LOCUS       NM_003614               1147 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens galanin receptor 3 (GALR3), mRNA.
ACCESSION   NM_003614
VERSION     NM_003614.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1147)
  AUTHORS   Kiezun,J., Godlewski,J., Krazinski,B.E., Kozielec,Z. and Kmiec,Z.
  TITLE     Galanin Receptors (GalR1, GalR2, and GalR3) Expression in
            Colorectal Cancer Tissue and Correlations to the Overall Survival
            and Poor Prognosis of CRC Patients
  JOURNAL   Int J Mol Sci 23 (7), 3735 (2022)
   PUBMED   35409094
  REMARK    GeneRIF: Galanin Receptors (GalR1, GalR2, and GalR3) Expression in
            Colorectal Cancer Tissue and Correlations to the Overall Survival
            and Poor Prognosis of CRC Patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1147)
  AUTHORS   Lee,Y.N., Reyes-Alcaraz,A., Yun,S., Lee,C.S., Hwang,J.I. and
            Seong,J.Y.
  TITLE     Exploring the molecular structures that confer ligand selectivity
            for galanin type II and III receptors
  JOURNAL   PLoS One 15 (3), e0230872 (2020)
   PUBMED   32231393
  REMARK    GeneRIF: molecular structures that confer ligand selectivity for
            galanin type II and III receptors
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1147)
  AUTHORS   Sternberg,F., Vidali,S., Holub,B.S., Stockinger,J., Brunner,S.M.,
            Ebner,S., Koller,A., Trost,A., Reitsamer,H.A., Schwarzenbacher,D.,
            Lang,R. and Kofler,B.
  TITLE     Lack of Galanin Receptor 3 Alleviates Psoriasis by Altering
            Vascularization, Immune Cell Infiltration, and Cytokine Expression
  JOURNAL   J Invest Dermatol 138 (1), 199-207 (2018)
   PUBMED   28844939
  REMARK    GeneRIF: Study showed that galanin receptor 3 is present in
            endothelial cells in human and murine dermal vessels and is
            co-expressed with nestin in neo-vessels of psoriatic patients.
REFERENCE   4  (bases 1 to 1147)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   5  (bases 1 to 1147)
  AUTHORS   Barde,S., Ruegg,J., Prud'homme,J., Ekstrom,T.J., Palkovits,M.,
            Turecki,G., Bagdy,G., Ihnatko,R., Theodorsson,E., Juhasz,G.,
            Diaz-Heijtz,R., Mechawar,N. and Hokfelt,T.G.
  TITLE     Alterations in the neuropeptide galanin system in major depressive
            disorder involve levels of transcripts, methylation, and peptide
  JOURNAL   Proc Natl Acad Sci U S A 113 (52), E8472-E8481 (2016)
   PUBMED   27940914
  REMARK    GeneRIF: GAL and its receptor GALR3 are differentially methylated
            and expressed in brains of major depressive disorder subjects in a
            region- and sex-specific manner.
REFERENCE   6  (bases 1 to 1147)
  AUTHORS   Lapsys,N.M., Furler,S.M., Henderson,N.K., Dutton,J.L., Hort,Y.J.,
            Eisman,J.A., Shine,J. and Iismaa,T.P.
  TITLE     A polymorphism in the human GALR3 galanin receptor gene (GALNR3)
  JOURNAL   Mol Cell Probes 13 (4), 325-327 (1999)
   PUBMED   10441207
REFERENCE   7  (bases 1 to 1147)
  AUTHORS   Iismaa,T.P., Fathi,Z., Hort,Y.J., Iben,L.G., Dutton,J.L., Baker,E.,
            Sutherland,G.R. and Shine,J.
  TITLE     Structural organization and chromosomal localization of three human
            galanin receptor genes
  JOURNAL   Ann N Y Acad Sci 863, 56-63 (1998)
   PUBMED   9928159
REFERENCE   8  (bases 1 to 1147)
  AUTHORS   Kolakowski,L.F. Jr., O'Neill,G.P., Howard,A.D., Broussard,S.R.,
            Sullivan,K.A., Feighner,S.D., Sawzdargo,M., Nguyen,T., Kargman,S.,
            Shiao,L.L., Hreniuk,D.L., Tan,C.P., Evans,J., Abramovitz,M.,
            Chateauneuf,A., Coulombe,N., Ng,G., Johnson,M.P., Tharian,A.,
            Khoshbouei,H., George,S.R., Smith,R.G. and O'Dowd,B.F.
  TITLE     Molecular characterization and expression of cloned human galanin
            receptors GALR2 and GALR3
  JOURNAL   J Neurochem 71 (6), 2239-2251 (1998)
   PUBMED   9832121
REFERENCE   9  (bases 1 to 1147)
  AUTHORS   Smith,K.E., Walker,M.W., Artymyshyn,R., Bard,J., Borowsky,B.,
            Tamm,J.A., Yao,W.J., Vaysse,P.J., Branchek,T.A., Gerald,C. and
            Jones,K.A.
  TITLE     Cloned human and rat galanin GALR3 receptors. Pharmacology and
            activation of G-protein inwardly rectifying K+ channels
  JOURNAL   J Biol Chem 273 (36), 23321-23326 (1998)
   PUBMED   9722565
REFERENCE   10 (bases 1 to 1147)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF073799.1.
            
            On May 17, 2019 this sequence version replaced NM_003614.1.
            
            Summary: The neuropeptide galanin modulates a variety of
            physiologic processes including cognition/memory, sensory/pain
            processing, hormone secretion, and feeding behavior.  The human
            galanin receptors are G protein-coupled receptors that functionally
            couple to their intracellular effector through distinct signaling
            pathways.  GALR3 is found in many tissues and may be expressed as
            1.4-, 2.4-, and 5-kb transcripts [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF073799.1, AY587582.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249041.3/ ENSP00000249041.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1147              AF073799.1         1-1147
FEATURES             Location/Qualifiers
     source          1..1147
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..1147
                     /gene="GALR3"
                     /note="galanin receptor 3"
                     /db_xref="GeneID:8484"
                     /db_xref="HGNC:HGNC:4134"
                     /db_xref="MIM:603692"
     exon            1..384
                     /gene="GALR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1132
                     /gene="GALR3"
                     /note="galanin receptor, family member 3; GAL3-R; GALR-3"
                     /codon_start=1
                     /product="galanin receptor type 3"
                     /protein_id="NP_003605.1"
                     /db_xref="CCDS:CCDS13958.1"
                     /db_xref="GeneID:8484"
                     /db_xref="HGNC:HGNC:4134"
                     /db_xref="MIM:603692"
                     /translation="MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQ
                     PGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLI
                     YLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSY
                     YGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPA
                     GAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLAS
                     HCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCP
                     GDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE"
     exon            385..1147
                     /gene="GALR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1128..1133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALR3"
                     /note="hexamer: AATAAA"
     polyA_site      1147
                     /gene="GALR3"
                     /note="major polyA site"
ORIGIN      
        1 tcccaggtgc ccgtctgatg gggagatggc tgatgcccag aacatttcac tggacagccc
       61 agggagtgtg ggggccgtgg cagtgcctgt ggtctttgcc ctaatcttcc tgctgggcac
      121 agtgggcaat gggctggtgc tggcagtgct cctgcagcct ggcccgagtg cctggcagga
      181 gcctggcagc accacggacc tgttcatcct caacctggcg gtggctgacc tctgcttcat
      241 cctgtgctgc gtgcccttcc aggccaccat ctacacgctg gatgcctggc tctttggggc
      301 cctcgtctgc aaggccgtgc acctgctcat ctacctcacc atgtacgcca gcagctttac
      361 gctggctgct gtctccgtgg acaggtacct ggccgtgcgg cacccgctgc gctcgcgcgc
      421 cctgcgcacg ccgcgtaacg cccgcgccgc agtggggctg gtgtggctgc tggcggcgct
      481 cttctcggcg ccctacctca gctactacgg caccgtgcgc tacggcgcgc tggagctctg
      541 cgtgcccgcc tgggaggacg cgcgccgccg cgccctggac gtggccacct tcgctgccgg
      601 ctacctgctg cccgtggctg tggtgagcct ggcctacggg cgcacgctgc gcttcctgtg
      661 ggccgccgtg ggtcccgcgg gcgcggcggc ggccgaggcg cggcggaggg cgacgggccg
      721 cgcggggcgc gccatgctgg cggtggccgc gctctacgcg ctctgctggg gtccgcacca
      781 cgcgctcatc ctgtgcttct ggtacggccg cttcgccttc agcccggcca cctacgcctg
      841 ccgcctggcc tcacactgcc tggcctacgc caactcctgc ctcaacccgc tcgtctacgc
      901 gctcgcctcg cgccacttcc gcgcgcgctt ccgccgcctg tggccgtgcg gccgccgacg
      961 ccgccaccgt gcccgccgcg ccttgcgtcg cgtccgcccc gcgtcctcgg gcccacccgg
     1021 ctgccccgga gacgcccggc ctagcgggag gctgctggct ggtggcggcc agggcccgga
     1081 gcccagggag ggacccgtcc acggcggaga ggctgcccga ggaccggaat aaaccctgcc
     1141 gcctgga
//
