LOCUS       NM_153606               2302 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens golgi associated RAB2 interactor family member 4
            (GARIN4), mRNA.
ACCESSION   NM_153606
VERSION     NM_153606.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2302)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2302)
  AUTHORS   Aizawa,M. and Fukuda,M.
  TITLE     Small GTPase Rab2B and Its Specific Binding Protein
            Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi
            Morphology
  JOURNAL   J Biol Chem 290 (36), 22250-22261 (2015)
   PUBMED   26209634
  REMARK    GeneRIF: Data identified Golgi-associated Rab2B interactor-like 4
            (GARI-L4) as a novel Golgi-resident Rab2B-specific binding protein
            whose knockdown induced fragmentation of the Golgi
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK301981.1, DB031502.1,
            AK315021.1, DB509538.1 and AK057358.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_153606.3.
            
            Summary: This gene encodes a protein that interacts with the Rab2B
            small GTPase and may be important for integrity of the Golgi body.
            A knockdown of this gene induces fragmentation of the Golgi,
            similar to the effect seen with a knockdown of the Rab2B small
            GTPase. The encoded protein has an N-terminal Rab-binding domain
            specific for Rab2B. [provided by RefSeq, Feb 2017].
            
            ##Evidence-Data-START##
            Transcript is intronless :: HM005622.1, BC035007.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294829.5/ ENSP00000294829.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AK301981.1         29-102
            75-503              DB031502.1         75-503
            504-2054            AK315021.1         155-1705
            2055-2298           DB509538.1         188-431
            2299-2302           AK057358.1         1939-1942
FEATURES             Location/Qualifiers
     source          1..2302
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3"
     gene            1..2302
                     /gene="GARIN4"
                     /gene_synonym="FAM71A; GARI-L4; GARIL4"
                     /note="golgi associated RAB2 interactor family member 4"
                     /db_xref="GeneID:149647"
                     /db_xref="HGNC:HGNC:26541"
                     /db_xref="MIM:619852"
     exon            1..2302
                     /gene="GARIN4"
                     /gene_synonym="FAM71A; GARI-L4; GARIL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..2189
                     /gene="GARIN4"
                     /gene_synonym="FAM71A; GARI-L4; GARIL4"
                     /note="Golgi-associated Rab2B interactor-like 4; protein
                     FAM71A; testis secretory sperm-binding protein Li 209a;
                     family with sequence similarity 71 member A; Golgi
                     associated RAB2 interactor protein 4; GARI-like 4"
                     /codon_start=1
                     /product="Golgi-associated RAB2 interactor protein 4"
                     /protein_id="NP_705834.2"
                     /db_xref="CCDS:CCDS1507.1"
                     /db_xref="GeneID:149647"
                     /db_xref="HGNC:HGNC:26541"
                     /db_xref="MIM:619852"
                     /translation="MNADFLLPYYTAQSGSSMSMFNTTMGKLQRQLYKGEYDIFKYAP
                     IFESDFIQITKRGEVIDVHNRVRMVTMGIARTSPILPLPDVMLLARPATGCEEYAGHG
                     QATKRKKRKAAKNLELTRLLPLRFVRISVQDHEKQQLRLKFATGRSCYLQLCPALDTR
                     DDLFAYWEKLIYLLRPPMESNSSTCGIPAEDMMWMPVFQEDRRSLGAVNLQGKGDQDQ
                     VSIQSLHMVSEVCGATSAAYAGGEGLQNDFNKPTNVLNASIPKTSTELAEEPATGGIK
                     EAAAAGAAAGAATGTVAGALSVAAANSAPGQVSAAIAGAATIGAGGNKGNMALAGTAS
                     MAPNSTKVAVAGAAGKSSEHVSSASMSLSREGSVSLAIAGVVLTSRTAAEADMDAAAG
                     PPVSTRQSKSSLSGQHGRERTQASAEGCKEGRERREKDRALGRSSHRRRTGESRHKTR
                     GDKIAQKSSSRSSFSHRANRDDKKEKGCGNPGSSRHRDSHKGVSHTPISKESRTSHKS
                     GRSLWTTSSGSSKGLGRVSSFLRNVRANLTTKVVGTPHGRDVNVMAKMAERSTNVAIA
                     ETAEGGQGLETVGSMTPDIMETVTFEAH"
     regulatory      2280..2285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GARIN4"
                     /gene_synonym="FAM71A; GARI-L4; GARIL4"
                     /note="hexamer: AATAAA"
     polyA_site      2302
                     /gene="GARIN4"
                     /gene_synonym="FAM71A; GARI-L4; GARIL4"
                     /note="major polyA site"
ORIGIN      
        1 agagagggtc gtcacttcct gtcactagga ctacagtttg tagtctctct cagggagaga
       61 gactacaaac tgtaattaaa aaaatcagag gtggaggtca gggggttagg tccagaagaa
      121 aacctctctg gagcccaccc tgcatctcta cgtcttggaa gagtctggag tccaggcacc
      181 ctacagcacc ccccacagca atcatccgtg ctcccacccc caccccggcc tctgggaggc
      241 tctgaggcaa cagtgggggc ctgtggggtg gggtgggatt gagagaccag ctgcagagac
      301 atctttgtga cccaggagca ccactggtcc ctcatctgcc accgaggcca aggaagaccc
      361 agagacctgc ctcaccagtg ctgccgttgt gctgaaagac aaccatgaat gctgattttc
      421 tgctgccgta ttatacggcc cagagtggct ccagcatgag catgttcaac accaccatgg
      481 ggaaactgca gcgacaactg tacaaggggg agtacgatat attcaagtat gcaccgatat
      541 ttgagagcga ctttatccag atcaccaaaa ggggagaagt gattgatgtg cacaaccgtg
      601 tccgtatggt gaccatgggc attgcacgta ccagccccat cctcccactc ccagatgtca
      661 tgctactggc acgaccggcc accggctgcg aagagtatgc tggacatggc caggccacca
      721 agagaaaaaa acgcaaggca gcaaagaact tagagctcac caggcttctg cccctgaggt
      781 ttgtacggat ctctgttcaa gaccatgaga aacaacagct gcgcctgaag ttcgccactg
      841 gcagatcttg ctatctgcaa ttgtgtcccg ctcttgacac acgggatgac ctctttgcct
      901 attgggaaaa actaatttac ctcttgcggc cacccatgga gagtaacagc agtacctgtg
      961 gcattccagc tgaagacatg atgtggatgc ctgtgtttca ggaagacagg aggagcctgg
     1021 gagccgtgaa ccttcaagga aagggggatc aggaccaggt cagcatccaa agcctccaca
     1081 tggtctctga ggtgtgtggg gccacctctg ctgcttatgc tggaggggag ggactccaaa
     1141 atgactttaa caaacccact aatgtgctca atgcatccat ccccaaaaca tctacagaac
     1201 ttgctgagga gccagcaaca ggggggatta aagaggcagc agcagcaggg gcagctgcag
     1261 gggcagcaac aggcaccgta gcaggtgcct tgagtgtggc agcagccaat tctgcccctg
     1321 gacaggtgag cgcagccata gctggggcgg ccaccatcgg tgcaggagga aacaaaggca
     1381 acatggccct tgcaggcact gccagcatgg ctccaaacag cacgaaggtg gctgtggcag
     1441 gggctgcagg caagtcctca gagcatgttt ccagcgcatc catgagcctt tcccgagagg
     1501 gcagtgtgag cctggccatt gcaggagtag tactgaccag caggacagct gcagaagcag
     1561 acatggatgc agcagcggga cctcccgtct ccacccggca gagcaagagc agcctgagtg
     1621 gacagcatgg aagggagcga acccaggcca gcgctgaagg ctgcaaggag gggagggaaa
     1681 gaagggaaaa ggacagggct ctcggaagga gttcccatcg ccgcaggaca ggtgaaagcc
     1741 gccacaaaac aaggggagac aagattgccc aaaagtcctc cagcaggtcc tcattcagcc
     1801 acagagccaa tagagatgac aaaaaggaga aaggctgtgg caacccgggg agcagcaggc
     1861 acagggactc gcataaaggt gtcagccaca cgcccatctc aaaggagtcc aggacctctc
     1921 acaaatctgg gaggagctta tggaccacca gttccggttc cagcaaggga cttggcaggg
     1981 tcagctcttt cctgaggaac gtcagagcca accttactac aaaagtagtg ggcacaccac
     2041 atggcagaga tgtgaacgtc atggctaaga tggcggagag gagcaccaac gtggccatcg
     2101 ccgagacagc agagggtggc caggggctgg agacggttgg ttctatgaca ccggacatca
     2161 tggagacagt gacctttgaa gcccattaaa taagacccag agctggaagc tgcaaaggag
     2221 cccagagctc atgggagtgt ccctggaaag cctattccag cgttctttac tgccgtttaa
     2281 ataaagaatc atacatctga aa
//
