LOCUS       XM_047440743            3277 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens phosphoribosylglycinamide
            formyltransferase, phosphoribosylglycinamide synthetase,
            phosphoribosylaminoimidazole synthetase (GART), transcript variant
            X2, mRNA.
ACCESSION   XM_047440743
VERSION     XM_047440743.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000021.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3277
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
     gene            1..3277
                     /gene="GART"
                     /gene_synonym="AIRS; GARS; GARTF; PAIS; PGFT; PRGS"
                     /note="phosphoribosylglycinamide formyltransferase,
                     phosphoribosylglycinamide synthetase,
                     phosphoribosylaminoimidazole synthetase; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 50 ESTs, 1498 long SRA reads, 7 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 5 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:2618"
                     /db_xref="HGNC:HGNC:4163"
                     /db_xref="MIM:138440"
     CDS             52..3084
                     /gene="GART"
                     /gene_synonym="AIRS; GARS; GARTF; PAIS; PGFT; PRGS"
                     /codon_start=1
                     /product="trifunctional purine biosynthetic protein
                     adenosine-3 isoform X1"
                     /protein_id="XP_047296699.1"
                     /db_xref="GeneID:2618"
                     /db_xref="HGNC:HGNC:4163"
                     /db_xref="MIM:138440"
                     /translation="MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEK
                     ISNTAISISDHTALAQFCKEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEAAQ
                     LESSKRFAKEFMDRHGIPTAQWKAFTKPEEACSFILSADFPALVVKASGLAAGKGVIV
                     AKSKEEACKAVQEIMQEKAFGAAGETIVIEELLDGEEVSCLCFTDGKTVAPMPPAQDH
                     KRLLEGDGGPNTGGMGAYCPAPQVSNDLLLKIKDTVLQRTVDGMQQEGTPYTGILYAG
                     IMLTKNGPKVLEFNCRFGDPECQVILPLLKSDLYEVIQSTLDGLLCTSLPVWLENHTA
                     LTVVMASKGYPGDYTKGVEITGFPEAQALGLEVFHAGTALKNGKVVTHGGRVLAVTAI
                     RENLISALEEAKKGLAAIKFEGAIYRKDVGFRAIAFLQQPRSLTYKESGVDIAAGNML
                     VKKIQPLAKATSRSGCKVDLGGFAGLFDLKAAGFKDPLLASGTDGVGTKLKIAQLCNK
                     HDTIGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSVTEAVVAGIAKACGKAGCAL
                     LGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLPHLERITEGDVVVGIASSGLHSNGF
                     SLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTRIYSHSLLPVLRSGHVKAFAHIT
                     GGGLLENIPRVLPEKLGVDLDAQTWRIPRVFSWLQQEGHLSEEEMARTFNCGVGAVLV
                     VSKEQTEQILRDIQQHKEEAWVIGSVVARAEGSPRVKVKNLIESMQINGSVLKNGSLT
                     NHFSFEKKKARVAVLISGTGSNLQALIDSTREPNSSAQIDIVISNKAAVAGLDKAERA
                     GIPTRVINHKLYKNRVEFDSAIDLVLEEFSIDIVCLAGFMRILSGPFVQKWNGKMLNI
                     HPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAEDVDAGQIILQEAVPVKRGDTVATL
                     SERVKLAEHKIFPAALQLVASGTVQLGENGKICWVKEE"
ORIGIN      
        1 tagaggtgct gacgtttgcg ccgcgcacga ctatgtccgc catacagaac aatggcagcc
       61 cgagtactta taattggcag tggaggaagg gaacatacgc tggcctggaa acttgcacag
      121 tctcatcatg tcaaacaagt gttggttgcc ccaggaaacg caggcactgc ctgctctgaa
      181 aagatttcaa ataccgccat ctcaatcagt gaccacactg cccttgctca attctgcaaa
      241 gagaagaaaa ttgaatttgt agttgttgga ccagaagcac ctctggctgc tgggattgtt
      301 gggaacctga ggtctgcagg agtgcaatgc tttggcccaa cagcagaagc ggctcagtta
      361 gagtccagca aaaggtttgc caaagagttt atggacagac atggaatccc aaccgcacaa
      421 tggaaggctt tcaccaaacc tgaagaagcc tgcagcttca ttttgagtgc agacttccct
      481 gctttggttg tgaaggccag tggtcttgca gctggaaaag gggtgattgt tgcaaagagc
      541 aaagaagagg cctgcaaagc tgtacaagag atcatgcagg agaaagcctt tggggcagct
      601 ggagaaacaa ttgtcattga agaacttctt gacggagaag aggtgtcgtg tctgtgtttc
      661 actgatggca agactgtggc ccccatgccc ccagcacagg accataagcg attactggag
      721 ggagatggtg gccctaacac agggggaatg ggagcctatt gtccagcccc tcaggtttct
      781 aatgatctat tactaaaaat taaagatact gttcttcaga ggacagtgga tggcatgcag
      841 caagagggta ctccatatac aggtattctc tatgctggaa taatgctgac caagaatggc
      901 ccaaaagttc tagagtttaa ttgccgtttt ggtgatccag agtgccaagt aatcctccca
      961 cttcttaaaa gtgatcttta tgaagtgatt cagtccacct tagatggact gctctgcaca
     1021 tctctgcctg tttggctaga aaaccacacc gccctaactg ttgtcatggc aagtaaaggt
     1081 tatcctggag actacaccaa gggtgtagag ataacagggt ttcctgaggc tcaagctcta
     1141 ggactggagg tgttccatgc aggcactgcc ctcaaaaatg gcaaagtagt aactcatggg
     1201 ggtagagttc ttgcagtcac agccatccgg gaaaatctca tatcagccct tgaggaagcc
     1261 aagaaaggac tagctgctat aaagtttgag ggagcaattt ataggaaaga cgtcggcttt
     1321 cgtgccatag ctttcctcca gcagcccagg agtttgactt acaaggaatc tggagtagat
     1381 atcgcagctg gaaatatgct ggtcaagaaa attcagcctt tagcaaaagc cacttccaga
     1441 tcaggctgta aagttgatct tggaggtttt gctggtcttt ttgatttaaa agcagctggt
     1501 ttcaaagatc cccttctggc ctctggaaca gatggcgttg gaactaaact aaagattgcc
     1561 cagctatgca ataaacatga taccattggt caagatttgg tagcaatgtg tgttaatgat
     1621 attctggcac aaggagcaga gcccctcttc ttccttgatt acttttcctg tggaaaactt
     1681 gacctcagtg taactgaagc tgttgttgct ggaattgcta aagcttgtgg aaaagctgga
     1741 tgtgctctcc ttggaggtga aacagcagaa atgcctgaca tgtatccccc tggagagtat
     1801 gacctagctg ggtttgccgt tggtgccatg gagcgagatc agaaactccc tcacctggaa
     1861 agaatcactg agggtgatgt tgttgttgga atagcttcat ctggtcttca tagcaatgga
     1921 tttagccttg tgaggaaaat cgtggcaaaa tcttccctcc agtactcctc tccagcacct
     1981 gatggttgtg gtgaccagac tttaggggac ttacttctca cgcctaccag aatctacagc
     2041 cattcactgt tacctgtcct acgttcagga catgtcaaag cctttgccca tattactggt
     2101 ggaggattac tagagaacat ccccagagtc ctccctgaga aacttggggt agatttagat
     2161 gcccagacct ggaggatccc cagggtcttc tcatggttgc agcaggaagg acacctctct
     2221 gaggaagaga tggccagaac atttaactgt ggggttggcg ctgtccttgt ggtatcaaag
     2281 gagcagacag agcagattct gagggatatc cagcagcaca aggaagaagc ctgggtgatt
     2341 ggcagtgtgg ttgcacgagc tgaaggttcc ccacgtgtga aagtcaagaa tctgattgaa
     2401 agcatgcaaa taaatgggtc agtgttgaag aatggctccc tgacaaatca tttctctttt
     2461 gaaaaaaaaa aggccagagt ggctgtctta atatctggaa caggatcgaa cctgcaagca
     2521 cttatagaca gtactcggga accaaatagc tctgcacaaa ttgatattgt tatctccaac
     2581 aaagccgcag tagctgggtt agataaagcg gaaagagctg gtattcccac tagagtaatt
     2641 aatcataaac tgtataaaaa tcgtgtagaa tttgacagtg caattgacct agtccttgaa
     2701 gagttctcca tagacatagt ctgtcttgca ggattcatga gaattctttc tggccccttt
     2761 gtccaaaagt ggaatggaaa aatgctcaat atccacccat ccttgctccc ttcttttaag
     2821 ggttcaaatg cccatgagca agccctggaa accggagtca cagttactgg gtgcactgta
     2881 cactttgtag ctgaagatgt ggatgctgga cagattattt tgcaagaagc tgttcccgtg
     2941 aagaggggtg atactgtcgc aactctttct gaaagagtaa aattagcaga acataaaata
     3001 tttcctgcag cccttcagct ggtggccagt ggaactgtac agcttggaga aaatggcaag
     3061 atctgttggg ttaaagagga atgaagcctt ttaattcaga aatggggcca gtttagaaag
     3121 aattatttgc tgtttgcatg gtggtttttt atcatggact tggcccaaaa gaaaaactgc
     3181 taaaagacaa aaaagacctc acccttactt catctatttt tttaataaat agagactcac
     3241 taaaaacaag actagttagt gcagcatatc tgagaca
//
