LOCUS       NM_001304431            3079 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens GRB2 binding adaptor protein, transmembrane (GAPT),
            transcript variant 3, mRNA.
ACCESSION   NM_001304431 XM_005248467
VERSION     NM_001304431.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3079)
  AUTHORS   Claudio,J.O., Liew,C.C., Dempsey,A.A., Cukerman,E., Stewart,A.K.,
            Na,E., Atkins,H.L., Iscove,N.N. and Hawley,R.G.
  TITLE     Identification of sequence-tagged transcripts differentially
            expressed within the human hematopoietic hierarchy
  JOURNAL   Genomics 50 (1), 44-52 (1998)
   PUBMED   9628821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA008727.1 and AC008814.6.
            
            On Jun 2, 2019 this sequence version replaced NM_001304431.1.
            
            Transcript Variant: This variant (3) has an alternate splice site
            in the 5' UTR and encodes the same protein, compared to variant 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.136734.1,
                                           SRR1660805.324246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000502276.6/ ENSP00000423113.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               DA008727.1         1-558
            559-3079            AC008814.6         72593-75113         c
FEATURES             Location/Qualifiers
     source          1..3079
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..3079
                     /gene="GAPT"
                     /gene_synonym="C5orf29"
                     /note="GRB2 binding adaptor protein, transmembrane"
                     /db_xref="GeneID:202309"
                     /db_xref="HGNC:HGNC:26588"
                     /db_xref="MIM:620440"
     exon            1..107
                     /gene="GAPT"
                     /gene_synonym="C5orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            108..235
                     /gene="GAPT"
                     /gene_synonym="C5orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            236..3079
                     /gene="GAPT"
                     /gene_synonym="C5orf29"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..999
                     /gene="GAPT"
                     /gene_synonym="C5orf29"
                     /note="GRB2-binding transmembrane adaptor; growth factor
                     receptor-bound protein 2-binding adapter protein,
                     transmembrane; GRB2-binding adapter protein,
                     transmembrane"
                     /codon_start=1
                     /product="protein GAPT"
                     /protein_id="NP_001291360.1"
                     /db_xref="CCDS:CCDS3975.1"
                     /db_xref="GeneID:202309"
                     /db_xref="HGNC:HGNC:26588"
                     /db_xref="MIM:620440"
                     /translation="MSKSCGNNLAAISVGISLLLLLVVCGIGCVWHWKHRVATRFTLP
                     RFLQRRSSRRKVCTKTFLGPRIIGLRHEISVETQDHKSAVRGNNTHDNYENVEAGPPK
                     AKGKTDKELYENTGQSNFEEHIYGNETSSDYYNFQKPRPSEVPQDEDIYILPDSY"
     regulatory      2322..2327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAPT"
                     /gene_synonym="C5orf29"
                     /note="hexamer: AATAAA"
     polyA_site      2346
                     /gene="GAPT"
                     /gene_synonym="C5orf29"
                     /note="major polyA site"
     regulatory      3055..3060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAPT"
                     /gene_synonym="C5orf29"
                     /note="hexamer: ATTAAA"
     polyA_site      3079
                     /gene="GAPT"
                     /gene_synonym="C5orf29"
ORIGIN      
        1 aaggaagtaa cccaccaaag tgaaaaagag gaacaagttc taacccaatg caggtttaaa
       61 acataaccaa aagaacaaaa gagagagctt gacacaccaa tcttgaggtt atcacgctat
      121 aatagagaat ggactcatta atatgggatt acagaggaag gaatggttaa gaaaaagaca
      181 tggcctctga ctgctccaaa aaaggataag cagggcttca cagaagaggt gacagaaaag
      241 gaagtggaat ggaataaaat cccccaatac agtacaatta tacattaatg gctgtaatgt
      301 gaagagcatc acacacgaag agagccatct tccagaaata agtttataca ctctctcctc
      361 taattgcatc aggactttac cagataatgt tcttccagat ctgaaaagga aaatgcctaa
      421 aagagcttcc aaactcattt ttgaataata ctaggctaca aagaattaca ctgtgaattc
      481 attaagggta acaccaaatc actaaacagc actgtttgta cagaaatgtc gaaaagctgt
      541 ggaaataatt tagcggccat ttctgtagga atttcgcttc ttttactctt agtggtttgt
      601 ggaattgggt gtgtttggca ctggaaacac cgtgttgcca cacgatttac cttaccgagg
      661 tttttacaaa ggagaagcag caggagaaaa gtctgtacta aaacattctt gggcccccgc
      721 atcattggct taaggcatga aatctcagtt gaaacccaag accacaaatc tgctgtcagg
      781 ggaaataaca cacacgacaa ctatgaaaat gtggaagcag gtcctcccaa agctaaagga
      841 aaaaccgata aggaactata tgaaaacaca gggcagtcta atttcgagga gcatatctat
      901 ggaaatgaga catcttctga ctattataac ttccagaagc ctcgtccttc tgaagttcct
      961 caagatgaag atatatacat tcttccagat tcatattagc ttttcaaaat attgactttt
     1021 gttattggat gataaatatt cactgtaatt tttcaacagc aaagacaagg aatcaaacta
     1081 aatgttgatc aactgtagac tggataaaga aaatgtggta cacatacacc atagaatatt
     1141 atgcagccgt aaaaaaagaa caaaactaac atgggaacag aaaatcaaat accacatatt
     1201 ctcacttaaa agtgggagct aaataataag aacacatgga gagaaggaga ggaacaacag
     1261 acactggggc ctacttgagg gaggacagtg gaaggaggga gaggttcagg gaaaaaaaaa
     1321 atatcaggta ctatgcttag tacacacatg atgaaataat ctgtacacca aacccccaag
     1381 tcacaagtgt tcctacataa caaacctgaa catgtacccc tgaacataaa attataatta
     1441 aaatattaaa aataattcac tgtgattttt attgtactga tgccattctt aatcaagttc
     1501 tgataagtgg atggtctctg cctatctcca cctttctgaa tcctatgtgt atcgctgtgg
     1561 attaattcta gatatcttct ccaccctcct tgcaccagac taaatctgta ttatgtgata
     1621 ttgattcttc cttctaaata ttacccgtta tctctttcct ttatttctac cattatcttt
     1681 atctggctca gaattattgt cataggctcc taactgttcc tcctgcttct agtttctacc
     1741 cactcaatca attaccgatg gtgttgccag atttatcttc agaaaatatt cctaacagcc
     1801 acattatttc tttcacttaa aatgttttaa tgccccctct ttgcaaaaga cataataccc
     1861 ataatttgaa ctccaaaatt tatggttttc cacaattggt tccaattcac ttttccagtg
     1921 acttctctta ctatctctca tttctttgcc ttcagcagaa tcatcttaaa acctgccaaa
     1981 cttatccttc cttcacagct ttgcttttct gcctcttctc tcaagcctgc ttcagatcat
     2041 aagttcttcc acacatctcc tgaatcactc caaacccgca tttacctttt tattttctga
     2101 tataagcttt gatgcctctt caattcttag gacatttaaa catatgaatg ttgccacagc
     2161 attttattac ctagcttcat atgaaaatgt cttaaattcc cacctaaatg aaaagaaact
     2221 gcccaaatgc ctagaacatc acataaggca ctaaatgcct catgttttac tgacgggaat
     2281 tgaattgtac attttgctga gtagttttga gaaaaaaatc taataaattc atctgttatt
     2341 catccataca aggaatattt gttgtgtctt ctatctactt gctattgtgc tgtgcacctg
     2401 agggacatgg gttggtggag gggttacaaa attaaaaaga gagacatgga tcctgaacac
     2461 atacagtcta gtaggaaaga aaacatagta aacaaatgaa tacgatgctg ctcatgaagc
     2521 tatgatagct catctctaaa tccactcttt tatttgctcc tctgaattgc ttgacctggg
     2581 cctctgcaaa catttctttt gccaggtgga tccattctat tctctaccaa tagggggcac
     2641 taaggaagac cgaaaggcag taggaggcaa cagggaattg ctcctgccta ttctttctgt
     2701 tgcccccgca ggaatttatt gccatgtggt ttactccagc atcactggtt gtttgcagct
     2761 ttctagtttc ttccatcatt cccaggacca gcttctctgc aacctgtcag aagcaccagc
     2821 accagccagg tggcaccctc ccttagactc tgacagccag actctccttc aacctcctga
     2881 agtggtgcag gagacaagtg gtaccctcag agttctgcgt cccagcctgg cagggctcct
     2941 cctctgaggt ctggtaactc tcagccaaga ttgttacagt tactatctct gtggtacctg
     3001 tgtccccttt tttgtttttc catcctgcca atgcctgttt agccaattat ctatattaaa
     3061 ttctctctgt taaaacaaa
//
