LOCUS       XM_006711951            3765 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens GRB2 associated regulator of MAPK1 subtype
            2 (GAREM2), transcript variant X4, mRNA.
ACCESSION   XM_006711951
VERSION     XM_006711951.5
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_006711951.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3765
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..3765
                     /gene="GAREM2"
                     /gene_synonym="FAM59B; GAREML"
                     /note="GRB2 associated regulator of MAPK1 subtype 2;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 2 mRNAs, 6 ESTs, 140 long SRA reads, 1
                     Protein, and 99% coverage of the annotated genomic feature
                     by RNAseq alignments, including 7 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:150946"
                     /db_xref="HGNC:HGNC:27172"
                     /db_xref="MIM:617999"
     CDS             134..2359
                     /gene="GAREM2"
                     /gene_synonym="FAM59B; GAREML"
                     /codon_start=1
                     /product="GRB2-associated and regulator of MAPK protein 2
                     isoform X3"
                     /protein_id="XP_006712014.1"
                     /db_xref="GeneID:150946"
                     /db_xref="HGNC:HGNC:27172"
                     /db_xref="MIM:617999"
                     /translation="MEKLAAGLAGLRWSMGAFPLDLIVSRCRLPTLACLGPGEYAEGV
                     SERDILLIHSCRQWTTVTAHTLEEGHYVIGPKIDIPLQYPGKFKLLEQARDVREPVRY
                     FSSVEEVASVFPDRIFVMEAITFSVKVVSGEFSEDSEVYNFTLHAGDELTLMGQAEIL
                     CAKTTKERSRFTTLLRKLGRAGALAGVGGGGPASAGAAGGTGGGGARPVKGKMPCLIC
                     MNHRTNESLSLPFQCQGRFSTRSPLELQMQEGEHTVRAIIERVRLPVNVLVPSRPPRN
                     PYDLHPVREGHCYKLVSIISKTVVLGLALRREGPAPLHFLLLTDTPRFALPQGLLAGD
                     PRVERLVRDSASYCRERFDPDEYSTAVREAPAELAEDCASPRRARLCLPAPRAPGLAR
                     APGPLAPAPAGEGDQEYVSPDWAAAPEPAAPPAEIPYEELWAHQGPEGLVRPPPGLDL
                     ISFGAAGPPRREPEAPPPPVPPKSEAVKEECRLLNAPPVPPRGGNGSGRLSSSPPVPP
                     RFPKLQPVHSPSSSLSYYSSGLQDGAGSRSGSGSPSPDTYSLYCYPCTWGDCKEPVLE
                     PFDPFELGQGSSPEPELLRSQEPRAVGTPGPGPRLSPLGPSKAFEPEGLVLHQVPTPL
                     SPAALQGPEAGGALFLTQGRLEGPPASPRDGATGFGVRDASSWQPPADLSALSLEEVS
                     RSLRFIGLSEDVVSFFARERIDGSIFVQLSEDILADDFHLTKLQVKKIMQFIKGWRPK
                     I"
ORIGIN      
        1 gcccgcggcc cggcggggct gccaggcggc gagcgccgcg gcggccccgg gaggtggcgg
       61 cgggcgcgag agcctgggcc gcgcgggact gaccgtcggg gccccgggac ggcggccccg
      121 gggcgcccat gccatggaga agctggcggc cgggctggcc ggcctgcgct ggagcatggg
      181 cgccttcccg ctcgacctca tcgtcagccg ctgccgcctg cccacgctcg cctgccttgg
      241 gccaggggag tacgccgagg gcgtcagtga gcgagacatc ctgctcatcc actcctgccg
      301 gcagtggaca acggtgacag ctcataccct ggaggagggc cactatgtca tcgggcccaa
      361 gatcgacatc cccctgcagt acccagggaa gttcaagctc ctggaacagg cccgggatgt
      421 gcgggagcca gtgaggtact tcagcagcgt ggaggaggtg gccagtgtct tccctgaccg
      481 catcttcgtg atggaagcca tcaccttcag cgtcaaggtg gtgtcgggcg agttcagcga
      541 ggacagcgag gtgtacaact tcacgctgca tgcgggcgac gagctcactc ttatgggcca
      601 ggcggagatc ctgtgcgcca agaccaccaa ggagcgctcg cgcttcacca ccctcctgcg
      661 aaagctgggc cgggccgggg cgctggccgg ggtgggcggc ggcggcccag cgagcgcggg
      721 ggccgcggga ggcactggcg gcgggggcgc caggccggtc aaaggcaaga tgccctgcct
      781 catctgcatg aaccaccgca ccaacgaaag cctgagcctg ccctttcagt gccagggccg
      841 cttcagcact cgcagcccgc tggagctgca gatgcaagag ggcgagcaca cggtgcgcgc
      901 catcatcgag cgcgtgaggc tgccggtgaa cgtgctggtg cccagccggc cgccgcgcaa
      961 cccctacgac ctgcacccgg tgcgggaggg tcattgctac aagctggtta gcatcatctc
     1021 caagacggtg gtgctggggc tggcgctgcg ccgcgagggc ccggcgccgc tgcacttcct
     1081 gctgctcacg gacacgccgc gcttcgcgct gccgcagggc ctgctggccg gggacccgcg
     1141 cgtcgagcgc ctggtgcgcg acagcgcctc ctactgccgc gagcgcttcg accccgacga
     1201 gtactccacg gccgtgcgcg aggcgccagc ggagctcgcc gaagactgcg ccagcccgcg
     1261 ccgcgcgcgc ctctgcctgc ccgcgccgcg cgcccccggg ctcgcccgcg cccccggccc
     1321 gctagcgccg gctcccgccg gcgagggcga ccaggagtac gtgagccccg actgggcagc
     1381 cgcgcccgag cccgccgcgc cgcccgccga gatcccctac gaggagttgt gggcgcacca
     1441 ggggcccgag ggcctcgtcc ggccgccccc agggctcgat ctcatctcct tcggggccgc
     1501 gggaccgccg cgtcgggagc cggaagcgcc gccgcctcca gtccctccca aatccgaggc
     1561 ggtgaaggag gagtgccgcc tgctcaatgc ccctccagtg cctccccggg gtggcaatgg
     1621 cagcggccgg ctctccagca gccccccggt tccccctcgc ttccccaagc tgcagccggt
     1681 acattccccc agctccagcc tctcctacta ctcctctggc ctccaggatg gggcgggttc
     1741 ccgcagtggc agtggctccc catcgccgga cacctactcc ctctattgct acccatgcac
     1801 ctggggagac tgcaaggaac cagtcctgga gcccttcgat ccctttgagc tggggcaggg
     1861 cagttctcca gagcctgagc tgctgcgttc tcaggagccc agagcagtgg ggacacctgg
     1921 gcctggaccc cgcctttcac cacttggccc ctccaaggcc tttgagcctg aaggtttggt
     1981 gctgcaccag gtccccaccc cactgtcacc agctgctctg cagggacccg aggcgggagg
     2041 agcacttttt ctaacccaag ggcgcctgga agggcctcct gccagtcccc gggatggagc
     2101 cacaggcttt ggagtccgag atgcctcctc ctggcagccc cctgctgacc tgtctgcact
     2161 ctccctggag gaggtctctc gcagtctgcg tttcatcggg ctctcagagg atgtggtgag
     2221 cttctttgcc cgagaacgca tcgatggtag catctttgtg cagctcagtg aggacatcct
     2281 ggcagatgac ttccacctca ccaagctgca ggtcaagaag atcatgcagt tcatcaaagg
     2341 ctggaggccc aagatctgaa ctgcccagct ggagctgcac agctggaatg ctggtatggg
     2401 ggccccaggt acagcactcc ggaggagcag gtgctgcctg caagaaggat ctatgtcgag
     2461 actgaggctg ctcagcagcc actgggtgga tccaggggag atgcatgtgg aaatgtggtc
     2521 ctctggggtc agacccctgc acgggacatc ttgcctttga gtgtgcagag tacatgggga
     2581 aggggctggg ggcaccactg tgtacctggg cccagtaagg catttgccgt gattcccaca
     2641 acggggtcaa aagctggcct tcagggtgac ctaacaccac ctcatgccct gctatagacc
     2701 ttcacaaacg acttccactg ctgaagcctg taggctctgt ttagagacaa gaagatggct
     2761 ggtaatttaa gcaccgattt cccaagtgcc cactctcctt tgtgctctgt tggcttttgg
     2821 cctaaagctg ccccagagtg agggtgtaga tgtctgtgtc tgtgagatgc ctttcccttc
     2881 cccctctgct ccaccgtggt tgaggggggt ggggcctggc cccgcacaca ggtgagtcgt
     2941 gtacaagcct aacccatggc acctcagagg ctccacctgt gggtcctggt tcatgggtga
     3001 caactttgga agagcacagc tctgcaattg acccgaccca cttatctagt taggaagcca
     3061 gacactgccc agatgactct agcaccctgg cttctgctct gactttactg cagctagtca
     3121 tccatccgtc aggtggcgtt cagtctcaga atactgattc cgtggaagag caggttgatt
     3181 taggtcagct tctccttgat tctagaagca agcggtagtc aaccacctcc aattccgcca
     3241 atctcttgcc cccatcattt gtctctgaca atacttggtg tttttccctg gttttctgtc
     3301 actggcacag gagggtacag ttgggagagt gcgttcctgg agctcagtcc tgcatttgtt
     3361 cacgtgcctc acagcaggcc tttgtgccct tgaatctcaa acatggggat ctgcttggta
     3421 cccagagctc tggtcattgt gtccaaccac acaccccacc ccatccgtgt cctccatctc
     3481 acccagaacc acagggtgcc cactagtgtc agggcccaaa gtgccagcct tctcttctgc
     3541 cttacctagt ctacctattt atttcctcca ctttttatct taaaagtagc taagccatgc
     3601 tggtgcccat actccaagca ggctgcctca gctcagagaa gtggtcagag agtagagcac
     3661 agaacctgtg atgtggggac atttggtttt cttgcagatc atttaatgaa tcctcaagga
     3721 ctaatgaaat aaatgctaga ctgctgaaga tgagtacaag tggca
//
