LOCUS       NM_001128926            5727 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens golgi associated RAB2 interactor 1A (GARIN1A),
            transcript variant 2, mRNA.
ACCESSION   NM_001128926
VERSION     NM_001128926.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5727)
  AUTHORS   Morohoshi,A., Miyata,H., Oyama,Y., Oura,S., Noda,T. and Ikawa,M.
  TITLE     FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome
            formation and male fertility in mice
  JOURNAL   Development 148 (21) (2021)
   PUBMED   34714330
REFERENCE   2  (bases 1 to 5727)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5727)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 5727)
  AUTHORS   Fukuda,M., Kanno,E., Ishibashi,K. and Itoh,T.
  TITLE     Large scale screening for novel rab effectors reveals unexpected
            broad Rab binding specificity
  JOURNAL   Mol Cell Proteomics 7 (6), 1031-1042 (2008)
   PUBMED   18256213
REFERENCE   5  (bases 1 to 5727)
  AUTHORS   Szafranski,K., Schindler,S., Taudien,S., Hiller,M., Huse,K.,
            Jahn,N., Schreiber,S., Backofen,R. and Platzer,M.
  TITLE     Violating the splicing rules: TG dinucleotides function as
            alternative 3' splice sites in U2-dependent introns
  JOURNAL   Genome Biol 8 (8), R154 (2007)
   PUBMED   17672918
  REMARK    GeneRIF: validated occurrence of an unusual TG 3' splice site in
            intron 1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY039605.1, BC105730.1 and AC018638.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001128926.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            acceptor splice site in the 5' coding region compared to variant 1.
            The resulting shorter isoform (b) lacks a 9 aa protein segment
            compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.179797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682356.1/ ENSP00000506740.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 HY039605.1         28-28
            2-1105              BC105730.1         1-1104
            1106-5727           AC018638.5         100252-104873       c
FEATURES             Location/Qualifiers
     source          1..5727
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..5727
                     /gene="GARIN1A"
                     /gene_synonym="FAM137B; FAM71F2; GARI"
                     /note="golgi associated RAB2 interactor 1A"
                     /db_xref="GeneID:346653"
                     /db_xref="HGNC:HGNC:27998"
                     /db_xref="MIM:619904"
     exon            1..259
                     /gene="GARIN1A"
                     /gene_synonym="FAM137B; FAM71F2; GARI"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1009
                     /gene="GARIN1A"
                     /gene_synonym="FAM137B; FAM71F2; GARI"
                     /note="isoform b is encoded by transcript variant 2;
                     family with sequence similarity 137, member B; protein
                     FAM71F2; Golgi-associated RAB2B interactor; family with
                     sequence similarity 71 member F2; Golgi associated RAB2
                     interactor protein 1A"
                     /codon_start=1
                     /product="Golgi-associated RAB2 interactor protein 1A
                     isoform b"
                     /protein_id="NP_001122398.1"
                     /db_xref="CCDS:CCDS47702.1"
                     /db_xref="GeneID:346653"
                     /db_xref="HGNC:HGNC:27998"
                     /db_xref="MIM:619904"
                     /translation="MSKIRGLPPEVREPGPGVELGVENGLLCQLIHSPEFNLFSNSVV
                     FESNFIQVTKPGNWRDVCEGSATVILGVTSSVPSLPLPNVLLMANVTWPQGPFTTWST
                     PGDAPVINLSRLLPLKYVELRIYDRLQRILRVRTVTEKIYYLKLHEKHPEIVFQFWVR
                     LVKILQKGLSITTKDPRIKFTHCLVPKMPTNSTETTPENSLLSSPQPSEPLVLLAAEQ
                     TSGSFSQLSGKPQLTADRNNDTAIEIDNCSSYKIPSPVASPINLNIPMRAALSHSLWE
                     QEDWNEHLLQVHIASYLGEHFLGA"
     exon            260..444
                     /gene="GARIN1A"
                     /gene_synonym="FAM137B; FAM71F2; GARI"
                     /inference="alignment:Splign:2.1.0"
     exon            445..694
                     /gene="GARIN1A"
                     /gene_synonym="FAM137B; FAM71F2; GARI"
                     /inference="alignment:Splign:2.1.0"
     exon            695..813
                     /gene="GARIN1A"
                     /gene_synonym="FAM137B; FAM71F2; GARI"
                     /inference="alignment:Splign:2.1.0"
     exon            814..5727
                     /gene="GARIN1A"
                     /gene_synonym="FAM137B; FAM71F2; GARI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1147..1152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GARIN1A"
                     /gene_synonym="FAM137B; FAM71F2; GARI"
                     /note="hexamer: AATAAA"
     polyA_site      1171
                     /gene="GARIN1A"
                     /gene_synonym="FAM137B; FAM71F2; GARI"
                     /note="major polyA site"
     regulatory      5699..5704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GARIN1A"
                     /gene_synonym="FAM137B; FAM71F2; GARI"
                     /note="hexamer: AATAAA"
     polyA_site      5727
                     /gene="GARIN1A"
                     /gene_synonym="FAM137B; FAM71F2; GARI"
                     /note="major polyA site"
ORIGIN      
        1 aggaaatgct ggggaggtgg gggcagatca catcaacatc ctggcattgg gctgggtcgg
       61 cgtggagccc cagaaatgtt cccaagccca ttcttaccaa gaaccaatga gtaaaatcag
      121 gggcctccca cctgaggtca gggaaccagg ccctggagtg gaacttgggg tggaaaatgg
      181 ccttctttgt caactgattc attctccaga attcaatttg ttctccaact cggtggtgtt
      241 tgaaagcaac tttatccagg tcactaagcc cgggaactgg agagatgtct gtgaagggtc
      301 tgccaccgtg atcctcgggg tcacctcctc ggtgccctcc ctgccactcc ccaatgtcct
      361 cctgatggcc aatgttacct ggccccaggg tccatttacc acctggagca cacctggtga
      421 cgccccagtc atcaacctca gcaggcttct ccccctgaag tacgtggagc tacgaatcta
      481 cgaccggctc cagcgcatcc tgagggttag gacagtgacc gaaaagatct actatctgaa
      541 gctccacgaa aaacacccag agattgtgtt tcaattctgg gtccgcttgg tgaaaattct
      601 gcagaaaggc ctgtccatca ccaccaaaga cccgagaatc aaattcactc actgcctggt
      661 gcccaagatg cccaccaact ccacagaaac aacacctgaa aacagcctcc tgtcatcccc
      721 ccagcccagc gagcccctcg tgctgctggc ggctgagcag accagtggca gtttctcaca
      781 gctctcagga aagccccagc tcacagcaga caggaacaat gacactgcca ttgaaataga
      841 caactgcagc agctacaaga taccctctcc agtggcatct ccaatcaatt tgaatatacc
      901 catgagagct gccttgagcc acagcctctg ggaacaagag gactggaatg agcaccttct
      961 acaagttcat atagccagtt acctaggaga gcacttcttg ggagcctgac acctaggcaa
     1021 aacatgctct tccttgcata cgtgtacttg ctaccacctc ttataatgct ccttttccac
     1081 tgtgagccaa gtgaccttgg gagaggtaag atggtgtttc caacaaggtg cttctctact
     1141 tccaccaata aacttccaag tgagtcccta atttttgcag gttgggctat agggaggctc
     1201 cagtttggga aaggactgac tgagaacagg agcagttttt ggaaaaatag gtgggaaaag
     1261 ttactgtctg tgtgtacaga gaactacctg agactgggta attttattta tttatttatt
     1321 tatttattta tttattttgg agatagagtc ttgctctgtc tccaggctgg agtacagtgg
     1381 tgcgatcatg gctcactgca acctccacct cctgggttca agcaattctc cagcctcagc
     1441 ctcccaagta gctgggacta caggcacaca ctacacctgg ctaagttttt atattttagt
     1501 agagatgggg tttcaccacg ttgcccaggc tggtctccag ctcctgagct caggccatcc
     1561 agtcacattg gcctctcaaa gggttaggat tacaggcgtg agccaccagg cccagcctcg
     1621 agtctgggta atttataaag aaaagaggtt taattggctc atggttcccc aggctgtaca
     1681 ggaagcatga ctggggaggc ctcaggaaac ttacaatcaa ggcagaaggc aaaagagaag
     1741 cagacctgtc ctacgagtct ggagcaggag aaagaaagaa gtgggaggtg ctatgcactt
     1801 ttaaacaacc aaatctcgtg agaactcact atcatgagaa cagcaaggag gaaatccacc
     1861 cccatgatcc aatcacctcc caccaggcac ctcctccaac actggggatt aaattcaaca
     1921 tgagatttgg gcagggagac agatccaaat catatatcag tctgctcagt tgaaaccaca
     1981 caatagccaa gcaaagccaa gaaagccagt ccaaggctgg cttggaaagg gcctctgagg
     2041 agaaatcaac tttcaaaggg gcagggggaa atagaggttg agctactgca agcccaaaat
     2101 aaaagaaatc ctgagaagga tggtaaccag ctggaagatt cctttgtgtt gctccactat
     2161 atcaagcaag aaattgagtc tttggctggg cgcggtggct cttgcctgta atcccagcac
     2221 tttgggaggc taaggtgtgc agatcacttg aggtcaggac ttcgagacca gcctggccaa
     2281 catggcaaag ccctgtctct acccaaaata caaaaattag ctggatgtgg tggtgcacac
     2341 ctgtagtccc agctactcag gaggttgagg caggagaatt gcttgaacca ggaggcagag
     2401 cttgcagtga gctgggatca tgccactgtg ctccagcctg ggtgacagag ccagactcca
     2461 tctcaaaaaa aaaaaaaaaa aaaaaaagaa taaattaggt cttcattgcc ctgtgttagt
     2521 gtaaagctat gaaggctccc ctggctcata caacatttca ttgctaatga aaacatggtg
     2581 aggaagatat tgactgccca tcaccagaaa ttctgattaa tttgactgtt tcttacccag
     2641 aacctaatga aagtgaactg gaagacatgg catctttgag tattgggaat ggggtaggag
     2701 ctttggccaa cctttataca catagggaat acttacaagg aaaataccat gactcctttt
     2761 tttttttttt tgagacagtc ttgttctgtt gcctaggctg gagtgcagtg gtgtgatctc
     2821 agctcactgc aacctccacc tctcaggttc aagcgattct tgtgcctcag cctcccaagt
     2881 agctgggatt acaggtgtga accaccagtc cggctaattt ttgtattttt agcagacaca
     2941 gggtttctcc atgttggcca ggctggtttt gatctcctga cctcaggtta tccaccctcc
     3001 tcggcctccc aaagtgctgg gattacaggc atgagccacc acgcccagcc ccaccacgcc
     3061 cactccaata tttaataagt atttgtcagg ctcctgctag gtgctagaca ctgcgtttga
     3121 cgctaagtat attggagaga acaagacaga cggacaagtt acctgccttg agggagggtc
     3181 tgggagagat gccaagtcct attttggaga catagtgaag ccattaatgt tgacctgatg
     3241 tctgagccac ccagtctgca aatgaaagct ggaggccctg ctttccagca tgtgtggttc
     3301 acatcctatg tggtgcagaa agaaagaaca tggttgccct cctcttgtgc atgctcagtt
     3361 gggctgagca gtcaaatctg gctgaattga gtcagaaaag acatctgagt taagaggatg
     3421 cctgatgctt gttggttttg tcttgcctcc agtaaaatta aaaacaagtt tcctttcagt
     3481 atgttacaat caaataagct gagcattgtt ggtgctggtg agggacatct agaagctgaa
     3541 cttagaaaag actaatgtgc agggtgattg tacttccaaa tgcatgcctg ttgtcctggt
     3601 atcattatta atacataccc atttcactct gagaagtgtc cctcagtgaa tcacaaatca
     3661 tgtggccatc ctatctatat ggcatactta taaacattga aaggcttgtc atccccactt
     3721 ctttgtcttg gtttaagcct tcatcagccc tcacctagac tattgtatta atagtaaccc
     3781 caggccaggc atggtggctc aggcctgtaa tcccagcact ttgggaggct gaggcgggca
     3841 gatcacgagg tcagaagttt gagaccagcc tggccaatat ggtgaaaccc catctctact
     3901 aaaaatacaa aaattagctg ggcatggtgg cgcacacctg tagtcccagc tactcgggag
     3961 gctgagacag aagaatctct tgaacctggg aggtggaggt tacagtgagc agagatggcg
     4021 ccaccgcact ccagcctggg cgacagagcc agattccgtc tcaaaataaa ataaagtaaa
     4081 atagtaaccc caattggtct cccagacttt atcatcatca tcatcataat agctaacatc
     4141 tttagaaatt tgctatcttc taagcactat gctgacttta caaagatcac ataaaccaca
     4201 ccacaagcca ttgagaagta gatcttatta ttacatttta taaatgataa accggagcca
     4261 cagagaggtt caagaacttg cttaaggtca cacaggtagt aagtagcaga gccaggactt
     4321 gaagccagtc tgtctaactc caaaatccaa attactcttg atgcctctcc aatgtcttcc
     4381 caactcattc ccttttcata cctctaacag agcaactttt tgacacataa atctgacaga
     4441 aaggaccagg cacggtggct catacctgta atcccagcac tttggaaggc caaggtgggc
     4501 agatcacttg aagtcagaag tttgagacca gcctggccaa catggtgaaa ccctgtctct
     4561 actaaaaatg tgaaaattag ccaggtgtgg tggtgcgcgt ctgtagtccc agctactcag
     4621 gaggctgagg caggagaatc tcttgaactg gggaggcaga ggttgcagtg agccgagatc
     4681 actccactgc gctctagcct gggcaacaga gcaagattcc atctcaaaaa aaaaaaaaat
     4741 atatctgact gagtttcctc cttaataaaa ccagaccctt tgacatgaaa tgactagacc
     4801 cctgcctctc tctccagcct ctccactggc cactgctgcc atagaatctt atgctcccac
     4861 catgccaaat ttcttgtggt tccctaaatg cgccatgttt gaagatactt tgaggacatt
     4921 gtatatactt ttgttctacc tgagatacat ttgcttactt tctccacata ttgccctcat
     4981 gacacttatc cttattgatg gatttcttca atgctactat tgtgccttac atgtgccttg
     5041 tattatagca tttttatagc atttctcacc caattgtggc tatttgttta catgtctgtc
     5101 tccttggtgg aactgtgaac tctgtcataa cagatgccat tttatgtcag ttagacttct
     5161 ttggttgcca gtaagagaag ctgactctaa tctaaaccaa aaggaattca ttggacggat
     5221 gtgggttggc tcacaaaatc aaagggacaa ctgcggagcc gatcttggaa tgctctgaca
     5281 ccagaacagc tctgtgaatt cagatagggg tagtgaattg accatttcat caaatgctgc
     5341 agcaagctag gtggtttccc caaaggaaat tgaggagtgt tacaagaaga ccattagggg
     5401 aacggttatc tggtggctga taataacaaa tttccatggc agtctctttg ctctctgttg
     5461 gaagaggtac tccaccatgg gccttgagca tctctacaca tccttgctaa gcgtgtcaaa
     5521 tttcaagtcc taactgtcct ctgtctctgg aggaggagac aggtttggtt actgtttgtt
     5581 gtaaaaatta ctgagccctt caccatgggt gcctcagctg tatgcaaagc cccttgtatt
     5641 gctgggggac agagcaactg gtactgccat gctggtgctc tggctgtttg ctgttggcaa
     5701 taaactattc tgttttggtt cattgaa
//
