LOCUS       NM_014568              10344 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens polypeptide N-acetylgalactosaminyltransferase 5
            (GALNT5), transcript variant 1, mRNA.
ACCESSION   NM_014568
VERSION     NM_014568.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10344)
  AUTHORS   Jia,Q., Zhu,Y., Yao,H., Yin,Y., Duan,Z., Zheng,J., Ma,D., Yang,M.,
            Yang,J., Zhang,J., Liu,D., Hua,R., Huo,Y., Fu,X., Sun,Y. and Liu,W.
  TITLE     Oncogenic GALNT5 confers FOLFIRINOX resistance via activating the
            MYH9/ NOTCH/ DDR axis in pancreatic ductal adenocarcinoma
  JOURNAL   Cell Death Dis 15 (10), 767 (2024)
   PUBMED   39433745
  REMARK    GeneRIF: Oncogenic GALNT5 confers FOLFIRINOX resistance via
            activating the MYH9/ NOTCH/ DDR axis in pancreatic ductal
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10344)
  AUTHORS   Guo,H., Zhao,L., Shi,B., Bao,J., Zheng,D., Zhou,B. and Shi,J.
  TITLE     GALNT5 uaRNA promotes gastric cancer progression through its
            interaction with HSP90
  JOURNAL   Oncogene 37 (33), 4505-4517 (2018)
   PUBMED   29743591
  REMARK    GeneRIF: The 5'-end stem-loop motifs of GALNT5 uaRNA promoted the
            binding of HSP90.
REFERENCE   3  (bases 1 to 10344)
  AUTHORS   Stiegelbauer,V., Vychytilova-Faltejskova,P., Karbiener,M.,
            Pehserl,A.M., Reicher,A., Resel,M., Heitzer,E., Ivan,C.,
            Bullock,M., Ling,H., Deutsch,A., Wulf-Goldenberg,A.,
            Adiprasito,J.B., Stoeger,H., Haybaeck,J., Svoboda,M., Stotz,M.,
            Hoefler,G., Slaby,O., Calin,G.A., Gerger,A. and Pichler,M.
  TITLE     miR-196b-5p Regulates Colorectal Cancer Cell Migration and
            Metastases through Interaction with HOXB7 and GALNT5
  JOURNAL   Clin Cancer Res 23 (17), 5255-5266 (2017)
   PUBMED   28533224
  REMARK    GeneRIF: miR-196b-5p inhibition led to significantly increased
            colorectal cancer cell migration/invasion and metastases formation
            in mice, whereas ectopic overexpression showed the opposite
            phenotype. Molecular profiling and target confirmation identified
            an interaction between miR-196b-5p and HOXB7 and GALNT5, which in
            turn regulated colorectal cancer cell migration
REFERENCE   4  (bases 1 to 10344)
  AUTHORS   Campos,D., Freitas,D., Gomes,J., Magalhaes,A., Steentoft,C.,
            Gomes,C., Vester-Christensen,M.B., Ferreira,J.A., Afonso,L.P.,
            Santos,L.L., Pinto de Sousa,J., Mandel,U., Clausen,H.,
            Vakhrushev,S.Y. and Reis,C.A.
  TITLE     Probing the O-glycoproteome of gastric cancer cell lines for
            biomarker discovery
  JOURNAL   Mol Cell Proteomics 14 (6), 1616-1629 (2015)
   PUBMED   25813380
  REMARK    GeneRIF: Two identified candidate O-glycoprotein biomarkers (CD44
            and GalNAc-T5) circulating with the STn glycoform were further
            validated as being expressed in gastric cancer tissue
REFERENCE   5  (bases 1 to 10344)
  AUTHORS   He,H., Shen,Z., Zhang,H., Wang,X., Tang,Z., Xu,J. and Sun,Y.
  TITLE     Clinical significance of polypeptide N-acetylgalactosaminyl
            transferase-5 (GalNAc-T5) expression in patients with gastric
            cancer
  JOURNAL   Br J Cancer 110 (8), 2021-2029 (2014)
   PUBMED   24619076
  REMARK    GeneRIF: of GalNAc-T5 expression in gastric cancer tissues might
            add some prognostic information for patients with this disease and
            lead to a more accurate classification under the TNM stage system
REFERENCE   6  (bases 1 to 10344)
  AUTHORS   Simmons,A.D., Musy,M.M., Lopes,C.S., Hwang,L.Y., Yang,Y.P. and
            Lovett,M.
  TITLE     A direct interaction between EXT proteins and glycosyltransferases
            is defective in hereditary multiple exostoses
  JOURNAL   Hum Mol Genet 8 (12), 2155-2164 (1999)
   PUBMED   10545594
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC142676.1, AY277591.1,
            AC016732.7 and BX117716.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014568.2.
            
            Summary: The protein encoded by this gene is a membrane-bound
            polypeptide N-acetylgalactosaminyltransferase that is found in the
            Golgi. The encoded protein catalyzes the first step in the
            mucin-type O-glycosylation of Golgi proteins, transfering an
            N-acetyl-D-galactosamine residue to a serine or threonine residue
            on the protein receptor. [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.92264.1,
                                           SRR1803612.98391.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259056.5/ ENSP00000259056.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2666              BC142676.1         108-2773
            2667-3254           AY277591.1         2544-3131
            3255-9930           AC016732.7         153268-159943
            9931-10344          BX117716.1         11-424              c
FEATURES             Location/Qualifiers
     source          1..10344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.1"
     gene            1..10344
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /note="polypeptide N-acetylgalactosaminyltransferase 5"
                     /db_xref="GeneID:11227"
                     /db_xref="HGNC:HGNC:4127"
                     /db_xref="MIM:615129"
     exon            1..1832
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /inference="alignment:Splign:2.1.0"
     CDS             379..3201
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /EC_number="2.4.1.41"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pp-GaNTase 5; polypeptide GalNAc transferase 5;
                     protein-UDP acetylgalactosaminyltransferase 5;
                     UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
                     5; UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 5 (GalNAc-T5)"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase 5
                     isoform 1"
                     /protein_id="NP_055383.1"
                     /db_xref="CCDS:CCDS2203.1"
                     /db_xref="GeneID:11227"
                     /db_xref="HGNC:HGNC:4127"
                     /db_xref="MIM:615129"
                     /translation="MNRIRKFFRGSGRVLAFIFVASVIWLLFDMAALRLSFSEINTRV
                     IKEDIVRRERIGFRVQPDQGKIFYSSIKEMKPPLRGHGKGAWGKENVRKTEESVLKVE
                     VDLDQTQRERKMQNALGRGKVVPLWHPAHLQTLPVTPNKQKTDGRGTKPEASSHQGTP
                     KQTTAQGAPKTSFIAAKGTQVVKISVHMGRVSLKQEPRKSHSPSSDTSKLAAERDLNV
                     TISLSTDRPKQRSQAVANERAHPASTAVPKSGEAMALNKTKTQSKEVNANKHKANTSL
                     PFPKFTVNSNRLRKQSINETPLGSLSKDDGARGAHGKKLNFSESHLVIITKEEEQKAD
                     PKEVSNSKTKTIFPKVLGKSQSKHISRNRSEMSSSSLAPHRVPLSQTNHALTGGLEPA
                     KINITAKAPSTEYNQSHIKALLPEDSGTHQVLRIDVTLSPRDPKAPGQFGRPVVVPHG
                     KEKEAERRWKEGNFNVYLSDLIPVDRAIEDTRPAGCAEQLVHNNLPTTSVIMCFVDEV
                     WSTLLRSVHSVINRSPPHLIKEILLVDDFSTKDYLKDNLDKYMSQFPKVRILRLKERH
                     GLIRARLAGAQNATGDVLTFLDSHVECNVGWLEPLLERVYLSRKKVACPVIEVINDKD
                     MSYMTVDNFQRGIFVWPMNFGWRTIPPDVIAKNRIKETDTIRCPVMAGGLFSIDKSYF
                     FELGTYDPGLDVWGGENMELSFKVWMCGGEIEIIPCSRVGHIFRNDNPYSFPKDRMKT
                     VERNLVRVAEVWLDEYKELFYGHGDHLIDQGLDVGNLTQQRELRKKLKCKSFKWYLEN
                     VFPDLRAPIVRASGVLINVALGKCISIENTTVILEDCDGSKELQQFNYTWLRLIKCGE
                     WCIAPIPDKGAVRLHPCDNRNKGLKWLHKSTSVFHPELVNHIVFENNQQLLCLEGNFS
                     QKILKVAACDPVKPYQKWKFEKYYEA"
     exon            1833..1999
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2119
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2255
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2375
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2493
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2817
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..2898
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3060
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..10344
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3233..3238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /note="hexamer: ATTAAA"
     polyA_site      3252
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /note="major polyA site"
     polyA_site      3945
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /note="major polyA site"
     regulatory      5909..5914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /note="hexamer: AATAAA"
     polyA_site      5927
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /note="major polyA site"
     regulatory      10320..10325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /note="hexamer: AATAAA"
     regulatory      10324..10329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
                     /note="hexamer: AATAAT"
     polyA_site      10338
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
     polyA_site      10344
                     /gene="GALNT5"
                     /gene_synonym="GALNAC-T5; GALNACT5"
ORIGIN      
        1 aatctggccc ccaccttttc ttgggcttgt aggaaggtgg acatgggctc ccggagacaa
       61 gacaagtgat atgttgaact gttcggtggc tggaatcaac tgctcctgga gtgacctaag
      121 gccagtgttt atcagaactt agccagggcc agccaagcag gcacagatgc tctgctatga
      181 aatgccacgc aggcagagac tgacaagcgg taggaactga gctttcccct tggactgctg
      241 cttcctgctg tgttcagggg agggggtcac tttctggcaa ctctgctgct gctgctgctg
      301 ctgctgctac ttcagcttcc tctccactca aggtaagcag gctaagggag ggcaggctgc
      361 tagggaaagc tttgtaccat gaacaggatc cgaaagtttt tccgaggaag tgggcgagtc
      421 ttggcattta tctttgtagc ttctgtcatc tggctcctct ttgacatggc agctctccgc
      481 ctctcattca gtgagatcaa cactcgggtc atcaaggaag acattgtgag gagggagcgg
      541 ataggattca gagttcagcc agaccaagga aaaatttttt acagcagcat aaaagagatg
      601 aaacctcccc taaggggaca tgggaaaggg gcatggggca aagagaatgt tagaaaaact
      661 gaggagagtg tgctcaaggt tgaggtggac ttggaccaaa cccagaggga aagaaaaatg
      721 cagaatgccc tgggaagggg caaggttgtg ccgttgtggc atcctgcaca tctgcagacc
      781 ctccctgtga ctcctaacaa gcagaagaca gacgggagag gcaccaaacc tgaagcctcc
      841 tctcaccagg ggacaccaaa gcaaacgaca gctcaggggg ctccaaagac ctcattcata
      901 gcagcaaaag gaactcaggt agtcaaaata tcagtacaca tgggacgtgt cagtttaaaa
      961 caggagcccc ggaagagtca tagtcccagc agtgacacat caaaactagc agctgaaagg
     1021 gacttgaatg tgaccatcag tcttagtact gatagaccaa agcagcgatc acaggcagta
     1081 gcaaacgaga gggcacaccc tgccagcaca gcagtgccga agtctgggga agccatggcc
     1141 ttaaacaaaa ctaagactca gagcaaagaa gtcaatgcaa ataaacacaa agccaatacg
     1201 agtcttcctt ttcctaagtt cactgtcaat tcaaatcgct taaggaagca atctattaat
     1261 gagacacctt tgggaagttt gtcaaaggat gatggagcta gaggggctca tgggaagaaa
     1321 ctcaatttct ctgaaagcca tcttgtgatt ataaccaaag aggaagagca aaaggcagac
     1381 cccaaagagg tctctaattc taaaaccaaa acaatatttc ctaaagtatt gggtaaaagc
     1441 caaagtaaac acatttccag gaatagaagt gagatgtctt cctcttcact tgctccacat
     1501 agagtgccac tgtcccaaac taaccatgct ttaactggag ggctagagcc agcaaaaatc
     1561 aacataactg ccaaagcccc ctctacagaa tacaaccaga gtcatataaa agccctttta
     1621 cctgaagaca gtggaacgca ccaggtgtta agaattgatg tgacactttc tccaagggac
     1681 cccaaagctc cagggcagtt tgggcgtcct gtagttgtcc cccatggaaa ggagaaggag
     1741 gcagaaagaa gatggaaaga aggaaacttc aatgtctacc ttagcgattt gatcccagtg
     1801 gatagagcca ttgaagacac cagacctgct ggatgtgcag agcagctagt tcacaataac
     1861 ctcccaacca ccagtgtcat catgtgcttt gtggatgaag tgtggtccac tctcctgaga
     1921 tctgttcaca gtgtcatcaa tcgctctcct ccacacctca tcaaggagat tctgctggta
     1981 gatgacttca gcaccaaaga ctatctaaaa gataatttgg ataaatacat gtcccagttt
     2041 ccaaaagttc ggattcttcg cctcaaagag agacatggct taataagggc caggctggca
     2101 ggagcacaga atgcaacagg tgatgtgttg acatttttag attctcatgt ggaatgtaac
     2161 gttggttggt tggaacctct tctggaaaga gtttatttaa gtagaaagaa agtggcctgt
     2221 ccagtaatcg aagtcatcaa tgataaggat atgagttaca tgacagtgga taactttcaa
     2281 agaggcatct ttgtgtggcc catgaacttt ggttggagaa caattcctcc agatgtcatt
     2341 gcaaaaaaca gaattaaaga aactgataca ataaggtgcc ctgtcatggc tggtggattg
     2401 ttttctattg acaaaagtta cttttttgaa cttggaacat acgaccctgg ccttgatgtt
     2461 tggggtgggg aaaatatgga gctctcattc aaggtgtgga tgtgtggtgg tgaaattgag
     2521 atcattccct gctcccgagt gggccatata ttcagaaatg acaatccata ttccttcccc
     2581 aaagaccgga tgaagacagt ggagcggaac ttggtgcggg ttgccgaggt ctggctggat
     2641 gagtataagg agctgttcta tggccacgga gaccacctca tcgaccaagg gctagatgtt
     2701 ggcaacctca cccagcaaag ggagctgcga aagaaactga agtgcaaaag tttcaaatgg
     2761 tacttggaga atgtctttcc tgacttaagg gctcccattg tgagagctag tggtgtgctt
     2821 attaatgtgg ctttgggtaa atgcatttcc attgaaaaca ctacagtcat tctggaagac
     2881 tgcgatggga gcaaagagct tcaacaattt aattacacct ggttaagact tattaaatgt
     2941 ggagaatggt gtatagcccc catccctgat aaaggagccg taaggctgca cccttgtgat
     3001 aacagaaaca aagggctaaa atggctgcat aaatcaacat cagtctttca tccagaactg
     3061 gtgaatcaca ttgtttttga aaacaatcag caattattat gcttggaagg aaatttttct
     3121 caaaagatcc tgaaagtagc tgcctgtgac ccagtgaagc catatcaaaa gtggaaattt
     3181 gaaaaatatt atgaagcctg aagtgtaact gatgttttta tatagtaaac ccattaaata
     3241 ctgtgaaaat aacactgaac ttggaaacta tatttctcag cggtagttta aattttcaat
     3301 tttaataaca tttgaatgga agatttttta taaatcacaa tatttggaat accaaaagat
     3361 gactcaggaa aacagtccaa cattggactg aagtccttct tcggaactgg gtggcctttg
     3421 aattgcctgc tttccaccct atgctagacc tcatcatgca aatttccctg tgaaagctaa
     3481 caggtaactg gaaatgaaga cagaaggact tgagaaagca tgaggatatt cccaatgact
     3541 atgtttggta ataatcagct cttctggccc acaagtagga atgatcaatg agaacttaac
     3601 ttagtccttt atttggggat tttttcatca aacaaaaatt tcttgagttc ttatggctag
     3661 aagacctcag atgcccacag ctgtcacgtt tgtgaaatcc ctccagacta catgcatgct
     3721 tacctaacag tttgaaatag tattgatcta ctgctggtaa ccctgcttga tggcagcatt
     3781 ttgatctaaa ttacataatg gtttttccca atctgaatca gtggaaaaaa atttaagtga
     3841 ggaagaagag gccttcaaat gcttatttaa ttctaggtat gaacactatt tcagttcatt
     3901 ttgtgctttt aaaactacag ttttaaagat ttatgatacc aataacttcc tagattcatg
     3961 tggatttttt ttaaggcaat gaaaaaaggc tggattataa cacactgtag taatcaaaaa
     4021 tgcatttaag cattgaatgc actctagtgc agggccaagt aagaggagtt gaaatgagta
     4081 aagcagaaat agagctgctg aaagtttctt ttatataaaa ataataaaat actactttag
     4141 atatagtagc attcacaggg atgaaatatg cgaaaaatgg gttctaaaat atttcaaagg
     4201 gaaaatgaag tgaaggaaac atcatgaaag gggaaaggaa tgaggtaaac aagtcttagg
     4261 aagagagtta agaaaaaatt ccgctggact tggccaaaga aagaagggga tctagtatct
     4321 ctatgaagga aaaaagagta aagccctcag tgtgaaccca gtgagaacac tgacaaattt
     4381 gggaaaagtt aaatactgat ttcatccaaa taaagcctct aatcttaagc ataccaatac
     4441 tttggcatac cagaagacac cttagaaatc aggatagcct ttgcattcat tttggtaaga
     4501 aaactgatgc tgagaggata aattacctaa aaatcttaaa acccaggcaa gttagtcaaa
     4561 gaatcaagat tagaattcag gtttccagag acagggctca ttctaatgcc tcaggtcact
     4621 ggcccgaaca aatctgcttc acagaattcc ttagaaagag atacacaatt ctttgctggg
     4681 attgggtccc tggaggacaa ccatactata ttcttgttaa tatgtttttt ctttttttaa
     4741 atttaaactt ttgttcagtt gagatgattg tgaaactagg tatctttcat tctgactcct
     4801 agtttaacat ttaattttga ctcccaatga gttacgtaaa agcaaaacta taactaagaa
     4861 tgggaaaaag aactatttct gcacatttgt aacatattta agatgttttc ttcatataat
     4921 tgaaaactgc agatgagtaa gagaatgact aggaaatgag atacagttat atgacacata
     4981 atgatgtttt agtcaacaat gaaccacata tttgacattg gtcccaaaag attatattaa
     5041 taatatggta tctttagtgt gcttttctat gtttagacac acaaatactc accatgatgt
     5101 tacaatagcc tacagtgttc aatacagtaa catgcacaag tttgtaacct aggagcaaca
     5161 gggattccat atagcctagg tgtgtagtag gctacctaca ccatctaggt ttgtgtaagt
     5221 acactctgat attcacacaa tgatgaaatt gcctaatgac acatttctca gaatgtattt
     5281 gtgttattaa atgatgcatg actctaattc ttttcaaaac agagccatat ggggcaaggg
     5341 ggatgggggg acgcaagtca gttgtcaaaa gactaattga gttactgaca aactgaacat
     5401 gctaggtgcc tcatgtaatt cttcatgtaa ctaaaaaatg ttgagaggtt tttttccccc
     5461 gggtatatag gctctctttt tatccgaaaa tagtttccac aaagaagtca actctgttct
     5521 gaaaaaaaat gaattgcatt ttgaatacac ttatctttgg gtatatcaac taaaggaagt
     5581 tggatttttt tccttaacag aaacttctgc agtcctctca gttcacatcc tttctgactt
     5641 taccctgaca aacttattat ataaagctat atttaaatct atattgtcaa tataacaaag
     5701 gattgttttt gaacatcaca aatttgttct tggatagaat tttatacatt gcttttcatc
     5761 atatatttgc tcagttactc taagaagcaa ggaactgatc actagttggg aatctatatg
     5821 ggcctaaact tgagtgtatt gatttattat tacatctact accaacattt tcttaagcat
     5881 agccttctaa attttttcag gagattagaa taaaggtata catgctactc ggtcttctgg
     5941 taattctagt gataaacctt tggatgagac aggtcctaat cagcactgaa ttcttcaata
     6001 ggaggctgtg ttacaggagc tacagatttt tccctggatt agcttaggtc attgccttta
     6061 ctttaaaaaa aaaaaaaaaa agtctatgca tcttgttacc ttgaatacaa gggtggtctt
     6121 gataatattt gacagcacta accaacttac caagccatct aagtgcttct gagacttttc
     6181 agtttgcaca atttctttct ccttttcaac agttacccag cgcttctgcc ctactctctt
     6241 gtaagctgac acagttgttg ttggtacaat cttgttctat caccagcatc aaatttgctt
     6301 aatactgctt gttgacatcc cctcagctgt cattcacagc aaaccaccat gtgccatgat
     6361 cacaatgtat tattagcttc gccacactaa tttggaaaca ttcttttaga tattaaaaca
     6421 ccttacttct agtattagtt tgggactgca gaggggcaaa gataccattt acagtatata
     6481 ggagtccaat attcccaacc aaccttgatt tcatgaatgg cttgtaatta tttctagcag
     6541 gcactcatgc aatagaataa gattgaaaca tgccagagag taccatcttt ctttgtttta
     6601 acatctctga ttgaattcct atattcagaa tacaagaaaa aaaatttacc aaccaggcgc
     6661 agtggctcac acctgtaatc ctagcacttt aggaggccaa ggtgggtgga tcatgaggtc
     6721 aggagttcaa gaccagcctg ggcaacatgg tgaaaccccg tctctactaa aaatacaaaa
     6781 attagctggg catggtggtg ggcgcctgta atcccagcta cctgggaggc tgaagcagga
     6841 gaattgcttg tacccgggag gtggaggttg cagtgagctg aaattgcgcc actgcactcc
     6901 agcctagaca acagagcaag actctatctc aaaaaataat aataataatt tttacctcag
     6961 aagaaagccc caaaatcttg gattaaaaca aaaaaatgac attgggtgat gggaaaaaag
     7021 aaaggaacta attatcattg agtgtgtgta ggtactattt gtgtaggtgc tatatgtgtc
     7081 ccatctcact gatgggtaca actcatcaaa tgactctcat tctccctgtt atatgaacaa
     7141 gaaggataac tcccacatac agatgaggaa tttggtaaat tgcccaaggt catcccacaa
     7201 gtaagagata aaacccagtt tccattttat ctggctcaaa aaaaatttct ctcactatac
     7261 catgctgcta tataattaat tttcttcttt acaaagggct gtcatctcag gtgggtgcat
     7321 ttaaaagttt cttggtctca gattactgat gccacagtat tgagatgaga ttgaattaaa
     7381 cccctttggc ctcttttgga tgttgtataa acagaaaaaa gaagcatggt ctctctctct
     7441 ctgtggtaac caattgatgt gtaggtataa acatggctac ccccacatgt tttgctgtga
     7501 tctatctctt tgacttcatg cagaacctat tctttttcat ctcctggacc aaatgtgaaa
     7561 gaaagaagtg gacatgtgga ggattctttc tctgtgaata atattgaaaa agctccattt
     7621 tctggggaaa tacccatggt tcattgtctg atgccaagaa agaattcagg acacagacac
     7681 acatgaggag tgggtttagg agtggaaagt ttaatagata aagaagagag tgagaaagct
     7741 tcctcatgtt gagaaagaca gttgctcaag agagggtttt ctgggtttgg ggcaagattt
     7801 gattgatttc atacagaggc ttgaggaggc ggtgattgat atacataggg cccggggatt
     7861 ggtttaacca ggtatactac ttacatagcc ggtgaaaaga ctggccctcc caccctaacc
     7921 ttttattatg caaatgcatc ttctacctgg ctgtcaccat gacatttgca cacgtggctt
     7981 cacttcacca gtgccatgtc acccacacac ctggtgacaa ggaaaaggga gcaggaatca
     8041 ccatattgaa tgtgcctggc ttccaggtac agctgctagc tttacatatg ggagcctcta
     8101 gcttgcatat ctatacttgc aacttgactt ttcaggctgc tttttgttag aaaataagtg
     8161 gcttgggggc tgctttttat taaaggaaaa atccaccgag aactatttta ccctttctaa
     8221 tggcctaaaa taaattttta atgactcctg tattaatatt accaaccctt gatccctcca
     8281 acctttaatc aaagctagca gattgctcat cttgaacaga aataaaaagt taaaaagttg
     8341 gagtccttta aaacacaaac catgactttt tattcctact cattgtgtag gttgtcacta
     8401 ctgtgctttt gcaacaactt ttgcatgggt tactcaatag ttgctacaag acaaaatgcc
     8461 ttacaattag aaaaaaaaat taaccagaga tattgtacaa aatatttatt ttttgacagt
     8521 tttgaataag ccatataaag tattatatat ccctaatgaa gcttaatgga tagtattcca
     8581 ggtgttggtg gtgtctgtat ctcaaagaaa gaaaaaaata acatcacact aaacagattt
     8641 aatgcctctg ttttcaacct aatggaacaa tagttatcat ttcaattaga gtcgctttgc
     8701 aagtttatgt gaatctttgc tttgtaaaaa cacatacaaa acacaaggga aaattctcat
     8761 tttccagcaa atacagcaac ttctaatatg ctgtttctaa taatgagtca ccatcaaata
     8821 agtaataaat atttttttca aaaacaagag ctttctgttt tattattgat tgacagatat
     8881 ttaccagttt aaggatattg gtcataagca tctatataat aaacccttta tattagatgt
     8941 taaattaaaa tttttcatag catgaataga tttttaagtg accactcaaa aacatagcaa
     9001 tttttgtaaa tatactgtat gtgtgtgtat atatatatat atatatatat attttttttt
     9061 ttgatgcttt gatctggaag aaagaaatat caagagtttc tattcacaac ataaagaaaa
     9121 taaaatgttt ttagatattt ttaactcttt caggtgtata gctttgtctg catctggcct
     9181 tctgcacaaa agtatctcaa gtgaacttac actctggata ccattttcca aacttgaagg
     9241 agtaatcaag ttcttaatta tcagggtgct tgttatttag ttgaagatta cacacatgtc
     9301 ttctgcttca aacaactacc ccaaatttgc tagttttata catattagct taaaaacaag
     9361 agaagccaaa gattaagtaa gtgaattgtg ttaaagattg cctgaaaaca tttgctaagg
     9421 ggagaataaa actaaaactg tggagtataa aggatgttgg aattaaacat ttttaagtac
     9481 tttttctttt gcatctgatc gactgaagtt attataaaga aggaatcaag tatgtaactt
     9541 taaattctag gtaaacatcc aaattacttt ctaaattcat ttccaaaatt ctcctgtgct
     9601 ggcagttagc tactagagat catcatttga ttttgtagtt tgccatgttc tgagtgagtt
     9661 cagctgctta ctactaccca tgtcattgtg tttgtattga ttgcctggct cagttatctc
     9721 atgttcttca tgaactatat acacattttc attgtcttta aacaatactg agttttgaag
     9781 ttaagtagaa tattgtaggg gttatcagaa acccatattc attgtggtat gtttctgtct
     9841 gatactttaa tattggtaaa tatagttttt gacattgcat tttacaatcc tattgttttt
     9901 tagagtgatg aaagttcaag ttttaagaga agtggttgcc tttctcatac tgtcaaacat
     9961 atttcttctt tattatactc tggtgcttta tccttctcca taattctcta ttattactta
    10021 ttttaaatgt tttccctatc acattgaaaa acttaaatgt ccgttctcca tttgaaaata
    10081 tgccaaaagt atgatcccat gtaaatatgc agaaacgatt gctatgaaaa tgtcagcata
    10141 gtttaaatgt attactctga tgattacaga gatttcttca agttgttcgt gttaagatgc
    10201 atcttaaaca tgatctcagt tccttaaaaa atgataaaaa tttttcatgt atattacata
    10261 tctacctacc agaaatcctt tttacaattt tatatacaat cattttaaga cctttttgaa
    10321 ataaataatg caaatgaact aaaa
//
