LOCUS       XM_011532566            3932 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens GRB2 associated regulator of MAPK1 subtype
            2 (GAREM2), transcript variant X3, mRNA.
ACCESSION   XM_011532566
VERSION     XM_011532566.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011532566.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3932
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..3932
                     /gene="GAREM2"
                     /gene_synonym="FAM59B; GAREML"
                     /note="GRB2 associated regulator of MAPK1 subtype 2;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 6 ESTs, 251 long SRA reads, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 1 sample with support for all
                     annotated introns"
                     /db_xref="GeneID:150946"
                     /db_xref="HGNC:HGNC:27172"
                     /db_xref="MIM:617999"
     CDS             259..2526
                     /gene="GAREM2"
                     /gene_synonym="FAM59B; GAREML"
                     /codon_start=1
                     /product="GRB2-associated and regulator of MAPK protein 2
                     isoform X2"
                     /protein_id="XP_011530868.1"
                     /db_xref="GeneID:150946"
                     /db_xref="HGNC:HGNC:27172"
                     /db_xref="MIM:617999"
                     /translation="MEAITFSVKVVSGEFSEDSEVYNFTLHAGDELTLMGQAEILCAK
                     TTKERSRFTTLLRKLGRAGALAGVGGGGPASAGAAGGTGGGGARPVKGKMPCLICMNH
                     RTNESLSLPFQCQGRFSTRSPLELQMQEGEHTVRAIIERVRLPVNVLVPSRPPRNPYD
                     LHPVREGHCYKLVSIISKTVVLGLALRREGPAPLHFLLLTDTPRFALPQGLLAGDPRV
                     ERLVRDSASYCRERFDPDEYSTAVREAPAELAEDCASPRRARLCLPAPRAPGLARAPG
                     PLAPAPAGEGDQEYVSPDWAAAPEPAAPPAEIPYEELWAHQGPEGLVRPPPGLDLISF
                     GAAGPPRREPEAPPPPVPPKSEAVKEECRLLNAPPVPPRGGNGSGRLSSSPPVPPRFP
                     KLQPVHSPSSSLSYYSSGLQDGAGSRSGSGSPSPDTYSLYCYPCTWGDCKVGESSSRP
                     APGPLPSTTQPSQASRALTEPLSGRAASLLGADTPVKTYHSCPPLFKPSHPQKRFAPF
                     GALNPFSGPAYPSGPSAALSSGPRTTSGPVATSGPAYSPGPASPGQAYSAAPPSSCAP
                     SSSSSSEWQEPVLEPFDPFELGQGSSPEPELLRSQEPRAVGTPGPGPRLSPLGPSKAF
                     EPEGLVLHQVPTPLSPAALQGPEAGGALFLTQGRLEGPPASPRDGATGFGVRDASSWQ
                     PPADLSALSLEEVSRSLRFIGLSEDVVSFFARERIDGSIFVQLSEDILADDFHLTKLQ
                     VKKIMQFIKGWRPKI"
ORIGIN      
        1 tgacagctca taccctggag gagggccact atgtcatcgg gcccaagatc gacatccccc
       61 tgcagtaccc agatgatgaa acggaaggct tgggggagga ggtgacttgc cccgtgtcac
      121 acatctagga aaggaagagc ctggccagat ccagggaagt tcaagctcct ggaacaggcc
      181 cgggatgtgc gggagccagt gaggtacttc agcagcgtgg aggaggtggc cagtgtcttc
      241 cctgaccgca tcttcgtgat ggaagccatc accttcagcg tcaaggtggt gtcgggcgag
      301 ttcagcgagg acagcgaggt gtacaacttc acgctgcatg cgggcgacga gctcactctt
      361 atgggccagg cggagatcct gtgcgccaag accaccaagg agcgctcgcg cttcaccacc
      421 ctcctgcgaa agctgggccg ggccggggcg ctggccgggg tgggcggcgg cggcccagcg
      481 agcgcggggg ccgcgggagg cactggcggc gggggcgcca ggccggtcaa aggcaagatg
      541 ccctgcctca tctgcatgaa ccaccgcacc aacgaaagcc tgagcctgcc ctttcagtgc
      601 cagggccgct tcagcactcg cagcccgctg gagctgcaga tgcaagaggg cgagcacacg
      661 gtgcgcgcca tcatcgagcg cgtgaggctg ccggtgaacg tgctggtgcc cagccggccg
      721 ccgcgcaacc cctacgacct gcacccggtg cgggagggtc attgctacaa gctggttagc
      781 atcatctcca agacggtggt gctggggctg gcgctgcgcc gcgagggccc ggcgccgctg
      841 cacttcctgc tgctcacgga cacgccgcgc ttcgcgctgc cgcagggcct gctggccggg
      901 gacccgcgcg tcgagcgcct ggtgcgcgac agcgcctcct actgccgcga gcgcttcgac
      961 cccgacgagt actccacggc cgtgcgcgag gcgccagcgg agctcgccga agactgcgcc
     1021 agcccgcgcc gcgcgcgcct ctgcctgccc gcgccgcgcg cccccgggct cgcccgcgcc
     1081 cccggcccgc tagcgccggc tcccgccggc gagggcgacc aggagtacgt gagccccgac
     1141 tgggcagccg cgcccgagcc cgccgcgccg cccgccgaga tcccctacga ggagttgtgg
     1201 gcgcaccagg ggcccgaggg cctcgtccgg ccgcccccag ggctcgatct catctccttc
     1261 ggggccgcgg gaccgccgcg tcgggagccg gaagcgccgc cgcctccagt ccctcccaaa
     1321 tccgaggcgg tgaaggagga gtgccgcctg ctcaatgccc ctccagtgcc tccccggggt
     1381 ggcaatggca gcggccggct ctccagcagc cccccggttc cccctcgctt ccccaagctg
     1441 cagccggtac attcccccag ctccagcctc tcctactact cctctggcct ccaggatggg
     1501 gcgggttccc gcagtggcag tggctcccca tcgccggaca cctactccct ctattgctac
     1561 ccatgcacct ggggagactg caaggtgggc gagtcctcta gccgcccagc ccccggtccc
     1621 ctaccctcaa ccacacagcc cagccaggcc tcccgggccc tcacagagcc tctgagcggt
     1681 cgagccgcct cccttctggg ggctgacacc cctgttaaga cctaccacag ctgccctcct
     1741 ctattcaagc cctcacatcc ccagaagcgc tttgctccgt ttggagctct caaccctttt
     1801 tccgggcctg cctacccctc aggcccttca gcggccttgt cttctgggcc cagaaccacc
     1861 tcgggtcctg tggctacctc tggccctgcg tattccccag gcccagcctc gccaggccag
     1921 gcctattcag ctgctccccc ctcctcctgc gccccctcct cctcctcttc ttctgaatgg
     1981 caggaaccag tcctggagcc cttcgatccc tttgagctgg ggcagggcag ttctccagag
     2041 cctgagctgc tgcgttctca ggagcccaga gcagtgggga cacctgggcc tggaccccgc
     2101 ctttcaccac ttggcccctc caaggccttt gagcctgaag gtttggtgct gcaccaggtc
     2161 cccaccccac tgtcaccagc tgctctgcag ggacccgagg cgggaggagc actttttcta
     2221 acccaagggc gcctggaagg gcctcctgcc agtccccggg atggagccac aggctttgga
     2281 gtccgagatg cctcctcctg gcagccccct gctgacctgt ctgcactctc cctggaggag
     2341 gtctctcgca gtctgcgttt catcgggctc tcagaggatg tggtgagctt ctttgcccga
     2401 gaacgcatcg atggtagcat ctttgtgcag ctcagtgagg acatcctggc agatgacttc
     2461 cacctcacca agctgcaggt caagaagatc atgcagttca tcaaaggctg gaggcccaag
     2521 atctgaactg cccagctgga gctgcacagc tggaatgctg gtatgggggc cccaggtaca
     2581 gcactccgga ggagcaggtg ctgcctgcaa gaaggatcta tgtcgagact gaggctgctc
     2641 agcagccact gggtggatcc aggggagatg catgtggaaa tgtggtcctc tggggtcaga
     2701 cccctgcacg ggacatcttg cctttgagtg tgcagagtac atggggaagg ggctgggggc
     2761 accactgtgt acctgggccc agtaaggcat ttgccgtgat tcccacaacg gggtcaaaag
     2821 ctggccttca gggtgaccta acaccacctc atgccctgct atagaccttc acaaacgact
     2881 tccactgctg aagcctgtag gctctgttta gagacaagaa gatggctggt aatttaagca
     2941 ccgatttccc aagtgcccac tctcctttgt gctctgttgg cttttggcct aaagctgccc
     3001 cagagtgagg gtgtagatgt ctgtgtctgt gagatgcctt tcccttcccc ctctgctcca
     3061 ccgtggttga ggggggtggg gcctggcccc gcacacaggt gagtcgtgta caagcctaac
     3121 ccatggcacc tcagaggctc cacctgtggg tcctggttca tgggtgacaa ctttggaaga
     3181 gcacagctct gcaattgacc cgacccactt atctagttag gaagccagac actgcccaga
     3241 tgactctagc accctggctt ctgctctgac tttactgcag ctagtcatcc atccgtcagg
     3301 tggcgttcag tctcagaata ctgattccgt ggaagagcag gttgatttag gtcagcttct
     3361 ccttgattct agaagcaagc ggtagtcaac cacctccaat tccgccaatc tcttgccccc
     3421 atcatttgtc tctgacaata cttggtgttt ttccctggtt ttctgtcact ggcacaggag
     3481 ggtacagttg ggagagtgcg ttcctggagc tcagtcctgc atttgttcac gtgcctcaca
     3541 gcaggccttt gtgcccttga atctcaaaca tggggatctg cttggtaccc agagctctgg
     3601 tcattgtgtc caaccacaca ccccacccca tccgtgtcct ccatctcacc cagaaccaca
     3661 gggtgcccac tagtgtcagg gcccaaagtg ccagccttct cttctgcctt acctagtcta
     3721 cctatttatt tcctccactt tttatcttaa aagtagctaa gccatgctgg tgcccatact
     3781 ccaagcaggc tgcctcagct cagagaagtg gtcagagagt agagcacaga acctgtgatg
     3841 tggggacatt tggttttctt gcagatcatt taatgaatcc tcaaggacta atgaaataaa
     3901 tgctagactg ctgaagatga gtacaagtgg ca
//
