LOCUS       NM_032638               3383 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens GATA binding protein 2 (GATA2), transcript variant 2,
            mRNA.
ACCESSION   NM_032638 NM_002050
VERSION     NM_032638.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3383)
  AUTHORS   Shen,S., Huang,Q., Liu,L., Zou,X., Kang,T. and Wu,J.
  TITLE     GATA2 downregulation contributes to pro-inflammatory phenotype and
            defective phagocytosis of pulmonary macrophages in chronic
            obstructive pulmonary disease
  JOURNAL   Aging (Albany NY) 16 (19), 12928-12951 (2024)
   PUBMED   39379099
  REMARK    GeneRIF: GATA2 downregulation contributes to pro-inflammatory
            phenotype and defective phagocytosis of pulmonary macrophages in
            chronic obstructive pulmonary disease.
REFERENCE   2  (bases 1 to 3383)
  AUTHORS   Jin,Z., Wang,H., Tang,R., Pan,B., Lee,H.J., Liu,S., Wang,L., Qin,J.
            and Xu,M.
  TITLE     GATA2 promotes castration-resistant prostate cancer development by
            suppressing IFN-beta axis-mediated antitumor immunity
  JOURNAL   Oncogene 43 (34), 2595-2610 (2024)
   PUBMED   39068217
  REMARK    GeneRIF: GATA2 promotes castration-resistant prostate cancer
            development by suppressing IFN-beta axis-mediated antitumor
            immunity.
REFERENCE   3  (bases 1 to 3383)
  AUTHORS   Wu,L., Wang,J., Song,D., You,Y. and Wang,Z.
  TITLE     Haemophagocytic lymphohistiocytosis caused by GATA2 deficiency: a
            report on three patients
  JOURNAL   BMC Infect Dis 24 (1), 482 (2024)
   PUBMED   38730328
  REMARK    GeneRIF: Haemophagocytic lymphohistiocytosis caused by GATA2
            deficiency: a report on three patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3383)
  AUTHORS   Pan,X., Minegishi,N., Harigae,H., Yamagiwa,H., Minegishi,M.,
            Akine,Y. and Yamamoto,M.
  TITLE     Identification of human GATA-2 gene distal IS exon and its
            expression in hematopoietic stem cell fractions
  JOURNAL   J Biochem 127 (1), 105-112 (2000)
   PUBMED   10731672
  REMARK    Erratum:[J Biochem (Tokyo). 2007 May;141(5):767]
REFERENCE   5  (bases 1 to 3383)
  AUTHORS   Fleenor,D.E., Langdon,S.D., deCastro,C.M. and Kaufman,R.E.
  TITLE     Comparison of human and Xenopus GATA-2 promoters
  JOURNAL   Gene 179 (2), 219-223 (1996)
   PUBMED   8972903
REFERENCE   6  (bases 1 to 3383)
  AUTHORS   Zhang,R., Min,W. and Sessa,W.C.
  TITLE     Functional analysis of the human endothelial nitric oxide synthase
            promoter. Sp1 and GATA factors are necessary for basal
            transcription in endothelial cells
  JOURNAL   J Biol Chem 270 (25), 15320-15326 (1995)
   PUBMED   7541039
  REMARK    GeneRIF: The GATA-2 transcription factor interacts with the human
            eNOS promoter at a region which includes a putative GATA site [-230
            to -226].
REFERENCE   7  (bases 1 to 3383)
  AUTHORS   Towatari,M., May,G.E., Marais,R., Perkins,G.R., Marshall,C.J.,
            Cowley,S. and Enver,T.
  TITLE     Regulation of GATA-2 phosphorylation by mitogen-activated protein
            kinase and interleukin-3
  JOURNAL   J Biol Chem 270 (8), 4101-4107 (1995)
   PUBMED   7876160
REFERENCE   8  (bases 1 to 3383)
  AUTHORS   Nagai,T., Harigae,H., Ishihara,H., Motohashi,H., Minegishi,N.,
            Tsuchiya,S., Hayashi,N., Gu,L., Andres,B., Engel,J.D. et al.
  TITLE     Transcription factor GATA-2 is expressed in erythroid, early
            myeloid, and CD34+ human leukemia-derived cell lines
  JOURNAL   Blood 84 (4), 1074-1084 (1994)
   PUBMED   7519472
REFERENCE   9  (bases 1 to 3383)
  AUTHORS   Dorfman,D.M., Wilson,D.B., Bruns,G.A. and Orkin,S.H.
  TITLE     Human transcription factor GATA-2. Evidence for regulation of
            preproendothelin-1 gene expression in endothelial cells
  JOURNAL   J Biol Chem 267 (2), 1279-1285 (1992)
   PUBMED   1370462
REFERENCE   10 (bases 1 to 3383)
  AUTHORS   Lee,M.E., Temizer,D.H., Clifford,J.A. and Quertermous,T.
  TITLE     Cloning of the GATA-binding protein that regulates endothelin-1
            gene expression in endothelial cells
  JOURNAL   J Biol Chem 266 (24), 16188-16192 (1991)
   PUBMED   1714909
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC080005.24, BC002557.2 and
            BC051342.1.
            
            On Aug 31, 2019 this sequence version replaced NM_032638.4.
            
            Summary: This gene encodes a member of the GATA family of
            zinc-finger transcription factors that are named for the consensus
            nucleotide sequence they bind in the promoter regions of target
            genes. The encoded protein plays an essential role in regulating
            transcription of genes involved in the development and
            proliferation of hematopoietic and endocrine cell lineages.
            Alternative splicing results in multiple transcript
            variants.[provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051342.1, SRR7346977.757529.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341105.7/ ENSP00000345681.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC080005.24        60434-60447         c
            15-362              BC002557.2         1-348
            363-363             AC080005.24        54263-54263         c
            364-1990            BC051342.1         348-1974
            1991-2273           AC080005.24        47783-48065         c
            2274-3383           BC051342.1         2258-3367
FEATURES             Location/Qualifiers
     source          1..3383
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3"
     gene            1..3383
                     /gene="GATA2"
                     /gene_synonym="DCML; IMD21; MONOMAC; NFE1B"
                     /note="GATA binding protein 2"
                     /db_xref="GeneID:2624"
                     /db_xref="HGNC:HGNC:4171"
                     /db_xref="MIM:137295"
     exon            1..303
                     /gene="GATA2"
                     /gene_synonym="DCML; IMD21; MONOMAC; NFE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            304..577
                     /gene="GATA2"
                     /gene_synonym="DCML; IMD21; MONOMAC; NFE1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..1791
                     /gene="GATA2"
                     /gene_synonym="DCML; IMD21; MONOMAC; NFE1B"
                     /note="isoform 1 is encoded by transcript variant 2;
                     endothelial transcription factor GATA-2"
                     /codon_start=1
                     /product="endothelial transcription factor GATA-2 isoform
                     1"
                     /protein_id="NP_116027.2"
                     /db_xref="CCDS:CCDS3049.1"
                     /db_xref="GeneID:2624"
                     /db_xref="HGNC:HGNC:4171"
                     /db_xref="MIM:137295"
                     /translation="MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDE
                     VDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGK
                     AALSAAAAHHHNPWTVSPFSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLT
                     PTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLT
                     ESMKMESGSPLRPGLATMGTQPATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPAS
                     SFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIK
                     PKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEG
                     IQTRNRKMSNKSKKSKKGAECFEELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSG
                     HILPTPTPIHPSSSLSFGHPHPSSMVTAMG"
     exon            578..1219
                     /gene="GATA2"
                     /gene_synonym="DCML; IMD21; MONOMAC; NFE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1365
                     /gene="GATA2"
                     /gene_synonym="DCML; IMD21; MONOMAC; NFE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1491
                     /gene="GATA2"
                     /gene_synonym="DCML; IMD21; MONOMAC; NFE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..3383
                     /gene="GATA2"
                     /gene_synonym="DCML; IMD21; MONOMAC; NFE1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3364..3369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GATA2"
                     /gene_synonym="DCML; IMD21; MONOMAC; NFE1B"
                     /note="hexamer: AATAAA"
     polyA_site      3383
                     /gene="GATA2"
                     /gene_synonym="DCML; IMD21; MONOMAC; NFE1B"
                     /note="major polyA site"
ORIGIN      
        1 gagagagagg cagcgtgagc gccaggaagg tagcgaggcc agcgtcgccc cgggactcgc
       61 tgctcaagtc tgtctattgc ctgccgccac atccatccta gcagggcccc gtcgcccacc
      121 aggcggacaa aagcggtccg ctgaacacca tgcggccgct cggcgtgccg cccaggctct
      181 gctggtgagc gccgccaccc cgcgcccagg tcccgcgagc ccgcctgccg cgcacctcgc
      241 cctgctccca gctctactcc aggccccgtc cgcccggggg cgccgcccac cgcgcctcgc
      301 tcgggccgtt gccgtctgca cccagaccct gagccgccgc cgccggccat ggaggtggcg
      361 cccgagcagc cgcgctggat ggcgcacccg gccgtgctga atgcgcagca ccccgactca
      421 caccacccgg gcctggcgca caactacatg gaacccgcgc agctgctgcc tccagacgag
      481 gtggacgtct tcttcaatca cctcgactcg cagggcaacc cctactatgc caaccccgct
      541 cacgcgcggg cgcgcgtctc ctacagcccc gcgcacgccc gcctgaccgg aggccagatg
      601 tgccgcccac acttgttgca cagcccgggt ttgccctggc tggacggggg caaagcagcc
      661 ctctctgccg ctgcggccca ccaccacaac ccctggaccg tgagcccctt ctccaagacg
      721 ccactgcacc cctcagctgc tggaggccct ggaggcccac tctctgtgta cccaggggct
      781 gggggtggga gcgggggagg cagcgggagc tcagtggcct ccctcacccc tacagcagcc
      841 cactctggct cccacctttt cggcttccca cccacgccac ccaaagaagt gtctcctgac
      901 cctagcacca cgggggctgc gtctccagcc tcatcttccg cggggggtag tgcagcccga
      961 ggagaggaca aggacggcgt caagtaccag gtgtcactga cggagagcat gaagatggaa
     1021 agtggcagtc ccctgcgccc aggcctagct actatgggca cccagcctgc tacacaccac
     1081 cccatcccca cctacccctc ctatgtgccg gcggctgccc acgactacag cagcggactc
     1141 ttccaccccg gaggcttcct ggggggaccg gcctccagct tcacccctaa gcagcgcagc
     1201 aaggctcgtt cctgttcaga aggccgggag tgtgtcaact gtggggccac agccacccct
     1261 ctctggcggc gggacggcac cggccactac ctgtgcaatg cctgtggcct ctaccacaag
     1321 atgaatgggc agaaccgacc actcatcaag cccaagcgaa gactgtcggc cgccagaaga
     1381 gccggcacct gttgtgcaaa ttgtcagacg acaaccacca ccttatggcg ccgaaacgcc
     1441 aacggggacc ctgtctgcaa cgcctgtggc ctctactaca agctgcacaa tgttaacagg
     1501 ccactgacca tgaagaagga agggatccag actcggaacc ggaagatgtc caacaagtcc
     1561 aagaagagca agaaaggggc ggagtgcttc gaggagctgt caaagtgcat gcaggagaag
     1621 tcatccccct tcagtgcagc tgccctggct ggacacatgg cacctgtggg ccacctcccg
     1681 cccttcagcc actccggaca catcctgccc actccgacgc ccatccaccc ctcctccagc
     1741 ctctccttcg gccaccccca cccgtccagc atggtgaccg ccatgggcta gggaacagat
     1801 ggacgtcgag gaccgggcac tcccgggatg ggtggaccaa acccttagca gcccagcatt
     1861 tcccgaaggc cgacaccact cctgccagcc cggctcggcc cagcaccccc tctcctggag
     1921 ggcgcccagc agcctgccag cagttactgt gaatgttccc caccgctgag aggctgcctc
     1981 cgcacctgac cgctgcccag gtggggtttc ctgcatggac agttgtttgg agaacaacaa
     2041 ggacaacttt atgtagagaa aaggagggga cgggacagac gaaggcaacc atttttagaa
     2101 ggaaaaagga ttaggcaaaa ataatttatt ttgctcttgt ttctaacaag gacttggaga
     2161 cttggtggtc tgagctgtcc caagtcctcc ggttcttcct cgggattggc gggtccactt
     2221 gccagggctc tgggggcaga tttgtgggga cctcagcctg caccctcttc tcctctggct
     2281 tccctctctg aaatagccga actccaggct gggctgagcc aaagccagag tggccacggc
     2341 ccagggaggg tgagctggtg cctgctttga cgggccaggc cctggagggc agagacaatc
     2401 acgggcggtc ctgcacagat tcccaggcca gggctgggtc acaggaagga aacaacattt
     2461 tcttgaaagg ggaaacgtct cccagatcgc tcccttggct ttgaggccga agctgctgtg
     2521 actgtgtccc cttactgagc gcaagccaca gcctgtcttg tcaggtggac cctgtaaata
     2581 catccttttt ctgctaaccc ttcaaccccc tcgcctccta ctctgagaca aaagaaaaaa
     2641 tattaaaaaa atgcataggc ttaactcgct gatgagttaa ttgttttatt tttaaactct
     2701 ttttgggtcc agttgattgt acgtagccac aggagccctg ctatgaaagg aataaaacct
     2761 acacacaagg ttggagcttt gcaattcttt ttggaaaaga gctgggatcc cacagcccta
     2821 gtatgaaagc tgggggtggg gaggggcctt tgctgccctt ggtttctggg ggctggttgg
     2881 catttgctgg cctggcaggg ggtgaaggca ggagttgggg gcaggtcagg accaggaccc
     2941 agggagaggc tgtgtccctg ctggggtctc aggtccagct ttactgtggc tgtctggatc
     3001 cttcccaagg tacagctgta tataaacgtg tcccgagctt agattctgta tgcggtgacg
     3061 gcggggtgtg gtggcctgtg aggggcccct ggcccaggag gaggattgtg ctgatgtagt
     3121 gaccaagtgc aatatgggcg ggcagtcgct gcagggagca ccacggccag aagtaactta
     3181 ttttgtacta gtgtccgcat aagaaaaaga atcggcagta ttttctgttt ttatgtttta
     3241 tttggcttgt tttattttgg attagtgaac taagttattg ttaattatgt acaacattta
     3301 tatattgtct gtaaaaaatg tatgctatcc tcttattcct ttaaagtgag tactgttaag
     3361 aataataaaa tactttttgt gaa
//
