LOCUS       NM_001128424            4875 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens golgi associated kinase 1B (GASK1B), transcript
            variant 3, mRNA.
ACCESSION   NM_001128424
VERSION     NM_001128424.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4875)
  AUTHORS   Hsu,C.Y., Chang,G.C., Chen,Y.J., Hsu,Y.C., Hsiao,Y.J., Su,K.Y.,
            Chen,H.Y., Lin,C.Y., Chen,J.S., Chen,Y.J., Hong,Q.S., Ku,W.H.,
            Wu,C.Y., Ho,B.C., Chiang,C.C., Yang,P.C. and Yu,S.L.
  TITLE     FAM198B Is Associated with Prolonged Survival and Inhibits
            Metastasis in Lung Adenocarcinoma via Blockage of ERK-Mediated
            MMP-1 Expression
  JOURNAL   Clin Cancer Res 24 (4), 916-926 (2018)
   PUBMED   29217529
  REMARK    GeneRIF: Data show that matrix metalloproteinase 1 (MMP-1) as a
            critical downstream target of golgi associated kinase 1B (FAM198B)
            and implicate FAM198B as a potential tumor suppressor and to be a
            prognostic marker in lung adenocarcinoma.
REFERENCE   2  (bases 1 to 4875)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   3  (bases 1 to 4875)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC043193.2, DA887770.1, AY358785.1, BC017701.1 and AC098679.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001128424.1.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1. Variants 2
            and 3 both encode isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.22728.1,
                                           SRR11853559.25332.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000585682.6/ ENSP00000465976.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               BC043193.2         26-301
            277-624             DA887770.1         154-501
            625-1443            AY358785.1         612-1430
            1444-4113           BC017701.1         417-3086
            4114-4114           AC098679.3         27186-27186         c
            4115-4753           BC017701.1         3088-3726
            4754-4754           AC098679.3         26546-26546         c
            4755-4769           BC017701.1         3728-3742
            4770-4875           AC098679.3         26425-26530         c
FEATURES             Location/Qualifiers
     source          1..4875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.1"
     gene            1..4875
                     /gene="GASK1B"
                     /gene_synonym="AD021; AD036; C4orf18; ENED; FAM198B"
                     /note="golgi associated kinase 1B"
                     /db_xref="GeneID:51313"
                     /db_xref="HGNC:HGNC:25312"
     exon            1..158
                     /gene="GASK1B"
                     /gene_synonym="AD021; AD036; C4orf18; ENED; FAM198B"
                     /inference="alignment:Splign:2.1.0"
     exon            159..1292
                     /gene="GASK1B"
                     /gene_synonym="AD021; AD036; C4orf18; ENED; FAM198B"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..1942
                     /gene="GASK1B"
                     /gene_synonym="AD021; AD036; C4orf18; ENED; FAM198B"
                     /note="isoform 2 is encoded by transcript variant 3;
                     expressed in nerve and epithelium during development;
                     protein FAM198B; family with sequence similarity 198
                     member B"
                     /codon_start=1
                     /product="Golgi-associated kinase 1B isoform 2"
                     /protein_id="NP_001121896.1"
                     /db_xref="CCDS:CCDS3798.1"
                     /db_xref="GeneID:51313"
                     /db_xref="HGNC:HGNC:25312"
                     /translation="MTCPDKPGQLINWFICSLCVPRVRKLWSSRRPRTRRNLLLGTAC
                     AIYLGFLVSQVGRASLQHGQAAEKGPHRSRDTAEPSFPEIPLDGTLAPPESQGNGSTL
                     QPNVVYITLRSKRSKPANIRGTVKPKRRKKHAVASAAPGQEALVGPSLQPQEAAREAD
                     AVAPGYAQGANLVKIGERPWRLVRGPGVRAGGPDFLQPSSRESNIRIYSESAPSWLSK
                     DDIRRMRLLADSAVAGLRPVSSRSGARLLVLEGGAPGAVLRCGPSPCGLLKQPLDMSE
                     VFAFHLDRILGLNRTLPSVSRKAEFIQDGRPCPIILWDASLSSASNDTHSSVKLTWGT
                     YQQLLKQKCWQNGRVPKPESGCTEIHHHEWSKMALFDFLLQIYNRLDTNCCGFRPRKE
                     DACVQNGLRPKCDDQGSAALAHIIQRKHDPRHLVFIDNKGFFDRSEDNLNFKLLEGIK
                     EFPASAVSVLKSQHLRQKLLQSLFLDKVYWESQGGRQGIEKLIDVIEHRAKILITYIN
                     AHGVKVLPMNE"
     exon            1293..1507
                     /gene="GASK1B"
                     /gene_synonym="AD021; AD036; C4orf18; ENED; FAM198B"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1734
                     /gene="GASK1B"
                     /gene_synonym="AD021; AD036; C4orf18; ENED; FAM198B"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..4875
                     /gene="GASK1B"
                     /gene_synonym="AD021; AD036; C4orf18; ENED; FAM198B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4475..4480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GASK1B"
                     /gene_synonym="AD021; AD036; C4orf18; ENED; FAM198B"
                     /note="hexamer: AATAAA"
     polyA_site      4495
                     /gene="GASK1B"
                     /gene_synonym="AD021; AD036; C4orf18; ENED; FAM198B"
     regulatory      4714..4719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GASK1B"
                     /gene_synonym="AD021; AD036; C4orf18; ENED; FAM198B"
                     /note="hexamer: AATATA"
     regulatory      4739..4744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GASK1B"
                     /gene_synonym="AD021; AD036; C4orf18; ENED; FAM198B"
                     /note="hexamer: AATAAA"
     polyA_site      4740
                     /gene="GASK1B"
                     /gene_synonym="AD021; AD036; C4orf18; ENED; FAM198B"
                     /note="major polyA site"
     polyA_site      4769
                     /gene="GASK1B"
                     /gene_synonym="AD021; AD036; C4orf18; ENED; FAM198B"
ORIGIN      
        1 acactataaa tgtctttcct tatctgtgtg tactcttatc tcactgttct attttttctc
       61 ctcatttata ttaactcttt cttacctttt tttctgaact tctaggcctt ctctttccag
      121 aactggtgga agacaaatga aacggccaag atggtaagaa acaagccgca tttctccttg
      181 gggagactga taatttaaaa ggtttgttgt gtcagaaaca ttcccagctt catcaccaac
      241 cctttccttc cacctctgcc cactggagac cacttatatc ccgaagcgga cgcggcagct
      301 gaagtcagga aaccatgcat cacattagca ggagccaact gcagacttta aactccgttc
      361 aacatgtgga tgcggcagag aaatgacctg tccagacaag ccggggcagc tcataaactg
      421 gttcatctgc tccctgtgcg tcccgcgggt gcgtaagctc tggagcagcc ggcgtccaag
      481 gacccggaga aaccttctgc tgggcactgc gtgtgccatc tacttgggct tcctggtgag
      541 ccaggtgggg agggcctctc tccagcatgg acaggcggct gagaaggggc cacatcgcag
      601 ccgcgacacc gccgagccat ccttccctga gatacccctg gatggtaccc tggcccctcc
      661 agagtcccag ggcaatgggt ccactctgca gcccaatgtg gtgtacatta ccctacgctc
      721 caagcgcagc aagccggcca atatccgtgg caccgtgaag cccaagcgca ggaaaaagca
      781 tgcagtggca tcggctgccc cagggcagga ggctttggtc ggaccatccc ttcagccgca
      841 ggaagcggca agggaagctg atgctgtagc acctgggtac gctcagggag caaacctggt
      901 taagattgga gagcgaccct ggaggttggt gcggggtccg ggagtgcgag ccgggggccc
      961 agacttcctg cagcccagct ccagggagag caacattagg atctacagcg agagcgcccc
     1021 ctcctggctg agcaaagatg acatccgaag aatgcgactc ttggcggaca gcgcagtggc
     1081 agggctccgg cctgtgtcct ctaggagcgg agcccgtttg ctggtgctgg aggggggcgc
     1141 acctggcgct gtgctccgct gtggccctag cccctgtggg cttctcaagc agcccttgga
     1201 catgagtgag gtgtttgcct tccacctaga caggatcctg gggctcaaca ggaccctgcc
     1261 gtctgtgagc aggaaagcag agttcatcca agatggccgc ccatgcccca tcattctttg
     1321 ggatgcatct ttatcttcag caagtaatga cacccattct tctgttaagc tcacctgggg
     1381 aacttatcag cagttgctga aacagaaatg ctggcagaat ggccgagtac ccaagcctga
     1441 atcgggttgt actgaaatac atcatcatga gtggtccaag atggcactct ttgatttttt
     1501 gttacagatt tataatcgct tagatacaaa ttgctgtgga ttcagacctc gcaaggaaga
     1561 tgcctgtgta cagaatggat tgaggccaaa atgtgatgac caaggttctg cggctctagc
     1621 acacattatc cagcgaaagc atgacccaag gcatttggtt tttatagaca acaagggttt
     1681 ctttgacagg agtgaagata acttaaactt caaattgtta gaaggcatca aagagtttcc
     1741 agcttctgca gtttctgttt tgaagagcca gcacttacgg cagaaacttc ttcagtctct
     1801 gtttcttgat aaagtgtatt gggaaagtca aggaggtaga caaggaattg aaaagcttat
     1861 cgatgtaata gaacacagag ccaaaattct tatcacctat atcaatgcac acggggtcaa
     1921 agtattacct atgaatgaat gacaaaagaa tcttctggct agggtgttag atatatttat
     1981 gcatttttgg ttttgttttt aaatcaagca catcaacctc aagcccgttt agcaatgagg
     2041 cagtgtagat gaatacgtaa aataaatgac tttaaccaag tagctataat gggacttagc
     2101 actgtatgca tacttaaaaa ggttttgaaa aacaaactac ttgagaaata tttgtttata
     2161 tttttctcta acatcatgct atgtgtcagt ctgaacatct gacaacagaa atttcagtta
     2221 ttattctagc taagttttga aaacatttgt catgctgttt aatagaaaac tgcaaaccag
     2281 agacactgac tccattaata aaccatattt tgtgccgttt tgactgttct gaccaaatac
     2341 taatgggaac aattcttgac gtttttctgt tgctgattgt taacatagag cagtctctac
     2401 actaccctga ggcaactcta cattggaaca ctgaggctta cagcctgcaa gagcatcaga
     2461 gctgaccata catttaaaca gaaatgctgg tttatttgca aaatcaccag tatattttct
     2521 attgtgtcta taaaaaatca gtcatttaag tacaagaatc atattttcca ttccttttta
     2581 gaaatttatt ttgttgtccc tatggaaatc attcacatct gacaatttat atgttaaaga
     2641 gttttactct ctctattttg gtccaatttg tatctagtgg ctgagaaatt aaataattct
     2701 aaagtatgaa gttacctatc tgaaaatgta cttacagagt atcattttaa aatggatgtc
     2761 tctttaaaaa ttttgttact tttaccaaca atgtaatata atttatgtat attttattaa
     2821 taatagtgaa ttccttaaaa tttgttctat gtacttatat ttaatttgat ttaatggtta
     2881 ctgcccagat attgagaatt ggttcaaata ttgagtgtgt ttcaatatat tatctggctt
     2941 atttcaacat gagtaatatg agcaaaataa gttaaaacct gcgtctgatc aattttcctc
     3001 atgactagaa ctaaaacagt aaatttggac aatattaagc ctcaaataat catctccaaa
     3061 ctccttctaa cactttttaa atcagattgg aagacatgga caaatcaggt tcatgtgttg
     3121 catctttatg tcctttgcca atatccaaga tcatcacata tggtagatat tcacatggag
     3181 tttcaaattc agaatagatt accattacct tcctgccctt acacatccta ctccttattt
     3241 aaaagttcta tttgtgactt ttcatttcct gaaagtttaa aaatacaatt tgagaatgtt
     3301 tataatacat tctctcctgt cttttcacgg ttacgtctgt tattgctgaa atacaccaca
     3361 ttttctttgt tctggtcaag gttaactcaa tatctgtgtg aaagagaact actaacaacg
     3421 ttacaataga ggctagattt gaaaaaaaaa atctatagat ctaattgata caattgtaga
     3481 acaaaatgtc aaaataatgt tttaagtata agagaagatg gaccaaggag agagagatca
     3541 tttgaaaatc taattgtagc ttttctaggc tcacattcat gtactacttt tagcaccctt
     3601 atgggctgtg ctcgccccct ggacagttga gctttggatt atcttcctct tcaattttcc
     3661 ctctattgac ccgagtgtct ccctctgctt ctacagattt atagtactcc ttggctcttt
     3721 tgagtctcca cttttactca ctgtctctgg gatttttaag atccttttct tctcttataa
     3781 atcatcctct taatgaaaat tagcctaaca aaagtttgga gactggaatc ctactttgag
     3841 ccactgactt gaaataactc ttttggcaag ttgcctgaca tcctgtctta ccaaggtggc
     3901 atatttgcat ttttactgct taaaacattt tttttttttt accatcttta tccaaattta
     3961 tcatattgat ggtaggacta acaggctttt tagaagctgg ctttaacttt gagtctcaag
     4021 ctacaatgct gttgggcagc ctggtcttcc cacgtgaggg tttaactttg tttatttgcc
     4081 tccagttatt ccaaaatgct tattaaatga aagtcccagg aacatgttta ttttagtcac
     4141 ctttgctttt taacaatttt gttttgtaat caatgagtaa ttcatgatga attatttttg
     4201 actaatggat agccgaaggc caggctttta attctaatag gtaatgttct tcttttgtct
     4261 tattgaaaca atgagaatac tctgtgcatt tcaaatgcac tccgattatg ctgtggtttt
     4321 attcacataa gcacaatatg tgttttattt ataacttcat aacaaactta taatataata
     4381 atttacctta gcagacatgc aaaagcttat tcttgtgtga cttactttct ttaagctaat
     4441 aatataaaaa taaatatgta tcttaaaaat ctataataaa acattagaaa ttaaagatat
     4501 gtgcttttta ttttgcagat gagttcattt gcttttgtag atgtgttttc agagctaggt
     4561 acagaggaat gtttgctacc tttagcggtg aaaaaagaaa gagagtcaag aattttgttg
     4621 gattgtgttt gtgtgtgcat atatttgata tcatcattat atttgtaatc tttggacttg
     4681 taatcatagc ctgtttattc tactgtgcca ttaaatatac tttaccttat acataacgaa
     4741 taaaatacct agaagtagat ttatttacac actgtcttat gaaattctta tgtttatgtc
     4801 agcacagaac aagcacacat ttagagcatt catctgaaaa ttatatggaa attgaacatg
     4861 ggtcaaataa agatg
//
