LOCUS       NM_001168241            4164 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens GRB2 associated regulator of MAPK1 subtype 2 (GAREM2),
            transcript variant 1, mRNA.
ACCESSION   NM_001168241 XR_041887 XR_041888 XR_041889
VERSION     NM_001168241.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4164)
  AUTHORS   Taniguchi,T., Tanaka,S., Ishii,A., Watanabe,M., Fujitani,N.,
            Sugeo,A., Gotoh,S., Ohta,T., Hiyoshi,M., Matsuzaki,H., Sakai,N. and
            Konishi,H.
  TITLE     A brain-specific Grb2-associated regulator of extracellular
            signal-regulated kinase (Erk)/mitogen-activated protein kinase
            (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of
            neuroblastoma cells by regulating Erk signaling
  JOURNAL   J Biol Chem 288 (41), 29934-29942 (2013)
   PUBMED   24003223
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011742.3, AB124552.1, CX759737.1 and AA736392.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001168241.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB124552.1, ERR3218371.375479.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000401533.7/ ENSP00000384593.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC011742.3         122877-122879
            4-1479              AB124552.1         1-1476
            1480-1480           AC011742.3         134984-134984
            1481-3305           AB124552.1         1478-3302
            3306-3456           CX759737.1         557-707
            3457-4145           AB124552.1         3454-4142
            4146-4164           AA736392.1         13-31               c
FEATURES             Location/Qualifiers
     source          1..4164
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..4164
                     /gene="GAREM2"
                     /gene_synonym="FAM59B; GAREML"
                     /note="GRB2 associated regulator of MAPK1 subtype 2"
                     /db_xref="GeneID:150946"
                     /db_xref="HGNC:HGNC:27172"
                     /db_xref="MIM:617999"
     exon            1..245
                     /gene="GAREM2"
                     /gene_synonym="FAM59B; GAREML"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..2758
                     /gene="GAREM2"
                     /gene_synonym="FAM59B; GAREML"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM59B; family with sequence similarity 59, member
                     B; GRB2-associated and regulator of MAPK1-like;
                     GRB2-associated and regulator of MAPK protein-like; GRB2
                     associated, regulator of MAPK1-like; GRB2 associated
                     regulator of MAPK1 2; GRB2-associated and regulator of
                     MAPK protein 2"
                     /codon_start=1
                     /product="GRB2-associated and regulator of MAPK protein 2
                     isoform 1"
                     /protein_id="NP_001161713.1"
                     /db_xref="CCDS:CCDS54336.1"
                     /db_xref="GeneID:150946"
                     /db_xref="HGNC:HGNC:27172"
                     /db_xref="MIM:617999"
                     /translation="MEKLAAGLAGLRWSMGAFPLDLIVSRCRLPTLACLGPGEYAEGV
                     SERDILLIHSCRQWTTVTAHTLEEGHYVIGPKIDIPLQYPGKFKLLEQARDVREPVRY
                     FSSVEEVASVFPDRIFVMEAITFSVKVVSGEFSEDSEVYNFTLHAGDELTLMGQAEIL
                     CAKTTKERSRFTTLLRKLGRAGALAGVGGGGPASAGAAGGTGGGGARPVKGKMPCLIC
                     MNHRTNESLSLPFQCQGRFSTRSPLELQMQEGEHTVRAIIERVRLPVNVLVPSRPPRN
                     PYDLHPVREGHCYKLVSIISKTVVLGLALRREGPAPLHFLLLTDTPRFALPQGLLAGD
                     PRVERLVRDSASYCRERFDPDEYSTAVREAPAELAEDCASPRRARLCLPAPRAPGLAR
                     APGPLAPAPAGEGDQEYVSPDWAAAPEPAAPPAEIPYEELWAHQGPEGLVRPPPGLDL
                     ISFGAAGPPRREPEAPPPPVPPKSEAVKEECRLLNAPPVPPRGGNGSGRLSSSPPVPP
                     RFPKLQPVHSPSSSLSYYSSGLQDGAGSRSGSGSPSPDTYSLYCYPCTWGDCKVGESS
                     SRPAPGPLPSTTQPSQASRALTEPLSGRAASLLGADTPVKTYHSCPPLFKPSHPQKRF
                     APFGALNPFSGPAYPSGPSAALSSGPRTTSGPVATSGPAYSPGPASPGQAYSAAPPSS
                     CAPSSSSSSEWQEPVLEPFDPFELGQGSSPEPELLRSQEPRAVGTPGPGPRLSPLGPS
                     KAFEPEGLVLHQVPTPLSPAALQGPEAGGALFLTQGRLEGPPASPRDGATGFGVRDAS
                     SWQPPADLSALSLEEVSRSLRFIGLSEDVVSFFARERIDGSIFVQLSEDILADDFHLT
                     KLQVKKIMQFIKGWRPKI"
     exon            246..386
                     /gene="GAREM2"
                     /gene_synonym="FAM59B; GAREML"
                     /inference="alignment:Splign:2.1.0"
     exon            387..517
                     /gene="GAREM2"
                     /gene_synonym="FAM59B; GAREML"
                     /inference="alignment:Splign:2.1.0"
     exon            518..1561
                     /gene="GAREM2"
                     /gene_synonym="FAM59B; GAREML"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1731
                     /gene="GAREM2"
                     /gene_synonym="FAM59B; GAREML"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..4164
                     /gene="GAREM2"
                     /gene_synonym="FAM59B; GAREML"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4127..4132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAREM2"
                     /gene_synonym="FAM59B; GAREML"
                     /note="hexamer: AATAAA"
     polyA_site      4164
                     /gene="GAREM2"
                     /gene_synonym="FAM59B; GAREML"
                     /note="major polyA site"
ORIGIN      
        1 gcccgcggcc cggcggggct gccaggcggc gagcgccgcg gcggccccgg gaggtggcgg
       61 cgggcgcgag agcctgggcc gcgcgggact gaccgtcggg gccccgggac ggcggccccg
      121 gggcgcccat gccatggaga agctggcggc cgggctggcc ggcctgcgct ggagcatggg
      181 cgccttcccg ctcgacctca tcgtcagccg ctgccgcctg cccacgctcg cctgccttgg
      241 gccaggggag tacgccgagg gcgtcagtga gcgagacatc ctgctcatcc actcctgccg
      301 gcagtggaca acggtgacag ctcataccct ggaggagggc cactatgtca tcgggcccaa
      361 gatcgacatc cccctgcagt acccagggaa gttcaagctc ctggaacagg cccgggatgt
      421 gcgggagcca gtgaggtact tcagcagcgt ggaggaggtg gccagtgtct tccctgaccg
      481 catcttcgtg atggaagcca tcaccttcag cgtcaaggtg gtgtcgggcg agttcagcga
      541 ggacagcgag gtgtacaact tcacgctgca tgcgggcgac gagctcactc ttatgggcca
      601 ggcggagatc ctgtgcgcca agaccaccaa ggagcgctcg cgcttcacca ccctcctgcg
      661 aaagctgggc cgggccgggg cgctggccgg ggtgggcggc ggcggcccag cgagcgcggg
      721 ggccgcggga ggcactggcg gcgggggcgc caggccggtc aaaggcaaga tgccctgcct
      781 catctgcatg aaccaccgca ccaacgaaag cctgagcctg ccctttcagt gccagggccg
      841 cttcagcact cgcagcccgc tggagctgca gatgcaagag ggcgagcaca cggtgcgcgc
      901 catcatcgag cgcgtgaggc tgccggtgaa cgtgctggtg cccagccggc cgccgcgcaa
      961 cccctacgac ctgcacccgg tgcgggaggg tcattgctac aagctggtta gcatcatctc
     1021 caagacggtg gtgctggggc tggcgctgcg ccgcgagggc ccggcgccgc tgcacttcct
     1081 gctgctcacg gacacgccgc gcttcgcgct gccgcagggc ctgctggccg gggacccgcg
     1141 cgtcgagcgc ctggtgcgcg acagcgcctc ctactgccgc gagcgcttcg accccgacga
     1201 gtactccacg gccgtgcgcg aggcgccagc ggagctcgcc gaagactgcg ccagcccgcg
     1261 ccgcgcgcgc ctctgcctgc ccgcgccgcg cgcccccggg ctcgcccgcg cccccggccc
     1321 gctagcgccg gctcccgccg gcgagggcga ccaggagtac gtgagccccg actgggcagc
     1381 cgcgcccgag cccgccgcgc cgcccgccga gatcccctac gaggagttgt gggcgcacca
     1441 ggggcccgag ggcctcgtcc ggccgccccc agggctcgat ctcatctcct tcggggccgc
     1501 gggaccgccg cgtcgggagc cggaagcgcc gccgcctcca gtccctccca aatccgaggc
     1561 ggtgaaggag gagtgccgcc tgctcaatgc ccctccagtg cctccccggg gtggcaatgg
     1621 cagcggccgg ctctccagca gccccccggt tccccctcgc ttccccaagc tgcagccggt
     1681 acattccccc agctccagcc tctcctacta ctcctctggc ctccaggatg gggcgggttc
     1741 ccgcagtggc agtggctccc catcgccgga cacctactcc ctctattgct acccatgcac
     1801 ctggggagac tgcaaggtgg gcgagtcctc tagccgccca gcccccggtc ccctaccctc
     1861 aaccacacag cccagccagg cctcccgggc cctcacagag cctctgagcg gtcgagccgc
     1921 ctcccttctg ggggctgaca cccctgttaa gacctaccac agctgccctc ctctattcaa
     1981 gccctcacat ccccagaagc gctttgctcc gtttggagct ctcaaccctt tttccgggcc
     2041 tgcctacccc tcaggccctt cagcggcctt gtcttctggg cccagaacca cctcgggtcc
     2101 tgtggctacc tctggccctg cgtattcccc aggcccagcc tcgccaggcc aggcctattc
     2161 agctgctccc ccctcctcct gcgccccctc ctcctcctct tcttctgaat ggcaggaacc
     2221 agtcctggag cccttcgatc cctttgagct ggggcagggc agttctccag agcctgagct
     2281 gctgcgttct caggagccca gagcagtggg gacacctggg cctggacccc gcctttcacc
     2341 acttggcccc tccaaggcct ttgagcctga aggtttggtg ctgcaccagg tccccacccc
     2401 actgtcacca gctgctctgc agggacccga ggcgggagga gcactttttc taacccaagg
     2461 gcgcctggaa gggcctcctg ccagtccccg ggatggagcc acaggctttg gagtccgaga
     2521 tgcctcctcc tggcagcccc ctgctgacct gtctgcactc tccctggagg aggtctctcg
     2581 cagtctgcgt ttcatcgggc tctcagagga tgtggtgagc ttctttgccc gagaacgcat
     2641 cgatggtagc atctttgtgc agctcagtga ggacatcctg gcagatgact tccacctcac
     2701 caagctgcag gtcaagaaga tcatgcagtt catcaaaggc tggaggccca agatctgaac
     2761 tgcccagctg gagctgcaca gctggaatgc tggtatgggg gccccaggta cagcactccg
     2821 gaggagcagg tgctgcctgc aagaaggatc tatgtcgaga ctgaggctgc tcagcagcca
     2881 ctgggtggat ccaggggaga tgcatgtgga aatgtggtcc tctggggtca gacccctgca
     2941 cgggacatct tgcctttgag tgtgcagagt acatggggaa ggggctgggg gcaccactgt
     3001 gtacctgggc ccagtaaggc atttgccgtg attcccacaa cggggtcaaa agctggcctt
     3061 cagggtgacc taacaccacc tcatgccctg ctatagacct tcacaaacga cttccactgc
     3121 tgaagcctgt aggctctgtt tagagacaag aagatggctg gtaatttaag caccgatttc
     3181 ccaagtgccc actctccttt gtgctctgtt ggcttttggc ctaaagctgc cccagagtga
     3241 gggtgtagat gtctgtgtct gtgagatgcc tttcccttcc ccctctgctc caccgtggtt
     3301 gaggggggtg gggcctggcc ccgcacacag gtgagtcgtg tacaagccta acccatggca
     3361 cctcagaggc tccacctgtg ggtcctggtt catgggtgac aactttggaa gagcacagct
     3421 ctgcaattga cccgacccac ttatctagtt aggaagccag acactgccca gatgactcta
     3481 gcaccctggc ttctgctctg actttactgc agctagtcat ccatccgtca ggtggcgttc
     3541 agtctcagaa tactgattcc gtggaagagc aggttgattt aggtcagctt ctccttgatt
     3601 ctagaagcaa gcggtagtca accacctcca attccgccaa tctcttgccc ccatcatttg
     3661 tctctgacaa tacttggtgt ttttccctgg ttttctgtca ctggcacagg agggtacagt
     3721 tgggagagtg cgttcctgga gctcagtcct gcatttgttc acgtgcctca cagcaggcct
     3781 ttgtgccctt gaatctcaaa catggggatc tgcttggtac ccagagctct ggtcattgtg
     3841 tccaaccaca caccccaccc catccgtgtc ctccatctca cccagaacca cagggtgccc
     3901 actagtgtca gggcccaaag tgccagcctt ctcttctgcc ttacctagtc tacctattta
     3961 tttcctccac tttttatctt aaaagtagct aagccatgct ggtgcccata ctccaagcag
     4021 gctgcctcag ctcagagaag tggtcagaga gtagagcaca gaacctgtga tgtggggaca
     4081 tttggttttc ttgcagatca tttaatgaat cctcaaggac taatgaaata aatgctagac
     4141 tgctgaagat gagtacaagt ggca
//
