LOCUS       NM_001362985            2859 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens growth arrest specific 2 like 1 (GAS2L1), transcript
            variant 5, mRNA.
ACCESSION   NM_001362985 XM_024452145
VERSION     NM_001362985.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2859)
  AUTHORS   Au,F.K.C., Hau,B.K.T. and Qi,R.Z.
  TITLE     Nek2-mediated GAS2L1 phosphorylation and centrosome-linker
            disassembly induce centrosome disjunction
  JOURNAL   J Cell Biol 219 (5) (2020)
   PUBMED   32289147
  REMARK    GeneRIF: Nek2-mediated GAS2L1 phosphorylation and centrosome-linker
            disassembly induce centrosome disjunction.
REFERENCE   2  (bases 1 to 2859)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2859)
  AUTHORS   Au,F.K., Jia,Y., Jiang,K., Grigoriev,I., Hau,B.K., Shen,Y., Du,S.,
            Akhmanova,A. and Qi,R.Z.
  TITLE     GAS2L1 Is a Centriole-Associated Protein Required for Centrosome
            Dynamics and Disjunction
  JOURNAL   Dev Cell 40 (1), 81-94 (2017)
   PUBMED   28017616
  REMARK    GeneRIF: This work reveals a GAS2L1-mediated centriole-tethering
            mechanism of microtubules and actin, which provide the forces
            required for centrosome dynamics and separation.
REFERENCE   4  (bases 1 to 2859)
  AUTHORS   Wolpin,B.M., Rizzato,C., Kraft,P., Kooperberg,C., Petersen,G.M.,
            Wang,Z., Arslan,A.A., Beane-Freeman,L., Bracci,P.M., Buring,J.,
            Canzian,F., Duell,E.J., Gallinger,S., Giles,G.G., Goodman,G.E.,
            Goodman,P.J., Jacobs,E.J., Kamineni,A., Klein,A.P., Kolonel,L.N.,
            Kulke,M.H., Li,D., Malats,N., Olson,S.H., Risch,H.A., Sesso,H.D.,
            Visvanathan,K., White,E., Zheng,W., Abnet,C.C., Albanes,D.,
            Andreotti,G., Austin,M.A., Barfield,R., Basso,D., Berndt,S.I.,
            Boutron-Ruault,M.C., Brotzman,M., Buchler,M.W.,
            Bueno-de-Mesquita,H.B., Bugert,P., Burdette,L., Campa,D.,
            Caporaso,N.E., Capurso,G., Chung,C., Cotterchio,M., Costello,E.,
            Elena,J., Funel,N., Gaziano,J.M., Giese,N.A., Giovannucci,E.L.,
            Goggins,M., Gorman,M.J., Gross,M., Haiman,C.A., Hassan,M.,
            Helzlsouer,K.J., Henderson,B.E., Holly,E.A., Hu,N., Hunter,D.J.,
            Innocenti,F., Jenab,M., Kaaks,R., Key,T.J., Khaw,K.T., Klein,E.A.,
            Kogevinas,M., Krogh,V., Kupcinskas,J., Kurtz,R.C., LaCroix,A.,
            Landi,M.T., Landi,S., Le Marchand,L., Mambrini,A., Mannisto,S.,
            Milne,R.L., Nakamura,Y., Oberg,A.L., Owzar,K., Patel,A.V.,
            Peeters,P.H., Peters,U., Pezzilli,R., Piepoli,A., Porta,M.,
            Real,F.X., Riboli,E., Rothman,N., Scarpa,A., Shu,X.O.,
            Silverman,D.T., Soucek,P., Sund,M., Talar-Wojnarowska,R.,
            Taylor,P.R., Theodoropoulos,G.E., Thornquist,M., Tjonneland,A.,
            Tobias,G.S., Trichopoulos,D., Vodicka,P., Wactawski-Wende,J.,
            Wentzensen,N., Wu,C., Yu,H., Yu,K., Zeleniuch-Jacquotte,A.,
            Hoover,R., Hartge,P., Fuchs,C., Chanock,S.J.,
            Stolzenberg-Solomon,R.S. and Amundadottir,L.T.
  TITLE     Genome-wide association study identifies multiple susceptibility
            loci for pancreatic cancer
  JOURNAL   Nat Genet 46 (9), 994-1000 (2014)
   PUBMED   25086665
REFERENCE   5  (bases 1 to 2859)
  AUTHORS   Stroud,M.J., Nazgiewicz,A., McKenzie,E.A., Wang,Y., Kammerer,R.A.
            and Ballestrem,C.
  TITLE     GAS2-like proteins mediate communication between microtubules and
            actin through interactions with end-binding proteins
  JOURNAL   J Cell Sci 127 (Pt 12), 2672-2682 (2014)
   PUBMED   24706950
  REMARK    GeneRIF: GAS2L1 and GAS2L2 are differentially involved in mediating
            the crosstalk between F-actin and microtubules.
REFERENCE   6  (bases 1 to 2859)
  AUTHORS   Saito,A., Fujikura-Ouchi,Y., Ito,C., Matsuoka,H., Shimoda,K. and
            Akiyama,K.
  TITLE     An association study on polymorphisms in the PEA15, ENTPD4, and
            GAS2L1 genes and schizophrenia
  JOURNAL   Psychiatry Res 185 (1-2), 9-15 (2011)
   PUBMED   20537721
  REMARK    GeneRIF: There was no significant difference in the frequency six
            marker haplotype in the GAS2L1 gene between the cases of
            schizophreina and controls.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2859)
  AUTHORS   Gamper,I., Koh,K.R., Ruau,D., Ullrich,K., Bartunkova,J., Piroth,D.,
            Hacker,C., Bartunek,P. and Zenke,M.
  TITLE     GAR22: a novel target gene of thyroid hormone receptor causes
            growth inhibition in human erythroid cells
  JOURNAL   Exp Hematol 37 (5), 539-548 (2009)
   PUBMED   19375645
  REMARK    GeneRIF: T3-induced genes identified basic transcription element
            binding protein 1/Kruppel-like factor 9 (BTEB1/KLF9) and GAR22 as
            TR target genes
REFERENCE   8  (bases 1 to 2859)
  AUTHORS   Goriounov,D., Leung,C.L. and Liem,R.K.
  TITLE     Protein products of human Gas2-related genes on chromosomes 17 and
            22 (hGAR17 and hGAR22) associate with both microfilaments and
            microtubules
  JOURNAL   J Cell Sci 116 (Pt 6), 1045-1058 (2003)
   PUBMED   12584248
  REMARK    GeneRIF: The beta isoforms of hGAR17 and hGAR22 appear to be able
            to crosslink microtubules and microfilaments
REFERENCE   9  (bases 1 to 2859)
  AUTHORS   Zucman-Rossi,J., Legoix,P. and Thomas,G.
  TITLE     Identification of new members of the Gas2 and Ras families in the
            22q12 chromosome region
  JOURNAL   Genomics 38 (3), 247-254 (1996)
   PUBMED   8975699
REFERENCE   10 (bases 1 to 2859)
  AUTHORS   Brancolini,C., Bottega,S. and Schneider,C.
  TITLE     Gas2, a growth arrest-specific protein, is a component of the
            microfilament network system
  JOURNAL   J Cell Biol 117 (6), 1251-1261 (1992)
   PUBMED   1607387
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002059.3 and KF459717.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 10, 2021 this sequence version replaced NM_001362985.2.
            
            Summary: This gene encodes a member of the growth arrest-specific 2
            protein family. This protein binds components of the cytoskeleton
            and may be involved in mediating interactions between microtubules
            and microfilaments. This protein localizes to the proximal end of
            mature centrioles and links centrosomes to both microtubules and
            actin. Alternate splicing results in multiple transcript variants.
            A pseudogene of this gene is found on chromosome 9. [provided by
            RefSeq, May 2018].
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 5 encode isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223602.1, SRR13170464.1324350.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000616432.5/ ENSP00000478908.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-504               AC002059.3         24583-25086
            505-1156            AC002059.3         26020-26671
            1157-1264           AC002059.3         28372-28479
            1265-1361           AC002059.3         28571-28667
            1362-1533           AC002059.3         28760-28931
            1534-1565           AC002059.3         29395-29426
            1566-1813           KF459717.1         1-248               c
            1814-2859           AC002059.3         29674-30719
FEATURES             Location/Qualifiers
     source          1..2859
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..2859
                     /gene="GAS2L1"
                     /gene_synonym="GAR22"
                     /note="growth arrest specific 2 like 1"
                     /db_xref="GeneID:10634"
                     /db_xref="HGNC:HGNC:16955"
                     /db_xref="MIM:602128"
     exon            1..504
                     /gene="GAS2L1"
                     /gene_synonym="GAR22"
                     /inference="alignment:Splign:2.1.0"
     exon            505..1156
                     /gene="GAS2L1"
                     /gene_synonym="GAR22"
                     /inference="alignment:Splign:2.1.0"
     CDS             524..2569
                     /gene="GAS2L1"
                     /gene_synonym="GAR22"
                     /note="isoform a is encoded by transcript variant 5;
                     GAS2-related protein on chromosome 22; GAS2-like protein
                     1; growth arrest-specific protein 2-like 1; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="GAS2-like protein 1 isoform a"
                     /protein_id="NP_001349914.1"
                     /db_xref="CCDS:CCDS74840.1"
                     /db_xref="GeneID:10634"
                     /db_xref="HGNC:HGNC:16955"
                     /db_xref="MIM:602128"
                     /translation="MADPVAGIAGSAAKSVRPFRSSEAYVEAMKEDLAEWLNALYGLG
                     LPGGGDGFLTGLATGTTLCQHANAVTEAARALAAARPARGVAFQAHSVVPGSFMARDN
                     VATFIGWCRVELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGLLAPRLVQF
                     EQEIERELRAAPPAPNAPAAGEDTTETAPAPGTPARGPRMTPSDLRNLDELVREILGR
                     CTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRC
                     SSTAHRPPQPRVCTFSPQRVSPTTSPRPASPVPGSERRGSRPEMTPVSLRSTKEGPET
                     PPRPRDQLPPHPRSRRYSGDSDSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTP
                     ASPRRPPALRSQSRDRLDRGRPRGAPGGRGAQLSVPSPARRARSQSREEQAVLLVRRD
                     RDGQHSWVPRGRGSGGSGRSTPQTPRARSPAAPRLSRVSSPSPELGTTPASIFRTPLQ
                     LDPQQEQQLFRRLEEEFLANARALEAVASVTPTGPAPDPARAPDPPAPDSAYCSSSSS
                     SSSLSVLGGKCGQPGDSGRTANGLPGPRSQALSSSSDEGSPCPGMGGPLDAPGSPLAC
                     TEPSRTWARGRMDTQPDRKPSRIPTPRGPRRPSGPAELGTWHALHSVTPRAEPDSWM"
     exon            1157..1264
                     /gene="GAS2L1"
                     /gene_synonym="GAR22"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1361
                     /gene="GAS2L1"
                     /gene_synonym="GAR22"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1533
                     /gene="GAS2L1"
                     /gene_synonym="GAR22"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..2859
                     /gene="GAS2L1"
                     /gene_synonym="GAR22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2839..2844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAS2L1"
                     /gene_synonym="GAR22"
                     /note="hexamer: AGTAAA"
     polyA_site      2859
                     /gene="GAS2L1"
                     /gene_synonym="GAR22"
                     /note="major polyA site"
ORIGIN      
        1 gctatcgctt cctgccttca tcttgggaac aggccgtgct gtgcgccagc ccggggagcc
       61 caccgtctgg ggaggggggc gattaaaagg tcccaacctc ctccccagga gaccaaagag
      121 gttggacggg gccccgggta ctaggctggg tgggggttgg gcgcctgggc cggtcgcagt
      181 tgtctggggg ccctggggct ctctgcgtcg agagcgctcg aagacccggg attcctggcc
      241 cgatcgcggg cggggggaga ccccagctcc accccagctc ccgccggctc ggggaagggg
      301 cggccccttt aagagcgcgc ggccccgccc gccccctccg ggcaggatcc gaattccagg
      361 gaggcggggc ggagacggcg gcgaggagga ggccgcggcg cgggacgcat agagctgcgg
      421 ctcgggcggc gcctccctgc ggcggcccgg cccggctccg gcccccgctg gggcaatgct
      481 ccccggggcc gcgggatgag ccagtgactc ggccggtccg ggcatggcag acccagtggc
      541 gggcatcgcg ggctcggcgg ccaagagcgt gcggccattt cgctccagtg aggcctacgt
      601 ggaggccatg aaggaggacc tggccgagtg gctcaatgcc ttgtacggcc tgggtctccc
      661 gggtggtggc gatggcttcc tgacagggct ggccacgggc acgaccctgt gccaacatgc
      721 caacgccgtg accgaggctg cccgtgcatt ggcagccgcc cgcccggccc gaggtgtggc
      781 cttccaggcg cacagtgtag tgcctggctc cttcatggcg cgcgacaacg tggccacctt
      841 catcggctgg tgccgcgtgg agctgggtgt gccggaggtg ctcatgtttg agactgagga
      901 cctggtgctg cgcaagaacg agaagagcgt ggtgctgtgc ctgctggagg tggcgcggcg
      961 tggggcacgc ctgggcctgc tggccccacg cctcgtgcag tttgagcagg agattgagcg
     1021 ggagctgcgt gctgcacccc cagcccccaa cgcccctgcc gctggggagg acaccactga
     1081 aaccgccccc gcaccaggga ctcctgcccg cggcccccgc atgacaccca gcgacctgcg
     1141 caacctcgac gagctggtga gggagattct gggccgctgc acctgccctg accagtttcc
     1201 catgatcaag gtctcagagg ggaagtaccg tgtgggggac tcgagcctgc tcatctttgt
     1261 gcgggtgctg aggagccacg tgatggtgcg agtgggtggt ggctgggaca cgctggagca
     1321 ttacctggac aagcacgacc cgtgccgctg ctcctccact gctcatcgcc caccccagcc
     1381 gagggtctgc accttttctc cacagagggt gtcgcccacc accagtcccc gccctgctag
     1441 cccagtccct gggagtgagc gccggggctc ccggcctgag atgactcccg ttagcttacg
     1501 aagcacaaag gaggggcccg agaccccacc caggccccgg gatcagctgc ccccccatcc
     1561 ccgctcccgc cgctactccg gggacagtga ctcctcagcc tcctccgccc agagcggccc
     1621 ccttggtacc cgcagtgatg acacaggcac tggcccccgg agggagcgac ccagccggcg
     1681 gctgaccaca ggcaccccgg cctctccgag acggcctcct gccctgcgca gccagtcccg
     1741 agaccggctg gatcgcggcc ggccccgggg ggccccagga ggcaggggag cccagctgtc
     1801 ggtccccagc cctgcccggc gggcccggag ccagagccgc gaggagcagg ctgtgctgct
     1861 tgtgcgcagg gatcgagacg ggcagcactc atgggtgcca aggggcaggg gcagtggggg
     1921 ctcgggcagg agcacccccc agactccccg tgcccgcagc cctgcagcac cccggctttc
     1981 ccgggtctcc agccccagtc cagagttggg caccacaccg gccagcatct tccgcacacc
     2041 cctgcagctc gacccgcagc aggagcagca gctgttccgg cgcctggaag aggagttcct
     2101 ggccaatgcc cgggcccttg aggctgttgc tagcgtgacc cccactggac cagcccctga
     2161 cccagctcgg gcccccgacc ctccagctcc tgactctgcc tattgttcct ccagttcctc
     2221 ctcttcgtcc ctcagcgtcc tgggtggcaa atgtggccaa cctggggact ctggccggac
     2281 ggccaatggg ctgcctgggc cccgaagcca agccctttcc agctcctccg atgaaggcag
     2341 cccctgccct ggcatggggg ggccactaga tgcacctggg agccccctgg cttgcactga
     2401 accctcgagg acctgggcac ggggtcggat ggacacacag ccagaccgta aaccctcacg
     2461 tatccccacg cctcggggcc cccgccgccc ctccggaccc gcagagctgg ggacatggca
     2521 tgccctgcac tcagtcaccc cgagggctga gccagattcc tggatgtgat ggaccagctc
     2581 agctgtcccc agaccccatc ccttctcctt ttcctttgtg gccttaaccc ttctgcatca
     2641 gggagccccc tctgcctctt gagtaccaga cctcatggga ccagacccct tgggaccaca
     2701 tggcacaatg ggacctctgt tgtacattcc ggttggggga tgagcgttgc tatttaatta
     2761 ctaatattat tgaatgcctt agaggaggcc gggcgagccc ggtgttctga agacctgtgg
     2821 cccagcagag cctctgacag taaagttttg ctccagcca
//
