LOCUS       NM_000805                465 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens gastrin (GAST), mRNA.
ACCESSION   NM_000805
VERSION     NM_000805.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Varga,A.J., Nemeth,I.B., Kemeny,L., Varga,J., Tiszlavicz,L.,
            Kumar,D., Dodd,S., Simpson,A.W.M., Buknicz,T., Beynon,R.,
            Simpson,D., Krenacs,T., Dockray,G.J. and Varro,A.
  TITLE     Elevated Serum Gastrin Is Associated with Melanoma Progression:
            Putative Role in Increased Migration and Invasion of Melanoma Cells
  JOURNAL   Int J Mol Sci 24 (23), 16851 (2023)
   PUBMED   38069171
  REMARK    GeneRIF: Elevated Serum Gastrin Is Associated with Melanoma
            Progression: Putative Role in Increased Migration and Invasion of
            Melanoma Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Iwanaga,T.
  TITLE     Anatomical basis of gastrin- and CCK-secreting cells and their
            functions. A review
  JOURNAL   Biomed Res 44 (3), 81-95 (2023)
   PUBMED   37258205
  REMARK    GeneRIF: Anatomical basis of gastrin- and CCK-secreting cells and
            their functions. A review.
            Review article
REFERENCE   3  (bases 1 to 465)
  AUTHORS   Hua,C. and Yu,D.
  TITLE     Correlation Study between Levels of Gastrin, Serum IGF-1, and GHBP
            and Growth and Development in Children with Short Stature Based on
            Big Data Analysis
  JOURNAL   Dis Markers 2022, 4614099 (2022)
   PUBMED   36061351
  REMARK    GeneRIF: Correlation Study between Levels of Gastrin, Serum IGF-1,
            and GHBP and Growth and Development in Children with Short Stature
            Based on Big Data Analysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 465)
  AUTHORS   Asfuroglu Kalkan,E., Kalkan,C., Gumussoy,M., Gucbey,O. and
            Soykan,I.
  TITLE     Prevalence and predictors of colonoscopic findings in patients with
            autoimmune gastritis
  JOURNAL   J Investig Med 70 (1), 73-78 (2022)
   PUBMED   34341100
  REMARK    GeneRIF: Prevalence and predictors of colonoscopic findings in
            patients with autoimmune gastritis.
REFERENCE   5  (bases 1 to 465)
  AUTHORS   Galvin,S.G., Larraufie,P., Kay,R.G., Pitt,H., Bernard,E.,
            McGavigan,A.K., Brant,H., Hood,J., Sheldrake,L., Conder,S.,
            Atherton-Kemp,D., Lu,V.B., O'Flaherty,E.A.A., Roberts,G.P.,
            Ammala,C., Jermutus,L., Baker,D., Gribble,F.M. and Reimann,F.
  TITLE     Peptidomics of enteroendocrine cells and characterisation of
            potential effects of a novel preprogastrin derived-peptide on
            glucose tolerance in lean mice
  JOURNAL   Peptides 140, 170532 (2021)
   PUBMED   33744371
  REMARK    GeneRIF: Peptidomics of enteroendocrine cells and characterisation
            of potential effects of a novel preprogastrin derived-peptide on
            glucose tolerance in lean mice.
REFERENCE   6  (bases 1 to 465)
  AUTHORS   Pauwels,S., Najdovski,T., Dimaline,R., Lee,C.M. and
            Deschodt-Lanckman,M.
  TITLE     Degradation of human gastrin and CCK by endopeptidase 24.11:
            differential behaviour of the sulphated and unsulphated peptides
  JOURNAL   Biochim Biophys Acta 996 (1-2), 82-88 (1989)
   PUBMED   2736261
REFERENCE   7  (bases 1 to 465)
  AUTHORS   Higashimoto,Y., Himeno,S., Shinomura,Y., Nagao,K., Tamura,T. and
            Tarui,S.
  TITLE     Purification and structural determination of urinary NH2-terminal
            big gastrin fragments
  JOURNAL   Biochem Biophys Res Commun 160 (3), 1364-1370 (1989)
   PUBMED   2730647
REFERENCE   8  (bases 1 to 465)
  AUTHORS   Lund,T., Geurts van Kessel,A.H., Haun,S. and Dixon,J.E.
  TITLE     The genes for human gastrin and cholecystokinin are located on
            different chromosomes
  JOURNAL   Hum Genet 73 (1), 77-80 (1986)
   PUBMED   3011648
REFERENCE   9  (bases 1 to 465)
  AUTHORS   Polosatov,M.V., Klimov,P.K., Masevich,C.G., Samartsev,M.A. and
            Wunsch,E.
  TITLE     Interaction of synthetic human big gastrin with blood proteins of
            man and animals
  JOURNAL   Acta Hepatogastroenterol (Stuttg) 26 (2), 154-159 (1979)
   PUBMED   463490
REFERENCE   10 (bases 1 to 465)
  AUTHORS   Fritsch,W.P., Hausamen,T.U. and Scholten,T.
  TITLE     [Gastrointestinal hormones. I. Hormones of the gastrin group]
  JOURNAL   Z Gastroenterol 15 (4), 264-276 (1977)
   PUBMED   871064
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC130686.15 and AC109319.17.
            
            On Nov 22, 2018 this sequence version replaced NM_000805.4.
            
            Summary: Gastrin is a hormone whose main function is to stimulate
            secretion of hydrochloric acid by the gastric mucosa, which results
            in gastrin formation inhibition. This hormone also acts as a
            mitogenic factor for gastrointestinal epithelial cells. Gastrin has
            two biologically active peptide forms, G34 and G17. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM768289.1, BM768748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329402.4/ ENSP00000331358.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC130686.15        972-1028            c
            58-273              AC109319.17        10396-10611
            274-465             AC109319.17        10742-10933
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..465
                     /gene="GAST"
                     /gene_synonym="GAS"
                     /note="gastrin"
                     /db_xref="GeneID:2520"
                     /db_xref="HGNC:HGNC:4164"
                     /db_xref="MIM:137250"
     exon            1..57
                     /gene="GAST"
                     /gene_synonym="GAS"
                     /inference="alignment:Splign:2.1.0"
     exon            58..273
                     /gene="GAST"
                     /gene_synonym="GAS"
                     /inference="alignment:Splign:2.1.0"
     exon            274..465
                     /gene="GAST"
                     /gene_synonym="GAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      445..450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAST"
                     /gene_synonym="GAS"
                     /note="hexamer: AATAAA"
     polyA_site      465
                     /gene="GAST"
                     /gene_synonym="GAS"
                     /note="major polyA site"
ORIGIN      
        1 agagacctga gaggcaccag gcccagccgt ggcaccacac acctcccagc tctgcagacg
       61 agatgcagcg actgtgtgtg tatgtgctga tctttgcact ggctctggcc gccttctctg
      121 aagcttcttg gaagccccgc tcccagcagc cagatgcacc cttaggtaca ggggccaaca
      181 gggacctgga gctaccctgg ctggagcagc agggcccagc ctctcatcat cgaaggcagc
      241 tgggacccca gggtccccca cacctcgtgg cagacccgtc caagaagcag ggaccatggc
      301 tggaggaaga agaagaagcc tatggatgga tggacttcgg ccgccgcagt gctgaggatg
      361 agaactaaca atcctagaac caagcttcag agcctagcca cctcccaccc cactccagcc
      421 ctgtcccctg aaaaactgat caaaaataaa ctagtttcca gtgga
//
