LOCUS       NM_017423               4249 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens polypeptide N-acetylgalactosaminyltransferase 7
            (GALNT7), transcript variant 1, mRNA.
ACCESSION   NM_017423
VERSION     NM_017423.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4249)
  AUTHORS   Berkel,C. and Cacan,E.
  TITLE     The expression of O-linked glycosyltransferase GALNT7 in breast
            cancer is dependent on estrogen-, progesterone-, and HER2-receptor
            status, with prognostic implications
  JOURNAL   Glycoconj J 40 (6), 631-644 (2023)
   PUBMED   37947928
  REMARK    GeneRIF: The expression of O-linked glycosyltransferase GALNT7 in
            breast cancer is dependent on estrogen-, progesterone-, and
            HER2-receptor status, with prognostic implications.
REFERENCE   2  (bases 1 to 4249)
  AUTHORS   Li,J., Wan,X., Xie,D., Yuan,H., Pei,Q., Luo,Y., Chen,Y., Xian,J.
            and Ye,T.
  TITLE     SPDEF enhances cancer stem cell-like properties and tumorigenesis
            through directly promoting GALNT7 transcription in luminal breast
            cancer
  JOURNAL   Cell Death Dis 14 (8), 569 (2023)
   PUBMED   37633945
  REMARK    GeneRIF: SPDEF enhances cancer stem cell-like properties and
            tumorigenesis through directly promoting GALNT7 transcription in
            luminal breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4249)
  AUTHORS   Scott,E., Hodgson,K., Calle,B., Turner,H., Cheung,K., Bermudez,A.,
            Marques,F.J.G., Pye,H., Yo,E.C., Islam,K., Oo,H.Z., McClurg,U.L.,
            Wilson,L., Thomas,H., Frame,F.M., Orozco-Moreno,M., Bastian,K.,
            Arredondo,H.M., Roustan,C., Gray,M.A., Kelly,L., Tolson,A.,
            Mellor,E., Hysenaj,G., Goode,E.A., Garnham,R., Duxfield,A.,
            Heavey,S., Stopka-Farooqui,U., Haider,A., Freeman,A., Singh,S.,
            Johnston,E.W., Punwani,S., Knight,B., McCullagh,P., McGrath,J.,
            Crundwell,M., Harries,L., Bogdan,D., Westaby,D., Fowler,G.,
            Flohr,P., Yuan,W., Sharp,A., de Bono,J., Maitland,N.J.,
            Wisnovsky,S., Bertozzi,C.R., Heer,R., Guerrero,R.H., Daugaard,M.,
            Leivo,J., Whitaker,H., Pitteri,S., Wang,N., Elliott,D.J.,
            Schumann,B. and Munkley,J.
  TITLE     Upregulation of GALNT7 in prostate cancer modifies O-glycosylation
            and promotes tumour growth
  JOURNAL   Oncogene 42 (12), 926-937 (2023)
   PUBMED   36725887
  REMARK    GeneRIF: Upregulation of GALNT7 in prostate cancer modifies
            O-glycosylation and promotes tumour growth.
REFERENCE   4  (bases 1 to 4249)
  AUTHORS   Gao,F., Han,J., Jia,L., He,J., Wang,Y., Chen,M., Liu,X. and He,X.
  TITLE     MiR-30c facilitates natural killer cell cytotoxicity to lung cancer
            through targeting GALNT7
  JOURNAL   Genes Genomics 45 (2), 247-260 (2023)
   PUBMED   36040682
  REMARK    GeneRIF: MiR-30c facilitates natural killer cell cytotoxicity to
            lung cancer through targeting GALNT7.
REFERENCE   5  (bases 1 to 4249)
  AUTHORS   Wang,J.B., Chen,X.L., Han,Z.B., Wang,H.W., Wang,Z.H., Li,N.N. and
            Lin,Z.G.
  TITLE     Long non-coding RNA TP73-AS1 contributes to glioma tumorigenesis by
            sponging the miR-103a/GALNT7 pathway
  JOURNAL   Brain Res 1741, 146886 (2020)
   PUBMED   32416102
  REMARK    GeneRIF: Long non-coding RNA TP73-AS1 contributes to glioma
            tumorigenesis by sponging the miR-103a/GALNT7 pathway.
REFERENCE   6  (bases 1 to 4249)
  AUTHORS   Peng,R.Q., Wan,H.Y., Li,H.F., Liu,M., Li,X. and Tang,H.
  TITLE     MicroRNA-214 suppresses growth and invasiveness of cervical cancer
            cells by targeting UDP-N-acetyl-alpha-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferase 7
  JOURNAL   J Biol Chem 287 (17), 14301-14309 (2012)
   PUBMED   22399294
  REMARK    GeneRIF: miR-214 is a new regulator of GALNT7, and both miR-214 and
            GALNT7 play important roles in the pathogenesis of cervical cancer
REFERENCE   7  (bases 1 to 4249)
  AUTHORS   Gaziel-Sovran,A., Segura,M.F., Di Micco,R., Collins,M.K.,
            Hanniford,D., Vega-Saenz de Miera,E., Rakus,J.F., Dankert,J.F.,
            Shang,S., Kerbel,R.S., Bhardwaj,N., Shao,Y., Darvishian,F.,
            Zavadil,J., Erlebacher,A., Mahal,L.K., Osman,I. and Hernando,E.
  TITLE     miR-30b/30d regulation of GalNAc transferases enhances invasion and
            immunosuppression during metastasis
  JOURNAL   Cancer Cell 20 (1), 104-118 (2011)
   PUBMED   21741600
  REMARK    GeneRIF: Ectopic expression of miR-30b/30d promoted the metastatic
            behavior of melanoma cells by directly targeting the GalNAc
            transferase GALNT7.
REFERENCE   8  (bases 1 to 4249)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 4249)
  AUTHORS   Kahai,S., Lee,S.C., Lee,D.Y., Yang,J., Li,M., Wang,C.H., Jiang,Z.,
            Zhang,Y., Peng,C. and Yang,B.B.
  TITLE     MicroRNA miR-378 regulates nephronectin expression modulating
            osteoblast differentiation by targeting GalNT-7
  JOURNAL   PLoS One 4 (10), e7535 (2009)
   PUBMED   19844573
  REMARK    GeneRIF: MicroRNA miR-378 regulates nephronectin expression
            modulating osteoblast differentiation by targeting GalNT-7
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4249)
  AUTHORS   Bennett,E.P., Hassan,H., Hollingsworth,M.A. and Clausen,H.
  TITLE     A novel human UDP-N-acetyl-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for
            partial GalNAc-glycosylated acceptor substrates
  JOURNAL   FEBS Lett 460 (2), 226-230 (1999)
   PUBMED   10544240
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC046129.1, AJ002744.1,
            BC047468.1 and BC035303.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017423.2.
            
            Summary: This gene encodes GalNAc transferase 7, a member of the
            GalNAc-transferase family. The enzyme encoded by this gene controls
            the initiation step of mucin-type O-linked protein glycosylation
            and transfer of N-acetylgalactosamine to serine and threonine amino
            acid residues. This enzyme is a type II transmembrane protein and
            shares common sequence motifs with other family members. Unlike
            other family members, this enzyme shows exclusive specificity for
            partially GalNAc-glycosylated acceptor substrates and shows no
            activity with non-glycosylated peptides. This protein may function
            as a follow-up enzyme in the initiation step of O-glycosylation.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ002744.1, BC047468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265000.9/ ENSP00000265000.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BC046129.1         37-78
            43-587              AJ002744.1         50-594
            588-2010            BC046129.1         624-2046
            2011-2211           BC047468.1         2043-2243
            2212-3422           BC035303.1         1701-2911
            3423-4249           BC035303.1         2913-3739
FEATURES             Location/Qualifiers
     source          1..4249
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q34.1"
     gene            1..4249
                     /gene="GALNT7"
                     /gene_synonym="GALNAC-T7; GalNAcT7"
                     /note="polypeptide N-acetylgalactosaminyltransferase 7"
                     /db_xref="GeneID:51809"
                     /db_xref="HGNC:HGNC:4129"
                     /db_xref="MIM:605005"
     exon            1..151
                     /gene="GALNT7"
                     /gene_synonym="GALNAC-T7; GalNAcT7"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1999
                     /gene="GALNT7"
                     /gene_synonym="GALNAC-T7; GalNAcT7"
                     /EC_number="2.4.1.41"
                     /note="isoform 1 is encoded by transcript variant 1;
                     N-acetylgalactosaminyltransferase 7; pp-GaNTase 7;
                     polypeptide GalNAc transferase 7; protein-UDP
                     acetylgalactosaminyltransferase 7; UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase 7;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 7 (GalNAc-T7)"
                     /codon_start=1
                     /product="N-acetylgalactosaminyltransferase 7 isoform 1"
                     /protein_id="NP_059119.2"
                     /db_xref="CCDS:CCDS3815.1"
                     /db_xref="GeneID:51809"
                     /db_xref="HGNC:HGNC:4129"
                     /db_xref="MIM:605005"
                     /translation="MRLKIGFILRSLLVVGSFLGLVVLWSSLTPRPDDPSPLSRMRED
                     RDVNDPMPNRGGNGLAPGEDRFKPVVPWPHVEGVEVDLESIRRINKAKNEQEHHAGGD
                     SQKDIMQRQYLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGP
                     EFKQAIQASIKEFGFNMVASDMISLDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNE
                     GWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLDEYIKLWNGLVKVFRNER
                     REGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPLIDVIN
                     GNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTPQEKRLRKTKTEPYRSPAMAGGLF
                     AIEREFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGN
                     PPPIYVGSSPTLKNYVRVVEVWWDEYKDYFYASRPESQALPYGDISELKKFREDHNCK
                     SFKWFMEEIAYDITSHYPLPPKNVDWGEIRGFETAYCIDSMGKTNGGFVELGPCHRMG
                     GNQLFRINEANQLMQYDQCLTKGADGSKVMITHCNLNEFKEWQYFKNLHRFTHIPSGK
                     CLDRSEVLHQVFISNCDSSKTTQKWEMNNIHSV"
     exon            152..612
                     /gene="GALNT7"
                     /gene_synonym="GALNAC-T7; GalNAcT7"
                     /inference="alignment:Splign:2.1.0"
     exon            613..779
                     /gene="GALNT7"
                     /gene_synonym="GALNAC-T7; GalNAcT7"
                     /inference="alignment:Splign:2.1.0"
     exon            780..910
                     /gene="GALNT7"
                     /gene_synonym="GALNAC-T7; GalNAcT7"
                     /inference="alignment:Splign:2.1.0"
     exon            911..990
                     /gene="GALNT7"
                     /gene_synonym="GALNAC-T7; GalNAcT7"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1173
                     /gene="GALNT7"
                     /gene_synonym="GALNAC-T7; GalNAcT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1291
                     /gene="GALNT7"
                     /gene_synonym="GALNAC-T7; GalNAcT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1414
                     /gene="GALNT7"
                     /gene_synonym="GALNAC-T7; GalNAcT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1633
                     /gene="GALNT7"
                     /gene_synonym="GALNAC-T7; GalNAcT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1732
                     /gene="GALNT7"
                     /gene_synonym="GALNAC-T7; GalNAcT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1861
                     /gene="GALNT7"
                     /gene_synonym="GALNAC-T7; GalNAcT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..4249
                     /gene="GALNT7"
                     /gene_synonym="GALNAC-T7; GalNAcT7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4226..4231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT7"
                     /gene_synonym="GALNAC-T7; GalNAcT7"
                     /note="hexamer: AATAAA"
     polyA_site      4249
                     /gene="GALNT7"
                     /gene_synonym="GALNAC-T7; GalNAcT7"
                     /note="major polyA site"
ORIGIN      
        1 gtgagtctct cgccgccgga ggaagatgag gctgaagatt gggttcatct tacgcagttt
       61 gctggtggtg ggaagcttcc tggggctagt ggtcctctgg tcttccctga ccccgcggcc
      121 ggacgaccca agcccgctga gcaggatgag ggaagacaga gatgtcaatg accccatgcc
      181 caaccgaggc ggcaatggac tagctcctgg ggaggacaga ttcaaacctg tggtaccatg
      241 gcctcatgtt gaaggagtag aagtggactt agagtctatt agaagaataa acaaggccaa
      301 aaatgaacaa gagcaccatg ctggaggaga ttcccagaaa gatatcatgc agaggcagta
      361 tctcacattt aagcctcaga cattcaccta ccatgatcct gtgcttcgcc cagggatcct
      421 cggtaacttt gaacccaaag aacctgagcc tcctggagtg gttggtggcc ctggagagaa
      481 agccaagcca ttggttttgg gaccagaatt caaacaagca attcaagcca gcattaaaga
      541 gtttggattt aacatggtgg caagtgacat gatctcactg gaccgcagcg tcaatgactt
      601 acgccaagaa gaatgcaagt attggcatta tgatgaaaac ttgctcactt cgagcgttgt
      661 cattgtcttc cataatgaag gatggtcaac cctcatgaga acagtccaca gtgtaattaa
      721 aaggactcca aggaaatatt tagcagaaat tgtgttaatt gacgatttca gtaataaaga
      781 acacttaaaa gaaaaactgg atgaatatat taagctgtgg aatggcctag tgaaggtatt
      841 tcgaaatgaa agaagggaag gtttaattca agcacgaagt attggtgctc agaaggctaa
      901 acttggacag gttttgatat accttgatgc ccactgtgag gtggcagtta actggtatgc
      961 accacttgta gctcccatat ctaaggacag aaccatttgc actgtgccgc ttatagatgt
     1021 cataaatggc aacacatatg aaattatacc ccaagggggt ggtgatgaag atgggtatgc
     1081 ccgaggagca tgggattgga gtatgctctg gaaacgggtg cctctgaccc ctcaagagaa
     1141 gagactgaga aagacaaaaa ctgaaccgta tcggtcccca gccatggctg ggggattatt
     1201 tgccattgaa cgagagttct tctttgaatt gggtctctat gatccaggtc tccagatttg
     1261 gggtggtgaa aactttgaga tctcatacaa gatatggcag tgtggtggca aattattatt
     1321 tgttccttgt tctcgtgttg gacatatcta ccgtcttgag ggctggcaag gaaatcctcc
     1381 gcccatttat gttgggtctt ctccaactct gaagaattat gttagagttg tggaggtttg
     1441 gtgggatgaa tataaagact acttctatgc tagtcgtcct gaatcgcagg cattaccata
     1501 tggggatata tcggagctga aaaaatttcg agaagatcac aactgcaaaa gttttaagtg
     1561 gttcatggaa gaaatagctt atgatatcac ctcacactac cctttgccac ccaaaaatgt
     1621 tgactgggga gaaatcagag gcttcgaaac tgcttactgc attgatagca tgggaaaaac
     1681 aaatggaggc tttgttgaac taggaccctg ccacaggatg ggagggaatc agcttttcag
     1741 aatcaatgaa gcaaatcaac tcatgcagta tgaccagtgt ttgacaaagg gagctgatgg
     1801 atcaaaagtt atgattacac actgtaatct aaatgaattt aaggaatggc agtacttcaa
     1861 gaacctgcac agatttactc atattccttc aggaaagtgt ttagatcgct cagaggtcct
     1921 gcatcaagta ttcatctcca attgtgactc cagtaaaacg actcaaaaat gggaaatgaa
     1981 taacatccat agtgtttaga gagaaaaaaa taaaccaata acctacctac tgacaagtaa
     2041 atttatacag gactgaaaac cgcctgaaac ctgctgcaac tattgttatt aactctgtat
     2101 agctccaaac ctggaacctc ctgatcagtt tgaaggacat tgataaactg tgattttaca
     2161 ataacattat catctgcagt tactgtttac aagactgctt ttaccttaaa ctttgtagat
     2221 gtttacatct ttttgttgtg ttttaagatg atgttggtaa tttgtgcctt tagctctgtt
     2281 ttattagaca gagttaaagc atgttgtctt ctttgggatt acactcaggg gtctgaaagg
     2341 cagtttgatt tttattttta acacacttga aaaaaggttg gagtagccag actttcatat
     2401 ataacttggt gattatcaac ctgttgtgtc tttatttaat tttacatctt tttgaagcac
     2461 tgccacaggt tattagccaa ggtggccttc cttcacagtc atgctgcttt tttgaaaggt
     2521 gaatttcaac acatttagtg cctctttcat ttctcagtat atatttcaag agcttgtgat
     2581 gaaatctata ggatggtaat gatggacttg tcacctgtat ggggaatact tttactactc
     2641 agaaatgaat ttatgtgctg ccatttgcta taaagttgaa ctttgtatgg cttgaaaaag
     2701 aaatgacaat atggaacatc ccaaggctgt cccatagggt tggaagttgt gtagcattca
     2761 ctcccttacc tactggcatt cccagtgccc tctgtccata cctacttcta ggattgcaaa
     2821 ggagtcttcc aactagagaa aaattgtcca ctgacatttg ggatttactt ttctccaata
     2881 cctgccaata cagaaaacta ttatcagttg ttattgttat cccttgaaag cgagggtgac
     2941 aaaaacaaca aaacaccgtt ataaacacat caaaggttca ttctgactga ggtaagactt
     3001 tccaagccct tgttagatta ggccttataa aacttgtgtg cattataacc taagctgtgc
     3061 aacctgtgaa gccaagagtg aactgatgtt tcatttatat tttcatccaa atgacattat
     3121 ctgcacgttt ttaaaattta aaaacaaagg actatttaaa aatacagttt attaacaaac
     3181 gtgaactact ttctgttaca ttaggtgttc cctagtgttt cttaatttct ttttagaaag
     3241 tgtattttta ttagtatttt tccggtgaac agaagatttg tttggattta aacatttact
     3301 aagacagtac ctattaggaa aaccaaatat tgcaaatggt caattcgatt ttaatttctc
     3361 aaaagatact ctgttatcca gaagattaaa atgcctacat tgagtgctta aaaaaaaaaa
     3421 aacaactgtg atgatgtgag cagaatggca agtaagttaa gcatttttga tcctgtaatc
     3481 atggtatcat tacaatgaaa ggaattcaca aactactgcc agaggaagtt tgttttttaa
     3541 tttaagaggg aaatataacc tataaatttg tttcttccaa gcttagctct taaatttgga
     3601 gactcaaagt taaacatcct caacagagtt ttatttataa ttttgaattg tcaatttgta
     3661 ttttgctact gatctgtgat caaccatttt aactttcatc tctagggatg tttaacattt
     3721 ataattgcaa aataaaccaa ctataaaaaa agaaactaag agagaattgg tactttaatt
     3781 acttgtgtgt ttgcaaatag gctccatttt ccatgttgag tagattataa ccttattaac
     3841 tatgcatagg cctaagaaag gtggcaatga actgtgcatg taaattttaa atgggtactt
     3901 tgtgcaattc gttaaaagaa gatactctat gaatatgatt ctatatattg aaatcagaaa
     3961 acctaccaaa caaaaacatc agaagctgct gccataatga ctattttcta ctgtaggctg
     4021 ctttggaaat aattcccata tccttgcttt gtaagttggt aatatcacta tgcatttcta
     4081 cacattttat aaatttgatt tatgcagatt ttgatacact gtatgtttct gtagaaattg
     4141 tataaatatt caaaatttta ttaggataaa tttgagaaac ttacgtatat cttaattctg
     4201 ggttgcttgt tttttaggtg acaaaaataa aatattgtat tttaattca
//
