LOCUS       NM_004481               4423 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens polypeptide N-acetylgalactosaminyltransferase 2
            (GALNT2), transcript variant 1, mRNA.
ACCESSION   NM_004481
VERSION     NM_004481.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4423)
  AUTHORS   Trischitta,V., Antonucci,A., Adamski,J., Prehn,C., Menzaghi,C.,
            Marucci,A. and Di Paola,R.
  TITLE     GALNT2 expression is associated with glucose control and serum
            metabolites in patients with type 2 diabetes
  JOURNAL   Acta Diabetol 61 (8), 1007-1013 (2024)
   PUBMED   38627282
  REMARK    GeneRIF: GALNT2 expression is associated with glucose control and
            serum metabolites in patients with type 2 diabetes.
            Erratum:[Acta Diabetol. 2024 Aug;61(8):1015. doi:
            10.1007/s00592-024-02346-6.. PMID: 39115727]
REFERENCE   2  (bases 1 to 4423)
  AUTHORS   Dong,X., Leng,Y., Tian,T., Hu,Q., Chen,S., Liu,Y. and Shen,L.
  TITLE     GALNT2, an O-glycosylating enzyme, is a critical regulator of
            radioresistance of non-small cell lung cancer: evidence from an
            integrated multi-omics analysis
  JOURNAL   Cell Biol Toxicol 39 (6), 3159-3174 (2023)
   PUBMED   37597090
  REMARK    GeneRIF: GALNT2, an O-glycosylating enzyme, is a critical regulator
            of radioresistance of non-small cell lung cancer: evidence from an
            integrated multi-omics analysis.
REFERENCE   3  (bases 1 to 4423)
  AUTHORS   Di Paola,R., Marucci,A., Mangiacotti,D., Antonucci,A., Fontana,A.,
            Wang,X., Qi,L., Menzaghi,C. and Trischitta,V.
  TITLE     Leveraging Genetics to Address the Role of GALNT2 on Atherogenic
            Dyslipidemia
  JOURNAL   Adv Biol (Weinh) 7 (9), e2200319 (2023)
   PUBMED   36861373
  REMARK    GeneRIF: Leveraging Genetics to Address the Role of GALNT2 on
            Atherogenic Dyslipidemia.
REFERENCE   4  (bases 1 to 4423)
  AUTHORS   Liu,Y., Chen,P., Xu,L., Wang,B., Zhang,S. and Wang,X.
  TITLE     GALNT2 sustains glioma stem cells by promoting CD44 expression
  JOURNAL   Aging (Albany NY) 15 (6), 2208-2220 (2023)
   PUBMED   37000153
  REMARK    GeneRIF: GALNT2 sustains glioma stem cells by promoting CD44
            expression.
REFERENCE   5  (bases 1 to 4423)
  AUTHORS   Liao,Y.Y., Chuang,Y.T., Lin,H.Y., Lin,N.Y., Hsu,T.W., Hsieh,S.C.,
            Chen,S.T., Hung,J.S., Yang,H.J., Liang,J.T., Huang,M.C. and
            Huang,J.
  TITLE     GALNT2 promotes invasiveness of colorectal cancer cells partly
            through AXL
  JOURNAL   Mol Oncol 17 (1), 119-133 (2023)
   PUBMED   36409270
  REMARK    GeneRIF: GALNT2 promotes invasiveness of colorectal cancer cells
            partly through AXL.
REFERENCE   6  (bases 1 to 4423)
  AUTHORS   Rottger,S., White,J., Wandall,H.H., Olivo,J.C., Stark,A.,
            Bennett,E.P., Whitehouse,C., Berger,E.G., Clausen,H. and Nilsson,T.
  TITLE     Localization of three human polypeptide GalNAc-transferases in HeLa
            cells suggests initiation of O-linked glycosylation throughout the
            Golgi apparatus
  JOURNAL   J Cell Sci 111 (Pt 1), 45-60 (1998)
   PUBMED   9394011
REFERENCE   7  (bases 1 to 4423)
  AUTHORS   Muller,S., Goletz,S., Packer,N., Gooley,A., Lawson,A.M. and
            Hanisch,F.G.
  TITLE     Localization of O-glycosylation sites on glycopeptide fragments
            from lactation-associated MUC1. All putative sites within the
            tandem repeat are glycosylation targets in vivo
  JOURNAL   J Biol Chem 272 (40), 24780-24793 (1997)
   PUBMED   9312074
REFERENCE   8  (bases 1 to 4423)
  AUTHORS   Wandall,H.H., Hassan,H., Mirgorodskaya,E., Kristensen,A.K.,
            Roepstorff,P., Bennett,E.P., Nielsen,P.A., Hollingsworth,M.A.,
            Burchell,J., Taylor-Papadimitriou,J. and Clausen,H.
  TITLE     Substrate specificities of three members of the human
            UDP-N-acetyl-alpha-D-galactosamine:Polypeptide
            N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3
  JOURNAL   J Biol Chem 272 (38), 23503-23514 (1997)
   PUBMED   9295285
REFERENCE   9  (bases 1 to 4423)
  AUTHORS   Bennett,E.P., Hassan,H. and Clausen,H.
  TITLE     cDNA cloning and expression of a novel human
            UDP-N-acetyl-alpha-D-galactosamine. Polypeptide
            N-acetylgalactosaminyltransferase, GalNAc-t3
  JOURNAL   J Biol Chem 271 (29), 17006-17012 (1996)
   PUBMED   8663203
REFERENCE   10 (bases 1 to 4423)
  AUTHORS   White,T., Bennett,E.P., Takio,K., Sorensen,T., Bonding,N. and
            Clausen,H.
  TITLE     Purification and cDNA cloning of a human
            UDP-N-acetyl-alpha-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferase
  JOURNAL   J Biol Chem 270 (41), 24156-24165 (1995)
   PUBMED   7592619
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC041120.1, X85019.1,
            BC050583.1 and BE328743.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004481.4.
            
            Summary: This gene encodes a member of the glycosyltransferase 2
            protein family. Members of this family initiate mucin-type
            O-glycoslation of peptides in the Golgi apparatus. The encoded
            protein may be involved in O-linked glycosylation of the
            immunoglobulin A1 hinge region. This gene may influence
            triglyceride levels, and may be involved Type 2 diabetes, as well
            as several types of cancer. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041120.1, LC043140.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366672.5/ ENSP00000355632.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BC041120.1         30-72
            44-1759             X85019.1           1-1716
            1760-4421           BC050583.1         1369-4030
            4422-4423           BE328743.1         19-20               c
FEATURES             Location/Qualifiers
     source          1..4423
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..4423
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /note="polypeptide N-acetylgalactosaminyltransferase 2"
                     /db_xref="GeneID:2590"
                     /db_xref="HGNC:HGNC:4124"
                     /db_xref="MIM:602274"
     exon            1..169
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1759
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /EC_number="2.4.1.41"
                     /note="pp-GaNTase 2; polypeptide GalNAc transferase 2;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 2 (GalNAc-T2);
                     UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
                     2"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase 2
                     precursor"
                     /protein_id="NP_004472.1"
                     /db_xref="CCDS:CCDS1582.1"
                     /db_xref="GeneID:2590"
                     /db_xref="HGNC:HGNC:4124"
                     /db_xref="MIM:602274"
                     /translation="MRRRSRMLLCFAFLWVLGIAYYMYSGGGSALAGGAGGGAGRKED
                     WNEIDPIKKKDLHHSNGEEKAQSMETLPPGKVRWPDFNQEAYVGGTMVRSGQDPYARN
                     KFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVL
                     KKSPPHLIKEIILVDDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAK
                     VLTFLDSHCECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDW
                     NLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGE
                     NLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEY
                     KNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVPDHQDIAFGAL
                     QQGTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLI
                     KLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFT
                     LNLQQ"
     exon            170..263
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /inference="alignment:Splign:2.1.0"
     exon            264..417
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /inference="alignment:Splign:2.1.0"
     exon            418..516
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /inference="alignment:Splign:2.1.0"
     exon            517..584
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /inference="alignment:Splign:2.1.0"
     exon            585..650
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /inference="alignment:Splign:2.1.0"
     exon            651..772
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /inference="alignment:Splign:2.1.0"
     exon            773..860
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /inference="alignment:Splign:2.1.0"
     exon            861..948
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1052
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1179
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1272
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1356
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1483
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1603
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..4423
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2359..2364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /note="hexamer: TATAAA"
     polyA_site      2381
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /note="major polyA site"
     regulatory      4400..4405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /note="hexamer: AATAAA"
     polyA_site      4423
                     /gene="GALNT2"
                     /gene_synonym="CDG2T; GalNAc-T2"
                     /note="major polyA site"
ORIGIN      
        1 actcgcgagc agcggcggcc ccgccggcgg ccgagttggg agaatgcggc ggcgctcgcg
       61 gatgctgctc tgcttcgcct tcctgtgggt gctgggcatc gcctactaca tgtactcggg
      121 gggcggctct gcgctggccg ggggcgcggg cggcggcgcc ggcaggaagg aggactggaa
      181 tgaaattgac cccattaaaa agaaagacct tcatcacagc aatggagaag agaaagcaca
      241 aagcatggag accctccctc cagggaaagt acggtggcca gactttaacc aggaagctta
      301 tgttggaggg acgatggtcc gctccgggca ggacccttac gcccgcaaca agttcaacca
      361 ggtggagagt gataagcttc gaatggacag agccatccct gacacccggc atgaccagtg
      421 tcagcggaag cagtggcggg tggatctgcc ggccaccagc gtggtgatca cgtttcacaa
      481 tgaagccagg tcggccctac tcaggaccgt ggtcagcgtg cttaagaaaa gcccgcccca
      541 tctcataaaa gaaatcatct tggtggatga ctacagcaat gatcctgagg acggggctct
      601 cttggggaaa attgagaaag tgcgagttct tagaaatgat cgacgagaag gcctcatgcg
      661 ctcacgggtt cggggggccg atgctgccca agccaaggtc ctgaccttcc tggacagtca
      721 ctgcgagtgt aatgagcact ggctggagcc cctcctggaa agggtggcgg aggacaggac
      781 tcgggttgtg tcacccatca tcgatgtcat taatatggac aactttcagt atgtgggggc
      841 atctgctgac ttgaagggcg gttttgattg gaacttggta ttcaagtggg attacatgac
      901 gcctgagcag agaaggtccc ggcaggggaa cccagtcgcc cctataaaaa cccccatgat
      961 tgctggtggg ctgtttgtga tggataagtt ctattttgaa gaactgggga agtacgacat
     1021 gatgatggat gtgtggggag gagagaacct agagatctcg ttccgcgtgt ggcagtgtgg
     1081 tggcagcctg gagatcatcc cgtgcagccg tgtgggacac gtgttccgga agcagcaccc
     1141 ctacacgttc ccgggtggca gtggcactgt ctttgcccga aacacccgcc gggcagcaga
     1201 ggtctggatg gatgaataca aaaatttcta ttatgcagca gtgccttctg ctagaaacgt
     1261 tccttatgga aatattcaga gcagattgga gcttaggaag aaactcagct gcaagccttt
     1321 caaatggtac cttgaaaatg tctatccaga gttaagggtt ccagaccatc aggatatagc
     1381 ttttggggcc ttgcagcagg gaactaactg cctcgacact ttgggacact ttgctgatgg
     1441 tgtggttgga gtttatgaat gtcacaatgc tgggggaaac caggaatggg ccttgacgaa
     1501 ggagaagtcg gtgaagcaca tggatttgtg ccttactgtg gtggaccggg caccgggctc
     1561 tcttataaag ctgcagggct gccgagaaaa tgacagcaga cagaaatggg aacagatcga
     1621 gggcaactcc aagctgaggc acgtgggcag caacctgtgc ctggacagtc gcacggccaa
     1681 gagcgggggc ctaagcgtgg aggtgtgtgg cccggccctt tcgcagcagt ggaagttcac
     1741 gctcaacctg cagcagtagg agggtccggg aggccctgcc gtcctgtctc ctgcaccatt
     1801 gggtggagtc tggtgatcac attattgatt atgtttctta aactttccgc gaaactaata
     1861 tacctcagta ttccatcatg gtctgaaagt caaacttcgg caaggcacgg acgactgtgc
     1921 agacacagca gcggcaagaa gcgagaactg ccctccccct cctctcggtg cagcccagcc
     1981 gggccccctt ccccaggccg gagcgcccct cttccttcca gctttcactt ctgccggctc
     2041 cgcaactgag tgacacccag cgacaaccga ctggggagtg gtagaagcaa ctgaacggat
     2101 gcgtgcgagc tgaggacagg gcgggaggag ggggcacaca tgccccaggg gagcgaggag
     2161 aactcttgaa atctccattt tcaatccctt cgaaatcacg tatggtttcc acaaagccga
     2221 gtcgtgtcac gtggcaggtt tacgtcaata gtccctctct ctgctcctcc attcgcaagt
     2281 gtcttcctgg gccagactcc cctccacctc atgtacttgc tatattgagg atgaagtttt
     2341 ctatggtggg acactaaata taaagctata tagagaaaga atgtacggtc agttccctat
     2401 ggtttctgta gatcatcgtc atcttgtata ttccccacaa agccgttcgc agcttccggg
     2461 agaaggggcc agagcccggt ggggccagtt tctcacagag ggaggaggtg gcctttgtcc
     2521 cctggagccc gatcagccag ttggtgctac tgctgtggcc agctgggggg cttcctccag
     2581 accaccggcc tcggccccgg catccctgtt gggcgtcagc ctgagagtcc ctactgtgcg
     2641 tcagaatcca ccttgcgtgc tgtgcgtatc tgtgaacctg gagcggttac ttattttgac
     2701 agatatcact ttgggtcttt ttacattaaa tttcttttct ctaaggaata taagacatac
     2761 cccatagctc tgtgtgagcc agcaataccg ctgccccctg gcgacagggc agaccaatga
     2821 tgccaggcag ctgtcacacg ctagtattgg cttcattgtg atctgagccc tgcacgctgg
     2881 gccttcagaa ttaatggcca gcagtgtcag ggatgagccc gtcagccagg gcacaggcct
     2941 ggctcacagt cctgcacacc tgctggcctg gggagctcca gccaggcagc gagtcctgcc
     3001 ccgcccgcag ctccctccca caccccgcct ggccaagatg actgcttcag ggggctttgg
     3061 ggaaagaatt aggaagggtc agaaccaaac aatacctgct catttacact gaggattcag
     3121 ggcgggagac aggagccttg gggtcctgtt aaaccacaga cagttatgaa ctgaaagtca
     3181 taacggggag aggtgcctgg cttctacctg ggtgctcagg aatgttcctc gtcacccctg
     3241 ccactctgtg gtcggtgccc tgcttcctcc tccactcctg gccgccttct ccagcgccgc
     3301 acacacagat gctcagtctc agagaggctg gcacggcctg gcagtctgag aaaagcgtca
     3361 gttaggcaca cctgcaggcc cctcggtggg acagcggcgg ccttggagtt aggagccacc
     3421 ctgggaggtt gtgccggtgc catgctcctc cctgtgtctt gtatgaaagg ggccactgtg
     3481 tgtcttcctc cccggcggga gccccacatg tgtgcactgt aggacagcgg ccccgaggtg
     3541 gaagcctggc tggagggctg ccctataggt cttctcttcc cgcctcccct gccatgcaac
     3601 cagatgtgtt gtgagtgggc agcgtgcccc cacgctggag taactccgca cgcttctgtc
     3661 tttcacggtg ggcgctcggg gggagcctga ggaaaacccc cttaggtacc tgtgcgaggc
     3721 tgtggagtgc aggccagagc agggtgtgcg tagcccccag cacccaggtt cttctgtcag
     3781 accctgtgac ctgcgagctg ctactactgt aaggagggaa atggatgaat ctggctcgtt
     3841 ttaaaatcac gttttctgac gaatcctttg ccccttcacc tttaccccgc ccgcacccct
     3901 aggccctctc agccttccta tcatcccacg tgtctaccca gacccttgtg cggcccatgc
     3961 cctgggggcg gcgtcctgtc cctgagctgg gaggcggctt tggatggtcc gggcgtcaag
     4021 agcaggggtg ggccggggag gggtcctttg cggtgagcta tgtttacatg acacagtgtg
     4081 ccaaagtgac ttactgcggt tgcgttagtt tttaatcatc aggactatct caccctccca
     4141 ctcctgtttt taaaactcag aattctttcc taagagccct tcgagcaaag cgtgccgaag
     4201 ttagttgtct tctctgtgct ggtcctttct tatgtcctca taaaagctca gatgatggta
     4261 tctgtgagta tgttttgcaa attcaaaata tagtttggta attttttttt ccagttgatt
     4321 tttaaaaaga actgctgtac agagcttgta ctttgtccat tttatagatg gaaaccatcc
     4381 ttgaaaattg tttaacttaa ataaagagaa gatactttct aga
//
