LOCUS       NM_001480              10749 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens galanin receptor 1 (GALR1), mRNA.
ACCESSION   NM_001480
VERSION     NM_001480.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10749)
  AUTHORS   Gu,S., Qian,S., Lin,S., Ye,D., Li,Q., Yang,J., Ying,X., Li,Z.,
            Tang,M., Wang,J., Chen,K. and Jin,M.
  TITLE     Promoter hypermethylation of GALR1 acts as an early epigenetic
            susceptibility event in colorectal carcinogenesis
  JOURNAL   J Hum Genet 67 (9), 519-525 (2022)
   PUBMED   35606503
  REMARK    GeneRIF: Promoter hypermethylation of GALR1 acts as an early
            epigenetic susceptibility event in colorectal carcinogenesis.
REFERENCE   2  (bases 1 to 10749)
  AUTHORS   Kiezun,J., Godlewski,J., Krazinski,B.E., Kozielec,Z. and Kmiec,Z.
  TITLE     Galanin Receptors (GalR1, GalR2, and GalR3) Expression in
            Colorectal Cancer Tissue and Correlations to the Overall Survival
            and Poor Prognosis of CRC Patients
  JOURNAL   Int J Mol Sci 23 (7), 3735 (2022)
   PUBMED   35409094
  REMARK    GeneRIF: Galanin Receptors (GalR1, GalR2, and GalR3) Expression in
            Colorectal Cancer Tissue and Correlations to the Overall Survival
            and Poor Prognosis of CRC Patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10749)
  AUTHORS   Ning,X.H., Qi,Y.Y., Wang,F.X., Li,S.C., Jia,Z.K. and Yang,J.J.
  TITLE     A Three Protein-Coding Gene Prognostic Model Predicts Overall
            Survival in Bladder Cancer Patients
  JOURNAL   Biomed Res Int 2020, 7272960 (2020)
   PUBMED   33150179
  REMARK    GeneRIF: A Three Protein-Coding Gene Prognostic Model Predicts
            Overall Survival in Bladder Cancer Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10749)
  AUTHORS   Randesi,M., Levran,O., van den Brink,W., Blanken,P., van Ree,J.M.,
            Ott,J. and Kreek,M.J.
  TITLE     Further evidence for the association of GAL, GALR1 and NPY1R
            variants with opioid dependence
  JOURNAL   Pharmacogenomics 21 (13), 903-917 (2020)
   PUBMED   32757697
  REMARK    GeneRIF: Further evidence for the association of GAL, GALR1 and
            NPY1R variants with opioid dependence.
REFERENCE   5  (bases 1 to 10749)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 10749)
  AUTHORS   Lorimer,D.D. and Benya,R.V.
  TITLE     Cloning and quantification of galanin-1 receptor expression by
            mucosal cells lining the human gastrointestinal tract
  JOURNAL   Biochem Biophys Res Commun 222 (2), 379-385 (1996)
   PUBMED   8670213
REFERENCE   7  (bases 1 to 10749)
  AUTHORS   Kask,K., Berthold,M., Kahl,U., Nordvall,G. and Bartfai,T.
  TITLE     Delineation of the peptide binding site of the human galanin
            receptor
  JOURNAL   EMBO J 15 (2), 236-244 (1996)
   PUBMED   8617199
REFERENCE   8  (bases 1 to 10749)
  AUTHORS   Walli,R., Schafer,H., Morys-Wortmann,C., Paetzold,G., Nustede,R.
            and Schmidt,W.E.
  TITLE     Identification and biochemical characterization of the human brain
            galanin receptor
  JOURNAL   J Mol Endocrinol 13 (3), 347-356 (1994)
   PUBMED   7534460
REFERENCE   9  (bases 1 to 10749)
  AUTHORS   Habert-Ortoli,E., Amiranoff,B., Loquet,I., Laburthe,M. and
            Mayaux,J.F.
  TITLE     Molecular cloning of a functional human galanin receptor
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9780-9783 (1994)
   PUBMED   7524088
REFERENCE   10 (bases 1 to 10749)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100863.2 and U23854.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 9, 2019 this sequence version replaced NM_001480.3.
            
            Summary: The neuropeptide galanin elicits a range of biological
            effects by interaction with specific G-protein-coupled receptors.
            Galanin receptors are seven-transmembrane proteins shown to
            activate a variety of intracellular second-messenger pathways.
            GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go
            family.  GALR1 is widely expressed in the brain and spinal cord, as
            well as in peripheral sites such as the small intestine and heart.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.80604.1, U23854.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299727.5/ ENSP00000299727.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-701               AC100863.2         140035-140735
            702-1701            U23854.1           1-1000
            1702-10749          AC100863.2         159040-168087
FEATURES             Location/Qualifiers
     source          1..10749
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q23"
     gene            1..10749
                     /gene="GALR1"
                     /gene_synonym="GALNR; GALNR1"
                     /note="galanin receptor 1"
                     /db_xref="GeneID:2587"
                     /db_xref="HGNC:HGNC:4132"
                     /db_xref="MIM:600377"
     exon            1..1367
                     /gene="GALR1"
                     /gene_synonym="GALNR; GALNR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             702..1751
                     /gene="GALR1"
                     /gene_synonym="GALNR; GALNR1"
                     /note="GAL1-R; GALR-1"
                     /codon_start=1
                     /product="galanin receptor type 1"
                     /protein_id="NP_001471.2"
                     /db_xref="CCDS:CCDS12012.1"
                     /db_xref="GeneID:2587"
                     /db_xref="HGNC:HGNC:4132"
                     /db_xref="MIM:600377"
                     /translation="MELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIF
                     ALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWV
                     LGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIW
                     ALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICF
                     CYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFP
                     LTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKES
                     KSRIDTPPSTNCTHV"
     exon            1368..1433
                     /gene="GALR1"
                     /gene_synonym="GALNR; GALNR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..10749
                     /gene="GALR1"
                     /gene_synonym="GALNR; GALNR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2968..2973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALR1"
                     /gene_synonym="GALNR; GALNR1"
                     /note="hexamer: ATTAAA"
     polyA_site      2994
                     /gene="GALR1"
                     /gene_synonym="GALNR; GALNR1"
                     /note="major polyA site"
     regulatory      10729..10734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALR1"
                     /gene_synonym="GALNR; GALNR1"
                     /note="hexamer: AATAAA"
     polyA_site      10749
                     /gene="GALR1"
                     /gene_synonym="GALNR; GALNR1"
                     /note="major polyA site"
ORIGIN      
        1 gttttcgcct ctcagttgca gcagagaagc ccctggcacc cgactctatc caccaccagg
       61 aagcctccca aaagagctct cgccctgtgg acgactcgga atccctggaa aagccgggag
      121 ggagtcggag gcgccagccc actggggagg tggcgctggg cgcgcgggat gcgcggggag
      181 ccttctctgc aggagccgca cagtgcactg ctgcgcgctg ggcagtgcgg ggaagcgccg
      241 cgggaaggag cggctccgag caacaggtgc agcacgcagc ccctccggga gccagggaaa
      301 accgccggcg aagatctgga gcggtaaggc ggagagaagg gtctttccac ctgcgcggct
      361 gcagccggcg gatccctctt cccaggctcc gtggtcgcgc agcgggcgga ggcgcccggg
      421 aaggggaccc cagtgctctc gagatcaccg tcccttcccg agaaggtcca gctccgggct
      481 cccgaaccca ccctctctca gaaggtcccg gcgcaaagac ggtgccacca ggcacggcca
      541 ccggatcccc gctcccgctg gctcgcgcct cgggggaagc tcagactcct aaactcgcac
      601 tctccgtgct ttgcgccggg acccctggcc acccccggcg cctactatcc cgccctccct
      661 ccccgcgcgc cccgccgctc gccgggacag ccccgcgggc catggagctg gcggtcggga
      721 acctcagcga gggcaacgcg agctggccgg agccccccgc cccggagccc gggccgctgt
      781 tcggcatcgg cgtggagaac ttcgtcacgc tggtggtgtt cggcctgatc ttcgcgctgg
      841 gtgtgctggg caacagccta gtgatcaccg tgctggcgcg cagcaagccg ggcaagccgc
      901 ggagcaccac caacctgttc atcctcaacc tgagcatcgc cgacctggcc tacctgctct
      961 tctgcatccc cttccaggcc accgtgtacg cgctgcccac ctgggtgctg ggcgccttca
     1021 tctgcaagtt catccactac ttcttcaccg tgtccatgct ggtgagcatc ttcaccctgg
     1081 ccgcgatgtc cgtggaccgc tacgtggcca tcgtgcactc gcggcgctcc tcctccctca
     1141 gggtgtcccg caacgcgctg ctgggcgtgg gctgcatctg ggcgctgtcc attgccatgg
     1201 cctcgcccgt ggcctaccac cagggcctct tccacccgcg cgccagcaac cagaccttct
     1261 gctgggagca gtggcccgac cctcgccaca agaaggccta cgtggtgtgc accttcgtct
     1321 tcggctacct gctgccgctc ctgctcatct gcttctgcta tgccaaggtc cttaatcact
     1381 tgcataaaaa gttgaagaac atgtcaaaga agtctgaagc atccaagaaa aagactgcac
     1441 agacagttct ggtggtggtt gtggtgtttg gaatctcctg gctgccgcac cacatcatcc
     1501 atctctgggc tgagtttgga gttttcccgc tgacgccggc ttccttcctc ttcagaatca
     1561 ccgcccactg cctggcgtac agcaattcct ccgtgaatcc tatcatttat gcatttctct
     1621 ctgaaaattt caggaaggcc tataaacaag tgttcaagtg tcacattcgc aaagattcac
     1681 acctgagtga tactaaagaa agtaaaagtc gaatagacac cccaccatca accaattgta
     1741 ctcatgtgtg ataaaagata gagtatcctt atggttgagt ttccatataa gtggaccaga
     1801 cacagaaaca aacagaatga gctagtaagc gatgctgcaa cttgttatct taacaagaat
     1861 tcaagtcgtt ttaattaaat cccacgtgtg ttaaaaagta ctttgatcca tttaggaaat
     1921 tcctaggtct agtgagaatt atttttcaat tttattttag ttctaaatta tgtttcagaa
     1981 acaaaagaca atgctgtaca gttttattcc tcttcagaca tgaaagggaa catatatatt
     2041 ccatatatat gttcaactct tcatagattg tgaactggcc catcaatatg gtcaggaata
     2101 tttgcagtct acattttaaa gccaatttat ttagaaaaaa aaatttgagc tttaattctt
     2161 taattttaag agaagtaata ttgtgaacta tgtattttaa aatatgatca tggacacaca
     2221 atgatgaatt ttttggccat ttacatagac atatctatta agtggaaaga aggctttctg
     2281 aagtctgttt gcacaggtgg catttgcttc caattgtagc tagcgcacag agctttggaa
     2341 gcctgtcatt atgagataca gtcggtttac ctcaggagtc aattcagtgt tgtactggtg
     2401 acctgggatg cagtagtagg cactgttgat tcaaatttat cctgtgaaac tggctttata
     2461 gagttaacaa aacagagtca gagaccactg tcttaacagt ggaagatgca aataagtttt
     2521 tgagaataaa actggatttt gaaattttac attagtactt gacaaaagtt ttcattttgc
     2581 cttgaatgga acctactaaa aagagagatg aaaaaaaatc agcgaggttg atgtagataa
     2641 taatttctat gggaccaaag actagacaga attcagtaag tcacatgaag taatggtcat
     2701 gcctgtacat aaagcatatt tcatgtttga tttagatgac attcaaaaaa aatcatggga
     2761 ctgaatatac ctggggtatc ctatcttgta caaatgcatg ctttttcatt aaatttgtaa
     2821 tgatgtttaa tgaacatttc caccaaacat tatttcctct aaaaatgtta atttggggtt
     2881 aaaaccatca ccatttgaat ttcaaatgta gttttcatga caattttata ttgatgtgtg
     2941 tttacaatga gaaaatggca tgaaaatatt aaattgtctt gtatcggaaa agtacttttc
     3001 agactgtaag actttgatat gttttaggag gcaacaaaag caagaagttt tttttttgtt
     3061 tgtttgttaa aaaggatttg gccaagcaca gtggctcatg cctgtaattc cagcactttg
     3121 ggaggtccag ctgtgtggaa tgtacttgag ctcaggagtt tgagaccagt gtgggcaaca
     3181 tggcaaaact cggtctctac taaaaataca aaaattagct gggtgtggtg gcgcacgcct
     3241 gtagtttcag ctactctgga ggctgatgtg ggggatcacc tgagcccggg aggtccagga
     3301 tgcagtcagt caagactgca ccactgcact tcagcctgga tgacagagta agactctgtc
     3361 taaaatatat atatatatgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtaatgtacc
     3421 tctgtgccaa atcagcactc cacatgaaac atcaaatttt agataaaaat gcaaacttga
     3481 cataagcctt tggcatgcta atttttttag ctcattcact tactttcact aatcatattt
     3541 cagtgactag tgtttacatt tgcaatgtta ttaataactc tctggataaa aggaaagaaa
     3601 aacgttagaa agattttgaa gtgatgtatt atgtttgttg actagaagaa gaaattgtgt
     3661 ttatgtgtaa gtgagggtct taaagaatat gtcctttgca tcgaatgttt tttgcacttt
     3721 attcaaatat ataggagcag aaaaatttta tcctgacgat gatacttcct gtgatttgtg
     3781 gaacttgaag ttgctgttgc aaactccaga acaacttctt tgggtgtgaa ctcacaaaac
     3841 tgtgtaaaga agtgccttct tgttgtgttt gagtttgcat gaatggaaat gatttcttgc
     3901 accatggcta tttctttgtt ttctccttct gatctgtaag catataaatg gaagtattta
     3961 aaaaaatact gtagctaatg ttgctatttt ctagaggcat gccgaaaatg tgctgtgcct
     4021 ttggtccttc ccagatgcta ctggcacgtc tgaagcttga ggcatggtac aaaaagtaat
     4081 agcttgcgct tgaaaccccc ccccccccgc cactttgcta aatgtaaatg ctaattgttg
     4141 cattttacag ttagatagga tatacttcct gcatattgtc attctaatca attcctctta
     4201 ctcagagttt tggctgagtc tacttctaaa acaaattttg atagggataa tgacatcttc
     4261 tgcaaagatc taaacctcta caaaattttc tgaataaaga gtttcagaag aactcgtaaa
     4321 cagaatgaaa ttaaccagag aagtatagga gtgtgttgcg tttgccaagc atctgcttcc
     4381 cagctagatt tccccctaat atacaatgac caattctgaa gcaccttctt ttccgtcact
     4441 aaataaagac agcttcccaa ggacacactt tttctcccag catcaggttg agggagaaat
     4501 attgcttata cctttgaagt caggctgctt gaaactcaca ttttcagttt acttcaaaga
     4561 aaactgatgc tttctaagca gatttggctg tctcagtgcc caaggcagct gttattttcc
     4621 taggcttttt gctttcacgt aaggagacag gctttgggat atttagtagc tgaaatgctt
     4681 gctgtttcac atgcataagc aaccatttca gtgtcctgct gatgaataca gtgatgtgga
     4741 tggaaacgtt ttcttgtcct atatcctggg gataggaaac agattctctg tgctcttctg
     4801 accgggtatg tactcagcaa catgggggac tgaggccatt ttctgaatac tttaggtaaa
     4861 ttacttttgc ttttaactaa attgttttat tttacacatt gggagtaaaa ccatttccgc
     4921 cccatcccaa tctcttgtgc ttttatcttt tttatcctaa ctcacttcta tccagatttc
     4981 ctctcgataa tatttaccac agataaattc atctttcagc gcagatataa caaatcagag
     5041 tggggaggag agatgcttaa ggaactgcat gagtcatgca aggctcagaa cttcttgtgg
     5101 ctcaactcga aatcatattg cattcctgca ttctcccaga tgctttgagg cagtgcagcg
     5161 atcattctaa tatgttaact gagacccaag atctcagcag gagaggacag cttatccaag
     5221 catccctttc cttttcagtc atggccatgg ctatctgtaa acaccaaaat gctcatgctg
     5281 aagcagcatt acattgagga aaataaccta ttgggcagct tcatcatgtt cttgctttaa
     5341 atgatttatc aaatacatgt atgtaaacta catagtcact aactgcgaaa atacatcaat
     5401 gtggctactt cctctggaaa gttactgtct aaaatttgta aattttaatc ttcactgttg
     5461 cacatatttt ccatgtctta aatttgtaag tgggtttcta tgaaaggtaa tcgtattctt
     5521 cttgaccatt aaaaatgttg catgtaaggc tatttctcaa gtagatgtta atgacttgtt
     5581 taattattga cttacttatt ttaaaagctg tatgtagtaa gaacaagtag gtggtttaaa
     5641 attcagatag ttacatgttg gcctggaaag aacaaaatta tgaaatggta attatatctg
     5701 attttattta accatatttt aatattttct cttttagaag tggaaaagtt gagcctgagg
     5761 aagaatttaa aatgcttaag acatctttga tgggggctgt atttgcatta ggcagaggtg
     5821 tctaaggaga gtgtatcgtg tattgtgatg cattagcagg atgttttgtt catcgacttg
     5881 tgaaagtgct gtggataata gatggtggtt tcttttctta gtgtggcagg ttcactcaca
     5941 ttcatgtttt tgactttagc tgccatcctg gggttctgag ggtagcatgt ctgtttgact
     6001 gggcaagacc ctcacatacc ttggcaggcc ctggctttcg tttctctgtg gtgcctggtg
     6061 ctactcacag ggctgactca cgggcagatg ctccccatcc ttccccatag gccctgttcc
     6121 cgcatccgat gattctcagg ttttgttcta ggtgcagaaa tagtgggaga ggccataatc
     6181 gtgaatgatg aataagaagg gaaggtgggg ccgggcatgt gacttatgcc tgtaatccca
     6241 gcactttggg aggccgaggc aggtggatca cctgaggtcg ggagttcgag accagcctga
     6301 ccaacatgga gaaaacccgt ctctactaaa aatacaaaaa ttagctgggg gcacacatgt
     6361 gtgatcccag ctactcagga ggttgaggca ggagaattgc ttgaacccgg gaggtggagg
     6421 ttgcaatgag cctagattgc accattgcac tccagcctgg gcaacaagag tgaaactctg
     6481 tctcaaaaaa ataaaaatta aaaaaaaaaa agaaggtggc cagtgagggt tttatctttg
     6541 tattcactgg aaataacctc agctgaattt tctctctgaa tcttttcaat gttggctcca
     6601 tttgccatac tcagacaatt gcttgaagag ctgaactgtt agctcaagat ttcgttggca
     6661 ctgttggata gaaagcctct ccttttctgc tggagaagag atttctcagg ccaagttgtg
     6721 tagctccaaa ttctccgcaa ttagagaagg cacagtaaag aaaagatccc ttgctgatgg
     6781 aatggactgg aactgagctc cactgtttaa atttttgact ctcaggtagt ggtgatcgtt
     6841 atggtaaccc atgaactcgg atgaatttcg gggcctgctg tgggttttct atgggacacc
     6901 atataccaca gtactgtatt tcaaaatatt ggatattgat tatgaacact ggaactattt
     6961 atgtgtcatc attccaaaga ccattgtgat ctatgaagct cctttatttg ctggctagat
     7021 tgtccaaaaa caagctcact tgtttttggg caatctagcc aaggtgtcac ataatggaga
     7081 aaaatgcaga tggtcctgtg gctggtgtga atgaagaatg acctgggccc aacatagaac
     7141 ttttccagta tggtgagcat caaagtaggc agacatccaa aagccaagtg aagggcagat
     7201 agatccccag gtgccaccca ggctctgcag gcaaagctct cagggcccca tttgtgtttg
     7261 tgtggcctgc actgtgtaag tgtcgttccc ctaggacttc tgcaatggga taccaaagat
     7321 gacgtgtaag gccttcagta tataatggac ttgtgccaag tacctaaggg ttcactgcct
     7381 tgtttgagga atcgcagagc atcatttctg attggttctt agagcctgca tcttgtacca
     7441 ctgggacttc tggagacctc tggggaccgt tgactatgct gggagggtgc agaaatgaag
     7501 ctgatggcag aagcaggctc ccagctcctc ttcttctgct cagccaggtg attcttacct
     7561 ccattggcct ttggatgtct gcgtaataat ttgttgagaa tcattagaga acaactaatc
     7621 caaaaaatct atcatccttt atttgtgttg actttctgat tatgccttca ttcactcttt
     7681 ttattactta tacacatgtc tgtttttatt cttccctact cttttcttaa agttggtcat
     7741 atttctacac ttgagatctt ccagtttctg tgaatgttga ggggttcaca aagtggcttg
     7801 gcctcagacc tctatatcct tgttgttctg tttggactta ggactttttt cctggctatc
     7861 ctgccaatac ttttccatct aacagaaacg caagcttcaa gagcaagtta tttttataac
     7921 agatcatgtg agcaattcct ccatagcatt ggttgtagaa caggtcagtt ggcatgtggc
     7981 ctcctgaggg ccttgcatgg ggttctggac ccagcggggg ccacatctct gagaattcgt
     8041 tccctgtggg tgtctggggt gcatcgttac ttctgagatg ttatgactca gcagatgaga
     8101 tttgtccgtc tgctcagtga gaggaattcc aatgctgggt cttgactccc gctgcaggga
     8161 gctctctggg cccgggcatg ttggatggag ttgtgatggg tgtgcctccc tcggacttac
     8221 tctggccagg aactgcatct gctcctctaa ggagatttga gcaggtgaat ggagtttctg
     8281 tcattcctgg tctagagttc atgtgtgaag gtcaaatata ggtggggact tggcagcaca
     8341 caactctgag tgaaagacac gatcagcgtg atagacaggt gtcttgctat gtgacttgcc
     8401 attgcggtca ctggttatac aaagtctctg tttagaaata gcaaagatcc aagaaagcag
     8461 aagagtgggg gtgggagtgg ggctaaatgt gttgctcttc agtggaaatc tgcccatttt
     8521 gttgaaaaga aaggaaacag ggtacacaaa tgctgtttgg gaacattgtg tcaggatcac
     8581 ctagctttga cgatgagagt gttttttaaa acggaaacca tgtcattttc cttctagaga
     8641 gaatttcctg gtatgtcaat gtagcttcag aaataggtct cagtgttctg gctcagggcg
     8701 aggttacaaa agaggcttcg gtagcgtcct caggcccgcg tgccctgtgt tcttaacagc
     8761 ctcatggggc ctagaggaac ttttacatgg tagacactga gtgaatacac agattcctag
     8821 atttgagata ttttcaaaat agggctagca tgtataaaga atcaaactta gtcattccat
     8881 tgaagtgaaa ttggattata atttagaaat atttataagc cagaaatggt tgtgtaaatg
     8941 ttagttttca tattttggtt ttctaagagt cacattttat tgccatatag cacaaaattt
     9001 gacaatgagg tatagaaatc caaaattttc ttgggtacaa ttgaacaaat cttttaatct
     9061 cttcagttct atctgcctaa gtgaggagag tagttgtgga gcattgtaga aaggataaaa
     9121 tgaacattag gatactgagg gtttggtctg aattctgttt tttcattgct actggaagtg
     9181 ctgtctttgg tatcctcatg catacaagaa ggatttggaa aatgtcagtg agtttgaaac
     9241 tggctgtaca gttgaatgag ctgggcagtt gaaagtaccc gtgatgctct ggccttacct
     9301 tagatcagag attcttatat tttatcaagc atcagaatca cctgcagagc ttgttgaatg
     9361 cagattgttg gccacatctc cagaatttct cattcagtag atttgggatg gagcccaacg
     9421 atttgcagct ggtccagaga ccaccttgtg agatctacta cctgatttaa ttggtttgaa
     9481 ggtgaaggtg gagtccaggc tttttaaaac agtgtctgta ttttcagagc agataaccaa
     9541 tcaaattgag cagatggtct tttaaagtct aagcttctat ggttctgtga aaaaaattgt
     9601 ttacatggaa tttaaatcat tcagaatttt tattgcttac attgatcaga tccataaaat
     9661 atctgtttaa ctattacatt accctagcta cagaaatttg taagttttca aaagcatgaa
     9721 ggagtttaat aacttgtaag actttcagag attgttataa tttttgcctc aaaaaaataa
     9781 aataaaatag cttggtggaa aagagcacct atgcattcaa tttgtttccc tcaaatgcta
     9841 agggttaaaa tagtactcaa aattgttaga tgtgaagttt tgaacccagt gtttaaactc
     9901 agtgtttaaa tatttgcatg tctttctatg tgactgctaa tttttaacta cattattatc
     9961 tctaagagat aaataaactt tccctgtact taaagttttt aaattaagta tcttctgata
    10021 acataagtag tatgagtaag gaaaaaaaat ctatgtgtac tgtattttta aattttaata
    10081 aggtttgata tggtttggct ctgtgtctcc acccaaatct caccttgaat tgtaataatc
    10141 ctcacgtgtc aaggaccagc aggtggagat aattgaatta tggggccggt ttctctcata
    10201 ctgttcttgc gatagtgagt tctcaggaga tctgatggtt ttataagcat ctagcatttc
    10261 ccctgctggt acattctctc ttcgcctgct gccatccatg taagatgtga cttgctcctc
    10321 cttgctctct gccatgattg tgaggcttcc ccaccacttg gaaatgtaag tcaattaaac
    10381 cactttcttt agtaaattgc ccagtctcgg gtatgtcttt atcagcaatg tgaaaacgga
    10441 ctaatacaac gtgattgttt aaatgctgat atgaaagcag tgctgaatgt ggatcttctt
    10501 atgccagata ctgttataat tattctctag agagctggcc atacaattta tctcattatt
    10561 tatagatcta gcatgaatgc cagtaagctg acaaagccaa aagccaaaaa ctaagagttt
    10621 gtattaatcc agttaatgcc aaatctagtc atcctccatc atcctacctc tgtgttctgc
    10681 atgaaatata attggccttt gtgatggaac cagttttctt gcattgaaaa taaaatttgt
    10741 tcctcaaaa
//
