTa bladder cancer
            recurrence
  JOURNAL   Bratisl Lek Listy 125 (5), 311-317 (2024)
   PUBMED   38624056
  REMARK    GeneRIF: Expression of BCL2, TP53, FOXA1, and GATA3 in pTa bladder
            cancer recurrence.
REFERENCE   6  (bases 1 to 3083)
  AUTHORS   Siegel,M.D., Zhang,D.H., Ray,P. and Ray,A.
  TITLE     Activation of the interleukin-5 promoter by cAMP in murine EL-4
            cells requires the GATA-3 and CLE0 elements
  JOURNAL   J Biol Chem 270 (41), 24548-24555 (1995)
   PUBMED   7592673
REFERENCE   7  (bases 1 to 3083)
  AUTHORS   Marine,J. and Winoto,A.
  TITLE     The human enhancer-binding protein Gata3 binds to several T-cell
            receptor regulatory elements
  JOURNAL   Proc Natl Acad Sci U S A 88 (16), 7284-7288 (1991)
   PUBMED   1871134
REFERENCE   8  (bases 1 to 3083)
  AUTHORS   Joulin,V., Bories,D., Eleouet,J.F., Labastie,M.C., Chretien,S.,
            Mattei,M.G. and Romeo,P.H.
  TITLE     A T-cell specific TCR delta DNA binding protein is a member of the
            human GATA family
  JOURNAL   EMBO J 10 (7), 1809-1816 (1991)
   PUBMED   2050118
REFERENCE   9  (bases 1 to 3083)
  AUTHORS   Ko,L.J., Yamamoto,M., Leonard,M.W., George,K.M., Ting,P. and
            Engel,J.D.
  TITLE     Murine and human T-lymphocyte GATA-3 factors mediate transcription
            through a cis-regulatory element within the human T-cell receptor
            delta gene enhancer
  JOURNAL   Mol Cell Biol 11 (5), 2778-2784 (1991)
   PUBMED   2017177
REFERENCE   10 (bases 1 to 3083)
  AUTHORS   Ho,I.C., Vorhees,P., Marin,N., Oakley,B.K., Tsai,S.F., Orkin,S.H.
            and Leiden,J.M.
  TITLE     Human GATA-3: a lineage-restricted transcription factor that
            regulates the expression of the T cell receptor alpha gene
  JOURNAL   EMBO J 10 (5), 1187-1192 (1991)
   PUBMED   1827068
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390294.19, BC006793.1,
            BM152193.1, BC003070.2, BC006839.1, AI024501.1 and AI686327.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001002295.1.
            
            Summary: This gene encodes a protein which belongs to the GATA
            family of transcription factors. The protein contains two GATA-type
            zinc fingers and is an important regulator of T-cell development
            and plays an important role in endothelial cell biology. Defects in
            this gene are the cause of hypoparathyroidism with sensorineural
            deafness and renal dysplasia. [provided by RefSeq, Nov 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006793.1, SRR1163657.278544.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379328.9/ ENSP00000368632.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AL390294.19        52236-52251
            17-72               BC006793.1         1-56
            73-322              BC006793.1         59-308
            323-431             BM152193.1         295-403
            432-1351            BC003070.2         310-1229
            1352-2173           BC006793.1         1338-2159
            2174-2423           BC006793.1         2161-2410
            2424-2519           BC006839.1         287-382
            2520-2779           AI024501.1         5-264               c
            2780-3083           AI686327.1         2-305               c
FEATURES             Location/Qualifiers
     source          1..3083
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p14"
     gene            1..3083
                     /gene="GATA3"
                     /gene_synonym="HDR; HDRS"
                     /note="GATA binding protein 3"
                     /db_xref="GeneID:2625"
                     /db_xref="HGNC:HGNC:4172"
                     /db_xref="MIM:131320"
     exon            1..204
                     /gene="GATA3"
                     /gene_synonym="HDR; HDRS"
                     /inference="alignment:Splign:2.1.0"
     exon            205..814
                     /gene="GATA3"
                     /gene_synonym="HDR; HDRS"
                     /inference="alignment:Splign:2.1.0"
     CDS             574..1908
                     /gene="GATA3"
                     /gene_synonym="HDR; HDRS"
                     /note="isoform 1 is encoded by transcript variant 1;
                     trans-acting T-cell-specific transcription factor GATA-3;
                     GATA-binding factor 3"
                     /codon_start=1
                     /product="trans-acting T-cell-specific transcription
                     factor GATA-3 isoform 1"
                     /protein_id="NP_001002295.1"
                     /db_xref="CCDS:CCDS31143.1"
                     /db_xref="GeneID:2625"
                     /db_xref="HGNC:HGNC:4172"
                     /db_xref="MIM:131320"
                     /translation="MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLP
                     EEVDVLFNIDGQGNHVPPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKA
                     LGSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKD
                     VSPDPSLSTPGSAGSARQDEKECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHP
                     ITTYPPYVPEYSSGLFPPSSLLGGSPTGFGCKSRPKARSSTEGRECVNCGATSTPLWR
                     RDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNAN
                     GDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDSLEDFPKNSSF
                     NPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSSLSFGPHHPSSMVTAMG"
     exon            815..1351
                     /gene="GATA3"
                     /gene_synonym="HDR; HDRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1497
                     /gene="GATA3"
                     /gene_synonym="HDR; HDRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1623
                     /gene="GATA3"
                     /gene_synonym="HDR; HDRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..3083
                     /gene="GATA3"
                     /gene_synonym="HDR; HDRS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2750..2755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GATA3"
                     /gene_synonym="HDR; HDRS"
                     /note="hexamer: AATAAA"
     regulatory      2760..2765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GATA3"
                     /gene_synonym="HDR; HDRS"
                     /note="hexamer: ATTACA"
     polyA_site      2769
                     /gene="GATA3"
                     /gene_synonym="HDR; HDRS"
                     /note="major polyA site"
     polyA_site      2779
                     /gene="GATA3"
                     /gene_synonym="HDR; HDRS"
                     /note="major polyA site"
     regulatory      3058..3063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GATA3"
                     /gene_synonym="HDR; HDRS"
                     /note="hexamer: AATAAA"
     polyA_site      3083
                     /gene="GATA3"
                     /gene_synonym="HDR; HDRS"
ORIGIN      
        1 gaacactgag ctgcctggcg ccgtcttgat actttcagaa agaatgcatt ccctgtaaaa
       61 aaaaaaaaaa aatactgaga gagggagaga gagagagaag aagagagaga gacggaggga
      121 gagcgagaca gagcgagcaa cgcaatctga ccgagcaggt cgtacgccgc cgcctcctcc
      181 tcctctctgc tcttcgctac ccaggtgacc cgaggaggga ctccgcctcc gagcggctga
      241 ggaccccggt gcagaggagc ctggctcgca gaattgcaga gtcgtcgccc ctttttacaa
      301 cctggtcccg ttttattctg ccgtacccag tttttggatt tttgtcttcc ccttcttctc
      361 tttgctaaac gacccctcca agataatttt taaaaaacct tctcctttgc tcacctttgc
      421 ttcccagcct tcccatcccc ccaccgaaag caaatcattc aacgaccccc gaccctccga
      481 cggcaggagc cccccgacct cccaggcgga ccgccctccc tccccgcgcg cgggttccgg
      541 gcccggcgag agggcgcgag cacagccgag gccatggagg tgacggcgga ccagccgcgc
      601 tgggtgagcc accaccaccc cgccgtgctc aacgggcagc acccggacac gcaccacccg
      661 ggcctcagcc actcctacat ggacgcggcg cagtacccgc tgccggagga ggtggatgtg
      721 ctttttaaca tcgacggtca aggcaaccac gtcccgccct actacggaaa ctcggtcagg
      781 gccacggtgc agaggtaccc tccgacccac cacgggagcc aggtgtgccg cccgcctctg
      841 cttcatggat ccctaccctg gctggacggc ggcaaagccc tgggcagcca ccacaccgcc
      901 tccccctgga atctcagccc cttctccaag acgtccatcc accacggctc cccggggccc
      961 ctctccgtct accccccggc ctcgtcctcc tccttgtcgg ggggccacgc cagcccgcac
     1021 ctcttcacct tcccgcccac cccgccgaag gacgtctccc cggacccatc gctgtccacc
     1081 ccaggctcgg ccggctcggc ccggcaggac gagaaagagt gcctcaagta ccaggtgccc
     1141 ctgcccgaca gcatgaagct ggagtcgtcc cactcccgtg gcagcatgac cgccctgggt
     1201 ggagcctcct cgtcgaccca ccaccccatc accacctacc cgccctacgt gcccgagtac
     1261 agctccggac tcttcccccc cagcagcctg ctgggcggct cccccaccgg cttcggatgc
     1321 aagtccaggc ccaaggcccg gtccagcaca gaaggcaggg agtgtgtgaa ctgtggggca
     1381 acctcgaccc cactgtggcg gcgagatggc acgggacact acctgtgcaa cgcctgcggg
     1441 ctctatcaca aaatgaacgg acagaaccgg cccctcatta agcccaagcg aaggctgtct
     1501 gcagccagga gagcagggac gtcctgtgcg aactgtcaga ccaccacaac cacactctgg
     1561 aggaggaatg ccaatgggga ccctgtctgc aatgcctgtg ggctctacta caagcttcac
     1621 aatattaaca gacccctgac tatgaagaag gaaggcatcc agaccagaaa ccgaaaaatg
     1681 tctagcaaat ccaaaaagtg caaaaaagtg catgactcac tggaggactt ccccaagaac
     1741 agctcgttta acccggccgc cctctccaga cacatgtcct ccctgagcca catctcgccc
     1801 ttcagccact ccagccacat gctgaccacg cccacgccga tgcacccgcc atccagcctg
     1861 tcctttggac cacaccaccc ctccagcatg gtcaccgcca tgggttagag ccctgctcga
     1921 tgctcacagg gcccccagcg agagtccctg cagtcccttt cgacttgcat ttttgcagga
     1981 gcagtatcat gaagcctaaa cgcgatggat atatgttttt gaaggcagaa agcaaaatta
     2041 tgtttgccac tttgcaaagg agctcactgt ggtgtctgtg ttccaaccac tgaatctgga
     2101 ccccatctgt gaataagcca ttctgactca tatcccctat ttaacagggt ctctagtgct
     2161 gtgaaaaaaa aaatgctgaa cattgcatat aacttatatt gtaagaaata ctgtacaatg
     2221 actttattgc atctgggtag ctgtaaggca tgaaggatgc caagaagttt aaggaatatg
     2281 ggagaaatag tgtggaaatt aagaagaaac taggtctgat attcaaatgg acaaactgcc
     2341 agttttgttt cctttcactg gccacagttg tttgatgcat taaaagaaaa taaaaaaaag
     2401 aaaaaagaga aaagaaaaaa aaagaaaaaa gttgtaggcg aatcatttgt tcaaagctgt
     2461 tggcctctgc aaaggaaata ccagttctgg gcaatcagtg ttaccgttca ccagttgccg
     2521 ttgagggttt cagagagcct ttttctaggc ctacatgctt tgtgaacaag tccctgtaat
     2581 tgttgtttgt atgtataatt caaagcacca aaataagaaa agatgtagat ttatttcatc
     2641 atattataca gaccgaactg ttgtataaat ttatttactg ctagtcttaa gaactgcttt
     2701 ctttcgtttg tttgtttcaa tattttcctt ctctctcaat ttttggttga ataaactaga
     2761 ttacattcag ttggcctaag gtggttgtgc tcggagggtt tcttgtttct tttccatttt
     2821 gtttttggat gatatttatt aaatagcttc taagagtccg gcggcatctg tcttgtccct
     2881 attcctgcag cctgtgctga gggtagcagt gtatgagcta ccagcgtgca tgtcagcgac
     2941 cctggcccga caggccacgt cctgcaatcg gcccggctgc ctcttcgccc tgtcgtgttc
     3001 tgtgttagtg atcactgcct ttaatacagt ctgttggaat aatattataa gcataataat
     3061 aaagtgaaaa tattttaaaa cta
//
