LOCUS       NM_001308429            1375 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens golgi associated RAB2 interactor 5A (GARIN5A),
            transcript variant 1, mRNA.
ACCESSION   NM_001308429 XM_005258472
VERSION     NM_001308429.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1375)
  AUTHORS   Takahama,M., Fukuda,M., Ohbayashi,N., Kozaki,T., Misawa,T.,
            Okamoto,T., Matsuura,Y., Akira,S. and Saitoh,T.
  TITLE     The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate
            Immune Responses
  JOURNAL   Cell Rep 20 (12), 2944-2954 (2017)
   PUBMED   28930687
  REMARK    GeneRIF: The RAB2B-GARIL5 complex promotes cytosolic DNA-induced
            innate immune responses (Golgi-associated Rab2B interactor-like 5 =
            GARIL5, also known as FAM71E1)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020909.9, BC071737.1 and AK131032.1.
            
            On May 17, 2019 this sequence version replaced NM_001308429.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA311163.1, AL513574.3 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000600100.6/ ENSP00000472421.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC020909.9         75053-75154         c
            103-643             BC071737.1         1-541
            644-1375            AK131032.1         1-732
FEATURES             Location/Qualifiers
     source          1..1375
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1375
                     /gene="GARIN5A"
                     /gene_synonym="FAM71E1; GARIL5"
                     /note="golgi associated RAB2 interactor 5A"
                     /db_xref="GeneID:112703"
                     /db_xref="HGNC:HGNC:25107"
                     /db_xref="MIM:619890"
     exon            1..719
                     /gene="GARIN5A"
                     /gene_synonym="FAM71E1; GARIL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             461..1204
                     /gene="GARIN5A"
                     /gene_synonym="FAM71E1; GARIL5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM71E1; GARI like 5; family with sequence
                     similarity 71 member E1; Golgi associated RAB2 interactor
                     protein 5A"
                     /codon_start=1
                     /product="Golgi-associated RAB2 interactor protein 5A
                     isoform 1"
                     /protein_id="NP_001295358.1"
                     /db_xref="CCDS:CCDS77337.1"
                     /db_xref="GeneID:112703"
                     /db_xref="HGNC:HGNC:25107"
                     /db_xref="MIM:619890"
                     /translation="MGPPLWPDLQEPPPPGTSSQIRSPLLCDVIKPAPHHDVTVRVVP
                     PPRFLPLLLRPLPSDGDIAMRRDRGPKPALGGAGEVEPGGMAASPTGRPRRLQRYLQS
                     GEFDQFRDFPIFESNFVQFCPDIYPAPTSDLWPQVTRLGEVANEVTMGVAASSPALEL
                     PDLLLLAGPAKENGHLQLFGLFPLKFVQLFVHDKSRCQLEVKLNTSRTFYLQLRAPLK
                     TRDREFGQWVRLLYRLRFLSASAVPFTQE"
     exon            720..820
                     /gene="GARIN5A"
                     /gene_synonym="FAM71E1; GARIL5"
                     /inference="alignment:Splign:2.1.0"
     exon            821..999
                     /gene="GARIN5A"
                     /gene_synonym="FAM71E1; GARIL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1207
                     /gene="GARIN5A"
                     /gene_synonym="FAM71E1; GARIL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1375
                     /gene="GARIN5A"
                     /gene_synonym="FAM71E1; GARIL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1349..1354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GARIN5A"
                     /gene_synonym="FAM71E1; GARIL5"
                     /note="hexamer: AATAAA"
     polyA_site      1375
                     /gene="GARIN5A"
                     /gene_synonym="FAM71E1; GARIL5"
                     /note="major polyA site"
ORIGIN      
        1 agtccttgca acccggtgca ctggcgaggc ccctcctgcg cgtgcgtgac tgaggcctgg
       61 ctttccaggg atctcccacc tcttccctct cagccctgcg cagcctcctt ccgtctgtaa
      121 ctcacctaaa gacccaagac ctgcgacatc cgtagaccgc gcccgctatg cacagctaaa
      181 gagcactcac ccctcgcgca ccagtcccgg cccggcagcc gctgccccgg gctcgactgg
      241 gcgctgctac cgccatcagc aagagcagga gcagccgggt tgccccagcg ctggctgccg
      301 ccatctcggc ttcttcccac cagcgaaggg acggctgtga gccaagagcc gcggagcacg
      361 ccgggaggaa caggccgcat cctgacgccc gtgcgcctgc gctgggcccc ggcacctgcg
      421 cactggcacc cgtccgcacc tggggcctga cgtcagcagg atggggccgc ccctttggcc
      481 tgatctccag gagccgcccc ctccagggac gtcatcacaa atcaggagcc cgctcttgtg
      541 tgacgtcata aagcccgctc cgcatcatga cgtcacagtg cgcgtagtcc cgccccctcg
      601 ctttctccct ctgctcctcc gtccgctccc gtcggacggg gacattgcaa tgaggcggga
      661 tcgcggccct aagccggccc tgggtggagc tggcgaggtg gaaccaggtg ggatggcagc
      721 ctctcccacg ggccgtccca gacggctcca acgctacctc cagagcggcg aattcgacca
      781 gtttcgggac ttccccatct ttgagagcaa cttcgtacag ttctgccccg acatctatcc
      841 tgccccgacc tctgacctct ggccccaggt gactcggttg ggagaagttg ccaacgaggt
      901 caccatgggg gtggcagcct ccagtccagc cctggagctc ccggacctat tgcttctggc
      961 cggccctgcc aaggagaacg gacacctgca actcttcggg ctgttcccct tgaagttcgt
     1021 ccagctcttt gtccacgaca aaagccggtg tcagctcgag gtcaagttga acaccagccg
     1081 caccttctac ttgcagctgc gggccccact caagacccga gaccgagagt tcggccagtg
     1141 ggtgcggctg ctctaccgcc tgcgcttcct ctctgcttct gctgtgccct tcacgcagga
     1201 gtaagagccc caaggcgtgg aagccagact tgaccccaag acctctgaac tctggggact
     1261 ctgagtcttc cagcatcctt caaggtcacc gaatgaccag agatcaaagt accttgcctc
     1321 agggccgggc agatgagata ttaaagttaa taaaggtcag tccattaaga accaa
//
