LOCUS       NM_032293               3552 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens GTPase activating Rap/RanGAP domain like 3 (GARNL3),
            transcript variant 1, mRNA.
ACCESSION   NM_032293
VERSION     NM_032293.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3552)
  AUTHORS   Luykx,J.J., Bakker,S.C., Lentjes,E., Neeleman,M., Strengman,E.,
            Mentink,L., DeYoung,J., de Jong,S., Sul,J.H., Eskin,E., van
            Eijk,K., van Setten,J., Buizer-Voskamp,J.E., Cantor,R.M., Lu,A.,
            van Amerongen,M., van Dongen,E.P., Keijzers,P., Kappen,T.,
            Borgdorff,P., Bruins,P., Derks,E.M., Kahn,R.S. and Ophoff,R.A.
  TITLE     Genome-wide association study of monoamine metabolite levels in
            human cerebrospinal fluid
  JOURNAL   Mol Psychiatry 19 (2), 228-234 (2014)
   PUBMED   23319000
REFERENCE   2  (bases 1 to 3552)
  AUTHORS   Ferreira,M.A., O'Donovan,M.C., Meng,Y.A., Jones,I.R.,
            Ruderfer,D.M., Jones,L., Fan,J., Kirov,G., Perlis,R.H., Green,E.K.,
            Smoller,J.W., Grozeva,D., Stone,J., Nikolov,I., Chambert,K.,
            Hamshere,M.L., Nimgaonkar,V.L., Moskvina,V., Thase,M.E., Caesar,S.,
            Sachs,G.S., Franklin,J., Gordon-Smith,K., Ardlie,K.G.,
            Gabriel,S.B., Fraser,C., Blumenstiel,B., Defelice,M., Breen,G.,
            Gill,M., Morris,D.W., Elkin,A., Muir,W.J., McGhee,K.A.,
            Williamson,R., MacIntyre,D.J., MacLean,A.W., St,C.D., Robinson,M.,
            Van Beck,M., Pereira,A.C., Kandaswamy,R., McQuillin,A.,
            Collier,D.A., Bass,N.J., Young,A.H., Lawrence,J., Ferrier,I.N.,
            Anjorin,A., Farmer,A., Curtis,D., Scolnick,E.M., McGuffin,P.,
            Daly,M.J., Corvin,A.P., Holmans,P.A., Blackwood,D.H., Gurling,H.M.,
            Owen,M.J., Purcell,S.M., Sklar,P. and Craddock,N.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Collaborative genome-wide association analysis supports a role for
            ANK3 and CACNA1C in bipolar disorder
  JOURNAL   Nat Genet 40 (9), 1056-1058 (2008)
   PUBMED   18711365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK293732.1, DA183830.1, BC034983.2 and AL445222.9.
            
            On Nov 23, 2018 this sequence version replaced NM_032293.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.30622.1,
                                           SRR1803616.254804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373387.9/ ENSP00000362485.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AK293732.1         196-287
            93-204              DA183830.1         392-503
            205-3358            AK293732.1         400-3553
            3359-3441           BC034983.2         3266-3348
            3442-3552           AL445222.9         49344-49454
FEATURES             Location/Qualifiers
     source          1..3552
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     gene            1..3552
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /note="GTPase activating Rap/RanGAP domain like 3"
                     /db_xref="GeneID:84253"
                     /db_xref="HGNC:HGNC:25425"
     exon            1..248
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..3146
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /note="isoform a is encoded by transcript variant 1;
                     GTPase activating RANGAP domain-like 3; GTPase-activating
                     Rap/Ran-GAP domain-like protein 3"
                     /codon_start=1
                     /product="GTPase-activating Rap/Ran-GAP domain-like
                     protein 3 isoform a"
                     /protein_id="NP_115669.3"
                     /db_xref="CCDS:CCDS6869.2"
                     /db_xref="GeneID:84253"
                     /db_xref="HGNC:HGNC:25425"
                     /translation="MVVDFCRRFVARSLCIILMKHFCSSSVSEDLGCRRGDFSRKHYG
                     SVELLISSDADGAIQRAGRFRVENGSSDENATALPGTWRRTDVHLENPEYHTRWYFKY
                     FLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKT
                     LSVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDD
                     EMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIMF
                     HVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVR
                     YNQQNDNYRLKIFSEESVPLFGPPLPTPPVFTDHQEFRDFLLVKLINGEKATLETPTF
                     AQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFVRI
                     GQALKLKSIVRGDAPSSLAASGICKKEPWEPQCFCSNFPHEAVCADPWGQALLVSTDA
                     GVLLVDDDLPSVPVFDRTLPVKQMHVLETLDLLVLRADKGKDARLFVFRLSALQKGLE
                     GKQAGKSRSDCRENKLEKTKGCHLYAINTHHSRELRIVVAIRNKLLLITRKHNKPSGV
                     TSTSLLSPLSESPVEEFQYIREICLSDSPMVMTLVDGPAEESDNLICVAYRHQFDVVN
                     ESTGEAFRLHHVEANRVNFVAAIDVYEDGEAGLLLCYNYSCIYKKVCPFNGGSFLVQP
                     SASDFQFCWNQAPYAIVCAFPYLLAFTTDSMEIRLVVNGNLVHTAVVPQLQLVASRSD
                     IYFTATAAVNEVSSGGSSKGASARNSPQTPPGRDTPVFPSSLGEGEIQSKNLYKIPLR
                     NLVGRSIERPLKSPLVSKVITPPTPISVGLAAIPVTHSLSLSRMEIKEIASRTRRELL
                     GLSDEGGPKSEGAPKAKSKPRKRLEESQGGPKPGAVRSSSSDRIPSGSLESASTSEAN
                     PEGHSASSDQDPVADREGSPVSGSSPFQLTAFSDEDIIDLK"
     exon            249..323
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..423
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..542
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..607
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..671
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            672..698
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..774
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..873
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..977
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1086
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1132
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1239
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1355
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1460
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1535
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1647
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1746
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1863
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2039
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2198
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2265
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2373
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2492
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2631
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2847
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..2974
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3552
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3407..3412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /note="hexamer: AATAAA"
     polyA_site      3431
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /note="major polyA site"
     regulatory      3484..3489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /note="hexamer: ATTACA"
     polyA_site      3505
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
     regulatory      3526..3531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
                     /note="hexamer: AAGAAA"
     polyA_site      3552
                     /gene="GARNL3"
                     /gene_synonym="bA356B19.1"
ORIGIN      
        1 aggctctgca atggctgctg gggactgtgt ctgttgcaag gaggctcccc tgcagtgagg
       61 agccggggca ctgcaagtct gttccatagc agcccttttt gcaaatggta gttgattttt
      121 gcagaaggtt tgtggccaga tcgctatgta taatactgat gaagcatttt tgttccagct
      181 ctgtctcgga agacctaggc tgtagacgtg gggatttcag taggaaacat tatggatctg
      241 tggagctgct tatttccagt gatgctgatg gagccatcca aagggctgga agattcagag
      301 tggaaaatgg ctcttcagat gagaatgcaa ctgccctgcc tggtacttgg cgaagaacag
      361 acgtgcactt agagaaccca gaataccaca ccagatggta tttcaaatat tttttaggac
      421 aagtccatca gaactacatt ggaaacgatg ccgagaagag ccctttcttc ttgtccgtga
      481 ccctttctga ccaaaacaat caacgtgtcc ctcaataccg tgcaattctt tggagaaaaa
      541 caggtaccca gaaaatatgc cttccctaca gtcccacaaa aactctttct gtgaagtcca
      601 tcttaagtgc catgaatctg gacaaatttg agaaaggccc cagggaaatt tttcatcctg
      661 aaatacaaaa ggacttgctg gttcttgaag aacaagaggg ctctgtgaat ttcaagtttg
      721 gggttctttt tgccaaagat gggcagctca ctgatgatga gatgttcagc aatgaaattg
      781 gaagcgagcc ttttcaaaaa tttttaaatc ttctgggtga cacaatcact ctaaagggct
      841 ggacgggcta ccgtggcggt ctggatacca aaaatgatac cacagggata cattcagttt
      901 atactgtgta ccaagggcat gagatcatgt ttcatgtttc caccatgttg ccatattcca
      961 aagagaacaa acagcaggtg gaaaggaaac gccacattgg aaacgatatc gtcaccattg
     1021 tgttccaaga aggagaggaa tcttctcctg cctttaagcc ttccatgatc cgctcccact
     1081 ttacacatat ttttgcctta gtgagataca atcaacaaaa tgacaattac aggctgaaaa
     1141 tattttcaga agagagcgta ccactctttg gccctccctt gccaactcca ccagtgttta
     1201 cagaccacca ggaattcagg gactttttgc tagtgaaatt aattaatggt gaaaaagcca
     1261 ctttggaaac cccaacattt gcccagaaac gtcggcgtac cctggatatg ttgattagat
     1321 ctttacacca ggatttgatg ccagatttgc ataagaacat gcttaataga cgatctttta
     1381 gtgatgtctt accagagtca cccaagtcag cgcggaagaa agaggaggcc cgccaggcgg
     1441 agtttgttag aatagggcag gcactaaaac tgaaatccat tgtgagaggg gatgctccat
     1501 caagcttggc agcttcaggg atctgtaaaa aagagccgtg ggagccccag tgtttctgca
     1561 gtaatttccc tcatgaagcc gtgtgtgcag atccctgggg ccaggccttg ctggtttcca
     1621 ctgatgctgg cgtcttgcta gtggatgatg accttccatc agtgcccgtg tttgacagaa
     1681 ctctgccagt gaagcaaatg catgtgcttg agaccctgga ccttctggtt ctcagagcag
     1741 acaaaggaaa agatgctcgc ctctttgtct tcaggctaag tgctctgcaa aagggccttg
     1801 aggggaagca ggctgggaag agcaggtctg actgcagaga aaacaagttg gagaaaacaa
     1861 aaggctgcca cctgtatgct attaacactc accacagcag agagctgagg attgtggttg
     1921 caattcggaa taaactgctt ctgatcacaa gaaaacacaa caagccaagc ggggtcacca
     1981 gcacctcatt gttatctccc ctgtctgagt cacctgttga agaattccag tacatcaggg
     2041 agatctgtct gtctgactct cccatggtga tgaccttagt ggatgggcca gctgaagaga
     2101 gtgacaatct catctgtgtg gcttatcgac accaatttga tgtggtgaat gagagcacag
     2161 gagaagcctt caggctgcac cacgtggagg ccaacagggt taattttgtt gcagctattg
     2221 atgtgtacga agatggagaa gctggtttgc tgttgtgtta caactacagt tgcatctata
     2281 aaaaggtttg cccctttaat ggtggctctt ttttggttca accttctgcg tcagatttcc
     2341 agttctgttg gaaccaggct ccctatgcaa ttgtctgtgc tttcccgtat ctcctggcct
     2401 tcaccaccga ctccatggag atccgcctgg tggtgaacgg gaacctggtc cacactgcag
     2461 tcgtgccgca gctgcagctg gtggcctcca ggtcggatat atacttcaca gcaactgcag
     2521 ctgtgaatga ggtctcatct ggaggcagct ccaagggggc cagtgcccga aattctcctc
     2581 agacaccccc gggccgagat actccagtat ttccttcttc cctgggggaa ggtgaaattc
     2641 aatcaaaaaa tctgtacaag attccactta gaaacctcgt gggcagaagc atcgaacgac
     2701 ctctgaagtc acccttagtc tccaaggtca tcaccccacc cactcccatc agtgtgggcc
     2761 ttgctgccat tccagtcacg cactccttgt ccctgtctcg catggagatc aaagaaatag
     2821 caagcaggac ccgcagggaa ctactgggcc tctcggatga aggtggaccc aagtcagaag
     2881 gagcgccaaa ggccaaatca aaaccccgga agcggttaga agaaagccaa ggaggcccca
     2941 agccaggggc agtgaggtca tctagcagtg acaggatccc atcaggctcc ttggaaagtg
     3001 cttctacttc cgaagccaac cctgaggggc actcagccag ctctgaccag gaccctgtgg
     3061 cagacagaga gggcagcccg gtctccggca gcagcccctt ccagctcacg gctttctccg
     3121 atgaagacat tatagacttg aagtaacaga gttgaatctc atttgccatc tttagttttc
     3181 ttatggaggt ttatactctt taaacagttc tgatgtaatt tctcaacaaa atgtggcttt
     3241 tagcctgtca gtgatctatt ggaccaaacc ttctgcacac tcggccagtt ccctctccaa
     3301 tgtccggtgc catctttcct gacctttgtt tctttctgtt caggaaccat cagtcccctt
     3361 gtaataaagg tggtagattt cattgaggtt ttagattgaa actttgaata aatcaaaaat
     3421 actcattctt atttactgca accttctcat attttatata cttagatgga aaattatttt
     3481 ttcattacag ttttgattta tgtcacataa tgtgtttctt ttataaagaa aagtcgttgc
     3541 tttttaactt ta
//
