LOCUS       XM_011529526            3570 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens phosphoribosylglycinamide
            formyltransferase, phosphoribosylglycinamide synthetase,
            phosphoribosylaminoimidazole synthetase (GART), transcript variant
            X5, mRNA.
ACCESSION   XM_011529526
VERSION     XM_011529526.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000021.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011529526.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 7% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3570
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
     gene            1..3570
                     /gene="GART"
                     /gene_synonym="AIRS; GARS; GARTF; PAIS; PGFT; PRGS"
                     /note="phosphoribosylglycinamide formyltransferase,
                     phosphoribosylglycinamide synthetase,
                     phosphoribosylaminoimidazole synthetase; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 53 ESTs, 1630 long SRA reads, 7 Proteins, and
                     93% coverage of the annotated genomic feature by RNAseq
                     alignments, including 61 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:2618"
                     /db_xref="HGNC:HGNC:4163"
                     /db_xref="MIM:138440"
     CDS             345..3377
                     /gene="GART"
                     /gene_synonym="AIRS; GARS; GARTF; PAIS; PGFT; PRGS"
                     /codon_start=1
                     /product="trifunctional purine biosynthetic protein
                     adenosine-3 isoform X1"
                     /protein_id="XP_011527828.1"
                     /db_xref="GeneID:2618"
                     /db_xref="HGNC:HGNC:4163"
                     /db_xref="MIM:138440"
                     /translation="MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEK
                     ISNTAISISDHTALAQFCKEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEAAQ
                     LESSKRFAKEFMDRHGIPTAQWKAFTKPEEACSFILSADFPALVVKASGLAAGKGVIV
                     AKSKEEACKAVQEIMQEKAFGAAGETIVIEELLDGEEVSCLCFTDGKTVAPMPPAQDH
                     KRLLEGDGGPNTGGMGAYCPAPQVSNDLLLKIKDTVLQRTVDGMQQEGTPYTGILYAG
                     IMLTKNGPKVLEFNCRFGDPECQVILPLLKSDLYEVIQSTLDGLLCTSLPVWLENHTA
                     LTVVMASKGYPGDYTKGVEITGFPEAQALGLEVFHAGTALKNGKVVTHGGRVLAVTAI
                     RENLISALEEAKKGLAAIKFEGAIYRKDVGFRAIAFLQQPRSLTYKESGVDIAAGNML
                     VKKIQPLAKATSRSGCKVDLGGFAGLFDLKAAGFKDPLLASGTDGVGTKLKIAQLCNK
                     HDTIGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSVTEAVVAGIAKACGKAGCAL
                     LGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLPHLERITEGDVVVGIASSGLHSNGF
                     SLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTRIYSHSLLPVLRSGHVKAFAHIT
                     GGGLLENIPRVLPEKLGVDLDAQTWRIPRVFSWLQQEGHLSEEEMARTFNCGVGAVLV
                     VSKEQTEQILRDIQQHKEEAWVIGSVVARAEGSPRVKVKNLIESMQINGSVLKNGSLT
                     NHFSFEKKKARVAVLISGTGSNLQALIDSTREPNSSAQIDIVISNKAAVAGLDKAERA
                     GIPTRVINHKLYKNRVEFDSAIDLVLEEFSIDIVCLAGFMRILSGPFVQKWNGKMLNI
                     HPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAEDVDAGQIILQEAVPVKRGDTVATL
                     SERVKLAEHKIFPAALQLVASGTVQLGENGKICWVKEE"
ORIGIN      
        1 ggtgctgacg tttgcgccgc gcacgactat gtccgccatg ttagtgtctg acgcaggcgc
       61 cattacagga gccgtctctc ttgaggcgac cgtgtccgca taagttgtca gtccccagca
      121 gtgtttggga gccttaacag gcttgctaag tgcctgagat taaaggcgaa gaggaagaag
      181 agcaagaagg gcaacccggt gtttaacaca cggctttcag gcgctctcag gtggcgccaa
      241 gttcagtttc gacagggata tgcatccggg agagaatttt tcagcccccg cccccactgg
      301 catgtttcat tttcctttgg aatttctgct ttacagacag aacaatggca gcccgagtac
      361 ttataattgg cagtggagga agggaacata cgctggcctg gaaacttgca cagtctcatc
      421 atgtcaaaca agtgttggtt gccccaggaa acgcaggcac tgcctgctct gaaaagattt
      481 caaataccgc catctcaatc agtgaccaca ctgcccttgc tcaattctgc aaagagaaga
      541 aaattgaatt tgtagttgtt ggaccagaag cacctctggc tgctgggatt gttgggaacc
      601 tgaggtctgc aggagtgcaa tgctttggcc caacagcaga agcggctcag ttagagtcca
      661 gcaaaaggtt tgccaaagag tttatggaca gacatggaat cccaaccgca caatggaagg
      721 ctttcaccaa acctgaagaa gcctgcagct tcattttgag tgcagacttc cctgctttgg
      781 ttgtgaaggc cagtggtctt gcagctggaa aaggggtgat tgttgcaaag agcaaagaag
      841 aggcctgcaa agctgtacaa gagatcatgc aggagaaagc ctttggggca gctggagaaa
      901 caattgtcat tgaagaactt cttgacggag aagaggtgtc gtgtctgtgt ttcactgatg
      961 gcaagactgt ggcccccatg cccccagcac aggaccataa gcgattactg gagggagatg
     1021 gtggccctaa cacaggggga atgggagcct attgtccagc ccctcaggtt tctaatgatc
     1081 tattactaaa aattaaagat actgttcttc agaggacagt ggatggcatg cagcaagagg
     1141 gtactccata tacaggtatt ctctatgctg gaataatgct gaccaagaat ggcccaaaag
     1201 ttctagagtt taattgccgt tttggtgatc cagagtgcca agtaatcctc ccacttctta
     1261 aaagtgatct ttatgaagtg attcagtcca ccttagatgg actgctctgc acatctctgc
     1321 ctgtttggct agaaaaccac accgccctaa ctgttgtcat ggcaagtaaa ggttatcctg
     1381 gagactacac caagggtgta gagataacag ggtttcctga ggctcaagct ctaggactgg
     1441 aggtgttcca tgcaggcact gccctcaaaa atggcaaagt agtaactcat gggggtagag
     1501 ttcttgcagt cacagccatc cgggaaaatc tcatatcagc ccttgaggaa gccaagaaag
     1561 gactagctgc tataaagttt gagggagcaa tttataggaa agacgtcggc tttcgtgcca
     1621 tagctttcct ccagcagccc aggagtttga cttacaagga atctggagta gatatcgcag
     1681 ctggaaatat gctggtcaag aaaattcagc ctttagcaaa agccacttcc agatcaggct
     1741 gtaaagttga tcttggaggt tttgctggtc tttttgattt aaaagcagct ggtttcaaag
     1801 atccccttct ggcctctgga acagatggcg ttggaactaa actaaagatt gcccagctat
     1861 gcaataaaca tgataccatt ggtcaagatt tggtagcaat gtgtgttaat gatattctgg
     1921 cacaaggagc agagcccctc ttcttccttg attacttttc ctgtggaaaa cttgacctca
     1981 gtgtaactga agctgttgtt gctggaattg ctaaagcttg tggaaaagct ggatgtgctc
     2041 tccttggagg tgaaacagca gaaatgcctg acatgtatcc ccctggagag tatgacctag
     2101 ctgggtttgc cgttggtgcc atggagcgag atcagaaact ccctcacctg gaaagaatca
     2161 ctgagggtga tgttgttgtt ggaatagctt catctggtct tcatagcaat ggatttagcc
     2221 ttgtgaggaa aatcgtggca aaatcttccc tccagtactc ctctccagca cctgatggtt
     2281 gtggtgacca gactttaggg gacttacttc tcacgcctac cagaatctac agccattcac
     2341 tgttacctgt cctacgttca ggacatgtca aagcctttgc ccatattact ggtggaggat
     2401 tactagagaa catccccaga gtcctccctg agaaacttgg ggtagattta gatgcccaga
     2461 cctggaggat ccccagggtc ttctcatggt tgcagcagga aggacacctc tctgaggaag
     2521 agatggccag aacatttaac tgtggggttg gcgctgtcct tgtggtatca aaggagcaga
     2581 cagagcagat tctgagggat atccagcagc acaaggaaga agcctgggtg attggcagtg
     2641 tggttgcacg agctgaaggt tccccacgtg tgaaagtcaa gaatctgatt gaaagcatgc
     2701 aaataaatgg gtcagtgttg aagaatggct ccctgacaaa tcatttctct tttgaaaaaa
     2761 aaaaggccag agtggctgtc ttaatatctg gaacaggatc gaacctgcaa gcacttatag
     2821 acagtactcg ggaaccaaat agctctgcac aaattgatat tgttatctcc aacaaagccg
     2881 cagtagctgg gttagataaa gcggaaagag ctggtattcc cactagagta attaatcata
     2941 aactgtataa aaatcgtgta gaatttgaca gtgcaattga cctagtcctt gaagagttct
     3001 ccatagacat agtctgtctt gcaggattca tgagaattct ttctggcccc tttgtccaaa
     3061 agtggaatgg aaaaatgctc aatatccacc catccttgct cccttctttt aagggttcaa
     3121 atgcccatga gcaagccctg gaaaccggag tcacagttac tgggtgcact gtacactttg
     3181 tagctgaaga tgtggatgct ggacagatta ttttgcaaga agctgttccc gtgaagaggg
     3241 gtgatactgt cgcaactctt tctgaaagag taaaattagc agaacataaa atatttcctg
     3301 cagcccttca gctggtggcc agtggaactg tacagcttgg agaaaatggc aagatctgtt
     3361 gggttaaaga ggaatgaagc cttttaattc agaaatgggg ccagtttaga aagaattatt
     3421 tgctgtttgc atggtggttt tttatcatgg acttggccca aaagaaaaac tgctaaaaga
     3481 caaaaaagac ctcaccctta cttcatctat ttttttaata aatagagact cactaaaaac
     3541 aagactagtt agtgcagcat atctgagaca
//
