LOCUS       NM_001481               3094 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens growth arrest specific 8 (GAS8), transcript variant 1,
            mRNA.
ACCESSION   NM_001481
VERSION     NM_001481.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3094)
  AUTHORS   Zhang,J., He,X., Wu,H., Zhang,X., Yang,S., Liu,C., Liu,S., Hua,R.,
            Zhou,S., Zhao,S., Hu,F., Zhang,J., Liu,W., Cheng,H., Gao,Y.,
            Zhang,F., Cao,Y. and Liu,M.
  TITLE     Loss of DRC1 function leads to multiple morphological abnormalities
            of the sperm flagella and male infertility in human and mouse
  JOURNAL   Hum Mol Genet 30 (21), 1996-2011 (2021)
   PUBMED   34169321
REFERENCE   2  (bases 1 to 3094)
  AUTHORS   Wu,X., Jiang,T., Huang,R. and Xiao,X.
  TITLE     LncRNA GAS8-AS1 downregulates lncRNA NEAT1 to inhibit glioblastoma
            cell proliferation
  JOURNAL   Brain Behav 11 (6), e02128 (2021)
   PUBMED   33942556
  REMARK    GeneRIF: LncRNA GAS8-AS1 downregulates lncRNA NEAT1 to inhibit
            glioblastoma cell proliferation.
REFERENCE   3  (bases 1 to 3094)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3094)
  AUTHORS   Dashti,S., Taherian-Esfahani,Z., Kholghi-Oskooei,V.,
            Ghafouri-Fard,S. and Taheri,M.
  TITLE     Expression analysis of growth arrest specific 8 and its anti-sense
            in breast cancer tissues
  JOURNAL   Exp Mol Pathol 114, 104414 (2020)
   PUBMED   32165089
  REMARK    GeneRIF: Expression analysis of growth arrest specific 8 and its
            anti-sense in breast cancer tissues.
REFERENCE   5  (bases 1 to 3094)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3094)
  AUTHORS   Ralston,K.S. and Hill,K.L.
  TITLE     Trypanin, a component of the flagellar Dynein regulatory complex,
            is essential in bloodstream form African trypanosomes
  JOURNAL   PLoS Pathog 2 (9), e101 (2006)
   PUBMED   17009870
REFERENCE   7  (bases 1 to 3094)
  AUTHORS   Colantonio,J.R., Bekker,J.M., Kim,S.J., Morrissey,K.M.,
            Crosbie,R.H. and Hill,K.L.
  TITLE     Expanding the role of the dynein regulatory complex to non-axonemal
            functions: association of GAS11 with the Golgi apparatus
  JOURNAL   Traffic 7 (5), 538-548 (2006)
   PUBMED   16643277
REFERENCE   8  (bases 1 to 3094)
  AUTHORS   Yeh,S.D., Chen,Y.J., Chang,A.C., Ray,R., She,B.R., Lee,W.S.,
            Chiang,H.S., Cohen,S.N. and Lin-Chao,S.
  TITLE     Isolation and properties of Gas8, a growth arrest-specific gene
            regulated during male gametogenesis to produce a protein associated
            with the sperm motility apparatus
  JOURNAL   J Biol Chem 277 (8), 6311-6317 (2002)
   PUBMED   11751847
REFERENCE   9  (bases 1 to 3094)
  AUTHORS   Hill,K.L., Hutchings,N.R., Grandgenett,P.M. and Donelson,J.E.
  TITLE     T lymphocyte-triggering factor of african trypanosomes is
            associated with the flagellar fraction of the cytoskeleton and
            represents a new family of proteins that are present in several
            divergent eukaryotes
  JOURNAL   J Biol Chem 275 (50), 39369-39378 (2000)
   PUBMED   10969087
REFERENCE   10 (bases 1 to 3094)
  AUTHORS   Whitmore,S.A., Settasatian,C., Crawford,J., Lower,K.M.,
            McCallum,B., Seshadri,R., Cornelisse,C.J., Moerland,E.W.,
            Cleton-Jansen,A.M., Tipping,A.J., Mathew,C.G., Savnio,M.,
            Savoia,A., Verlander,P., Auerbach,A.D., Van Berkel,C., Pronk,J.C.,
            Doggett,N.A. and Callen,D.F.
  TITLE     Characterization and screening for mutations of the growth
            arrest-specific 11 (GAS11) and C16orf3 genes at 16q24.3 in breast
            cancer
  JOURNAL   Genomics 52 (3), 325-331 (1998)
   PUBMED   9790751
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC104785.1, AF050079.1 and
            BX647947.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001481.2.
            
            Summary: This gene includes 11 exons spanning 25 kb and maps to a
            region of chromosome 16 that is sometimes deleted in breast and
            prostrate cancer. The second intron contains an apparently
            intronless gene, C16orf3, that is transcribed in the opposite
            orientation. This gene is a putative tumor suppressor gene. Several
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Oct 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.260046.1, GQ891399.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268699.9/ ENSP00000268699.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1856              BC104785.1         66-1921
            1857-2675           AF050079.1         1937-2755
            2676-3094           BX647947.1         2743-3161
FEATURES             Location/Qualifiers
     source          1..3094
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..3094
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
                     /note="growth arrest specific 8"
                     /db_xref="GeneID:2622"
                     /db_xref="HGNC:HGNC:4166"
                     /db_xref="MIM:605178"
     exon            1..45
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1479
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
                     /note="isoform a is encoded by transcript variant 1;
                     growth arrest-specific protein 8; GAS-11; growth
                     arrest-specific protein 11; dynein regulatory complex
                     subunit 4; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="dynein regulatory complex subunit 4 isoform a"
                     /protein_id="NP_001472.1"
                     /db_xref="CCDS:CCDS10992.1"
                     /db_xref="GeneID:2622"
                     /db_xref="HGNC:HGNC:4166"
                     /db_xref="MIM:605178"
                     /translation="MAPKKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDR
                     EREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKV
                     KHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVV
                     KNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQ
                     IHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQN
                     KRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQR
                     FTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAAS
                     NLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLRTYEAKLLAFGIPLD
                     NVGFKPLETAVIGQTLGQGPAGLVGTPT"
     exon            46..132
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
                     /inference="alignment:Splign:2.1.0"
     exon            133..330
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
                     /inference="alignment:Splign:2.1.0"
     exon            331..537
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
                     /inference="alignment:Splign:2.1.0"
     exon            538..592
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
                     /inference="alignment:Splign:2.1.0"
     exon            593..798
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
                     /inference="alignment:Splign:2.1.0"
     exon            799..966
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1053
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1263
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1329
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..3094
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1586..1591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
                     /note="hexamer: AATGAA"
     polyA_site      1606
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
                     /note="major polyA site"
     regulatory      3074..3079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
                     /note="hexamer: TATAAA"
     polyA_site      3094
                     /gene="GAS8"
                     /gene_synonym="CILD33; DRC4; GAS11"
ORIGIN      
        1 gccctggtcc cggagtcgcc gctgggcctg tccgctggcg tcatggcacc gaaaaagaaa
       61 gggaagaaag gcaaagccaa aggcaccccg attgtcgatg ggctcgctcc agaggacatg
      121 agcaaggagc aggtggagga gcatgtcagc cgcatccggg aggagctgga ccgcgagcgg
      181 gaggaacgaa actacttcca gctggagcgg gacaagatcc acaccttctg ggagatcaca
      241 cggaggcagc tggaggagaa gaaggctgag ctgcggaaca aagaccggga gatggaagaa
      301 gccgaggaga ggcaccaggt ggagatcaag gtgtacaagc agaaagtgaa gcacctgcta
      361 tatgagcacc agaacaacct gacagagatg aaggctgagg gcactgtagt catgaagctg
      421 gcacagaaag agcaccgcat acaggagagt gtgctgcgca aggacatgcg ggcactgaag
      481 gtggagctca aggagcagga gctggccagt gaggtggtgg tgaagaacct gcggctgaaa
      541 cacaccgagg agatcaccag gatgcggaat gattttgaga ggcaagttcg agaaattgag
      601 gccaagtatg ataagaagat gaagatgctg agggacgaac tcgacttgcg gagaaagact
      661 gagctccacg aagtggagga gaggaagaat ggccagatcc acacgctgat gcagcgccac
      721 gaggaggcct tcaccgacat taagaactac tacaacgaca tcaccctcaa caacctggcc
      781 ctcatcaact ccctcaagga gcagatggag gacatgcgga agaaggagga ccacctggag
      841 agggagatgg cagaggtgtc tgggcagaac aagcgcctgg cagaccctct ccagaaggct
      901 cgggaggaga tgagcgagat gcagaaacag ctcgcaaact acgagaggga caagcagatc
      961 ctgctttgca caaaagcccg tttgaaagtc agggagaaag agctgaaaga cctgcagtgg
     1021 gagcatgaag tgttagagca gcgattcacc aaggtgcagc aggagcggga cgagctctat
     1081 cggaagttca ccgcagccat ccaggaggtg cagcagaaga cagggttcaa gaacctcgtg
     1141 ctagaacgca agctgcaggc tctgagcgcc gctgtggaga agaaggaggt gcagttcaac
     1201 gaggtcctgg ctgcctctaa cctggaccct gcagccctga cgctggtgtc ccgcaagctg
     1261 gaggatgttc ttgagtcgaa gaacagcacc atcaaggacc tgcagtatga gctggcccag
     1321 gtctgtaagg cccataacga cctgctgcgc acgtatgagg caaagctgct ggccttcggg
     1381 atccctctgg acaacgtggg cttcaagccc ttggaaacag ctgtgatcgg acagacactg
     1441 ggccagggcc ccgcgggact ggtgggcacc ccgacgtagc tgcccccctg gggggccaca
     1501 gcccagagaa ccagcctagg aacactcggg atgacacccc ttatcacacc aaggacagca
     1561 agttttttag attttatcat cagcaaatga aagcttttca catgttcttg ccatcctctt
     1621 tcctggctct gtggaggaga accacctgca ggaccctcac ccatggtgtc cctgtcgctc
     1681 ccttccctgg gtgccgcacg tccagcctgt gtccaggcct actccctggt ctcacctccg
     1741 accacagtcg gcggcacctt ctcagagtgc cccgcactca cctgggggtt ggggcagtgc
     1801 cgcgctgtgc tgcctgtctt cgcgccactg ttgtcccacc gaatggacag ctttgcaggt
     1861 gctggcacta acttcattga cacctgagtc acagctgccc agtgggattc tccagggggc
     1921 cgggacttcc ctaggaagtg gtgagccaat gctccctgat gagcacaaag cccgctctgt
     1981 tgagggctgg gtgggtgcag ccagcgtgcg ggaacgggca ggcagcctcc cgctgccagt
     2041 cttcgctcta actccctcgg taggtgatgt aggaccaggg gcacgtggaa cttctgggcc
     2101 ttgctggtga tggttaaaac aacctgagat ggagaggcca ggagagagta taaggggata
     2161 gcagcaaacc acctatctgg ccccaacaca cctgagagaa ttcagcagcc cagactgagg
     2221 gtctgggatg gggtgaacct tccgcaccag agggacactc cacagaagcc acagcccagt
     2281 aagtcaggcg cttctgcggc ggctccagtg tggggtgagg cagtgaggtt aggcccagag
     2341 agctggagtt ggctcagatg aaaacctctg tcaacaaaga ggggatgaat cacccttggc
     2401 ccagcctccc cacaaagcct gaccctgggc aggtgagtga cgggtgtgtc ctcgtagagt
     2461 ctattgctgc ctggacacct ttcttttggg agctcaaagc aagtgagctc acctacctgc
     2521 caccgcccag gaccagtctg cccactgcct aaatgatgcc cggccagcag gacctggcct
     2581 gcagatccca gtgagtcatg agcctcagcc ccctccagcc cactggggct ctcacctcca
     2641 catgtgggta gaagctttcc tgccccctct tcctccagta gccctcagtg tcgaaggtga
     2701 gcttgtaggt gcctgccttc atctggtcca ggacagtgac catctgggtc tgtgtagctg
     2761 gggagaggat gaggctgcag agatggggac cagaagcccc ccaccccagc tttcctgggt
     2821 ctgcatccca gtgggcctca gacactgccc tgccacctgt cagacttggg tgagcagaca
     2881 cagtgaggct gttaggtcct gcagttccag agcagtctag ggacaccact gccctgtctt
     2941 taggaaatca caacacagag aagcaaaaag ggaaaaagtc tcccacaatt tatcccatga
     3001 gcaagaacca ctttatagct ggcatatatt tttccagatt ttctctatgc ataagtatat
     3061 ttgtttaaaa acttataaag tggattatac tatt
//
