LOCUS       NM_001129908            3389 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens golgi associated kinase 1A (GASK1A), mRNA.
ACCESSION   NM_001129908 XM_001133294 XM_001724952 XM_001725043
VERSION     NM_001129908.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3389)
  AUTHORS   Liu,J., Zhang,Z., Xu,J., Song,X., Yuan,W., Miao,M., Liang,H. and
            Du,J.
  TITLE     Genome-wide DNA methylation changes in placenta tissues associated
            with small for gestational age newborns; cohort study in the
            Chinese population
  JOURNAL   Epigenomics 11 (12), 1399-1412 (2019)
   PUBMED   31596135
  REMARK    GeneRIF: Results find that in the male newborns whose mother had
            preconception folic acid (FA) supplementation, five sites within
            FAM198A had a reduced methylation than appropriate for gestational
            age controls.
REFERENCE   2  (bases 1 to 3389)
  AUTHORS   Goldstein,J.I., Jarskog,L.F., Hilliard,C., Alfirevic,A., Duncan,L.,
            Fourches,D., Huang,H., Lek,M., Neale,B.M., Ripke,S., Shianna,K.,
            Szatkiewicz,J.P., Tropsha,A., van den Oord,E.J., Cascorbi,I.,
            Dettling,M., Gazit,E., Goff,D.C., Holden,A.L., Kelly,D.L.,
            Malhotra,A.K., Nielsen,J., Pirmohamed,M., Rujescu,D., Werge,T.,
            Levy,D.L., Josiassen,R.C., Kennedy,J.L., Lieberman,J.A., Daly,M.J.
            and Sullivan,P.F.
  TITLE     Clozapine-induced agranulocytosis is associated with rare HLA-DQB1
            and HLA-B alleles
  JOURNAL   Nat Commun 5, 4757 (2014)
   PUBMED   25187353
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3389)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 3389)
  AUTHORS   Bechtel,S., Rosenfelder,H., Duda,A., Schmidt,C.P., Ernst,U.,
            Wellenreuther,R., Mehrle,A., Schuster,C., Bahr,A., Blocker,H.,
            Heubner,D., Hoerlein,A., Michel,G., Wedler,H., Kohrer,K.,
            Ottenwalder,B., Poustka,A., Wiemann,S. and Schupp,I.
  TITLE     The full-ORF clone resource of the German cDNA Consortium
  JOURNAL   BMC Genomics 8, 399 (2007)
   PUBMED   17974005
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA262563.1, AC092042.2, AL117530.1 and BQ006782.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001129908.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.108702.1,
                                           SRR3476690.827890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000430121.3/ ENSP00000407301.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-528               DA262563.1         45-572
            529-1448            AC092042.2         71409-72328
            1449-1946           AL117530.1         736-1233
            1947-3358           AC092042.2         95222-96633
            3359-3389           BQ006782.1         17-47               c
FEATURES             Location/Qualifiers
     source          1..3389
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..3389
                     /gene="GASK1A"
                     /gene_synonym="C3orf41; FAM198A"
                     /note="golgi associated kinase 1A"
                     /db_xref="GeneID:729085"
                     /db_xref="HGNC:HGNC:24485"
                     /db_xref="MIM:620413"
     exon            1..335
                     /gene="GASK1A"
                     /gene_synonym="C3orf41; FAM198A"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..2060
                     /gene="GASK1A"
                     /gene_synonym="C3orf41; FAM198A"
                     /note="protein FAM198A; family with sequence similarity
                     198 member A"
                     /codon_start=1
                     /product="Golgi-associated kinase 1A precursor"
                     /protein_id="NP_001123380.2"
                     /db_xref="CCDS:CCDS46808.1"
                     /db_xref="GeneID:729085"
                     /db_xref="HGNC:HGNC:24485"
                     /db_xref="MIM:620413"
                     /translation="MASWLRRKLRGKRRPVIAFCLLMILSAMAVTRFPPQRPSAGPDP
                     GPMEPQGVTGAPATHIRQALSSSRRQRARNMGFWRSRALPRNSILVCAEEQGHRARVD
                     RSRESPGGDLRHPGRVRRDITLSGHPRLSTQHVVLLREDEVGDPGTKDLGHPQHGSPI
                     QETQSEVVTLVSPLPGSDMAALPAWRATSGLTLWPHTAEGRDLLGAENRALTGGQQAE
                     DPTLASGAHQWPGSVEKLQGSVWCDAETLLSSSRTGGQAPPWLTDHDVQMLRLLAQGE
                     VVDKARVPAHGQVLQVGFSTEAALQDLSSPRLSQLCSQGLCGLIKRPGDLPEVLSFHV
                     DRVLGLRRSLPAVARRFHSPLLPYRYTDGGARPVIWWAPDVQHLSDPDEDQNSLALGW
                     LQYQALLAHSCNWPGQAPCPGIHHTEWARLALFDFLLQVHDRLDRYCCGFEPEPSDPC
                     VEERLREKCQNPAELRLVHILVRSSDPSHLVYIDNAGNLQHPEDKLNFRLLEGIDGFP
                     ESAVKVLASGCLQNMLLKSLQMDPVFWESQGGAQGLKQVLQTLEQRGQVLLGHIQKHN
                     LTLFRDEDP"
     exon            336..1622
                     /gene="GASK1A"
                     /gene_synonym="C3orf41; FAM198A"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1745
                     /gene="GASK1A"
                     /gene_synonym="C3orf41; FAM198A"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1849
                     /gene="GASK1A"
                     /gene_synonym="C3orf41; FAM198A"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..3389
                     /gene="GASK1A"
                     /gene_synonym="C3orf41; FAM198A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2438..2443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GASK1A"
                     /gene_synonym="C3orf41; FAM198A"
                     /note="hexamer: AATAAA"
     polyA_site      2466
                     /gene="GASK1A"
                     /gene_synonym="C3orf41; FAM198A"
                     /note="major polyA site"
     regulatory      3364..3369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GASK1A"
                     /gene_synonym="C3orf41; FAM198A"
                     /note="hexamer: TATAAA"
     polyA_site      3389
                     /gene="GASK1A"
                     /gene_synonym="C3orf41; FAM198A"
                     /note="major polyA site"
ORIGIN      
        1 actttgcaaa ctctgcaaaa gtcccgagta gaccgcagag gctcgcggcc gcgggtaggc
       61 tccctcagat ccccgtagat ctcagtagat ccggcgtgta ttccccaccc gcggagtatc
      121 ccggtgtgca gcgatctccc gagagttggc gcagggccac ttggctgcag agaacgtgtg
      181 caccttcagt ccgggaaacc cgccccagcc gagtagccgc gcatcctggg aagcctggcg
      241 agccacggcg ccgggggcgg ccaaggggag gcgggatgag tctgcgagcc ggctgagcgc
      301 gccgaggagc cggccggggc accgccgggg acatggcgtc ttggctccgg agaaagctgc
      361 gtggcaagag gcggccagtg atagcgttct gcctcttgat gatcctatct gcgatggctg
      421 tcacccgctt tcccccacag cgtccatccg ccggcccaga ccctggtccc atggagcctc
      481 agggggtaac tggcgcccct gcaacccata tccggcaggc tttgagctcc agccggaggc
      541 agcgggcaag aaacatgggc ttctggagaa gccgtgcttt gcccaggaac tccatcttgg
      601 tctgtgctga ggagcaaggc catagagcaa gagtggacag aagcagggag tccccaggag
      661 gggacctcag gcatccaggg agggtgagga gggacattac tttgtcagga catccaagac
      721 tcagtactca gcatgttgtg ctcctgaggg aggatgaggt tggagatcca ggaaccaaag
      781 acctgggcca cccccagcat ggcagtccca tccaggagac acagagtgag gtggtcaccc
      841 tggtcagtcc actcccaggg agtgacatgg cagctttacc ggcttggaga gctacttctg
      901 ggctgacact ctggccccat acagcagaag gcagggatct gctgggagct gagaacagag
      961 ccttgactgg tgggcaacaa gcagaggatc ccaccttggc ctcaggagct catcagtggc
     1021 ctggctctgt tgagaagctg caagggtcag tatggtgtga tgctgagacg ctgttgagca
     1081 gctcgaggac tggtgggcag gctcccccat ggctgacaga ccacgatgtg cagatgctcc
     1141 gtctgttggc acagggggag gtggtggaca aagccagggt ccccgcccat gggcaggtgc
     1201 tacaggttgg cttctccact gaggctgccc ttcaggacct gtcctctccc aggctcagcc
     1261 aactctgttc ccaagggctc tgtggcctga tcaagaggcc tggggacctg cctgaggtcc
     1321 tgtccttcca cgtagatcgt gtgctggggc tgcgccggag cctacctgct gtggcccgcc
     1381 gcttccatag ccccctcctg ccctaccgat acacagacgg tggagcaagg cctgtcatct
     1441 ggtgggcacc cgatgtgcag cacctgagcg acccagatga ggatcagaac tctctggcct
     1501 tgggctggct gcagtatcag gccctgctgg cacacagctg caactggcca ggccaggccc
     1561 cgtgcccggg catccaccat accgagtggg cacgcctggc gctcttcgac ttcctgttgc
     1621 aggtccacga ccgcttggat cgctactgct gtggcttcga gcctgagccc tcagacccct
     1681 gtgtggaaga gaggctccga gagaaatgcc agaacccagc cgagctgcgg ctggtccaca
     1741 tcctggtccg gagcagcgat ccatctcacc tggtctacat cgataacgct ggcaaccttc
     1801 agcaccctga ggacaagctg aactttcggc tgctggaggg catagatggg tttcctgagt
     1861 ctgccgtgaa ggttctcgca tcagggtgtc tacagaacat gctgctgaag tcgctgcaga
     1921 tggacccagt gttctgggaa agccaaggcg gagcccaggg gctgaagcag gtcctccaga
     1981 ccctggagca gcgaggacag gtgctgctgg gacacatcca aaagcacaac ctcacactct
     2041 tcagggacga ggacccataa gccgcacaca gccctgagtc aatgagcatc catcctgatg
     2101 gccacatttt cttgggctca ctcatcttga ggacaaatgg gaaaagccag aagccagagg
     2161 ggcacaagga tgtcacggga tatttcacct gcctgggatg gtggaggtag tatggggttt
     2221 tcaatctcaa agcgtccctt tctgccttct cggctctggc tatttattcc cttgcaccaa
     2281 caaatacatt cgaaaatgtt ctgtgagctg ctcaagaaac tgtaaaaatg tgtgatgcac
     2341 gtgcatatgc agagtgggag aactttgtgt gtgtgtagag gtgtgtaggt gtgggtggca
     2401 tgtgtgcccg cctgcatgca atacctgaga ccaacctaat aaaggtacaa tcttcataga
     2461 actgcacttg cagcctggag ttgctctggc tgaaagtaga ctcaggctta agaaatgaaa
     2521 cataatgcgt ttgtctttat agactttaaa ttttcaatta ttactcagtt atgtttttgg
     2581 tttaaaaaat tataaaagtc taaaagtaat acatgctcag taaaaacaag tccataaaaa
     2641 atagaagcat atgacaaaaa gcataagtcc cacaaactcc ctagcggtgt gtatgtgtgt
     2701 gtgtgttatt catggtcaca ctacatgcaa attaaaaaat gaaagtgtgg tcatgctttg
     2761 tcaactcact atatttttac tttattaact atattctgta tcagccatct gaattgaccc
     2821 aatctttatt ggtgactgca tgaaattcca aggcagggat gtgtcatatt ttctttagct
     2881 ggtcccataa tcatgaacat ttaagtagct ccaatttttc atcaattaca gacattgccg
     2941 ccatgaacat gattgcatgg cgtgcaagta tttctgcgag gtagatttcc gtacgggatt
     3001 tctggggcaa agggtatggg cattcagtat tctgagagaa actgccaaat tgctctctga
     3061 aatggtggtg tcaatttaca tttctcccaa gagggtagga gactgattat ttttctacac
     3121 cttcaccaac acttggcatt ctcagacttt tgggtttttt ttggcctatt taggaggaaa
     3181 accgatttta aaagctgcat ttccttaatc atgaatgaag tcatctttcc acttatttgc
     3241 cagacatttg tattttcttt tctgcattgt ctttttgttt taagatgttt gccctttgct
     3301 tgttaatttg ttggaaatct ttgactctaa taagtgtgat caatcttttc tctgctgact
     3361 tggtataaat gttttcttcc agcctctaa
//
