LOCUS       NM_001034845            4021 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens polypeptide N-acetylgalactosaminyltransferase like 6
            (GALNTL6), mRNA.
ACCESSION   NM_001034845 XM_497981
VERSION     NM_001034845.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4021)
  AUTHORS   Diaz Ramirez,J., Alvarez-Herms,J., Castaneda-Babarro,A.,
            Larruskain,J., Ramirez de la Piscina,X., Borisov,O.V.,
            Semenova,E.A., Kostryukova,E.S., Kulemin,N.A., Andryushchenko,O.N.,
            Larin,A.K., Andryushchenko,L.B., Generozov,E.V., Ahmetov,I.I. and
            Odriozola,A.
  TITLE     The GALNTL6 Gene rs558129 Polymorphism Is Associated With Power
            Performance
  JOURNAL   J Strength Cond Res 34 (11), 3031-3036 (2020)
   PUBMED   33105351
  REMARK    GeneRIF: The GALNTL6 Gene rs558129 Polymorphism Is Associated With
            Power Performance.
REFERENCE   2  (bases 1 to 4021)
  AUTHORS   Raman,J., Guan,Y., Perrine,C.L., Gerken,T.A. and Tabak,L.A.
  TITLE     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferases: completion of the family tree
  JOURNAL   Glycobiology 22 (6), 768-777 (2012)
   PUBMED   22186971
  REMARK    Erratum:[Glycobiology. 2015 Apr;25(4):465. doi:
            10.1093/glycob/cwv003.. PMID: 25715345]
REFERENCE   3  (bases 1 to 4021)
  AUTHORS   Peng,C., Togayachi,A., Kwon,Y.D., Xie,C., Wu,G., Zou,X., Sato,T.,
            Ito,H., Tachibana,K., Kubota,T., Noce,T., Narimatsu,H. and Zhang,Y.
  TITLE     Identification of a novel human UDP-GalNAc transferase with unique
            catalytic activity and expression profile
  JOURNAL   Biochem Biophys Res Commun 402 (4), 680-686 (2010)
   PUBMED   20977886
  REMARK    GeneRIF: a novel member of the human ppGalNAc-T family,
            ppGalNAc-T20, which has high homology with human ppGalNAc-T10 was
            identified.
REFERENCE   4  (bases 1 to 4021)
  AUTHORS   Uhl,G.R., Liu,Q.R., Drgon,T., Johnson,C., Walther,D., Rose,J.E.,
            David,S.P., Niaura,R. and Lerman,C.
  TITLE     Molecular genetics of successful smoking cessation: convergent
            genome-wide association study results
  JOURNAL   Arch Gen Psychiatry 65 (6), 683-693 (2008)
   PUBMED   18519826
  REMARK    GeneRIF: Clinical trial and genome-wide association study of
            gene-disease association, gene-environment interaction, and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025561.6, AJ626725.1, BX108658.1 and AC131952.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001034845.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047551.1, SRR1660803.31102.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMN03465404
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000506823.6/ ENSP00000423313.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-587               AC025561.6         121952-122538
            588-894             AC025561.6         122960-123266
            895-2562            AJ626725.1         88-1755
            2563-2870           BX108658.1         166-473
            2871-4021           AC131952.1         63113-64263
FEATURES             Location/Qualifiers
     source          1..4021
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q34.1"
     gene            1..4021
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /note="polypeptide N-acetylgalactosaminyltransferase like
                     6"
                     /db_xref="GeneID:442117"
                     /db_xref="HGNC:HGNC:33844"
                     /db_xref="MIM:615138"
     exon            1..587
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /inference="alignment:Splign:2.1.0"
     exon            588..894
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /inference="alignment:Splign:2.1.0"
     CDS             757..2562
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /EC_number="2.4.1.41"
                     /note="GalNAc transferase 17; UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase 17; GaNTase 17;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase-like 6; polypeptide
                     GalNAc transferase-like 6;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 20; galNAc-T17;
                     pp-GaNTase 17; polypeptide GalNAc transferase 17;
                     protein-UDP acetylgalactosaminyltransferase 17; putative
                     polypeptide N-acetylgalactosaminyltransferase 17"
                     /codon_start=1
                     /product="polypeptide
                     N-acetylgalactosaminyltransferase-like 6"
                     /protein_id="NP_001030017.2"
                     /db_xref="CCDS:CCDS34104.1"
                     /db_xref="GeneID:442117"
                     /db_xref="HGNC:HGNC:33844"
                     /db_xref="MIM:615138"
                     /translation="MKRKQKRFLQMTLLFTVALIFLPNVGLWSLYKDKHLVKSAEPGE
                     QQTFPLGLGDGQFYSWTDGLRRKDWHDYESIQKEAMRSGKGEHGKPYPLTEEDHDDSA
                     YRENGFNIFVSNNIALERSLPDIRHANCKHKMYLERLPNTSIIIPFHNEGWTSLLRTI
                     HSIINRTPGSLIAEIILVDDFSEREHLKDKLEEYMARFSKVRIVRTKKREGLIRTRLL
                     GASMARGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQAG
                     DAMRGAFDWEMYYKRIPIPPELQRADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGL
                     EIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYVPYKVPSGTSLARNLKRVAETW
                     MDEFAEYIYQRRPEYRHLSTGDISAQKELRKQLKCKDFKWFMAAVAWDVPKYYPPVEP
                     PPAAWGEIRNVAANLCVDSKHGATGTELRLDICVKDGSERTWSHEQLFTFGWREDIRP
                     GEPLHTRKFCFDAISHNSPVTLYDCHGMKGNQLWGYRKDRTLFHPVSNSCMDCNPAEK
                     KIFMARCDPLSETQQWIFEHINMTVLEKFNHHANS"
     exon            895..1003
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1142
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1309
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1495
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1679
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1797
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1905
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2127
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2244
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2394
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..4021
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3530..3535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /note="hexamer: AATAAA"
     polyA_site      3561
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
     regulatory      4003..4008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /note="hexamer: AATAAA"
     polyA_site      4021
                     /gene="GALNTL6"
                     /gene_synonym="GalNAc-T6L; GALNACT20; GALNT17"
                     /note="major polyA site"
ORIGIN      
        1 gcagacacca gcgacgtctc cgcggaaggc aggcgccggg gagtggggcg cgggcgaccg
       61 tgtgcagccg cggcgcatct ccgccttccg ctcctcctcg cagcgccctc gtccgcttcc
      121 aagcccagca cagacttcgg tttctccgcc tccatcccct ttacgagaag aggagatcaa
      181 aaaatattgc cctttaggtg ctcgtgatgg tcctgtgggt tcgttcagtt gccagaaaag
      241 aatggtaaca tgaacagcgg agcgtgagag cgtcaccggg ggaagggacg agattgatgg
      301 gcagagcgct cacttctcag aggatcgcat tccgaggacc gcgcgaggaa gggacgtcgc
      361 ggcgccacca cttcctggct ggactccgct gacatctgta gcctcctttc caccaggttc
      421 ccggggctcc cagccgctgc ctgcagagga gcgtgtagac agcgcgcgag ggtccggcac
      481 ttcgtggacc tccatccgaa ccggagttct gcccggatcc cgagtccctg gatcccggtg
      541 gagcccgccg gcaagctggc tccggaggga gttgaacttg agttcagatg gccaactccc
      601 tctgaatcct gcagattggt gctgagcacg caacaaaagt ttgtagcttc tcagtttctg
      661 gtgcttcgca ggggagagga aaggaatttg acattaaaca caagaagcag tcagggagcc
      721 atctccttta acttttcttc tctgttacca tttgcaatga agaggaaaca gaagagattt
      781 ctgcagatga ctttgttgtt cacggtggct ttaattttcc tgcctaacgt tggtctctgg
      841 tctctgtaca aggataagca cctggtgaag tcagcggagc ccggggagca gcagacattt
      901 ccactgggcc tgggagatgg gcaattctat tcatggacag atggtttgag aagaaaggac
      961 tggcatgact atgaaagcat tcagaaagag gctatgcgct cagggaaagg tgaacatggg
     1021 aaaccttacc cccttactga agaggaccat gatgactcag cttacaggga aaatggtttt
     1081 aatattttcg tcagcaacaa tattgctcta gagaggtctc tgccagatat tcgtcatgct
     1141 aactgtaagc ataagatgta tctggaaagg ctgccaaaca ccagcatcat tatcccattt
     1201 cataatgaag gttggacttc actcctgcgg accatacaca gtataattaa ccgaacccca
     1261 gggagtctga tagcagaaat cattctagta gatgacttca gtgagagaga acacctgaag
     1321 gataaattgg aagaatacat ggcccgattt tccaaagtga ggattgttcg caccaagaaa
     1381 agagaaggac tcatccggac ccgtctcctg ggggcatcta tggccagagg agaagtcctg
     1441 acattcctgg actcccactg cgaggtcaat gtgaactggc tgcccccact cctcaaccaa
     1501 attgcactaa accacaaaac catcgtgtgt cccatgatcg atgtcattga ccacaatcac
     1561 ttcgggtatg aggcacaagc tggggatgcc atgcgaggag ccttcgactg ggaaatgtac
     1621 tacaaaagaa tccccatccc tccagagctc cagagggcag atcccagcga cccttttgag
     1681 tctcctgtta tggctggagg tctctttgct gtggatcgga aatggttttg ggaattgggt
     1741 ggctatgatc caggtttaga aatctgggga ggagaacagt atgaaatctc ttttaaggtt
     1801 tggatgtgtg gaggagaaat gtttgatgtt ccatgttcta gagttggtca tatctacagg
     1861 aagtacgttc catacaaagt tccatctggg acaagcctgg caagaaacct gaagcgggta
     1921 gctgagacct ggatggatga atttgccgag tacatttacc agcggcggcc ggagtacagg
     1981 catctctcca cgggggacat ctctgcccag aaggagctgc gcaagcagct caagtgcaag
     2041 gacttcaaat ggttcatggc tgctgtggcc tgggacgtgc ctaaatacta ccctccagtg
     2101 gagcccccgc ctgctgcctg gggggagatc cgaaatgtgg cagcaaatct ctgtgtggac
     2161 agcaagcatg gagccaccgg aacagagctg aggctggaca tctgtgtcaa ggatggttct
     2221 gaaagaacat ggtctcatga acagcttttt acctttggat ggagagaaga tattcgaccc
     2281 ggtgagccac tgcatacccg gaaattctgc tttgatgcga tctcacacaa cagccccgtt
     2341 acactctatg actgtcatgg catgaagggg aaccagctct ggggataccg gaaggacaga
     2401 acattattcc atcctgtgag caacagctgc atggattgca accccgcaga gaagaagatt
     2461 ttcatggcca gatgtgaccc tctctctgag actcagcagt ggatttttga acacattaat
     2521 atgactgttt tagaaaaatt taaccaccat gccaactcct agaaagaaga aaggaagaaa
     2581 gagtgattac ctacaggtta taaattaaat tttagccagc atctgggtcg aaggagtcag
     2641 gaataacatt tcctcgatcc aggaaggctg gtttaaaaat ttgcaaatgc catgtcaaag
     2701 taggttgttt tgaagaactt cctgcatctg aagaacttgg ctgagaatct caccagctgc
     2761 ttctgagaac tcgagactag cagttccctt gctggccaag ggcaaagata atttagggac
     2821 ttttcaaaac aactgctgag ctaataaatc ctagcatttc tcaggtcaaa tcctgcagta
     2881 gtgagtagct atgaatggat cctattaact gggtgggagg ggggtgaaaa tggagtgcat
     2941 gactgctctg acaacctgag gatatcacag gtttagaact agccaagctt aaggggtgag
     3001 ctgtactctt tggtgccatt ctctgactaa gaatgggttc agcaggttta acccttaaaa
     3061 gtgctgcaga tgatttcaga gtgctcacac tattctgttt tttttatttt tatttttaaa
     3121 tgagggtgca atatctaatg taagacttaa attacataat gaaatggaca tccagtgttc
     3181 ccattctttc gtttatattt gccatttttt tttcagagca aagtttcttt tttatgaaag
     3241 ttcatgctcc atgaatccac tgaatttcta attcagtgcc cttctatgaa tccagttaaa
     3301 aacaaaagca aaagcaaaaa tctatgctat caagttactc caaagaaaga tttcacagaa
     3361 gcagcaaaac catataagat ttaggagagg gacttccctg ggaaatctat ttttactttt
     3421 ctattatttt taaaatctta aaagtctgat atttgtccag tcataatttt tattaagcaa
     3481 ggaaatggag tgagtttgat gtaatttgtt taggagattc ttaaacccaa ataaatctac
     3541 actccaagtg atatgtgaaa atggcttagt tcacttcaat tctgtttagt cagtggtggg
     3601 agcttagaag tggttttatt tgttcgtttg tttgggtttt gcttttgttt tttatttttt
     3661 tcttgttttt tttttgtagt gttgaattaa tgatgttctt ttatttggaa gctcataaaa
     3721 ggaattacca ttaataaagt gtttctgaca ccattttctg ttaatgggac aatatttcgg
     3781 ggatgaagaa aggaatgctc cgaaaactaa atggaacact taatccttaa agcaattttt
     3841 tactgttcaa taatatcaca ttgggggaag aaaacacagg tatcaaggtg gttcttggga
     3901 aaaaagaatc atgtttatta tatatctctc aagttttttt ggtataaaaa tgttttaact
     3961 ttgctttctt tttggttttt gtttgaagtt ggttttcctg ttaataaaaa tttatataac
     4021 a
//
