LOCUS       NM_002045               1498 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens growth associated protein 43 (GAP43), transcript
            variant 2, mRNA.
ACCESSION   NM_002045
VERSION     NM_002045.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1498)
  AUTHORS   Li,D., Sun,Y., Ding,L., Fu,Y., Zhou,J., Yu,J.T. and Tan,L.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Associations of Growth-Associated Protein 43 with Cerebral
            Microbleeds: A Longitudinal Study
  JOURNAL   J Alzheimers Dis 97 (4), 1913-1922 (2024)
   PUBMED   38339928
  REMARK    GeneRIF: Associations of Growth-Associated Protein 43 with Cerebral
            Microbleeds: A Longitudinal Study.
REFERENCE   2  (bases 1 to 1498)
  AUTHORS   Lan,G., Du,J., Chen,X., Wang,Q., Han,Y. and Guo,T.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Association of APOE-epsilon4 and GAP-43-related presynaptic loss
            with beta-amyloid, tau, neurodegeneration, and cognitive decline
  JOURNAL   Neurobiol Aging 132, 209-219 (2023)
   PUBMED   37852045
  REMARK    GeneRIF: Association of APOE-epsilon4 and GAP-43-related
            presynaptic loss with beta-amyloid, tau, neurodegeneration, and
            cognitive decline.
REFERENCE   3  (bases 1 to 1498)
  AUTHORS   Yang,Y., Shi,W., Li,C., Li,L., Li,J., Chen,Y., Shi,Q., Xie,Z.,
            Wang,M., Zhang,H., Zhao,X., Chen,Y., Li,R., Liu,S., Ye,Z., Zhang,L.
            and Liang,X.
  TITLE     Growth associated protein 43 deficiency promotes podocyte injury by
            activating the calmodulin/calcineurin pathway under hyperglycemia
  JOURNAL   Biochem Biophys Res Commun 656, 104-114 (2023)
   PUBMED   36963347
  REMARK    GeneRIF: Growth associated protein 43 deficiency promotes podocyte
            injury by activating the calmodulin/calcineurin pathway under
            hyperglycemia.
REFERENCE   4  (bases 1 to 1498)
  AUTHORS   Watson,D.C., Bayik,D., Storevik,S., Moreino,S.S., Sprowls,S.A.,
            Han,J., Augustsson,M.T., Lauko,A., Sravya,P., Rosland,G.V.,
            Troike,K., Tronstad,K.J., Wang,S., Sarnow,K., Kay,K., Lunavat,T.R.,
            Silver,D.J., Dayal,S., Joseph,J.V., Mulkearns-Hubert,E.,
            Ystaas,L.A.R., Deshpande,G., Guyon,J., Zhou,Y., Magaut,C.R.,
            Seder,J., Neises,L., Williford,S.E., Meiser,J., Scott,A.J.,
            Sajjakulnukit,P., Mears,J.A., Bjerkvig,R., Chakraborty,A.,
            Daubon,T., Cheng,F., Lyssiotis,C.A., Wahl,D.R., Hjelmeland,A.B.,
            Hossain,J.A., Miletic,H. and Lathia,J.D.
  TITLE     GAP43-dependent mitochondria transfer from astrocytes enhances
            glioblastoma tumorigenicity
  JOURNAL   Nat Cancer 4 (5), 648-664 (2023)
   PUBMED   37169842
  REMARK    GeneRIF: GAP43-dependent mitochondria transfer from astrocytes
            enhances glioblastoma tumorigenicity.
REFERENCE   5  (bases 1 to 1498)
  AUTHORS   Krigers,A., Demetz,M., Moser,P., Kerschbaumer,J., Brawanski,K.R.,
            Fritsch,H., Thome,C. and Freyschlag,C.F.
  TITLE     Impact of GAP-43, Cx43 and actin expression on the outcome and
            overall survival in diffuse and anaplastic gliomas
  JOURNAL   Sci Rep 13 (1), 2024 (2023)
   PUBMED   36739296
  REMARK    GeneRIF: Impact of GAP-43, Cx43 and actin expression on the outcome
            and overall survival in diffuse and anaplastic gliomas.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1498)
  AUTHORS   Fantini,F. and Johansson,O.
  TITLE     Expression of growth-associated protein 43 and nerve growth factor
            receptor in human skin: a comparative immunohistochemical
            investigation
  JOURNAL   J Invest Dermatol 99 (6), 734-742 (1992)
   PUBMED   1281863
REFERENCE   7  (bases 1 to 1498)
  AUTHORS   Spencer,S.A., Schuh,S.M., Liu,W.S. and Willard,M.B.
  TITLE     GAP-43, a protein associated with axon growth, is phosphorylated at
            three sites in cultured neurons and rat brain
  JOURNAL   J Biol Chem 267 (13), 9059-9064 (1992)
   PUBMED   1533624
REFERENCE   8  (bases 1 to 1498)
  AUTHORS   Mercken,M., Lubke,U., Vandermeeren,M., Gheuens,J. and
            Oestreicher,A.B.
  TITLE     Immunocytochemical detection of the growth-associated protein B-50
            by newly characterized monoclonal antibodies in human brain and
            muscle
  JOURNAL   J Neurobiol 23 (3), 309-321 (1992)
   PUBMED   1385623
REFERENCE   9  (bases 1 to 1498)
  AUTHORS   Apel,E.D., Litchfield,D.W., Clark,R.H., Krebs,E.G. and Storm,D.R.
  TITLE     Phosphorylation of neuromodulin (GAP-43) by casein kinase II.
            Identification of phosphorylation sites and regulation by
            calmodulin
  JOURNAL   J Biol Chem 266 (16), 10544-10551 (1991)
   PUBMED   1828073
REFERENCE   10 (bases 1 to 1498)
  AUTHORS   Apel,E.D., Byford,M.F., Au,D., Walsh,K.A. and Storm,D.R.
  TITLE     Identification of the protein kinase C phosphorylation site in
            neuromodulin
  JOURNAL   Biochemistry 29 (9), 2330-2335 (1990)
   PUBMED   2140056
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA701390.1, AK313658.1,
            AK123311.1 and BX648458.1.
            
            On Jun 2, 2019 this sequence version replaced NM_002045.3.
            
            Summary: The protein encoded by this gene has been termed a
            'growth' or 'plasticity' protein because it is expressed at high
            levels in neuronal growth cones during development and axonal
            regeneration. This protein is considered a crucial component of an
            effective regenerative response in the nervous system.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) lacks an internal exon and has
            an upstream AUG start codon, as compared to variant 1. The
            resulting isoform 2 has a shorter and distinct N-terminus, as
            compared to variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1022853.1,
                                           SRR3476690.340416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305124.11/ ENSP00000305010.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                DA701390.1         207-303
            98-897              AK313658.1         1-800
            898-1436            AK123311.1         1363-1901
            1437-1498           BX648458.1         1711-1772
FEATURES             Location/Qualifiers
     source          1..1498
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.31"
     gene            1..1498
                     /gene="GAP43"
                     /gene_synonym="B-50; GAP-43; PP46"
                     /note="growth associated protein 43"
                     /db_xref="GeneID:2596"
                     /db_xref="HGNC:HGNC:4140"
                     /db_xref="MIM:162060"
     exon            1..210
                     /gene="GAP43"
                     /gene_synonym="B-50; GAP-43; PP46"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..897
                     /gene="GAP43"
                     /gene_synonym="B-50; GAP-43; PP46"
                     /note="isoform 2 is encoded by transcript variant 2;
                     neuromodulin; nerve growth-related peptide GAP43; axonal
                     membrane protein GAP-43; protein F1; calmodulin-binding
                     protein P-57; neural phosphoprotein B-50; neuron
                     growth-associated protein 43"
                     /codon_start=1
                     /product="neuromodulin isoform 2"
                     /protein_id="NP_002036.1"
                     /db_xref="CCDS:CCDS33830.1"
                     /db_xref="GeneID:2596"
                     /db_xref="HGNC:HGNC:4140"
                     /db_xref="MIM:162060"
                     /translation="MLCCMRRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRG
                     HITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPG
                     KAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP
                     AKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPK
                     ESARQDEGKEEEPEADQEHA"
     exon            211..808
                     /gene="GAP43"
                     /gene_synonym="B-50; GAP-43; PP46"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1498
                     /gene="GAP43"
                     /gene_synonym="B-50; GAP-43; PP46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1411..1416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAP43"
                     /gene_synonym="B-50; GAP-43; PP46"
                     /note="hexamer: AATAAA"
     polyA_site      1439
                     /gene="GAP43"
                     /gene_synonym="B-50; GAP-43; PP46"
                     /note="major polyA site"
     regulatory      1477..1482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAP43"
                     /gene_synonym="B-50; GAP-43; PP46"
                     /note="hexamer: AATAAA"
     polyA_site      1498
                     /gene="GAP43"
                     /gene_synonym="B-50; GAP-43; PP46"
                     /note="major polyA site"
ORIGIN      
        1 acagttgctg ctaactgccc tggtgtgtgt gagggagaga gagggaggga gggagagaga
       61 gcgcgctagc gcgagagagc gagtgagcaa gcgagcagaa aagaggtgga gaggggggga
      121 ataagaaaga gagagaagga aaggagagaa ggcaggaaga aggcaaggga cgagacaacc
      181 atgctgtgct gtatgagaag aaccaaacag gttgaaaaaa atgatgacga ccaaaagatt
      241 gaacaagatg gtatcaaacc agaagataaa gctcataagg ccgcaaccaa aattcaggct
      301 agcttccgtg gacacataac aaggaaaaag ctcaaaggag agaagaagga tgatgtccaa
      361 gctgctgagg ctgaagctaa taagaaggat gaagcccctg ttgccgatgg ggtggagaag
      421 aagggagaag gcaccactac tgccgaagca gccccagcca ctggctccaa gcctgatgag
      481 cccggcaaag caggagaaac tccttccgag gagaagaagg gggagggtga tgctgccaca
      541 gagcaggcag ccccccaggc tcctgcatcc tcagaggaga aggccggctc agctgagaca
      601 gaaagtgcca ctaaagcttc cactgataac tcgccgtcct ccaaggctga agatgcccca
      661 gccaaggagg agcctaaaca agccgatgtg cctgctgctg tcactgctgc tgctgccacc
      721 acccctgccg cagaggatgc tgctgccaag gcaacagccc agcctccaac ggagactggg
      781 gagagcagcc aagctgaaga gaacatagaa gctgtagatg aaaccaaacc taaggaaagt
      841 gcccggcagg acgagggtaa agaagaggaa cctgaggctg accaagaaca tgcctgaact
      901 ctaagaaatg gctttccaca tccccaccct cccctctcct gagcctgtct ctccctaccc
      961 tcttctcagc tccactctga agtcccttcc tgtcctgctc acgtctgtga gtctgtcctt
     1021 tcccacccac tagccctctt tctctctgtg tggcaaacat ttaaaaaaaa aaaaaaaaag
     1081 caggaaagat cccaagtcaa acagtgtggc ttaaacattt tttgtttctt ggtgttgtta
     1141 tggcaagttt ttggtaatga tgattcaatc attttgggaa attcttgcac tgtatccaag
     1201 ttatttgatc tggtgcgtgt ggccctgtgg gagtccactt tcctctctct ctctctctct
     1261 gttccaagtg tgtgtgcaat gttccgttca tctgaggagt ccaaaatatc gagtgaattc
     1321 aaaatcattt ttgttttcct ccttttcaat gtgatggaat gaacaaaaag gaaaaaattc
     1381 aaaaaaccca gtttgtttta aaaataaata aataaagcaa atgtgccaat tagcgtaaac
     1441 ttgcggctct aaggctcctt tttcaacccg aatattaata aatcatgaga gtaatcaa
//
