LOCUS       NM_001145402            3191 bp    mRNA    linear   PRI 21-FEB-2025
DEFINITION  Homo sapiens golgi associated RAB2 interactor family member 5B
            (GARIN5B), mRNA.
ACCESSION   NM_001145402 XR_040337 XR_040338 XR_040339
VERSION     NM_001145402.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3191)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 3191)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020922.9, AK127979.1, BC031875.1, KF573705.1 and AL834316.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001145402.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used were based
            on transcript alignments and orthologous data. The predicted exon
            combination, which lacks full-length support, shows the most
            probable protein-coding potential for this gene, but it has not
            been experimentally validated.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2158188 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000424985.3/ ENSP00000398617.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC020922.9         71536-71543         c
            9-19                AK127979.1         1-11
            20-302              BC031875.1         1-283
            303-344             AC020922.9         71200-71241         c
            345-499             AC020922.9         70861-71015         c
            500-758             AC020922.9         70528-70786         c
            759-783             AC020922.9         69693-69717         c
            784-848             AC020922.9         69457-69521         c
            849-952             AC020922.9         69283-69386         c
            953-1005            AC020922.9         69136-69188         c
            1006-1082           AC020922.9         68976-69052         c
            1083-2423           AC020922.9         66922-68262         c
            2424-2526           KF573705.1         6-108               c
            2527-2917           AC020922.9         66428-66818         c
            2918-3003           AC020922.9         63543-63628         c
            3004-3186           AC020922.9         63196-63378         c
            3187-3191           AL834316.1         1937-1941
FEATURES             Location/Qualifiers
     source          1..3191
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..3191
                     /gene="GARIN5B"
                     /gene_synonym="C19orf16; FAM71E2"
                     /note="golgi associated RAB2 interactor family member 5B"
                     /db_xref="GeneID:284418"
                     /db_xref="HGNC:HGNC:25278"
                     /db_xref="MIM:621103"
     exon            1..344
                     /gene="GARIN5B"
                     /gene_synonym="C19orf16; FAM71E2"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2963
                     /gene="GARIN5B"
                     /gene_synonym="C19orf16; FAM71E2"
                     /note="protein FAM71E2; putative protein FAM71E2; family
                     with sequence similarity 71 member E2; Golgi associated
                     RAB2 interactor protein 5B"
                     /codon_start=1
                     /product="Golgi-associated RAB2 interactor protein 5B"
                     /protein_id="NP_001138874.1"
                     /db_xref="GeneID:284418"
                     /db_xref="HGNC:HGNC:25278"
                     /db_xref="MIM:621103"
                     /translation="MIWLRNRRCLEPLQGTPKWVPVLGELQKTLQKGEYLPLRPLPMF
                     ESNFVQVTHQGGPVFVNHRTNRLAMGVAASLPGLVLPDILLIGQPAEDRDCSGLVLTR
                     MIPLDLVHLCVHDLSAWRLKLRLVSGRQYYLALDAPDNEVGFLFHCWVRLINLLQEPA
                     PTWTPRTTRTAPLDMPLAEAPASTWHLQDQPISRHAVRVAERNFPHKTVAAQRQRKAK
                     ALKRSFKSQAVGDSVPLIWSQLEHADVRKKPAEKKSHSDPRPDRTHTQIRLPEKTSIT
                     TWTIFSIISSTANQTQSSPKACTSASDEATGQGHVVESPSHCVSADSPDGFFLGSCSS
                     LDPCLWHQDTEDLMDSGGSTLSSAASGLAPYPPAACLSTPYSSIPRGREKAGPMGSHQ
                     GPGPPPCQKAPSGLVTSCKAPFLVDQSQKLPAVPASSWKPPPGLAPPQKAPAASAPPR
                     KAPAVPAPSQKAPAVPAPSQKAPAIPAPSRKASAASASPRKASAVPAPPQKTPPPSQK
                     APSVPTIPQKAVSPTAPKKKSLLLPAPSQKALPTSPTEYQMALSPPASRGKLPGDFDV
                     LPTGIPGRAVLERSQSGGKPEPVVTVRTQETDVVEMTTQAKSPESPFTVTKKESKDIL
                     ISQTKEVTLEAFRGQGKLEDWAHWAKLEERSPDLPGVRSKELEQRKRWVKAKELAVEG
                     PSQEHSRPFSVEALTLTKLMITANSKEQPSKSALVSLPSWLLATPQASATSMMASVPS
                     RPGQLSLLEGKPVVVREQPESHTWVKEGKRPWGEMKEQPWGEMKEPPWDPKGPPKVPF
                     RSKPTSASLKREGISQAPIPLTASPWEDLRPSPLSETLISKMEATARASQQPKRVSQE
                     PMRMPAQHPLATVGSSSEILLPMLLELETVRNTATKAEEIQEESGVLNLLPSLQHSQH
                     SEWPDAGA"
     exon            345..499
                     /gene="GARIN5B"
                     /gene_synonym="C19orf16; FAM71E2"
                     /inference="alignment:Splign:2.1.0"
     exon            500..758
                     /gene="GARIN5B"
                     /gene_synonym="C19orf16; FAM71E2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..783
                     /gene="GARIN5B"
                     /gene_synonym="C19orf16; FAM71E2"
                     /inference="alignment:Splign:2.1.0"
     exon            784..848
                     /gene="GARIN5B"
                     /gene_synonym="C19orf16; FAM71E2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..952
                     /gene="GARIN5B"
                     /gene_synonym="C19orf16; FAM71E2"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1005
                     /gene="GARIN5B"
                     /gene_synonym="C19orf16; FAM71E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1082
                     /gene="GARIN5B"
                     /gene_synonym="C19orf16; FAM71E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..2917
                     /gene="GARIN5B"
                     /gene_synonym="C19orf16; FAM71E2"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3003
                     /gene="GARIN5B"
                     /gene_synonym="C19orf16; FAM71E2"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3191
                     /gene="GARIN5B"
                     /gene_synonym="C19orf16; FAM71E2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3168..3173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GARIN5B"
                     /gene_synonym="C19orf16; FAM71E2"
                     /note="hexamer: ATTAAA"
     polyA_site      3191
                     /gene="GARIN5B"
                     /gene_synonym="C19orf16; FAM71E2"
                     /note="major polyA site"
ORIGIN      
        1 agacccctgc tgtccaccct ggcagggcca tggcggaggc ccgagtctcc cagcctgggg
       61 catctccacg ctctgtaacg ctgagctcca ggcacccgtg aagccccacg ggtcaaggct
      121 ggtgggccgg ggctgggagg cctgcacgcc tgggttctgg gtccctaaac cagtacccat
      181 ccaccacagc caccatgatc tggcttcgaa acaggaggtg ccttgagccg ctccagggca
      241 ccccgaagtg ggtccctgtt ctgggggagc tgcaaaagac cctccagaag ggcgagtacc
      301 tgcccctccg tccgctgccc atgttcgaga gtaactttgt tcaggtgacc catcaagggg
      361 gcccagtgtt cgtgaatcac agaaccaacc ggctggccat gggcgtggcc gcctccctgc
      421 caggcctggt gttgcctgac atcttgctga tcggccagcc cgccgaggac agggactgct
      481 ccggcctcgt gctgaccagg atgatccccc tggacctcgt ccacctctgc gtccatgacc
      541 tctctgcctg gcgcctgaag ctgcgcctgg tctcgggccg ccagtactac ctggccctgg
      601 acgcccctga caacgaggtg ggcttcctgt tccactgctg ggtccgcctc atcaacctgc
      661 ttcaggagcc ggctcccacc tggaccccca ggaccacgcg cacggccccc ctggatatgc
      721 cgctggccga agcgcctgcc tccacctggc acctgcagga ccagcccatc agcagacatg
      781 cagtcagggt tgctgagcgc aactttccgc ataagacggt ggctgctcag agacagagga
      841 aggccaaggc gctcaagcgc agtttcaagt ctcaggccgt gggcgactct gtgcccctca
      901 tctggtcgca gctggagcat gctgacgtca ggaagaaacc tgcagaaaag aagtcccact
      961 cagacccccg ccccgacaga actcacaccc aaatccgctt gcctgagaag accagcatca
     1021 ccacctggac catcttcagc atcatttcca gcaccgccaa ccagacacag tcctctccaa
     1081 aggcctgcac atctgcatct gatgaagcca caggccaggg acatgtggtt gagagccctt
     1141 cacactgtgt ctcagctgac agccctgatg gcttctttct gggctcctgc agctccctgg
     1201 acccgtgcct gtggcatcag gacacggaag acctcatgga ctctgggggc agcactttgt
     1261 cgtctgctgc ctccggtctg gctccctatc ccccggctgc ctgcctctcc acaccctact
     1321 cttccatccc caggggcagg gaaaaggccg ggcctatggg ctcccaccag gggccggggc
     1381 caccaccctg ccagaaggcc ccatctggcc ttgtcacatc ttgtaaggca ccgttccttg
     1441 ttgaccagtc ccagaagctc ccagctgtac ctgcttcatc gtggaaaccc ccacctggat
     1501 tggctcctcc ccagaaggcc ccagctgcgt cagctcctcc ccggaaggcc ccagctgtac
     1561 ctgctccatc ccagaaggcc ccagccgtac ctgctccatc ccagaaggcc ccagccatac
     1621 ctgctccatc ccggaaggcc tcagctgcgt cagcttctcc ccgaaaggcc tcagccgtac
     1681 ctgccccacc ccagaagacc ccacccccat ctcagaaggc cccatctgta cctaccattc
     1741 cccagaaggc tgtgtccccc actgctccaa agaagaaatc tctactcctc cctgccccat
     1801 cccagaaggc tctgccaacc tcacctaccg aataccagat ggcgctgagc ccgcctgcct
     1861 cacgggggaa gctccctggc gattttgacg tgttgccaac aggaattcct ggaagagccg
     1921 tgctggagag aagccagtct ggagggaaac cggagccggt ggtgacggtg cgcacccagg
     1981 agacagacgt ggtggagatg acgactcagg ccaagtcccc ggagtcgccc ttcaccgtga
     2041 ccaagaagga gtccaaggac atcctgatta gccaaaccaa ggaggtgacc ctggaggcct
     2101 tcaggggcca ggggaagttg gaggactggg cccactgggc gaagcttgaa gagaggtccc
     2161 cggacctgcc tggcgtgaga tccaaggagt tggagcagcg gaagagatgg gtcaaggcca
     2221 aggaactggc cgtcgagggc ccctcccagg agcacagcag gcccttctct gtggaagcgc
     2281 tcaccctcac caagctcatg atcacggcca actccaaaga gcagccctcg aaatccgctt
     2341 tggtctcact tccctcctgg ctcttggcga ctccgcaggc gtcggccacg tcaatgatgg
     2401 cttcagtgcc ctcccgcccc ggccagctgt ccttactgga ggggaagcca gtggtggtca
     2461 gagagcagcc agagtcgcac acctgggtga aggagggcaa gcggccatgg ggcgagatga
     2521 aggagcagcc atggggcgag atgaaggagc caccctggga ccccaagggg ccacccaagg
     2581 tgccctttcg ctccaagccc acctctgcca gtctgaagag ggaaggaatc tcccaggcgc
     2641 ctatccccct gaccgcctca ccgtgggagg acttacggcc atcgcccctc tcggagaccc
     2701 tcatctcaaa gatggaggcc acagccaggg cgtcccagca gcccaagagg gtgtcgcagg
     2761 agcccatgag gatgccagcc cagcaccccc tggccactgt ggggtcgtct tcagaaattc
     2821 ttttgcccat gctcttagaa cttgaaactg tgaggaacac ggccaccaag gcagaggaga
     2881 tacaggagga atcgggcgtc ttgaaccttc tgcccagcct gcagcactcc cagcactccg
     2941 agtggccgga tgcgggggct taacctcagt tggaaactgt ccagaggagc ccagcgctgc
     3001 caggccccga gggttctgtg cgcaccgact gtaggaagcg gaatgttgaa agccgcttgg
     3061 ggggatttgc cccctctggt agataccaga actatggata tgcctttata tattgggggg
     3121 cggggggggg cgggggcgag cccgtggagc cgcccaactt cgcagagatt aaagcttgag
     3181 cctgagactc a
//
