LOCUS       NM_002048               3145 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens growth arrest specific 1 (GAS1), mRNA.
ACCESSION   NM_002048
VERSION     NM_002048.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3145)
  AUTHORS   King,C.M., Ding,W., Eshelman,M.A. and Yochum,G.S.
  TITLE     TCF7L1 regulates colorectal cancer cell migration by repressing
            GAS1 expression
  JOURNAL   Sci Rep 14 (1), 12477 (2024)
   PUBMED   38816533
  REMARK    GeneRIF: TCF7L1 regulates colorectal cancer cell migration by
            repressing GAS1 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3145)
  AUTHORS   Seppala,M., Thivichon-Prince,B., Xavier,G.M., Shaffie,N.,
            Sangani,I., Birjandi,A.A., Rooney,J., Lau,J.N.S., Dhaliwal,R.,
            Rossi,O., Riaz,M.A., Stonehouse-Smith,D., Wang,Y.,
            Papageorgiou,S.N., Viriot,L. and Cobourne,M.T.
  TITLE     Gas1 Regulates Patterning of the Murine and Human Dentitions
            through Sonic Hedgehog
  JOURNAL   J Dent Res 101 (4), 473-482 (2022)
   PUBMED   34796774
  REMARK    GeneRIF: Gas1 Regulates Patterning of the Murine and Human
            Dentitions through Sonic Hedgehog.
REFERENCE   3  (bases 1 to 3145)
  AUTHORS   Sarkar,S., Poon,C.C., Mirzaei,R., Rawji,K.S., Hader,W., Bose,P.,
            Kelly,J., Dunn,J.F. and Yong,V.W.
  TITLE     Microglia induces Gas1 expression in human brain tumor-initiating
            cells to reduce tumorigenecity
  JOURNAL   Sci Rep 8 (1), 15286 (2018)
   PUBMED   30327548
  REMARK    GeneRIF: This study has identified Gas1 as a novel factor and
            mechanism through which microglia arrest the growth of human brain
            tumor-initiating cells for anti-tumor property.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3145)
  AUTHORS   Sanchez-Hernandez,L., Hernandez-Soto,J., Vergara,P., Gonzalez,R.O.
            and Segovia,J.
  TITLE     Additive effects of the combined expression of soluble forms of
            GAS1 and PTEN inhibiting glioblastoma growth
  JOURNAL   Gene Ther 25 (6), 439-449 (2018)
   PUBMED   29941984
  REMARK    GeneRIF: t is relevant to investigate the potential additive effect
            of the overexpression of GAS1 and PTEN on tumor growth. In
            particular, we employed secreted forms of both GAS1 (tGAS1) and
            PTEN (PTEN-LONG, or PTEN-L) and tested their combined effect on
            glioma cells.
REFERENCE   5  (bases 1 to 3145)
  AUTHORS   Conceicao,A.L., Da Silva,C.T., Badial,R.M., Valsechi,M.C.,
            Stuqui,B., Goncalves,J.D., Jasiulionis,M.G., De Freitas Calmon,M.
            and Rahal,P.
  TITLE     Downregulation of OCLN and GAS1 in clear cell renal cell carcinoma
  JOURNAL   Oncol Rep 37 (3), 1487-1496 (2017)
   PUBMED   28184927
  REMARK    GeneRIF: Downregulation of GAS1 is associated with clear cell renal
            cell carcinoma.
REFERENCE   6  (bases 1 to 3145)
  AUTHORS   Wicking,C., Breen,M., Negus,K., Berkman,J., Evdokiou,A., Cowled,P.,
            Chenevix-Trench,G. and Wainwright,B.
  TITLE     The human growth-arrest-specific gene GAS1 maps outside the
            candidate region of the gene for nevoid basal cell carcinoma
            syndrome
  JOURNAL   Cytogenet Cell Genet 68 (1-2), 119-121 (1995)
   PUBMED   7956349
REFERENCE   7  (bases 1 to 3145)
  AUTHORS   Del Sal,G., Collavin,L., Ruaro,M.E., Edomi,P., Saccone,S.,
            Valle,G.D. and Schneider,C.
  TITLE     Structure, function, and chromosome mapping of the
            growth-suppressing human homologue of the murine gas1 gene
  JOURNAL   Proc Natl Acad Sci U S A 91 (5), 1848-1852 (1994)
   PUBMED   8127893
REFERENCE   8  (bases 1 to 3145)
  AUTHORS   Evdokiou,A., Webb,G.C., Peters,G.B., Dobrovic,A., O'Keefe,D.S.,
            Forbes,I.J. and Cowled,P.A.
  TITLE     Localization of the human growth arrest-specific gene (GAS1) to
            chromosome bands 9q21.3-q22, a region frequently deleted in myeloid
            malignancies
  JOURNAL   Genomics 18 (3), 731-733 (1993)
   PUBMED   8307588
REFERENCE   9  (bases 1 to 3145)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
REFERENCE   10 (bases 1 to 3145)
  AUTHORS   Del Sal,G., Ruaro,M.E., Philipson,L. and Schneider,C.
  TITLE     The growth arrest-specific gene, gas1, is involved in growth
            suppression
  JOURNAL   Cell 70 (4), 595-607 (1992)
   PUBMED   1505026
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158149.14, L13698.1,
            BC132682.1 and BM661942.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002048.2.
            
            Summary: Growth arrest-specific 1 plays a role in growth
            suppression.  GAS1 blocks entry to S phase and prevents cycling of
            normal and transformed cells.  Gas1 is a putative tumor suppressor
            gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: ERR279833.2917.1, L13698.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298743.9/ ENSP00000298743.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               AL158149.14        64640-64956         c
            318-1373            L13698.1           1-1056
            1374-1969           BC132682.1         732-1327
            1970-3046           L13698.1           1653-2729
            3047-3145           BM661942.1         17-115              c
FEATURES             Location/Qualifiers
     source          1..3145
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.33"
     gene            1..3145
                     /gene="GAS1"
                     /note="growth arrest specific 1"
                     /db_xref="GeneID:2619"
                     /db_xref="HGNC:HGNC:4165"
                     /db_xref="MIM:139185"
     exon            1..3145
                     /gene="GAS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             728..1765
                     /gene="GAS1"
                     /note="Growth arrest-specific gene-1; growth
                     arrest-specific protein 1; GAS-1"
                     /codon_start=1
                     /product="growth arrest-specific protein 1 precursor"
                     /protein_id="NP_002039.2"
                     /db_xref="CCDS:CCDS6674.1"
                     /db_xref="GeneID:2619"
                     /db_xref="HGNC:HGNC:4165"
                     /db_xref="MIM:139185"
                     /translation="MVAALLGGGGEARGGTVPGAWLCLMALLQLLGSAPRGSGLAHGR
                     RLICWQALLQCQGEPECSYAYNQYAEACAPVLAQHGGGDAPGAAAAAFPASAASFSSR
                     WRCPSHCISALIQLNHTRRGPALEDCDCAQDENCKSTKRAIEPCLPRTSGGGAGGPGA
                     GGVMGCTEARRRCDRDSRCNLALSRYLTYCGKVFNGLRCTDECRTVIEDMLAMPKAAL
                     LNDCVCDGLERPICESVKENMARLCFGAELGNGPGSSGSDGGLDDYYDEDYDDEQRTG
                     GAGGEQPLDDDDGVPHPPRPGSGAAASGGRGDLPYGPGRRSSGGGGRLAPRGAWTPLA
                     SILLLLLGPLF"
     regulatory      3123..3128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAS1"
                     /note="hexamer: AGTAAA"
     polyA_site      3145
                     /gene="GAS1"
                     /note="major polyA site"
ORIGIN      
        1 agccgggctc agcggatccg ctccccgggc tcttggtcac ccgagaagct gccgccgagt
       61 gaagccaggg agccgctctc cggcagcgcc gactttcttg ttctccccgc gcttcccgga
      121 aagagctccc cggagctctg cggaggccgg ggttgccgcg ggcggagggg gaggggacgc
      181 ggggcggccg ggccgcggga aggcgggcag cgcgcggacg ccgggccagg aagcggcgcg
      241 atgcgagaga ccgcggcggc ggtggcggcg gcgaggcact gagcccagga ggaaggagcc
      301 gccgcggccg cagcgcgagc agccggcacg gggacagccg gccgcacaac ggatctgcag
      361 gcgcggagca aaatgcaccc gccgcgccgc gcggtcctgc agccccgcca cggccccgcg
      421 gcccgcaccc ccccggggcg acagtgagcc tctcccgcca ccaccggggg ccgagcggag
      481 ggctctcggg tgggagagcg ggaccagatc tcgacagctg ttcatttcca ggaagccacc
      541 gcagccagag cgaaagggga ccttctgcca ccagcggggc atcagccagc ggcgcgcatg
      601 gatttatgaa gacactcatg caagaagtgg gcaggacttg gacaaacttt tccaccggct
      661 ccgcgtccgc cgctccccgc gcctcgtctc ctttcccctc ctctcccggc ggccgccgct
      721 gcccgcgatg gtggccgcgc tgctgggcgg cggcggcgag gcccgcgggg ggacagtgcc
      781 gggcgcctgg ctgtgcctga tggcgctgct gcagctgctg ggctcggcgc cgcggggatc
      841 ggggctggcg cacggccgcc gcctcatctg ctggcaggcg ctgctgcagt gccaggggga
      901 gccggagtgc agctacgcct acaaccagta cgccgaggcg tgcgcgccgg tgctggcgca
      961 gcacggcggg ggcgacgcgc ccggggccgc cgccgccgct ttcccggcct cggccgcctc
     1021 tttctcgtcg cgctggcgct gcccgagtca ctgcatctcg gccctcattc agctcaacca
     1081 cacgcgccgc gggcccgccc tggaggactg tgactgcgcg caggacgaga actgcaagtc
     1141 caccaagcgc gccattgagc cgtgcctgcc ccggacgagc ggcggcggcg cgggcggccc
     1201 cggcgcgggc ggggtcatgg gctgcaccga ggcccggcgg cgctgcgacc gcgacagccg
     1261 ctgcaacctg gcgctgagcc gctacctgac ctactgcggc aaagtcttca acgggctgcg
     1321 ctgcacggac gaatgccgca ccgtcattga ggacatgctg gctatgccca aggcggcgct
     1381 gctcaacgac tgcgtgtgcg acggcctcga gcggcccatc tgcgagtcgg tcaaggagaa
     1441 catggcccgc ctgtgcttcg gcgccgagct gggcaacggc cccggcagca gcggctcgga
     1501 cgggggcctg gacgactact acgatgagga ctacgatgac gagcagcgca ccgggggcgc
     1561 gggtggtgag cagccgctgg acgacgacga cggcgtcccg cacccaccgc gcccgggcag
     1621 cggcgctgct gcatcgggcg gccgcgggga cctgccctat gggcctgggc gcaggagcag
     1681 cggcggcggc ggccgcttgg cgccccgggg cgcctggacc ccactcgcct ccatcttgct
     1741 gctgctgctt gggccgctct tttagccctc gcgccccccg ccgttggctg cgggagagcc
     1801 cgcgtcccac tcccgtgctc gcctcgaccc cgcgccgggc acctgtggct tgggacagat
     1861 agaagggatg gttggggata cttcccaaaa ctttttccaa gtcaacttgg tgtagccggt
     1921 tccccggcca cgactctggg cacttcccct gaagctcctc tccggagctt gacttcttgg
     1981 acctcctccc ccgccccaat tccaagctcc agaaactccc aactcgtctg ccgtccagaa
     2041 agctagctgc agtgttcagg acgtccggga ggaagcaagc atgtggggga cagaacagta
     2101 gtcctggact cgaaagggaa ggtgctgacc agtggggcct tagcaatttg aagggttggg
     2161 aaggaggaat tatatttgca aaggggctgt ctattagcat atttcctttg agggggcaaa
     2221 aaaaagtgcc agtatcgact tttacagatt gtggccagtg aggatattat aatcctatgt
     2281 aaacagaaaa gtcccactta ccgattcatt ctttcactgt ttgtatctgc gcccagaatt
     2341 ctcagtgacg tgggggtgag ggtgggtggc gattgcctta gagggaaccc ctaaattggt
     2401 tttggataag tttgagccct tgaccttaat ttcattgcta ccactctgat ctcttagcac
     2461 atttcttagg attaagggtc caaaaatgct gatctaaggg gttgccatgg tgttgaacaa
     2521 tgcaactttt tatttaaaaa agctctgcac tgccatgtat gaaagtctct ttatgatgtt
     2581 tgtttttttg tcatttttgt tctttacatc aagaaatttt atgtttaaat atgcggagaa
     2641 tgtatattgc ctctgctcct atcagggttg ctaaaccctg gtacatcgta tataaaatgt
     2701 attaaaactg gggtttgtta ccagttgctg tactttgtat atagaatttt tataaattgt
     2761 atgcttcaga aataatttat ttttaaaaag aaattaaaag ttttaaactc acatccatat
     2821 tacacctttc ccccctgaaa tgtatagaat ccatttgtca tcaggaatca aaacccacag
     2881 tccattgtga agtgtgctat atttagaaca gtcttaaaat gtacagtgta ttttatagaa
     2941 ttgaagttaa cattcttatt ttcaagagaa tttatggacg ttgtagaaat gtacaaatgc
     3001 atttccaaac tgccttaaac gttgtatttt tatagacatg ttttttaaaa atcctaagtt
     3061 tttaaataac tatggatttg tgtatttttt ttggttattt gttttattaa aacatgtaca
     3121 tcagtaaaga gttttaaaca atgaa
//
