LOCUS       NM_001143830            2236 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens growth arrest specific 2 (GAS2), transcript variant 3,
            mRNA.
ACCESSION   NM_001143830
VERSION     NM_001143830.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2236)
  AUTHORS   Zhang,L., Zheng,D., Xu,L., Wang,H., Zhang,S., Shi,J. and Jin,N.
  TITLE     A novel variant in GAS2 is associated with autosomal dominant
            nonsyndromic hearing impairment in a Chinese family
  JOURNAL   Hum Genomics 18 (1), 73 (2024)
   PUBMED   38956677
  REMARK    GeneRIF: A novel variant in GAS2 is associated with autosomal
            dominant nonsyndromic hearing impairment in a Chinese family.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2236)
  AUTHORS   Ma,W., Wan,Y., Zhang,J., Yao,J., Wang,Y., Lu,J., Liu,H., Huang,X.,
            Zhang,X., Zhou,H., He,Y., Wu,D., Wang,J. and Zhao,Y.
  TITLE     Growth arrest-specific protein 2 (GAS2) interacts with CXCR4 to
            promote T-cell leukemogenesis partially via c-MYC
  JOURNAL   Mol Oncol 16 (20), 3720-3734 (2022)
   PUBMED   36054080
  REMARK    GeneRIF: Growth arrest-specific protein 2 (GAS2) interacts with
            CXCR4 to promote T-cell leukemogenesis partially via c-MYC.
REFERENCE   3  (bases 1 to 2236)
  AUTHORS   Chen,T., Rohacek,A.M., Caporizzo,M., Nankali,A., Smits,J.J.,
            Oostrik,J., Lanting,C.P., Kucuk,E., Gilissen,C., van de Kamp,J.M.,
            Pennings,R.J.E., Rakowiecki,S.M., Kaestner,K.H., Ohlemiller,K.K.,
            Oghalai,J.S., Kremer,H., Prosser,B.L. and Epstein,D.J.
  TITLE     Cochlear supporting cells require GAS2 for cytoskeletal
            architecture and hearing
  JOURNAL   Dev Cell 56 (10), 1526-1540 (2021)
   PUBMED   33964205
  REMARK    GeneRIF: Cochlear supporting cells require GAS2 for cytoskeletal
            architecture and hearing.
REFERENCE   4  (bases 1 to 2236)
  AUTHORS   Zhang,N., Zhao,C., Zhang,X., Cui,X., Zhao,Y., Yang,J. and Gao,X.
  TITLE     Growth arrest-specific 2 protein family: Structure and function
  JOURNAL   Cell Prolif 54 (1), e12934 (2021)
   PUBMED   33103301
  REMARK    GeneRIF: Growth arrest-specific 2 protein family: Structure and
            function.
            Review article
REFERENCE   5  (bases 1 to 2236)
  AUTHORS   Sui,R. and Piao,H.Z.
  TITLE     UCHL1 enhances the malignant development of glioma via targeting
            GAS2
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (11), 6195-6203 (2020)
   PUBMED   32572885
  REMARK    GeneRIF: UCHL1 enhances the malignant development of glioma via
            targeting GAS2.
REFERENCE   6  (bases 1 to 2236)
  AUTHORS   Sgorbissa,A., Benetti,R., Marzinotto,S., Schneider,C. and
            Brancolini,C.
  TITLE     Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro:
            implications for microfilament reorganization during apoptosis
  JOURNAL   J Cell Sci 112 (Pt 23), 4475-4482 (1999)
   PUBMED   10564664
REFERENCE   7  (bases 1 to 2236)
  AUTHORS   Collavin,L., Buzzai,M., Saccone,S., Bernard,L., Federico,C.,
            DellaValle,G., Brancolini,C. and Schneider,C.
  TITLE     cDNA characterization and chromosome mapping of the human GAS2 gene
  JOURNAL   Genomics 48 (2), 265-269 (1998)
   PUBMED   9521882
REFERENCE   8  (bases 1 to 2236)
  AUTHORS   Brancolini,C., Bottega,S. and Schneider,C.
  TITLE     Gas2, a growth arrest-specific protein, is a component of the
            microfilament network system
  JOURNAL   J Cell Biol 117 (6), 1251-1261 (1992)
   PUBMED   1607387
REFERENCE   9  (bases 1 to 2236)
  AUTHORS   Schneider,C., King,R.M. and Philipson,L.
  TITLE     Genes specifically expressed at growth arrest of mammalian cells
  JOURNAL   Cell 54 (6), 787-793 (1988)
   PUBMED   3409319
REFERENCE   10 (bases 1 to 2236)
  AUTHORS   Olson,R.E., Morello,J.A. and Kieff,E.D.
  TITLE     Antibiotic treatment of oral anaerobic infections
  JOURNAL   J Oral Surg 33 (8), 619-621 (1975)
   PUBMED   1056466
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC103801.2 and AC006299.1.
            
            On Jan 19, 2021 this sequence version replaced NM_001143830.2.
            
            Summary: The protein encoded by this gene is a caspase-3 substrate
            that plays a role in regulating microfilament and cell shape
            changes during apoptosis. It can also modulate cell susceptibility
            to p53-dependent apoptosis by inhibiting calpain activity.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, May 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313734.1, SRR14038192.1546919.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000454584.7/ ENSP00000401145.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               AC103801.2         122191-122479       c
            290-454             AC103801.2         114076-114240       c
            455-576             AC103801.2         103301-103422       c
            577-718             AC103801.2         62657-62798         c
            719-782             AC103801.2         51322-51385         c
            783-924             AC103801.2         39829-39970         c
            925-1032            AC103801.2         33137-33244         c
            1033-2236           AC006299.1         114569-115772       c
FEATURES             Location/Qualifiers
     source          1..2236
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.3"
     gene            1..2236
                     /gene="GAS2"
                     /gene_synonym="DFNB125; GAS-2"
                     /note="growth arrest specific 2"
                     /db_xref="GeneID:2620"
                     /db_xref="HGNC:HGNC:4167"
                     /db_xref="MIM:602835"
     exon            1..289
                     /gene="GAS2"
                     /gene_synonym="DFNB125; GAS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            290..454
                     /gene="GAS2"
                     /gene_synonym="DFNB125; GAS-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..1251
                     /gene="GAS2"
                     /gene_synonym="DFNB125; GAS-2"
                     /note="isoform a is encoded by transcript variant 3;
                     growth arrest-specific protein 2"
                     /codon_start=1
                     /product="growth arrest-specific protein 2 isoform a"
                     /protein_id="NP_001137302.1"
                     /db_xref="CCDS:CCDS7858.1"
                     /db_xref="GeneID:2620"
                     /db_xref="HGNC:HGNC:4167"
                     /db_xref="MIM:602835"
                     /translation="MCTALSPKVRSGPGLSDMHQYSQWLASRHEANLLPMKEDLALWL
                     TNLLGKEITAETFMEKLDNGALLCQLAETMQEKFKESMDANKPTKNLPLKKIPCKTSA
                     PSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYG
                     VEPPGLIKLEKEIEQEETLSAPSPSPSPSSKSSGKKSTGNLLDDAVKRISEDPPCKCP
                     NKFCVERLSQGRYRVGEKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQISR
                     VDGKTSPIQSKSPTLKDMNPDNYLVVSASYKAKKEIK"
     exon            455..576
                     /gene="GAS2"
                     /gene_synonym="DFNB125; GAS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..718
                     /gene="GAS2"
                     /gene_synonym="DFNB125; GAS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..782
                     /gene="GAS2"
                     /gene_synonym="DFNB125; GAS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            783..924
                     /gene="GAS2"
                     /gene_synonym="DFNB125; GAS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1032
                     /gene="GAS2"
                     /gene_synonym="DFNB125; GAS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..2236
                     /gene="GAS2"
                     /gene_synonym="DFNB125; GAS-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1440..1445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAS2"
                     /gene_synonym="DFNB125; GAS-2"
                     /note="hexamer: AAGAAA"
     polyA_site      1458
                     /gene="GAS2"
                     /gene_synonym="DFNB125; GAS-2"
     regulatory      2209..2214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAS2"
                     /gene_synonym="DFNB125; GAS-2"
                     /note="hexamer: ATTAAA"
     polyA_site      2236
                     /gene="GAS2"
                     /gene_synonym="DFNB125; GAS-2"
                     /note="major polyA site"
ORIGIN      
        1 agcattttac ttccgctcgg tctatgagga ctgatgaaat gtaggaaatc tgtttctggc
       61 agggagaaaa aatcgttttc ccaaacagca ctaaaaggag ccatcagaga agtatgaaga
      121 ggggtagtgc ggctgtagct gctgccgctg ccgccaggct ggtggggtgc ggggagcggc
      181 tgctgcagga cctgtgcctg gagggggccg gccccgagaa gctgcaggag cccagcccgg
      241 agcccaagcg cctctgagag ccgccagcag cccagctcgg gacgcggggg tattacaagt
      301 ggataaataa tgtgcactgc tctgagccca aaggtacgca gtggacctgg cctctctgat
      361 atgcatcagt atagccaatg gctagccagc agacatgaag ctaatttgct accaatgaaa
      421 gaagatctgg ccttgtggtt aaccaatcta ttagggaagg agattacagc agaaactttt
      481 atggagaagt tggacaatgg tgccttgctc tgtcaacttg cagaaactat gcaggagaaa
      541 ttcaaggaga gcatggatgc taacaagccc acaaagaatc taccgttgaa gaagatccca
      601 tgcaaaacca gtgcaccctc gggctccttt tttgccagag acaatacagc aaatttctta
      661 tcctggtgcc gagatttagg ggtggatgaa acgtgtctat ttgaatcgga aggtttggtc
      721 ctccacaagc aacccagaga agtgtgtctc tgtctgctag agcttggccg gattgcagcc
      781 aggtatggtg tggagcctcc tggtttgata aagctggaaa aagagattga acaagaagaa
      841 acactttctg ccccttctcc ttcaccttct ccttcatcaa agtcttctgg aaaaaagagt
      901 acaggaaact tactggatga tgcagtgaaa cgaatttctg aagatcctcc ttgcaaatgc
      961 ccaaacaagt tctgtgtgga gcggctctcc caaggaagat accgagtggg agaaaagatc
     1021 ctcttcatta ggatgctgca caacaaacat gtcatggtcc gtgtgggagg aggctgggaa
     1081 acttttgcag ggtatttgtt gaaacacgac ccctgccgaa tgctgcagat ctcccgtgtg
     1141 gatggcaaaa catcccctat ccaaagcaaa tctccaactc taaaggacat gaatccagat
     1201 aactacttgg tggtctctgc cagttataag gctaagaagg aaattaagtg aaacaaattg
     1261 gtcatgacaa ggggaccctc ataatggcct gtatccactt ctccagtata gtcagtttag
     1321 ttcatatgtt ctgaaaactg ttttggagaa agatagacag aaaaatgtca tcatattgaa
     1381 aaatgttcaa agagtagcac tatttatttt taatgcttct gtagaatatg acctattaaa
     1441 agaaaatcta aactcaaatt taaattatcc aaattttagg caaattatta tttctcaata
     1501 tgcgaacaca gtatttagaa cacaatatta gaaacacaat tctaactaaa gataaataag
     1561 gagaaaacat ttaggatttg cagataagtc aacagaaagt gcctgcttta cactcatgag
     1621 taaaagcact ccagacattt ttataattgc aagattttta tgcttttttt tttttttttt
     1681 tacaaaatga tgattagtgt gataatgtgc tgcaaaaaat atccaacagc actacacata
     1741 agtacagagt attcacaata gtaatatgtt actggaaagg ccacttccga aaagtttaca
     1801 ttcacttgga aggctgcctt aaagtatatc tcttatctat gaccaaatat ctggggtact
     1861 tttagaagtt ttcagtacac ccccttagag aatagcttat gagttatttc acacattcct
     1921 gagcacatgg ctgtgtttag aatgatctag tgtaattcat acatgagctg acatacgttg
     1981 atactttgac gagtaaattg tacagtcaaa tgttcattga tttcatgtta tttcaaagca
     2041 ttttcttatt aaaaatatat ctttagttaa tcctattttg ctatgctttc tagtaaagta
     2101 aattcactgt agctaatgat gttacagact tacgtatacc cttgtatacc tgggacaggg
     2161 ctgttttata ccaataaaca gcaaaatatt gtccttactc attcaagaat taaaaggata
     2221 aattttaaaa atgtta
//
