LOCUS       NM_000820               2508 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens growth arrest specific 6 (GAS6), mRNA.
ACCESSION   NM_000820 XM_942084 XM_945682 XM_945684 XM_945685
VERSION     NM_000820.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2508)
  AUTHORS   Perez,F., Iribarren,M.L., Olexen,C.M., Ruera,C.N., Errasti,A.E.,
            Guzman,L., Garbi,L., Carrera Silva,E.A. and Chirdo,F.G.
  TITLE     Duodenal mucosa of untreated celiac disease patients has altered
            expression of the GAS6 and PROS1 and the negative regulator
            tyrosine kinase TAM receptors subfamily
  JOURNAL   Clin Immunol 263, 110202 (2024)
   PUBMED   38575045
  REMARK    GeneRIF: Duodenal mucosa of untreated celiac disease patients has
            altered expression of the GAS6 and PROS1 and the negative regulator
            tyrosine kinase TAM receptors subfamily.
REFERENCE   2  (bases 1 to 2508)
  AUTHORS   Baskol,G., Yetkin,M.O., Sevim,D.G., Guclu,K., Arda,H.,
            Saracoglu,H., Gahramanov,K. and Evereklioglu,C.
  TITLE     Serum GAS6, sAXL, IL-10, NO, and BCL-2 levels are decreased in
            patients with Behcet's disease
  JOURNAL   Indian J Ophthalmol 72 (Suppl 3), S468-S472 (2024)
   PUBMED   38648454
  REMARK    GeneRIF: Serum GAS6, sAXL, IL-10, NO, and BCL-2 levels are
            decreased in patients with Behcet's disease.
REFERENCE   3  (bases 1 to 2508)
  AUTHORS   Hayashi,M., Abe,K., Sugaya,T., Takahata,Y., Fujita,M., Takahashi,A.
            and Ohira,H.
  TITLE     Influence of serum Gas6 levels on prognosis in patients with
            hepatocellular carcinoma
  JOURNAL   Jpn J Clin Oncol 54 (1), 62-69 (2024)
   PUBMED   37801445
  REMARK    GeneRIF: Influence of serum Gas6 levels on prognosis in patients
            with hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 2508)
  AUTHORS   Cheng,Y., Yang,X., Wang,Y., Ding,Q., Huang,Y. and Zhang,C.
  TITLE     The role of the Gas6/TAM signal pathway in the LPS-induced
            pulmonary epithelial cells injury
  JOURNAL   Mol Immunol 163, 181-187 (2023)
   PUBMED   37820442
  REMARK    GeneRIF: The role of the Gas6/TAM signal pathway in the LPS-induced
            pulmonary epithelial cells injury.
REFERENCE   5  (bases 1 to 2508)
  AUTHORS   Laurance,S., Lemarie,C.A. and Blostein,M.D.
  TITLE     Growth arrest-specific gene 6 (gas6) and vascular hemostasis
  JOURNAL   Adv Nutr 3 (2), 196-203 (2012)
   PUBMED   22516727
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2508)
  AUTHORS   Saccone,S., Marcandalli,P., Gostissa,M., Schneider,C. and Della
            Valle,G.
  TITLE     Assignment of the human GAS6 gene to chromosome 13q34 by
            fluorescence in situ hybridization
  JOURNAL   Genomics 30 (1), 129-131 (1995)
   PUBMED   8595896
REFERENCE   7  (bases 1 to 2508)
  AUTHORS   Godowski,P.J., Mark,M.R., Chen,J., Sadick,M.D., Raab,H. and
            Hammonds,R.G.
  TITLE     Reevaluation of the roles of protein S and Gas6 as ligands for the
            receptor tyrosine kinase Rse/Tyro 3
  JOURNAL   Cell 82 (3), 355-358 (1995)
   PUBMED   7634325
REFERENCE   8  (bases 1 to 2508)
  AUTHORS   Stitt,T.N., Conn,G., Goret,M., Lai,C., Bruno,J., Radzlejewski,C.,
            Mattsson,K., Fisher,J., Gies,D.R., Jones,P.F., Masiakowski,P.,
            Ryan,T.E., Tobkes,N.J., Chen,D.H., DiStefano,P.S., Long,G.L.,
            Basilico,C., Goldfarb,M.P., Lemke,G., Glass,D.J. and
            Yancopoulos,G.D.
  TITLE     The anticoagulation factor protein S and its relative, Gas6, are
            ligands for the Tyro 3/Axl family of receptor tyrosine kinases
  JOURNAL   Cell 80 (4), 661-670 (1995)
   PUBMED   7867073
REFERENCE   9  (bases 1 to 2508)
  AUTHORS   Varnum,B.C., Young,C., Elliott,G., Garcia,A., Bartley,T.D.,
            Fridell,Y.W., Hunt,R.W., Trail,G., Clogston,C., Toso,R.J. et al.
  TITLE     Axl receptor tyrosine kinase stimulated by the vitamin K-dependent
            protein encoded by growth-arrest-specific gene 6
  JOURNAL   Nature 373 (6515), 623-626 (1995)
   PUBMED   7854420
REFERENCE   10 (bases 1 to 2508)
  AUTHORS   Manfioletti,G., Brancolini,C., Avanzi,G. and Schneider,C.
  TITLE     The protein encoded by a growth arrest-specific gene (gas6) is a
            new member of the vitamin K-dependent proteins related to protein
            S, a negative coregulator in the blood coagulation cascade
  JOURNAL   Mol Cell Biol 13 (8), 4976-4985 (1993)
   PUBMED   8336730
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY038614.1, BC038984.1 and
            AA045119.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000820.3.
            
            Summary: This gene encodes a gamma-carboxyglutamic acid
            (Gla)-containing protein thought to be involved in the stimulation
            of cell proliferation. This gene is frequently overexpressed in
            many cancers and has been implicated as an adverse prognostic
            marker. Elevated protein levels are additionally associated with a
            variety of disease states, including venous thromboembolic disease,
            systemic lupus erythematosus, chronic renal failure, and
            preeclampsia. [provided by RefSeq, Aug 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279841.6559.1, BC030708.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327773.7/ ENSP00000331831.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                HY038614.1         19-43
            26-2499             BC038984.1         1-2474
            2500-2508           AA045119.1         23-31               c
FEATURES             Location/Qualifiers
     source          1..2508
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..2508
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /note="growth arrest specific 6"
                     /db_xref="GeneID:2621"
                     /db_xref="HGNC:HGNC:4168"
                     /db_xref="MIM:600441"
     exon            1..244
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..2193
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /note="AXL stimulatory factor; growth arrest-specific
                     protein 6; AXL receptor tyrosine kinase ligand"
                     /codon_start=1
                     /product="growth arrest-specific protein 6 precursor"
                     /protein_id="NP_000811.1"
                     /db_xref="CCDS:CCDS45072.1"
                     /db_xref="GeneID:2621"
                     /db_xref="HGNC:HGNC:4168"
                     /db_xref="MIM:600441"
                     /translation="MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRP
                     RQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSP
                     YTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNEC
                     SQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGS
                     YSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDT
                     CEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGIL
                     LFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLV
                     IKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNW
                     LNGEDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVE
                     VVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALME
                     IKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAG
                     GLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA"
     exon            245..411
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /inference="alignment:Splign:2.1.0"
     exon            412..436
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /inference="alignment:Splign:2.1.0"
     exon            437..499
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /inference="alignment:Splign:2.1.0"
     exon            500..622
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /inference="alignment:Splign:2.1.0"
     exon            623..745
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /inference="alignment:Splign:2.1.0"
     exon            746..868
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /inference="alignment:Splign:2.1.0"
     exon            869..990
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1109
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1299
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1464
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1633
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1809
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..2038
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2508
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2481..2486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /note="hexamer: AATAAA"
     polyA_site      2508
                     /gene="GAS6"
                     /gene_synonym="AXLLG; AXSF"
                     /note="major polyA site"
ORIGIN      
        1 agaccgagcg cttgaggtgc cgcagccgcc gccgccgccg ccgccgcgat gtgaccttca
       61 gggccgccag gacgggatga ccggagcctc cgccccgcgg cgcccgcggc tcgcctcggc
      121 ctcccgggcg ctctgaccgc gcgtccccgg cccgccatgg ccccttcgct ctcgcccggg
      181 cccgccgccc tgcgccgcgc gccgcagctg ctgctgctgc tgctggccgc ggagtgcgcg
      241 cttgccgcgc tgttgccggc gcgcgaggcc acgcagttcc tgcggcccag gcagcgccgc
      301 gcctttcagg tcttcgagga ggccaagcag ggccacctgg agagggagtg cgtggaggag
      361 ctgtgcagcc gcgaggaggc gcgggaggtg ttcgagaacg accccgagac ggattatttt
      421 tacccaagat acttagactg catcaacaag tatgggtctc cgtacaccaa aaactcaggc
      481 ttcgccacct gcgtgcaaaa cctgcctgac cagtgcacgc ccaacccctg cgataggaag
      541 gggacccaag cctgccagga cctcatgggc aacttcttct gcctgtgtaa agctggctgg
      601 gggggccggc tctgcgacaa agatgtcaac gaatgcagcc aggagaacgg gggctgcctc
      661 cagatctgcc acaacaagcc gggtagcttc cactgttcct gccacagcgg cttcgagctc
      721 tcctctgatg gcaggacctg ccaagacata gacgagtgcg cagactcgga ggcctgcggg
      781 gaggcgcgct gcaagaacct gcccggctcc tactcctgcc tctgtgacga gggctttgcg
      841 tacagctccc aggagaaggc ttgccgagat gtggacgagt gtctgcaggg ccgctgtgag
      901 caggtctgcg tgaactcccc agggagctac acctgccact gtgacgggcg tgggggcctc
      961 aagctgtccc aggacatgga cacctgtgag gacatcttgc cgtgcgtgcc cttcagcgtg
     1021 gccaagagtg tgaagtcctt gtacctgggc cggatgttca gtgggacccc cgtgatccga
     1081 ctgcgcttca agaggctgca gcccaccagg ctggtagctg agtttgactt ccggaccttt
     1141 gaccccgagg gcatcctcct ctttgccgga ggccaccagg acagcacctg gatcgtgctg
     1201 gccctgagag ccggccggct ggagctgcag ctgcgctaca acggtgtcgg ccgtgtcacc
     1261 agcagcggcc cggtcatcaa ccatggcatg tggcagacaa tctctgttga ggagctggcg
     1321 cggaatctgg tcatcaaggt caacagggat gctgtcatga aaatcgcggt ggccggggac
     1381 ttgttccaac cggagcgagg actgtatcat ctgaacctga ccgtgggagg tattcccttc
     1441 catgagaagg acctcgtgca gcctataaac cctcgtctgg atggctgcat gaggagctgg
     1501 aactggctga acggagaaga caccaccatc caggaaacgg tgaaagtgaa cacgaggatg
     1561 cagtgcttct cggtgacgga gagaggctct ttctaccccg ggagcggctt cgccttctac
     1621 agcctggact acatgcggac ccctctggac gtcgggactg aatcaacctg ggaagtagaa
     1681 gtcgtggctc acatccgccc agccgcagac acaggcgtgc tgtttgcgct ctgggccccc
     1741 gacctccgtg ccgtgcctct ctctgtggca ctggtagact atcactccac gaagaaactc
     1801 aagaagcagc tggtggtcct ggccgtggag catacggcct tggccctaat ggagatcaag
     1861 gtctgcgacg gccaagagca cgtggtcacc gtctcgctga gggacggtga ggccaccctg
     1921 gaggtggacg gcaccagggg ccagagcgag gtgagcgccg cgcagctgca ggagaggctg
     1981 gccgtgctcg agaggcacct gcggagcccc gtgctcacct ttgctggcgg cctgccagat
     2041 gtgccggtga cttcagcgcc agtcaccgcg ttctaccgcg gctgcatgac actggaggtc
     2101 aaccggaggc tgctggacct ggacgaggcg gcgtacaagc acagcgacat cacggcccac
     2161 tcctgccccc ccgtggagcc cgccgcagcc taggccccca cgggacgcgg caggcttctc
     2221 agtctctgtc cgagacagcc gggaggagcc tgggggctcc tcaccacgtg gggccatgct
     2281 gagagctggg ctttcctctg tgaccatccc ggcctgtaac atatctgtaa atagtgagat
     2341 ggacttgggg cctctgacgc cgcgcactca gccgtgggcc cgggcgcggg gaggccggcg
     2401 cagcgcagag cgggctcgaa gaaaataatt ctctattatt tttattacca agcgcttctt
     2461 tctgactcta aaatatggaa aataaaatat ttacagaaag ctttgtaa
//
