LOCUS       NM_007210               5307 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens polypeptide N-acetylgalactosaminyltransferase 6
            (GALNT6), mRNA.
ACCESSION   NM_007210
VERSION     NM_007210.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5307)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5307)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5307)
  AUTHORS   Liu,C., Li,Z., Xu,L., Shi,Y., Zhang,X., Shi,S., Hou,K., Fan,Y.,
            Li,C., Wang,X., Zhou,L., Liu,Y., Qu,X. and Che,X.
  TITLE     GALNT6 promotes breast cancer metastasis by increasing mucin-type
            O-glycosylation of alpha2M
  JOURNAL   Aging (Albany NY) 12 (12), 11794-11811 (2020)
   PUBMED   32559179
  REMARK    GeneRIF: GALNT6 promotes breast cancer metastasis by increasing
            mucin-type O-glycosylation of alpha2M.
REFERENCE   4  (bases 1 to 5307)
  AUTHORS   Song,J., Liu,W., Wang,J., Hao,J., Wang,Y., You,X., Du,X., Zhou,Y.,
            Ben,J., Zhang,X., Ye,M. and Wang,Q.
  TITLE     GALNT6 promotes invasion and metastasis of human lung
            adenocarcinoma cells through O-glycosylating chaperone protein
            GRP78
  JOURNAL   Cell Death Dis 11 (5), 352 (2020)
   PUBMED   32393740
  REMARK    GeneRIF: GALNT6 promotes invasion and metastasis of human lung
            adenocarcinoma cells through O-glycosylating chaperone protein
            GRP78.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5307)
  AUTHORS   de Las Rivas,M., Paul Daniel,E.J., Narimatsu,Y., Companon,I.,
            Kato,K., Hermosilla,P., Thureau,A., Ceballos-Laita,L., Coelho,H.,
            Bernado,P., Marcelo,F., Hansen,L., Maeda,R., Lostao,A., Corzana,F.,
            Clausen,H., Gerken,T.A. and Hurtado-Guerrero,R.
  TITLE     Molecular basis for fibroblast growth factor 23 O-glycosylation by
            GalNAc-T3
  JOURNAL   Nat Chem Biol 16 (3), 351-360 (2020)
   PUBMED   31932717
REFERENCE   6  (bases 1 to 5307)
  AUTHORS   Park,J.H., Katagiri,T., Chung,S., Kijima,K. and Nakamura,Y.
  TITLE     Polypeptide N-acetylgalactosaminyltransferase 6 disrupts mammary
            acinar morphogenesis through O-glycosylation of fibronectin
  JOURNAL   Neoplasia 13 (4), 320-326 (2011)
   PUBMED   21472136
  REMARK    GeneRIF: GALNT6-fibronectin pathway should be a critical component
            for breast cancer development and progression.
REFERENCE   7  (bases 1 to 5307)
  AUTHORS   Gomes,J., Marcos,N.T., Berois,N., Osinaga,E., Magalhaes,A.,
            Pinto-de-Sousa,J., Almeida,R., Gartner,F. and Reis,C.A.
  TITLE     Expression of UDP-N-acetyl-D-galactosamine: polypeptide
            N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal
            metaplasia, and gastric carcinoma
  JOURNAL   J Histochem Cytochem 57 (1), 79-86 (2009)
   PUBMED   18854599
  REMARK    GeneRIF: ppGalNAc-T6 is an IHC marker associated with venous
            invasion in gastric carcinoma and may contribute to the
            understanding of the molecular mechanisms that underlie aberrant
            glycosylation in gastric carcinogenesis and in gastric carcinoma.
REFERENCE   8  (bases 1 to 5307)
  AUTHORS   Patani,N., Jiang,W. and Mokbel,K.
  TITLE     Prognostic utility of glycosyltransferase expression in breast
            cancer
  JOURNAL   Cancer Genomics Proteomics 5 (6), 333-340 (2008)
   PUBMED   19287074
  REMARK    GeneRIF: Expression of ppGalNAc-T6 is significantly higher in
            breast cancer compared to 'normal'/benign breast tissue samples.
            ST6GalNAc-I expression in breast cancer is associated with better
            prognosis.
REFERENCE   9  (bases 1 to 5307)
  AUTHORS   Argueso,P., Tisdale,A., Mandel,U., Letko,E., Foster,C.S. and
            Gipson,I.K.
  TITLE     The cell-layer- and cell-type-specific distribution of
            GalNAc-transferases in the ocular surface epithelia is altered
            during keratinization
  JOURNAL   Invest Ophthalmol Vis Sci 44 (1), 86-92 (2003)
   PUBMED   12506059
REFERENCE   10 (bases 1 to 5307)
  AUTHORS   Bennett,E.P., Hassan,H., Mandel,U., Hollingsworth,M.A., Akisawa,N.,
            Ikematsu,Y., Merkx,G., van Kessel,A.G., Olofsson,S. and Clausen,H.
  TITLE     Cloning and characterization of a close homologue of human
            UDP-N-acetyl-alpha-D-galactosamine:Polypeptide
            N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6.
            Evidence for genetic but not functional redundancy
  JOURNAL   J Biol Chem 274 (36), 25362-25370 (1999)
   PUBMED   10464263
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB001644.1, BC035822.1 and
            AC046135.15.
            
            On Nov 23, 2018 this sequence version replaced NM_007210.3.
            
            Summary: This gene encodes a member of the
            UDP-N-acetyl-alpha-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes.
            GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi
            apparatus by catalyzing the transfer of GalNAc to serine and
            threonine residues on target proteins. They are characterized by an
            N-terminal transmembrane domain, a stem region, a lumenal catalytic
            domain containing a GT1 motif and Gal/GalNAc transferase motif, and
            a C-terminal ricin/lectin-like domain. GalNAc-Ts have different,
            but overlapping, substrate specificities and patterns of
            expression. The encoded protein is capable of glycosylating
            fibronectin peptide in vitro and is expressed in a fibroblast cell
            line, indicating that it may be involved in the synthesis of
            oncofetal fibronectin. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035822.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356317.8/ ENSP00000348668.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               DB001644.1         186-305
            121-2644            BC035822.1         134-2657
            2645-4510           AC046135.15        108099-109964       c
            4511-5307           AC046135.15        107302-108098       c
FEATURES             Location/Qualifiers
     source          1..5307
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..5307
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /note="polypeptide N-acetylgalactosaminyltransferase 6"
                     /db_xref="GeneID:11226"
                     /db_xref="HGNC:HGNC:4128"
                     /db_xref="MIM:605148"
     exon            1..120
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /inference="alignment:Splign:2.1.0"
     exon            121..208
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /inference="alignment:Splign:2.1.0"
     exon            209..802
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..2180
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /EC_number="2.4.1.41"
                     /note="GalNAc transferase 6; UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase 6; protein-UDP
                     acetylgalactosaminyltransferase 6;
                     UDP-N-acetyl-alpha-D-galactosamine: polypeptide
                     N-acetylgalactosaminyltransferase 6; pp-GaNTase 6;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 6 (GalNAc-T6);
                     polypeptide GalNAc transferase 6"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase 6"
                     /protein_id="NP_009141.2"
                     /db_xref="CCDS:CCDS8813.1"
                     /db_xref="GeneID:11226"
                     /db_xref="HGNC:HGNC:4128"
                     /db_xref="MIM:605148"
                     /translation="MRLLRRRHMPLRLAMVGCAFVLFLFLLHRDVSSREEATEKPWLK
                     SLVSRKDHVLDLMLEAMNNLRDSMPKLQIRAPEAQQTLFSINQSCLPGFYTPAELKPF
                     WERPPQDPNAPGADGKAFQKSKWTPLETQEKEEGYKKHCFNAFASDRISLQRSLGPDT
                     RPPECVDQKFRRCPPLATTSVIIVFHNEAWSTLLRTVYSVLHTTPAILLKEIILVDDA
                     STEEHLKEKLEQYVKQLQVVRVVRQEERKGLITARLLGASVAQAEVLTFLDAHCECFH
                     GWLEPLLARIAEDKTVVVSPDIVTIDLNTFEFAKPVQRGRVHSRGNFDWSLTFGWETL
                     PPHEKQRRKDETYPIKSPTFAGGLFSISKSYFEHIGTYDNQMEIWGGENVEMSFRVWQ
                     CGGQLEIIPCSVVGHVFRTKSPHTFPKGTSVIARNQVRLAEVWMDSYKKIFYRRNLQA
                     AKMAQEKSFGDISERLQLREQLHCHNFSWYLHNVYPEMFVPDLTPTFYGAIKNLGTNQ
                     CLDVGENNRGGKPLIMYSCHGLGGNQYFEYTTQRDLRHNIAKQLCLHVSKGALGLGSC
                     HFTGKNSQVPKDEEWELAQDQLIRNSGSGTCLTSQDKKPAMAPCNPSDPHQLWLFV"
     exon            803..975
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1125
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1360
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1478
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1679
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1811
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1913
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2066
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..5307
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4659..4664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /note="hexamer: AATAAA"
     polyA_site      4689
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /note="major polyA site"
     regulatory      5286..5291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
                     /note="hexamer: TATAAA"
     polyA_site      5307
                     /gene="GALNT6"
                     /gene_synonym="GALNAC-T6; GalNAcT6"
ORIGIN      
        1 ccctcctgcc ttcgctctct gctggtcgcg gtggcctgta gctcctccct cggtaggacc
       61 cccctccacc ttggcgctta cgagatgaat gaggagccca gacctctgga acttggaggg
      121 ttgttcagat tcccaggctg acaaaaagga gaaacagctt ttacttgcat ccagggccaa
      181 tcatcgcaga cccagacgtc tgcagagggc tgaggcccca gcttgtggcc accacaacgt
      241 atcaagctat ctccagggtt gggctcagga ctcagagctg acgcagctgg ggtgcccctt
      301 ggttctggag gatgaggctc ctccgcagac gccacatgcc cctgcgcctg gccatggtgg
      361 gctgcgcctt tgtgctcttc ctcttcctcc tgcataggga tgtgagcagc agagaggagg
      421 ccacagagaa gccgtggctg aagtccctgg tgagccggaa ggatcacgtc ctggacctca
      481 tgctggaggc catgaacaac cttagagatt caatgcccaa gctccaaatc agggctccag
      541 aagcccagca gactctgttc tccataaacc agtcctgcct ccctgggttc tataccccag
      601 ctgaactgaa gcccttctgg gaacggccac cacaggaccc caatgcccct ggggcagatg
      661 gaaaagcatt tcagaagagc aagtggaccc ccctggagac ccaggaaaag gaagaaggct
      721 ataagaagca ctgtttcaat gcctttgcca gcgaccggat ctccctgcag aggtccctgg
      781 ggccagacac ccgaccacct gagtgtgtgg accagaagtt ccggcgctgc cccccactgg
      841 ccaccaccag cgtgatcatt gtgttccaca acgaagcctg gtccacactg ctgcgaacag
      901 tgtacagcgt cctacacacc acccctgcca tcttgctcaa ggagatcata ctggtggatg
      961 atgccagcac agaggagcac ctaaaggaga agctggagca gtacgtgaag cagctgcagg
     1021 tggtgagggt ggtgcggcag gaggagcgga aggggctgat caccgcccgg ctgctggggg
     1081 ccagcgtggc acaggcggag gtgctcacgt tcctggatgc ccactgtgag tgcttccacg
     1141 gctggctgga gcccctcctg gctcgaatcg ctgaggacaa gacagtggtg gtgagcccag
     1201 acatcgtcac catcgacctt aatacttttg agttcgccaa gcccgtccag aggggcagag
     1261 tccatagccg aggcaacttt gactggagcc tgaccttcgg ctgggaaaca cttcctccac
     1321 atgagaagca gaggcgcaag gatgaaacct accccatcaa atccccgacg tttgctggtg
     1381 gcctcttctc catctccaag tcctactttg agcacatcgg tacctatgat aatcagatgg
     1441 agatctgggg aggggagaac gtggaaatgt ccttccgggt gtggcagtgt gggggccagc
     1501 tggagatcat cccctgctct gtcgtaggcc atgtgttccg gaccaagagc ccccacacct
     1561 tccccaaggg cactagtgtc attgctcgca atcaagtgcg cctggcagag gtctggatgg
     1621 acagctacaa gaagattttc tataggagaa atctgcaggc agcaaagatg gcccaagaga
     1681 aatccttcgg tgacatttcg gaacgactgc agctgaggga acaactgcac tgtcacaact
     1741 tttcctggta cctgcacaat gtctacccag agatgtttgt tcctgacctg acgcccacct
     1801 tctatggtgc catcaagaac ctcggcacca accaatgcct ggatgtgggt gagaacaacc
     1861 gcggggggaa gcccctcatc atgtactcct gccacggcct tggcggcaac cagtactttg
     1921 agtacacaac tcagagggac cttcgccaca acatcgcaaa gcagctgtgt ctacatgtca
     1981 gcaagggtgc tctgggcctt gggagctgtc acttcactgg caagaatagc caggtcccca
     2041 aggacgagga atgggaattg gcccaggatc agctcatcag gaactcagga tctggtacct
     2101 gcctgacatc ccaggacaaa aagccagcca tggccccctg caatcccagt gacccccatc
     2161 agttgtggct ctttgtctag gacccagatc atccccagag agagccccca caagctcctc
     2221 aggaaacagg attgctgatg tctgggaacc tgatcaccag cttctctgga ggccgtaaag
     2281 atggatttct aaacccactg ggtggcaagg caggaccttc ctaatccttg caacaacatt
     2341 gggcccattt tctttccttc acaccgatgg aagagaccat taggacatat atttagccta
     2401 gcgttttcct gttctagaaa tagaggctcc caaagtaggg aaggcagctg ggggagggtt
     2461 cagggcagca atgctgagtt caagaaaagt acttcaggct gggcacagtg gctcatgcct
     2521 gaaatcctag cactttggga agacaatgtg ggagaatggc ttgagcccag gagttcaaga
     2581 ccggcctgag caacatagtg aggatcccat ctctacgccc accctccccc cggcaaaaaa
     2641 aaaaagctgg gtatggtggc ttatgcctgt agtcgcagct actcagaagg ctgaggtggg
     2701 aggattgctt gttccccgga ggttgaagct acagtgagcc ttgattgtgt cactgcactc
     2761 cagcctgggc aacaggtaag actctgtctc aaaaaaaaac aaaaaagaag aagaaaagta
     2821 cttctacagc catgtcctat tccttgatca tccaaagcac ctgcagagtc cagtgaaatg
     2881 atatattctg gctgggcaca gtggctcaca cctgtaatcc tagcactttg ggaggccaag
     2941 gcaggtggat cacctgaggt cagaagtttg aaaccagcct ggactacatg gtgaaactcc
     3001 atctctacta aaagtacaaa aattagctgg gcatgatggc acgcacctgc agtcccagct
     3061 acttgggagg ctgaggcagg agaatcactc gaacccagga ggcagaggtt gcagtgagcc
     3121 aagacagcac cattgcaccc cagcctgagc aacaagagcg aaactccatc tcaggaaaaa
     3181 aaaaaaaaaa aaaagtatat tctaacagac agatcagagg tctaagagat cctcccttgc
     3241 tattattacc tgaagtctgt agaactgttt acagatatct ccttgacagg tgtcctttat
     3301 cttactttat ctgtacagta atcctgtgag aaagacagga cagaaaccac tgtgcctatt
     3361 ttacagatac gaaaactgag acacaggtaa aggggcttgt ctgtagtccc atagctagca
     3421 gatggctgga gccaagactg aggctcgttc ttcaatgctg agccagggct ccttccgctg
     3481 caccacaaga acgctagacc actcgccacc agccttctca ttccctcttc ctccattcta
     3541 atcatttcta gctggctggc ctccacagag cataggaaaa cagccagggc cgggcacggt
     3601 ggctcatgcc tgtaatctca acactctggg aggccgagcc gggtggataa cctgaggtca
     3661 ggaattcgag accagcctgg ccaacatggt aaaaccccat ctctactaaa aatataaaaa
     3721 ttagccaggc atggtggcgc acacctgtaa tcccagctac tcaagaggct gaggcaggag
     3781 aattgcttaa atctgggagg cggaagttgc agtgagccaa gatcgcgcca ctgaactcca
     3841 gcctaggcaa caagagcaaa actccatctc caaaaaaaag aaaggaaaaa cagggccagg
     3901 tagccattgt ggagagagca cacttaggaa tcctgggatg ttagtgttaa aagaaagctc
     3961 ctggagccag tgattctcag gtttgtccca gaaccctttt ttctaagccc catataaaag
     4021 gtagattaaa aaaacaaagt agcatgagtg aaattgagag agggacaggt aatgccttcc
     4081 agcccctaac ttctaacaat ctggaagcac aacgtgaaaa tcacgtagcc caaccctatc
     4141 attttcatat tatgaaactg agtccaggta agtgaatctg tccaaggtca cccagcaagg
     4201 tatcagtagc cctgagggta aggactctga taaggctcgg gagggtcctg gaaagcctga
     4261 ggcggcagga agagtgtgca gagttgagcg tgtctggaag gctgatccac tgctgggccc
     4321 acatcaaagc ccccatgggg agcagacccg actgcacatg gctcttttgc tggaagaaga
     4381 gcatggctgc gcagaggact aaaatttcat ctgggaaggc ttcttttgac tgtcagtagc
     4441 aggatgtcac cagatgaggg tgctatggga ccacagctgt ctttgttccc attgcaactc
     4501 aaccctgcgg gaggccgcct acatccctga gagccttctg gagcctacag aggagacatt
     4561 ggccagccaa aaggaaagga gtggccaggg tacgacctgg agtagggaag ggaaaaagtt
     4621 cccggaaaga agagaattgg atgagaggtc tcagtggaaa taaaggtttt ctggcattgg
     4681 tcaaggaaac tcgcgttgtg ttctcttacc tgtgttgtcc cttagctgaa tcagttgatt
     4741 tgggctatga agaaccacac acatctgaaa agttctgtta cagccactgt ctcatgtccc
     4801 caaacattct ctggccctaa atctagctta tgtattgtgt caagcacgtg gagacgtgag
     4861 acgtcaaacg aggtcctgtc cccgtggaac tcacacgcta aatgtaagca aatcatagca
     4921 agcctggaga tgctccaaga ggtgctggat gagttagaag gagcaattcc ttccacttag
     4981 ggaatcagat aaggcctcac aaagatggca atgtttgacc taagacctcg gaagatgagt
     5041 cctcagatgg gaagggctca ataagcagag ttgttacaca ggcagcagcc tggcaggagc
     5101 aaagccacag aggacatgtg gccccagtgg gtctgagaaa cccagaggac attggggtga
     5161 gggagtgact ggtgtagaag ctggaagatc agagttacat catgaatttc aggggcccta
     5221 ggcactttag ccttcacgga gctcttgctc cattcaaaaa aaaattaatg ttatgactat
     5281 gttggtataa agatgaatgt aatccag
//
