LOCUS       NM_001168368            4108 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens polypeptide N-acetylgalactosaminyltransferase 16
            (GALNT16), transcript variant 1, mRNA.
ACCESSION   NM_001168368
VERSION     NM_001168368.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4108)
  AUTHORS   Peng,C., Tan,Y., Yang,P., Jin,K., Zhang,C., Peng,W., Wang,L.,
            Zhou,J., Chen,R., Wang,T., Jin,C., Ji,J., Feng,Y., Tang,J. and
            Sun,Y.
  TITLE     Circ-GALNT16 restrains colorectal cancer progression by enhancing
            the SUMOylation of hnRNPK
  JOURNAL   J Exp Clin Cancer Res 40 (1), 272 (2021)
   PUBMED   34452628
  REMARK    GeneRIF: Circ-GALNT16 restrains colorectal cancer progression by
            enhancing the SUMOylation of hnRNPK.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4108)
  AUTHORS   Wu,H., He,G., Song,T., Zhang,Y., Chen,X., Chen,H., Xiong,W.,
            Sun,C., Zhao,C. and Chen,Y.
  TITLE     Evaluation of GALNT16 polymorphisms to breast cancer risk in
            Chinese population
  JOURNAL   Mol Genet Genomic Med 7 (8), e848 (2019)
   PUBMED   31286696
  REMARK    GeneRIF: rs2105269 and rs72625676 were associated with higher
            breast cancer (BC) risk in younger patients with age </=51. For
            rs1275678 polymorphism, there was a significantly decreased risk of
            BC among older patients. rs2105269 was associated with tumor size
            and lymph node metastasis. Study suggests that GALNT16
            polymorphisms are associated with BC susceptibility in Chinese
            population.
REFERENCE   3  (bases 1 to 4108)
  AUTHORS   Raman,J., Guan,Y., Perrine,C.L., Gerken,T.A. and Tabak,L.A.
  TITLE     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferases: completion of the family tree
  JOURNAL   Glycobiology 22 (6), 768-777 (2012)
   PUBMED   22186971
  REMARK    Erratum:[Glycobiology. 2015 Apr;25(4):465. doi:
            10.1093/glycob/cwv003.. PMID: 25715345]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA493083.1, AK289745.1, AL359317.3, AK091426.1 and AL157996.8.
            
            On Nov 22, 2018 this sequence version replaced NM_001168368.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.2925.1,
                                           SRR1660807.41969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448469.8/ ENSP00000402970.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                DA493083.1         195-242
            49-733              AK289745.1         2-686
            734-734             AL359317.3         204006-204006
            735-2313            AK289745.1         688-2266
            2314-2684           AK091426.1         641-1011
            2685-2685           AL157996.8         165624-165624       c
            2686-4108           AK091426.1         1013-2435
FEATURES             Location/Qualifiers
     source          1..4108
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.1"
     gene            1..4108
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /note="polypeptide N-acetylgalactosaminyltransferase 16"
                     /db_xref="GeneID:57452"
                     /db_xref="HGNC:HGNC:23233"
                     /db_xref="MIM:615132"
     exon            1..310
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1810
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /EC_number="2.4.1.41"
                     /note="putative polypeptide
                     N-acetylgalactosaminyltransferase-like protein 1;
                     polypeptide GalNAc transferase 16;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 16; galNAc-T-like
                     protein 1; pp-GaNTase-like protein 1; polypeptide GalNAc
                     transferase-like protein 1; protein-UDP
                     acetylgalactosaminyltransferase-like protein 1;
                     UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase-like protein 1;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase-like 1"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase
                     16"
                     /protein_id="NP_001161840.1"
                     /db_xref="CCDS:CCDS32107.1"
                     /db_xref="GeneID:57452"
                     /db_xref="HGNC:HGNC:23233"
                     /db_xref="MIM:615132"
                     /translation="MRKIRANAIAILTVAWILGTFYYLWQDNRAHAASSGGRGAQRAG
                     RRSEQLREDRTIPLIVTGTPSKGFDEKAYLSAKQLKAGEDPYRQHAFNQLESDKLSPD
                     RPIRDTRHYSCPSVSYSSDLPATSVIITFHNEARSTLLRTVKSVLNRTPANLIQEIIL
                     VDDFSSDPEDCLLLTRIPKVKCLRNDRREGLIRSRVRGADVAAATVLTFLDSHCEVNT
                     EWLPPMLQRVKEDHTRVVSPIIDVISLDNFAYLAASADLRGGFDWSLHFKWEQIPLEQ
                     KMTRTDPTRPIRTPVIAGGIFVIDKSWFNHLGKYDAQMDIWGGENFELSFRVWMCGGS
                     LEIVPCSRVGHVFRKRHPYNFPEGNALTYIRNTKRTAEVWMDEYKQYYYEARPSAIGK
                     AFGSVATRIEQRKKMNCKSFRWYLENVYPELTVPVKEALPGIIKQGVNCLESQGQNTA
                     GDFLLGMGICRGSAKNPQPAQAWLFSDHLIQQQGKCLAATSTLMSSPGSPVILQMCNP
                     REGKQKWRRKGSFIQHSVSGLCLETKPAQLVTSKCQADAQAQQWQLLPHT"
     exon            311..468
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..567
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..635
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..701
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..823
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            824..911
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..996
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1100
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1227
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1320
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1404
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1546
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1672
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..4108
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2619..2624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /note="hexamer: ATTAAA"
     polyA_site      2639
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
     regulatory      4086..4091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /note="hexamer: AATAAA"
     polyA_site      4108
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /note="major polyA site"
ORIGIN      
        1 ctcctttttc tgctctgcag gactgagcag ctaggcgcga gcgaaaacaa acagctgggg
       61 ctgcgagcgc ccccgccccg gccccgagag cacgccggcc cagtccccca cctggggcgc
      121 ccgtctgccc accatgagga agatccgcgc caatgccatc gccatcctga ccgtagcctg
      181 gatcctgggc actttctact acttatggca ggacaaccga gcccacgcag catcctccgg
      241 cggccggggc gcgcagaggg caggcaggag gtcggagcag ctccgcgagg accgcaccat
      301 cccgctcatt gtgacaggaa ctccctcgaa aggctttgat gagaaggcct acctgtcggc
      361 caagcagctg aaggctggag aggaccccta cagacagcac gccttcaacc agctggagag
      421 tgacaagctg agcccagacc ggcccatccg ggacacccgc cattacagct gcccatctgt
      481 gtcctactcc tcggacctgc cagccaccag cgtcatcatc accttccaca atgaggcccg
      541 ttccaccctg ctgcgcacag tgaagagtgt cctgaaccga actcctgcca acttgatcca
      601 ggagatcatt ttagtggatg acttcagctc agatccggaa gactgtctac tcctgaccag
      661 gatccccaag gtcaagtgcc tgcgcaatga tcggcgggaa gggctgatcc ggtcccgagt
      721 gcgtggggcg gacgtggctg cagctaccgt tctcaccttt ctggatagcc actgcgaagt
      781 gaacaccgag tggctgccgc ccatgctgca gcgggtgaag gaggaccaca cccgcgtggt
      841 gagtcccatc attgatgtca tcagtctgga taattttgcc taccttgcag catctgctga
      901 ccttcgtgga gggttcgact ggagcctgca tttcaagtgg gagcagatcc ctcttgagca
      961 gaagatgacc cggacagacc ccaccaggcc cataaggacg cctgtcatag ctggaggaat
     1021 cttcgtgatc gacaagtcct ggtttaacca cttgggaaag tatgatgccc agatggacat
     1081 ctggggggga gagaattttg agctctcctt cagggtgtgg atgtgtggtg gcagtctgga
     1141 gatcgtcccc tgcagccggg tgggccatgt cttcaggaaa cggcacccct acaacttccc
     1201 tgagggtaat gccctcacct acatcaggaa tactaagcgc actgcagaag tgtggatgga
     1261 tgaatacaag caatactact atgaggcccg gccctcggcc atcgggaagg ccttcggcag
     1321 tgtggctacg cggatagagc agaggaagaa gatgaactgc aagtccttcc gctggtacct
     1381 ggagaacgtc tacccagagc tcacggtccc cgtgaaggaa gcactccccg gcatcattaa
     1441 gcagggggtg aactgcttag aatctcaggg ccagaacaca gctggtgact tcctgcttgg
     1501 aatggggatc tgcagagggt ctgccaagaa cccgcagccc gcccaggcat ggctgttcag
     1561 tgaccacctc atccagcagc aggggaagtg cctggctgcc acctccacct taatgtcctc
     1621 ccctggatcc ccagtcatac tgcagatgtg caaccctaga gaaggcaagc agaaatggag
     1681 gagaaaagga tctttcatcc agcattcagt cagtggcctc tgcctggaga caaagcctgc
     1741 ccagctggtg accagcaagt gtcaggctga cgcccaggcc cagcagtggc agctgttgcc
     1801 acacacatga cggtagccct ggggcctcct gtaccttttg catgagactt cgggaccgga
     1861 agggggttag ggtgggggag tgcaaagtgg gctgttccca tctcctcaca tttctgccag
     1921 gaccatcagc aaatacccac catgacacac gttctccaaa gcttgttcta ggagggcgca
     1981 ggcgggcacg ccccgatgcc ctcagtgctg tcctggcctt gccccgggag aggagatggt
     2041 cagggtgctg gactgttgct gggtagagac tgagtaggtg cccctggccc tttgtcctct
     2101 cccttggcgc ttcttggggc tgggacaata gtgtgtggtc tctcccttgt tgcccggaga
     2161 aagcaaggac agaagcccac acaggggtct tttgggtcat gaggcccagc tgtgcaggca
     2221 ggcagggcca ggggaaattg ggcagcatgg atggagaggc tgaaggctgg gaagagggaa
     2281 ggggagaggg gcagcctgca ggggtagctg aagaacagga aggaggtgag aagcccggtg
     2341 acctgtcaga gatgccaagc ccagggtggc actgggttgg gtggggacgg atggtgtctt
     2401 ggcagcaaag gatgggtaat ttgcaaatga acatggatag aagagcagca aagcaccaaa
     2461 agaacaaggt ctcttaccca ggacacagtc ccttccacac tttaccagcc ccagggtctg
     2521 agcccgacgc tgcctcttcc ggtcctgtgc ctgtgggtgc ccacattctt agcaagaggc
     2581 tgcagaggga tctttagggg aagattcggg cgtagtttat taaacagact ccacttctat
     2641 ttggccatgt gtcaggctga gacctctctc tcgggcatta atgaacagct agtgccctgt
     2701 ccctgccgcc aggacccact gaaaggacgg gtagccacac acatccctga gtagtcccag
     2761 cctcatttgt catttttgac tcctgctttc tcaaaggttt ttgcctctgt caatacagca
     2821 tcatgggtgg ttggaaagaa gggaacttcc cttctggacc aagaacagcc cctaagtcat
     2881 tagggttcaa cctcaccctt attcccctcc ccgctacagg agcccctaag tcattagggc
     2941 tcaacctcac ccttattccc ctccctacta caggagggat tttcttgaag ggtcagctat
     3001 tgcactgtgc tgggaggctg gctgtggctc ctgtttgtga agagaactcc cagttccttt
     3061 tcacagccgc tgagaacaca tccacacatc taccccacgg ccttgtcttg gaactgctcc
     3121 tgctatcccc acaccctgct tcctcacccc actggctctt gggcaaatga ctgttggtac
     3181 caggaccctg ggggtctccc ctacaaagca gaccagcctg gggcagatat acctaccaca
     3241 ggagccccct gtctttcata ggccaaggat ccacataccc atagagttca tggattctag
     3301 agggtctagg aatctcttga aattgtccct aaaatactgc atgtgtgtgc atacatgcat
     3361 tttcctgggg aaaaagtcca tggcttctaa aagaggtccc tgatccccaa agggcctgaa
     3421 cctctgctct ggattgaagc cactgtctgc ccaagctgcc accccctaat cttcctccct
     3481 ggcgtgctca aactgccatc gcctgctccc tccacacggc ccttggggtc agcagccaag
     3541 tgtctgtggt ccgcagcacc tgctctggag ggctctccag cagtttcgcc tcctgactct
     3601 caccagcgtc ctctcggcag cactcccgtg cccaagtgca cccctctgga cttgccagcg
     3661 caggcccctt cgctcccagg gccatgcttt gcctgtcctc tgtcgtgatg tttcttccgc
     3721 agccaggtgc agcctcagat cccctgttca tctgggaagc ctcctgccac agcttaggac
     3781 agaactgggc ccagggcaaa ggcctctccc cagaggatgg actagaaggc ctgggccaca
     3841 ctcgggcatg gacctttggg gctggggagc cggggctgcg cctgttgaat gtaagaggac
     3901 tgctgaccag agggccttca agagggtctc tctgtccttt gctgtggtca gatcaggctc
     3961 tgcacttatc agccggtcct ttgtggcaac gcagccctgt tctgtttttg cttttcctct
     4021 tcttgaccaa agcatgtgcc actagctgtc cttgaggacc tcgtctttat gaaacacaca
     4081 cctggaataa aaccacttct tacatgtc
//
